Negative / Null Result ReportOpen accessMedicine
Ksenija Vučićević, Vladimir Jakovljević, Nataša Čolović et al. · 2016 · Journal of Medical Biochemistry
Summary Background: In chronic lymphocytic leukemia (CLL), in vivo apoptotic resistance of malignant B lymphocytes results, in part, from the intrinsic defects of their apoptotic machinery. These include genetic alterations and aberrant expression of many apoptosis regulators, among which the Bcl2 family members play a central role. Aim: The aim of this study was to investigate the association of pro-apoptotic Bax gene expression and Bcl2/Bax ratio with the clinical features of CLL patients as well as with molecular prognostic markers, namely the mutational status of rearranged immunoglobulin
View details →Negative / Null Result ReportOpen accessMedicine
Heikki Joensuu, Filippo de Braud, G Grignagni et al. · 2011 · British Journal of Cancer
BACKGROUND: Vatalanib (PTK787/ZK 222584) inhibits a few tyrosine kinases including KIT, platelet-derived growth factor receptors (PDGFRs) and vascular endothelial growth factor receptors (VEGFRs). We report efficacy and safety results of…
View details →Negative / Null Result ReportOpen accessMedicine
Linnet Ongeri, Valentine Wanga, Phelgona Otieno et al. · 2018 · BMC Psychiatry
BACKGROUND: Few longitudinal studies have examined associations between risk factors during pregnancy and mental health outcomes during the postpartum period. We used a cohort study design to estimate the prevalence, incidence and correlates of significant postpartum depressive symptoms in Kenyan women. METHODS: We recruited adult women residing in an urban, resource-poor setting and attending maternal and child health clinics in two public hospitals in Nairobi, Kenya. A translated Kiswahili Edinburgh Postpartum Depression Scale was used to screen for depressive symptoms at baseline assessment
View details →Negative / Null Result ReportOpen accessPsychology
Byung‐Jik Kim, Julak Lee · 2024 · Humanities and Social Sciences Communications
The rapid adoption of artificial intelligence (AI) in organizations has transformed the nature of work, presenting both opportunities and challenges for employees. This study utilizes several theories to investigate the relationships…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Kenneth E. Westerman, Paola Sebastiani, Paul F. Jacques et al. · 2019 · Clinical Epigenetics
BACKGROUND: Epigenome-wide association studies using DNA methylation have the potential to uncover novel biomarkers and mechanisms of cardiovascular disease (CVD) risk. However, the direction of causation for these associations is not always clear, and investigations to-date have often failed to replicate at the level of individual loci. METHODS: Here, we undertook module- and region-based DNA methylation analyses of incident CVD in the Women's Health Initiative (WHI) and Framingham Heart Study Offspring Cohort (FHS) in order to find more robust epigenetic biomarkers for cardiovascular risk. W
View details →Negative / Null Result ReportOpen accessPsychology
Paul M.G. Emmelkamp · 2012 · BMC Medicine
A series of primarily laboratory-based studies found attention bias modification in socially anxious participants to lead to reduced anxiety. It is argued that the failure to replicate the positive results of attention bias modification in the study of Carlbring et al. may be due to reasons other than the application through the Internet. A number of controlled studies failed to replicate the positive effects of attention bias modification in clinically rather than subclinically socially anxious subjects. Given the lack of robust evidence for attention bias modification in clinically socially
View details →Negative / Null Result ReportOpen accessMedicine
Matthew Ginks, Anoop Shetty, Pier D. Lambiase et al. · 2012 · Circulation Arrhythmia and Electrophysiology
BACKGROUND: There is considerable heterogeneity in the myocardial substrate of patients undergoing cardiac resynchronization therapy (CRT), in particular in the etiology of heart failure and in the location of conduction block within the…
View details →Negative / Null Result ReportOpen accessMedicine
Toby M. Maher, Ulrich Costabel, Marilyn K. Glassberg et al. · 2020 · European Respiratory Journal
This phase 2, randomised, double-blind, placebo-controlled trial evaluated the efficacy and safety of lebrikizumab, an interleukin (IL)-13 monoclonal antibody, alone or with background pirfenidone therapy, in patients with idiopathic pulmonary fibrosis (IPF). Patients with IPF aged ≥40 years with forced vital capacity (FVC) of 40%–100% predicted and diffusing capacity for carbon monoxide of 25%–90% predicted and who were treatment-naïve (cohort A) or receiving pirfenidone (2403 mg·day −1 ; cohort B) were randomised 1:1 to receive lebrikizumab 250 mg or placebo subcutaneously every 4 weeks. The
View details →Negative / Null Result ReportOpen accessMathematics
Edward J. Mills, Isabella Ghement, Christopher O’Regan et al. · 2011 · PLoS ONE
BACKGROUND: Indirect comparisons are becoming increasingly popular for evaluating medical treatments that have not been compared head-to-head in randomized clinical trials (RCTs). While indirect methods have grown in popularity and acceptance, little is known about the fragility of confidence interval estimations and hypothesis testing relying on this method. METHODS: We present the findings of a simulation study that examined the fragility of indirect confidence interval estimation and hypothesis testing relying on the adjusted indirect method. FINDINGS: Our results suggest that, for the sett
View details →Negative / Null Result ReportPsychology
Kuldhir S. Bhati · 2014 · Psychological Reports
Matching clients and counselors on the basis of heuristics, such as gender, is common in clinical practice. Considerable research has examined the effect of gender matching on the therapeutic alliance with equivocal results. Researchers…
View details →Negative / Null Result ReportOpen accessMedicine
Mary Beth Callan, Reema Patel, Ann H. Rux et al. · 2013 · Vox Sanguinis
BACKGROUND AND OBJECTIVES: Studies in mice suggest that rapid transfusions of red blood cells (RBCs), refrigerator stored for longer durations, induce a pro-inflammatory cytokine response. Studies in human neonates confirm these findings;…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Daniel Garrido‐Sanz, Senka Čaušević, Jordan Vacheron et al. · 2023 · Microbiome
BACKGROUND: Plant-beneficial bacterial inoculants are of great interest in agriculture as they have the potential to promote plant growth and health. However, the inoculation of the rhizosphere microbiome often results in a suboptimal or transient colonization, which is due to a variety of factors that influence the fate of the inoculant. To better understand the fate of plant-beneficial inoculants in complex rhizosphere microbiomes, composed by hundreds of genotypes and multifactorial selection mechanisms, controlled studies with high-complexity soil microbiomes are needed. RESULTS: We analys
View details →Negative / Null Result ReportOpen accessPsychology
Ana Blasco‐Belled, Carles Alsinet · 2022 · Scandinavian Journal of Psychology
The proliferation of mental health research is orienting its efforts towards the exploration of psychological well-being. One of the main burdens is the measurement challenges reported by the widely used Psychological Well-Being Scale…
View details →Negative / Null Result ReportOpen accessMedicine
Sari Mäkelä, Sari Aaltonen, Tellervo Korhonen et al. · 2017 · Scandinavian Journal of Medicine and Science in Sports
Because sustained physical activity is important for a healthy life, this paper examined whether a greater diversity of sport activities during adolescence predicts higher levels of leisure-time physical activity (LTPA) in adulthood. From…
View details →Negative / Null Result ReportOpen accessNeuroscience
Anna‐Katharina R. Bauer, Manuela Jaeger, Jeremy D. Thorne et al. · 2015 · Brain Research
The dynamic attending theory as originally proposed by Jones, 1976. Psychol. Rev. 83(5), 323-355 posits that tone sequences presented at a regular rhythm entrain attentional oscillations and thereby facilitate the processing of sounds…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Rebecca C. Richmond, Gemma C. Sharp, Georgia Herbert et al. · 2018 · International Journal of Epidemiology
BACKGROUND: It has been proposed that maternal folic-acid supplement use may alter the DNA-methylation patterns of the offspring during the in-utero period, which could influence development and later-life health outcomes. Evidence from human studies suggests a role for prenatal folate levels in influencing DNA methylation in early life, but this has not been extended to consider persistent effects into adulthood. METHODS: To better elucidate the long-term impact of maternal folic acid in pregnancy on DNA methylation in offspring, we carried out an epigenome-wide association study (EWAS) neste
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Yishak Gecho · 2014 · Social Sciences
Due to sever land scarcity, high population pressure and recurrent drought, farm households in the study area widely engage in and pursue diverse activities as livelihood strategies. The carrying capacity of agriculture to attain food and…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Frederiek Sperna Weiland, Clément Tisseuil, Hans H. Dürr et al. · 2012 · Hydrology and earth system sciences
Abstract. Potential evaporation (PET) is one of the main inputs of hydrological models. Yet, there is limited consensus on which PET equation is most applicable in hydrological climate impact assessments. In this study six different methods to derive global scale reference PET daily time series from Climate Forecast System Reanalysis (CFSR) data are compared: Penman-Monteith, Priestley-Taylor and original and re-calibrated versions of the Hargreaves and Blaney-Criddle method. The calculated PET time series are (1) evaluated against global monthly Penman-Monteith PET time series calculated from
View details →Negative / Null Result ReportMedicine
Andy Sun, Hung‐Pin Lin, Yi‐Ping Wang et al. · 2011 · Journal of Oral Pathology and Medicine
BACKGROUND: Atrophic glossitis (AG) is considered to be a marker of nutritional deficiency. In this study, we evaluated whether there was an intimate association of the deficiency of hemoglobin, iron, vitamin B12 or folic acid, high blood…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Maria D. S. Nunes, Marlies Dolezal, Christian Schlötterer · 2013 · Molecular Ecology
Strict maternal inheritance is considered a hallmark of animal mtDNA. Although recent reports suggest that paternal leakage occurs in a broad range of species, it is still considered an exceptionally rare event. To evaluate the impact of paternal leakage on the evolution of mtDNA, it is essential to reliably estimate the frequency of paternal leakage in natural populations. Using allele-specific real-time quantitative PCR (RT-qPCR), we show that heteroplasmy is common in natural populations with at least 14% of the individuals carrying multiple mitochondrial haplotypes. However, the average fr
View details →Negative / Null Result ReportBusiness, Management and Accounting
Maria Steinmeier, Michael Stich · 2017 · European Accounting Review
This study analyzes the effect of sustainability assurance (SA) on managerial investment decisions in terms of sustainability investment (SI) efficiency. We hypothesize that SA improves the set of information available for managerial…
View details →Negative / Null Result ReportOpen accessMedicine
Glauber Ribeiro de Sousa Araújo, Fernanda L. Fonseca, Bruno Pontes et al. · 2012 · PLoS ONE
Capsule production is common among bacterial species, but relatively rare in eukaryotic microorganisms. Members of the fungal Cryptococcus genus are known to produce capsules, which are major determinants of virulence in the highly pathogenic species Cryptococcus neoformans and Cryptococcus gattii. Although the lack of virulence of many species of the Cryptococcus genus can be explained solely by the lack of mammalian thermotolerance, it is uncertain whether the capsules from these organisms are comparable to those of the pathogenic cryptococci. In this study, we compared the characteristic of
View details →Negative / Null Result ReportOpen accessEngineering
Ana Marin, Damien Lacroix · 2015 · Interface Focus
Rapid prototyping techniques have been widely used in tissue engineering to fabricate scaffolds with controlled architecture. Despite the ability of these techniques to fabricate regular structures, the consistency with which these regular…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Ergün Doğan, Tuck Cheong Tang · 2011 · International Business & Economics Research Journal (IBER)
This study aims to determine the direction of causality between national income and government expenditures for Indonesia, Malaysia, Philippines, Singapore, and Thailand. Granger causality tests are used to investigate the causal links…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Daniel Kwabena Twerefou, Frank Adusah‐Poku, William Bekoe · 2016 · Environmental & Socio-economic Studies
Abstract The Environmental Kuznets Curve (EKC) hypothesis postulates an inverted U-shaped relationship between different pollutants and economic growth. In Ghana, as in many other developing countries, there exist scanty studies that confirm or otherwise the EKC hypothesis with regards to CO 2 emissions as well as the factors that drive CO 2 emissions. This work aims to bridge this knowledge gap by addressing these two major questions using data from 1970 to 2010 and the Auto Regressive Distributed Lag (ARDL) Bounds Testing approach. The results rather suggest a U-shaped relationship between p
View details →Negative / Null Result ReportOpen accessMedicine
Longjiang Xiong, Siyun Li, Min Dai · 2019 · Journal of Orthopaedic Surgery and Research
BACKGROUND: Despite the availability of several biomarkers, the diagnosis of periprosthetic joint infection (PJI) continues to be challenging. Serum D-dimer assessment is a widely available test that detects fibrinolytic activities and has been reported as an inflammatory biomarker. However, quite a few articles have reported the diagnostic efficiency of D-dimer for PJI. METHODS: This prospective study enrolled patients who had undergone total joint arthroplasty, were suspected of PJI, and also prepared for revision arthroplasty. PJI was defined using the Musculoskeletal Infection Society crit
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Umar Abbas Ibrahim, Abdulqudus Isiaka · 2020 · European Journal of Business and Management
This study examined the effect of financial leverage on firm value with evidence from a sample of selected companies quoted on the Nigerian Stock Exchange. The study adopts a panel data analysis using secondary data obtained from the financial statements of the selected companies over the period 2014-2018. The sample of 18 firms studied was selected through the convenient sampling technique. The level of financial leverage was denominated by long term debt to equity ratio. This work is the first Nigerian study to utilize the Tobin’s q ratio as a proxy of firm value. Other variables proven in l
View details →Negative / Null Result ReportMedicine
Cynthia Braden, Lenore Hawley, Jody Newman et al. · 2010 · Brain Injury
OBJECTIVES: To evaluate the feasibility of improving impaired social communication skills in persons with traumatic brain injury (TBI) and concomitant neurological or psychiatric conditions, using an intervention with evidence of efficacy…
View details →Negative / Null Result ReportOpen accessMedicine
Raanan Marants, Elena Qirjazi, Claire Grant et al. · 2019 · Journal of the American Society of Nephrology
Significance Statement Residual renal function (RRF) characteristically declines after patients with ESRD initiate dialysis. Although RRF preservation correlates with improved outcomes, poor understanding of the pathophysiology underlying…
View details →Negative / Null Result ReportOpen accessMedicine
Lai-ping Zhong, Chen-ping Zhang, Guo-xin Ren et al. · 2015 · Oncotarget
// Lai-ping Zhong 1 , Chen-ping Zhang 1 , Guo-xin Ren 1 , Wei Guo 1 , William N. William Jr 2 , Christopher S. Hong 3 , Jian Sun 1 , Han-guang Zhu 1 , Wen-yong Tu 1 , Jiang Li 4 , Yi-li Cai 1 , Qiu-ming Yin 1 , Li-zhen Wang 4 , Zhong-he Wang 1 , Yong-jie Hu 1 , Tong Ji 1 , Wen-jun Yang 1 , Wei-min Ye 1 , Jun Li 1 , Yue He 1 , Yan-an Wang 1 , Li-qun Xu 1 , Zhengping Zhuang 3 , J. Jack Lee 5 , Jeffrey N. Myers 6 and Zhi-yuan Zhang 1 1 Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicin
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