DNA methylation modules associate with incident cardiovascular disease and cumulative risk factor exposure
Kenneth E. Westerman; Paola Sebastiani; Paul F. Jacques; Simin Liu; Dawn L. DeMeo; José M. Ordovás · 2019 · Clinical Epigenetics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
The finding, in one line
“However, the direction of causation for these associations is not always clear, and investigations to-date have often failed to replicate at the level of individual loci.”
Abstract
BACKGROUND: Epigenome-wide association studies using DNA methylation have the potential to uncover novel biomarkers and mechanisms of cardiovascular disease (CVD) risk. However, the direction of causation for these associations is not always clear, and investigations to-date have often failed to replicate at the level of individual loci. METHODS: Here, we undertook module- and region-based DNA methylation analyses of incident CVD in the Women's Health Initiative (WHI) and Framingham Heart Study Offspring Cohort (FHS) in order to find more robust epigenetic biomarkers for cardiovascular risk. W
Abstract by Kenneth E. Westerman; Paola Sebastiani; Paul F. Jacques; Simin Liu; Dawn L. DeMeo; José M. Ordovás, Clinical Epigenetics (2019) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s13148-019-0705-2