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19,895 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Lack of association between common polymorphisms associated with successful aging and longevity in the population of Sardinian Blue Zone.

Errigo A, Dore MP, Mocci G et al. · 2024 · Scientific reports

More than two decades ago, in the central-eastern region of the Mediterranean island of Sardinia, a mountain area was identified where the population displays exceptional longevity, especially among men (the Longevity Blue Zone, LBZ). This…

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Negative / Null Result ReportOpen accessMedicine

Effect of Supplementation with Red Rooibos Tea on Body Composition, Metabolic Outcomes, and Movement in Ovariectomized Sprague-Dawley Rats.

Feld RS, Ianiero MA, Goncharow MK et al. · 2026 · Current developments in nutrition

Background Menopause is associated with increases in visceral adipose tissue, reductions in lean mass, and a reduced energy expenditure. The ovariectomized (OVX) rat model can be used to model these changes and to test potential…

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Negative / Null Result ReportOpen accessMedicine

Effects of a Moisturizer and Emollient on the Stratum Corneum Assessed by Confocal Raman Spectroscopy in Patients With and Without Atopic Dermatitis: An Assessor-Blinded Prospective Cohort Study.

Fukuda R, Hashimoto R, Pak K et al. · 2026 · Health science reports

Background and aims Atopic dermatitis (AD) is characterized by impaired skin barrier function and reduced moisturizing factors. Moisturizers and emollients restore the barrier through distinct mechanisms, but their longitudinal molecular…

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Negative / Null Result ReportMedicine

Melatonin Prevents Thymic Atrophy but Does Not Protect Against Disruption of T Cell Maturation Related to Cyclophosphamide Exposure.

Pimenta GF, Dourado TMH, de Souza KDB et al. · 2025 · Cell biochemistry and function

Increased oxidative stress and apoptosis are key mechanisms of thymic atrophy induced by cyclophosphamide (CYP). Atrophy leads to changes in the thymic microenvironment and disrupts T cell maturation. The hormone melatonin displays…

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Negative / Null Result ReportMedicine

Statins Do Not Significantly Affect Oxidative Nitrosative Stress Biomarkers in the PREVENT Randomized Clinical Trial.

Makhlin I, Demissei BG, D'Agostino R et al. · 2024 · Clinical cancer research : an official journal of the American Association for Cancer Research

Purpose Preventing Anthracycline Cardiovascular Toxicity with Statins (PREVENT; NCT01988571) randomized patients with breast cancer or lymphoma receiving anthracyclines to atorvastatin 40 mg daily or placebo. We evaluated the effects of…

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Negative / Null Result ReportOpen accessMedicine

Clinical efficacy of anti-amyloid antibodies in apolipoprotein E ε4 homozygotes: A Bayesian reanalysis of lecanemab and donanemab phase 3 results.

Teipel S, Tang Y, Khachaturian A · 2025 · Alzheimer's & dementia (New York, N. Y.)

Introduction We aimed to determine the clinical efficacy of treating apolipoprotein E (ApoE) ε4 homozygotes with recently approved anti-amyloid antibodies. Methods Data were derived from supplementary analyses in the regulatory studies…

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Negative / Null Result ReportOpen accessMedicine

Could MOTS-c Levels in Children with Type 1 Diabetes Mellitus Be an Indicator for Early Diabetic Kidney Disease?

Girişgen İ, Altıncık SA, Avcı E et al. · 2025 · Journal of clinical research in pediatric endocrinology

Objective To compare serum mitochondrial open reading frame of 12S rRNA-c (MOTS-c) levels, a new potential biomarker for oxidative stress, in children with type 1 diabetes mellitus (T1DM) and healthy children. A further aim was to…

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Negative / Null Result ReportOpen accessMedicine

Generalisability of Maternal Genetic Risk Score for Birth Weight Across Racial Identity and Ancestry: A Secondary Analysis of a Prospective Cohort Study.

Tristani-Firouzi B, Pappas L, Joseph M et al. · 2026 · BJOG : an international journal of obstetrics and gynaecology

Objective Maternal genotypes may be useful to customise foetal growth assessment, but generalisability across diverse racial and ancestral groups remains uncertain. We assessed the generalisability of a genetic risk score for birth weight…

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Negative / Null Result ReportMedicine

Lack of association between periodontitis and rheumatoid arthritis.

Posada-López A, Duque JD, Pineda-Tamayo RA et al. · 2023 · Reumatologia clinica

Background and objective Periodontitis and rheumatoid arthritis (RA) have been associated in a bidirectional way. The objective of this study was to determine the association between clinical parameters of periodontitis and RA. Materials…

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Negative / Null Result ReportOpen accessMedicine

C-reactive protein and fatigue after subarachnoid haemorrhage.

Daniel S, Hou R, Galea I et al. · 2025 · Brain, behavior, & immunity - health

Background Subarachnoid haemorrhage (SAH) is a severe type of intracranial bleed that causes significant morbidity. One of the most overlooked yet commonly reported symptom is persistent fatigue. Fatigue in the general population has been…

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Negative / Null Result ReportOpen accessMedicine

Anthropometric indicators and dental caries in the pediatric population of rural communities in the peruvian amazon: a cross-sectional study.

Aquino-Canchari CR, Parraga Camayo EF, Ambrosio Huaman EN et al. · 2025 · Revista cientifica odontologica (Universidad Cientifica del Sur)

Introduction Dental caries and nutritional alterations are common in childhood, particularly in rural communities with limited access to health services. Objective To determine the association between anthropometric indicators and the…

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Negative / Null Result ReportOpen accessMedicine

Investigating the association between demographic factors and patient satisfaction with recovery in the early phase after non-catastrophic musculoskeletal injuries: a cross-sectional study.

Maleki M, Modarresi S · 2025 · BMC research notes

Background Orthopedic injuries can negatively impact both the physical and mental health of patients. Ensuring patient satisfaction with their recovery is crucial for meeting patient-centered goals and enhancing overall health outcomes.…

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Negative / Null Result ReportMedicine

Influence of matrix metalloproteinase 9 variant rs17576 on ischemic stroke risk and severity in acute coronary syndrome.

Bogari NM, Naffadi HM, Babalghith AO et al. · 2024 · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Background Ischemic injury is a common mechanism in both ischemic stroke (IS) and acute coronary syndrome (ACS). Matrix metalloproteinase 9 (MMP-9), an endopeptidase that degrades extracellular matrix, is important in the pathogenesis of…

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Negative / Null Result ReportOpen accessMedicine

Combined Prognostic Value of Nutritional and Inflammatory Indices for Predicting Functionally Significant Coronary Stenosis Verified by FFR: The PNI-SII-GINI Study.

Aydın MZ, Arin CB, Teber MK et al. · 2026 · Journal of inflammation research

Background Systemic inflammatory and nutritional indices have been associated with coronary artery disease burden and prognosis; however, their ability to predict lesion-level functional ischemia remains uncertain. This study evaluated…

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Negative / Null Result ReportOpen accessMedicine

Social norm intervention in real-world supermarkets in the Netherlands: A quasi-experimental evaluation of effects on perceived social norms and meat substitute purchases.

Wolfswinkel SMM, Raghoebar S, de Vet E et al. · 2026 · Applied psychology. Health and well-being

Social norm perceptions are implicit rules of conduct that describe what is normal and acceptable behavior. Changing social norm perceptions through textual and physical social norm communications can be a promising approach to changing…

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Negative / Null Result ReportOpen accessMedicine

Circulating Omentin Levels in Heart Failure: A Case-Control Study.

Currò D, Vergani E, Nicolazzi MA et al. · 2026 · International journal of molecular sciences

Cardiovascular diseases remain the leading cause of global mortality, with heart failure (HF) representing a critical clinical endpoint. HF is traditionally classified into two distinct phenotypes based on left ventricular ejection…

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