Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Shivani Srivastava, Harsh Pandey, Surya Kumar Singh et al. · 2019 · Advanced Pharmaceutical Bulletin
Purpose: Basically insulin is known to be secreted by β cells of the pancreas. Recently, it has also been found to be produced and expressed by intestinal epithelial cells with the help of L cells secreting glucagon like peptide 1 (GLP 1). Here, we have studied the same intestinal insulin expression property in T2D rats. Methods: Following 2 weeks of high fat diet (HFD) consumption, we have been given a single dose of streptozotocin (STZ) (35 mg/kg bw). Rats were then sacrificed after 1, 7 and 21 days. The GLP 1 analogue, liraglutide was also given to one group of diabetic rats, upto their res
View details →Negative / Null Result ReportOpen accessVeterinary medicine
Narges Sotoudeh, Mohammad Reza Namavar · 2022 · Veterinary Medicine and Science
Abstract Background A combination of ketamine‐xylazine (K‐X) is frequently used for anaesthesia in rats. Sex and age affect this cocktail dosage. Ketamine causes a hypnotic effect by blocking NMDA receptors located on the dendritic spine of the CA1 region. Objectives The present study aimed to find the optimal dosage of K‐X and its association with the changes in dendritic spine number of the CA1 region for aged and young rats of both sexes. Methods We injected 150–4 mg/kg of K‐X in young and 100–2 mg/kg in aged Wistar rats intraperitoneally and recorded the onset time and duration of anaesthe
View details →Negative / Null Result ReportOpen accessCities. Urban geography
Armand Fréjuis Akpa, Augustin Foster Chabossou · 2024 · Research in Globalization
The introduction of information and communication technology (ICT) has altered the way society operates things. ICT is used in various sectors, including agriculture. It can be used in the agricultural sector to distribute pricing and encourage agricultural commodity exports. The study aims to investigate the effect of ICT on cashew nut export in Benin using an autoregressive distributed lag (ARDL) approach. Data were collected over the period of 31 years (1990–2020) in Benin. The estimated results showed that mobile cellular telephone subscription is negatively and significantly correlated wi
View details →Negative / Null Result ReportOpen accessOphthalmology
V S Vijitha, Tarjani Vivek Dave, Somasheila I Murthy et al. · 2021 · Indian Journal of Ophthalmology
Purpose: To describe a series of sight-threatening ocular and adnexal involvement associated with dengue hemorrhagic fever and their treatment options. Methods: Retrospective, interventional, non-comparative case series. Medical records of patients who presented with ocular symptoms attributed to dengue hemorrhagic fever were reviewed. Demography, presenting features, and treatment outcomes were recorded. Outcome measures assessed included globe salvage, vision salvage, and visual improvement. The outcome was deemed as favorable if vision salvage was possible and unfavorable if the vision was
View details →Negative / Null Result ReportOpen accessAnimal culture
CUI Pei, LI Nan, LI Min et al. · 2025 · Siliao yanjiu
The experiment aimed to investigate the effects of adding chromium methionine (CrMet) to high carbohydrate feed on the growth performance, antioxidant capacity, serum biochemical indicators, and hepatopancreas health in common carp. A total of 180 healthy carp with an initial weight of (86.61±6.68) g were randomly divided into three groups, with three replicates per group and 20 carp per replicate. Three types of feed were prepared: Control group (CK, carbohydrate level 25%), high carbohydrate group (HCD, carbohydrate level 45%), and high carbohydrate feed supplemented with CrMet (HCD+Cr, 1 mg
View details →Negative / Null Result ReportOpen accessMedicine
Masoud Seifi, Shirin Farivar, Malihe Sadat Mirhosseini et al. · 2020 · Regeneration, Reconstruction & Restoration
Introduction: Stem cells have gained great attention in tissue engineering and curcumin is a natural phenolic product that had showed some positive effects on these cells. The aim of this study was to evaluate the effect of curcumin on the differentiation of human dental pulp stem cells (hDPSCs). Materials and Methods: In this experimental study, hDPSCs were isolated from human third molars and treated without and with different concentrations (5, 10 and 15 µM) of curcumin and dimethyl sulfoxide (DMSO) as solvent for curcumin. Proliferation of the cells was measured by methyl-thiazol-tetrazoli
View details →Negative / Null Result ReportOpen accessForestry
Irwan Mahakam Lesmono Aji, Raden Sutriono, Arna Diansyah · 2020 · Jurnal Belantara
This study aims to find out the effect of submersion by using 1% acetic acid, 100% palm juice, and 100% coconut water to break the dormancy of palm seeds at different maturity levels. The research was conducted in the Green House of Forestry Study Program, University of Mataram, using the experimental method with Complet Random Design (CRD) three factors. The first factor is the maturity level consists of 3 levels, the second factor is the submersion liquid substance consist of 3 levels, and the third factor is the period of submersion consist of 4 levels.The results of this study indicate tha
View details →Negative / Null Result ReportOpen accessDentistry
Zahra Hashemi Ardakani, Rashin Giti, Shima Dabiri et al. · 2021 · Dental Research Journal
Background: The flexural strength (FS) of a denture base material is of great concern, and many approaches have been used to strengthen the denture acrylic resins. The present study aimed to evaluate the effect of high-performance polymer (BioHPP) and metal mesh reinforcement on the FS of a heat-cured poly methyl methacrylate (PMMA) acrylic resin. Materials and Methods: This experimental study was done on 30 rectangular specimens (64 mm × 13 mm × 3 mm) of a heat-cured PMMA resin. The specimens were divided into three groups (n = 10) to be reinforced with either metal mesh or BioHPP mesh; one g
View details →Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Rui ZHENG, Xiaosong QIN, Wenjie LI et al. · 2011 · Chinese Journal of Lung Cancer
Background and objective It has been proven that Src played pivotal roles in carcinogenesis, cancer progression and metastasis. The aim of this study is to explore the roles of Src phosphorylation on lung cancer cells. Methods Western blot and immunoprecipitation was used to detect the expression and phosphorylation of Src in lung cancer cells. MTT and Boyden chamber assay was used to examine the effects of inhibition of Src phosphorylation on proliferation and invasion of lung cancer cells in vitro, respectively. Results pp60src was expressed in all lung cancer cell lines in this study. All 5
View details →Negative / Null Result ReportOpen accessFinance
Cindy Maycherles, Moh Muslikh · 2021 · Keunis
The purposes of this research are to analyze and obtain empirical evidence on the effect of usefulness perception, ease perception, and risk perception toward the use of BRI Internet banking in (Politeknik Negeri Semarang) Polines students both simultaneously and partially. The population of this research was Polines students of all departments from 2017 to 2019 as customers of BRI Internet banking users with a sample of 87 respondents. The research used primary and secondary data. The data analysis model uses the Multiple Linear Regression Analysis Model while the data analysis technique uses
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
M Dadvand Sarab, H Naghdi Badi, M Nasri et al. · 2008 · Journal of Medicinal Plants
Background: Basil (Ocimum basilicum L.) is a valuable medicinal and aromatic plant which is cultivated throughout the world. Therefore, it is necessary to determine effect of important agronomical factors on quality and quantity of its volatile oil. Objective: To determine plant density and nitrogen fertilization effects on quality and quantity yield of basil. Method: This study was done in Research farm of ACECR, Institute of Medicinal Plants & Natural Products Research in 2006 on the base of factorial experiment in randomized complete block design with four replications. All possible combina
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Alan J. Weaver, Timothy R. Borgogna, Galen O’Shea-Stone et al. · 2022 · Antibiotics
The rise in bacterial resistance to common antibiotics has raised an increased need for alternative treatment strategies. The natural antibacterial product, 18β-glycyrrhetinic acid (GRA) has shown efficacy against community-associated methicillin-resistant Staphylococcus aureus (MRSA), although its interactions against planktonic and biofilm modes of growth remain poorly understood. This investigation utilized biochemical and metabolic approaches to further elucidate the effects of GRA on MRSA. Prolonged exposure of planktonic MRSA cell cultures to GRA resulted in increased production of staph
View details →Negative / Null Result ReportOpen accessPublic aspects of medicine
Rob Horne, Caroline Sabin, Trudie Chalder et al. · 2025 · Programme Grants for Applied Research
Background Antiretroviral therapy has transformed human immunodeficiency virus infection intoa chronic condition associated with normal life expectancy. In the United Kingdom, the uptake of antiretroviral therapy is generally high, but a delay in starting antiretroviral therapy and non-adherence compromise the health and well-being of people living with human immunodeficiency virus, increase the risk of transmission of human immunodeficiency virus and increase National Health Service costs. Objectives The overall aim was to improve antiretroviral therapy uptake and adherence by addressing perc
View details →Negative / Null Result ReportOpen accessScience (General)
Ayodele Owonubi, Favour Kenneth Chiwendu · 2022 · UMYU Scientifica Journal
The objectives of this research were to investigate the nature of pH buffer capacity and evaluate its association selected soil characteristics the study area. Soil samples from ten profile pits from within the study area were collected from genetic horizons. Soil samples were tested in the laboratory for electrical conductivity and pH buffer capacity using standard procedures. Soil data were analyzed using descriptive statistics. One-way analysis of variance and correlation analysis were applied to determine effects and relationships of selected soil properties with soil pH buffer capacity. T
View details →Negative / Null Result ReportOpen accessTechnology
Domagoj Nakić, Katarina Licht, Hana Posavčić et al. · 2025 · Results in Engineering
Increasing amounts of sewage sludge (SS) and phosphorus-induced eutrophication are major global issues, and this study addresses both under a unified approach, by exploring the potential of biochar derived from SS gasification in an experimental plant as an efficient adsorbent for phosphate removal in synthetic wastewater. The key innovation involves the use of a novel biochar, generated as a byproduct of an innovative gasification process, without any additional pretreatment. This approach could help reduce both environmental and economic burdens in potential real-world applications. Pristine
View details →Negative / Null Result ReportOpen accessAgriculture (General)
A. S. Abdulrhman, Sh. M. M. Al-Atrushy · 2024 · The Iraqi Journal of Agricultural science
This investigation was aimed to study the effect of soil application of Bio health and foliar application with Tecamin max and Benzyl adenine on growth characteristic of sweet orange (Citrus sinensis L.) seedlings during two successive seasons (2020 and 2021). Bio health was added with three concentrations (0, 6 and 12 g.L-1) to the soil and foliar application of Tecamin max with three concentration (0, 5 and 10 ml.L-1), Benzyl adenine with three concentration (0, 100 and 200 mg. L-1) on the sweet orange seedlings which were brought from private nursery in Duhok city and have two- years old an
View details →Negative / Null Result ReportOpen accessPsychiatry
Roxoliana Tsisar, Kristen E. Zentner, Katherine Shettell et al. · 2026 · Frontiers in Psychiatry
BackgroundPsychoeducation for families of young adults with psychosis is an evidence-based intervention that alleviates carer burden. The implementation of programming is limited, leaving family carers shouldering a heavy burden without appropriate support.ObjectiveThis pre-post longitudinal pilot study evaluated the preliminary outcomes of a psychoeducational group intervention for family carers of young adults with psychosis, aimed at building skills and reducing carer burden to support recovery in their loved ones.MethodsThe intervention, co-developed and co-facilitated by healthcare profes
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Joanna Hajduk, Cyrill Brunner, Sebastian Malik et al. · 2020 · mAbs
Minor changes in the quality of biologically manufactured monoclonal antibodies (mAbs) can affect their bioactivity and efficacy. One of the most important variations concerns the N-glycosylation pattern, which directly affects an anti-tumor mechanism called antibody-dependent cell-meditated cytotoxicity (ADCC). Thus, careful engineering of mAbs is expected to enhance both protein-receptor binding and ADCC. The specific aim of this study is to evaluate the influence of terminal carbohydrates within the Fc region on the interaction with the FcγRIIIa/CD16a receptor in native and label-free condi
View details →Negative / Null Result ReportOpen accessMedicine (General)
Sepide Ghasemian, Zahra Hojjati Zidashti · 2018 · Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum
Background and Objectives: Iron can play an important role in exercise performance of women. The purpose of the present research was to determine the effects of combined exercise training and Feroglobin supplementation on serum iron and lipid profile in Women with iron deficiency anemia. Methods: In this study, 36 trained females with iron deficiency anemia (mean age, 26.8±6.3 years and body mass index, 19.55±4.4kg/m2) of Lahijan city, were selected as subjects and randomly divided into three groups of supplement+combined training, placebo+combined training, and control. Iron lev
View details →Negative / Null Result ReportOpen accessAgriculture (General)
Eleftheria Bempelou, Kyriaki Varikou, Antonios Nikolakakis et al. · 2026 · Agriculture
In Greece, the protection of olive orchards against the olive fruit fly ( Bactrocera oleae ), the most serious pest of olive fruits, is implemented through a national control program. This program is implemented by the Ministry of Rural Development and Food in co-operation with various public and private organizations. A new approach followed for this goal is the use of insecticide spray solutions combined with trophic attractant to attract and kill the olive fruit fly. In the present study, a method for the determination of the major insecticides, lambda-cyhalothrin and Spinosad, in their spr
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Wang J, Lu S, Zhang C et al. · 2025 · Drug Design, Development and Therapy
Jinglong Wang, Shijia Lu, Chenxiao Zhang, Junjie Wang, Huiru Wu, Guofei Li Department of Pharmacy, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People’s Republic of ChinaCorrespondence: Guofei Li, Department of Pharmacy, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Shenyang, 110004, People’s Republic of China, Tel/Fax +86-24-23925108, Email sylgf2009@163.comPropose: The co-treatment of ulcerative colitis with berberine hydrochloride (BBR), the Janus kinase(JAK) inhibitor Tofacitinib (TOFA), and Fligotinib (FIGA) is feasible and sophisti
View details →Negative / Null Result ReportOpen accessPhysiology
Lin Chang, Silin Fu, Jianghua Li et al. · 2022 · Frontiers in Physiology
Background: Knee injury is common in half-marathon runners, however, the effect of compression running pants on fatigue and knee proprioception remains unclear.Objectives: The study aims to investigate whether wearing compression running pants (CRP) and treadmill running stages affect knee proprioception and fatigue-related physiological responses during half-marathon running.Methods: Eighteen half-marathon runners completed two self-paced 21 km treadmill running trials, once wearing CRP and once wearing loose running shorts (LRS). For each 21 km run, RPE, heart rate, blood lactic acid, and kn
View details →Negative / Null Result ReportOpen accessMedicine
Galiya Iskakova, Bauyrzhan Iztayev, Auyelbek Iztayev et al. · 2025 · Scientific Reports
Abstract The quality of food products and a balanced diet play a key role in maintaining health and improving the quality of life. Due to the high popularity of pasta, a promising direction is the development of recipes that include whole grain flour, carrot powder and ion-ozonated water, which increase the nutritional value of the product and improve its chemical composition. The aim of this study was to optimise the technological modes of production of durum wheat pasta using carrot powder and ion-ozonated water to minimise the loss of dry matter (DM) during cooking and increase the protein
View details →Negative / Null Result ReportOpen accessBibliography. Library science. Information resources
WANG Weizheng, QIAO Hong, LI Xiaojun, WANG Jingjing · 2024 · Nongye tushu qingbao xuebao
[Purpose/Significance] Generative artificial intelligence (AI) technology has been widely used in many fields, and the application of this technology has become popular among researchers. However, there are few studies on the willingness of researchers willingness to accept generative AI. This leads to an insufficient understanding of the psychological mechanism, cognitive process and behavioral pattern of users' acceptance of generative AI, which limits the ability of theoretical innovation and practical exploration in user information behavior. This study focuses on researchers acceptance of
View details →Negative / Null Result Report
Michael P Thompson, Ilana Graetz, Naleef Fareed et al. · 2017 · Circulation: Cardiovascular Quality and Outcomes
Objective: With the goal of improving healthcare quality, Medicare has implemented a series of pay-for-performance initiatives and allocated substantial financial resources to promote meaningful use of electronic health records (EHRs). The…
View details →Negative / Null Result Report
Sally Caine, Mariam Alaverdashvili, Frederick Colbourne et al. · 2024 · PLOS ONE
Malnutrition after stroke may lessen the beneficial effects of rehabilitation on motor recovery through influences on both brain and skeletal muscle. Enriched rehabilitation (ER), a combination of environmental enrichment and forelimb…
View details →Negative / Null Result Report
Abigail Silva, Arielle Guzman, Charlotte Picard et al. · 2020 · Cancer Epidemiology, Biomarkers & Prevention
Abstract Background: Through its various provisions, the Patient Protection and Affordable Care Act (ACA) has the potential to increase access to cancer care, particularly among the most vulnerable, and reduce disparities in cancer care…
View details →Negative / Null Result Report
Siobhan Dickinson, Maryam Naghsh‐Nejad, Kees Van Gool et al. · 2026 · Australian Economic Review
ABSTRACT Research Question/Issue This study examines the impact of the Chronic Disease Dental Scheme (CDDS), introduced in 2007 to provide subsidised dental care for people with chronic conditions. Specifically, it asks whether the CDDS…
View details →Negative / Null Result Report
Hugh Adler, Kwong Tsang, Michael Abouyannis et al. · 2024 · Journal of Healthcare Simulation
Introduction: The Centre for Snakebite Research & Interventions at the Liverpool School of Tropical Medicine (LSTM) houses >150 venomous snakes. This includes the black mamba (Dendroaspis polylepis) which can cause life-threatening…
View details →Negative / Null Result Report
K Hirono, K Tsuboi, H Nakaoka et al. · 2025 · European Heart Journal
Abstract Background Dilated cardiomyopathy (DCM) is a progressive myocardial disorder with significant morbidity in children. Although pathogenic gene variants are detected in approximately 30–40% of DCM cases, the impact of sarcomere gene…
View details →