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19,735 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Impact of the COVID-19 Pandemic on the Crude Oil and Stock Markets in the US: A Time-Varying Analysis

Lu Liu, En‐Ze Wang, Chien‐Chiang Lee · 2020 · Energy RESEARCH LETTERS

This research explores the interaction among the COVID-19 pandemic, crude oil market and stock market in the U.S. by utilizing a time-varying parameter vector autoregression (TVP-VAR) model. Our results indicate that there is a negative connection between crude oil returns and stock returns. Interestingly, contrary to our intuition, we find that the COVID-19 pandemic cannot exert a negative effect but has a statistically significantly positive effect on crude oil returns and stock returns.

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Negative / Null Result ReportOpen accessNeuroscience

Different scaling of linear models and deep learning in UKBiobank brain images versus machine-learning datasets

Marc-André Schulz, B.T. Thomas Yeo, Joshua T Vogelstein et al. · 2020 · Nature Communications

Recently, deep learning has unlocked unprecedented success in various domains, especially using images, text, and speech. However, deep learning is only beneficial if the data have nonlinear relationships and if they are exploitable at available sample sizes. We systematically profiled the performance of deep, kernel, and linear models as a function of sample size on UKBiobank brain images against established machine learning references. On MNIST and Zalando Fashion, prediction accuracy consistently improves when escalating from linear models to shallow-nonlinear models, and further improves w

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Negative / Null Result ReportOpen accessNeuroscience

Large-scale replication study reveals a limit on probabilistic prediction in language comprehension

Mante S. Nieuwland, Stephen Politzer‐Ahles, Evelien Heyselaar et al. · 2018 · eLife

Do people routinely pre-activate the meaning and even the phonological form of upcoming words? The most acclaimed evidence for phonological prediction comes from a 2005 Nature Neuroscience publication by DeLong, Urbach and Kutas, who observed a graded modulation of electrical brain potentials (N400) to nouns and preceding articles by the probability that people use a word to continue the sentence fragment (‘cloze’). In our direct replication study spanning 9 laboratories (N=334), pre-registered replication-analyses and exploratory Bayes factor analyses successfully replicated the noun-results

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Negative / Null Result ReportOpen accessNeuroscience

The Influence of Socioeconomic Status on Children’s Brain Structure

Katarzyna Jednoróg, Irène Altarelli, Karla Monzalvo et al. · 2012 · PLoS ONE

Children's cognitive abilities and school achievements are deeply affected by parental socioeconomic status (SES). Numerous studies have reported lower cognitive performance in relation to unfavorable environments, but little is known about the effects of SES on the child's neural structures. Here, we systematically explore the association between SES and brain anatomy through MRI in a group of 23 healthy 10-year-old children with a wide range of parental SES. We confirm behaviorally that language is one of the cognitive domains most affected by SES. Furthermore, we observe widespread modifica

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Negative / Null Result ReportOpen accessEarth and Planetary Sciences

BAYSPLINE: A New Calibration for the Alkenone Paleothermometer

Jessica E. Tierney, Martin P. Tingley · 2018 · Paleoceanography and Paleoclimatology

Abstract The alkenone‐based U proxy is a cornerstone of paleoclimatology, providing insight into the temperature history of the Earth's surface ocean. Although the relationship between U and sea surface temperatures (SSTs) is robust and…

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Negative / Null Result ReportOpen accessPhysics and Astronomy

An ALMA [C ii] Survey of 27 Quasars at z > 5.94

Roberto Decarli, Fabian Walter, Bram P. Venemans et al. · 2018 · The Astrophysical Journal

Abstract We present a survey of the [C ii ] 158 μ m line and underlying far-infrared (FIR) dust continuum emission in a sample of 27 quasars using the Atacama Large Millimeter Array (ALMA) at resolution. The [C ii ] line was significantly…

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Negative / Null Result ReportMedicine

The effect of post-operative mechanical axis alignment on the survival of primary total knee replacements after a follow-up of 15 years

T.J. Bonner, William Eardley, Paul R. Patterson et al. · 2011 · Journal of Bone and Joint Surgery - British Volume

Correct positioning and alignment of components during primary total knee replacement (TKR) is widely accepted to be an important predictor of patient satisfaction and implant durability. This retrospective study reports the effect of the…

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Negative / Null Result ReportOpen accessSocial Sciences

Wealth, Health, and Child Development: Evidence from Administrative Data on Swedish Lottery Players *

David Cesarini, Erik Lindqvist, Robert Östling et al. · 2016 · The Quarterly Journal of Economics

Abstract We use administrative data on Swedish lottery players to estimate the causal impact of substantial wealth shocks on players’ own health and their children’s health and developmental outcomes. Our estimation sample is large,…

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Negative / Null Result ReportOpen accessEnvironmental Science

Conditions associated with protected area success in conservation and poverty reduction

Paul J. Ferraro, Merlin M. Hanauer, Katharine R. E. Sims · 2011 · Proceedings of the National Academy of Sciences

Protected areas are the dominant approach to protecting biodiversity and the supply of ecosystem services. Because these protected areas are often placed in regions with widespread poverty and because they can limit agricultural…

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Negative / Null Result ReportOpen accessMedicine

A study investigating the association between vitamin D and depression among university students in 39 countries

Dania Abdul Razzak Kouider, Nageeb Hassan, Yaser Mohammed Al‐Worafi · 2019 · Biomedical Research

Objectives: The aim of this study was to explore the association between vitamin D deficiency and depression among university students and to identify the factors affecting this association. Methodology: A cross-sectional study was…

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Negative / Null Result ReportOpen accessMedicine

Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus

Trevor Scobey, Boyd L. Yount, Amy Sims et al. · 2013 · Proceedings of the National Academy of Sciences

Severe acute respiratory syndrome with high mortality rates (~50%) is associated with a novel group 2c betacoronavirus designated Middle East respiratory syndrome coronavirus (MERS-CoV). We synthesized a panel of contiguous cDNAs that…

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Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Why Do Individual Investors Disregard Accounting Information? The Roles of Information Awareness and Acquisition Costs

Elizabeth Blankespoor, ED DEHAAN, John E. Wertz et al. · 2018 · Journal of Accounting Research

ABSTRACT We investigate the frictions that impede individual investors’ use of accounting information and, in particular, their costs of monitoring and acquiring accounting disclosures. We do so using an archival setting in which…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Maternal pre-pregnancy BMI and gestational weight gain, offspring DNA methylation and later offspring adiposity: findings from the Avon Longitudinal Study of Parents and Children

Gemma C. Sharp, Debbie A. Lawlor, Rebecca C. Richmond et al. · 2015 · International Journal of Epidemiology

BACKGROUND: Evidence suggests that in utero exposure to undernutrition and overnutrition might affect adiposity in later life. Epigenetic modification is suggested as a plausible mediating mechanism. METHODS: We used multivariable linear…

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Negative / Null Result ReportSocial Sciences

Is Putin’s popularity real?

Timothy Frye, Scott Gehlbach, Kyle L. Marquardt et al. · 2016 · Post-Soviet Affairs

Vladimir Putin has managed to achieve strikingly high public approval ratings throughout his time as president and prime minister of Russia. But is his popularity real, or are respondents lying to pollsters? We conducted a series of list…

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Negative / Null Result ReportOpen accessSocial Sciences

ONLINE VS. BLENDED LEARNING: DIFFERENCES IN INSTRUCTIONAL OUTCOMES AND LEARNER SATISFACTION

Doo Hun Lim, Michael L. Morris, Virginia W. Kupritz · 2019 · Online Learning

This study investigates differences in instructional and learner factors between two groups of learners exposed to online only and blended delivery formats, respectively, in an effort to compare learning outcomes and other instructional variables between online and blended delivery methods. Findings indicated that no significant differences existed in learning outcomes; however, significant differences existed in several instructional and learner factors between the two delivery format groups. Discussions about improving online or blended delivery method are presented based upon the research f

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Generalization and Dilution of Association Results from European GWAS in Populations of Non-European Ancestry: The PAGE Study

Christopher S. Carlson, Tara C. Matise, Kari E. North et al. · 2013 · PLoS Biology

The vast majority of genome-wide association study (GWAS) findings reported to date are from populations with European Ancestry (EA), and it is not yet clear how broadly the genetic associations described will generalize to populations of diverse ancestry. The Population Architecture Using Genomics and Epidemiology (PAGE) study is a consortium of multi-ancestry, population-based studies formed with the objective of refining our understanding of the genetic architecture of common traits emerging from GWAS. In the present analysis of five common diseases and traits, including body mass index, ty

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Negative / Null Result ReportOpen accessEnvironmental Science

Tropical sea surface temperatures for the past four centuries reconstructed from coral archives

Jessica E. Tierney, Nerilie J. Abram, Kevin J. Anchukaitis et al. · 2015 · Paleoceanography

Abstract Most annually resolved climate reconstructions of the Common Era are based on terrestrial data, making it a challenge to independently assess how recent climate changes have affected the oceans. Here as part of the Past Global…

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Negative / Null Result ReportOpen accessEngineering

Cobb Angle Measurement of Spine from X-Ray Images Using Convolutional Neural Network

Ming‐Huwi Horng, Chan‐Pang Kuok, Min-Jun Fu et al. · 2019 · Computational and Mathematical Methods in Medicine

Scoliosis is a common spinal condition where the spine curves to the side and thus deforms the spine. Curvature estimation provides a powerful index to evaluate the deformation severity of scoliosis. In current clinical diagnosis, the standard curvature estimation method for assessing the curvature quantitatively is done by measuring the Cobb angle, which is the angle between two lines, drawn perpendicular to the upper endplate of the uppermost vertebra involved and the lower endplate of the lowest vertebra involved. However, manual measurement of spine curvature requires considerable time and

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Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

New Evidence on the Aftermath of Financial Crises in Advanced Countries

Christina Romer, David Romer · 2017 · American Economic Review

This paper examines the aftermath of postwar financial crises in advanced countries. We construct a new semiannual series on financial distress in 24 OECD countries for the period 1967–2012. The series is based on assessments of the health…

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Negative / Null Result ReportMedicine

Phase III Trial of Vandetanib Compared With Erlotinib in Patients With Previously Treated Advanced Non–Small-Cell Lung Cancer

Ronald B. Natale, Sumitra Thongprasert, F. Anthony Greco et al. · 2011 · Journal of Clinical Oncology

PURPOSE: Vandetanib is a once-daily oral inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling. This phase III study assessed the efficacy of vandetanib versus erlotinib in unselected…

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Negative / Null Result ReportMedicine

Pan-Canadian Study of Mammography Screening and Mortality from Breast Cancer

Andrew J. Coldman, Norm Phillips, Christine Wilson et al. · 2014 · JNCI Journal of the National Cancer Institute

BACKGROUND: Screening with mammography has been shown by randomized controlled trials to reduce breast cancer mortality in women aged 40 to 74 years. Estimates from observational studies following screening implementation in different…

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Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

The forgotten flies: the importance of non-syrphid Diptera as pollinators

Katherine A. Orford, Ian P. Vaughan, Jane Memmott · 2015 · Proceedings of the Royal Society B Biological Sciences

Bees, hoverflies and butterflies are taxa frequently studied as pollinators in agricultural and conservation contexts. Although there are many records of non-syrphid Diptera visiting flowers, they are generally not regarded as important…

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Negative / Null Result ReportMedicine

Safety and efficacy of peripheral nerve stimulation of the occipital nerves for the management of chronic migraine: Results from a randomized, multicenter, double-blinded, controlled study

Stephen D. Silberstein, David W. Dodick, Joel R. Saper et al. · 2012 · Cephalalgia

BACKGROUND: Chronic migraine (CM) is a debilitating neurological disorder with few treatment options. Peripheral nerve stimulation (PNS) of the occipital nerves is a potentially promising therapy for CM patients. METHODS: In this…

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Negative / Null Result ReportBusiness, Management and Accounting

Do Big 4 Auditors Provide Higher Audit Quality after Controlling for the Endogenous Choice of Auditor?

John Daniel Eshleman, Peng Guo · 2014 · Auditing A Journal of Practice & Theory

SUMMARY: Recent research suggests that Big 4 auditors do not provide higher audit quality than other auditors, after controlling for the endogenous choice of auditor. We re-examine this issue using the incidence of accounting restatements…

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Negative / Null Result ReportOpen accessMathematics

Misuse of DeLong test to compare AUCs for nested models

Olga Demler, Michael Pencina, Ralph B. D’Agostino · 2012 · Statistics in Medicine

The area under the receiver operating characteristics curve (AUC of ROC) is a widely used measure of discrimination in risk prediction models. Routinely, the Mann-Whitney statistics is used as an estimator of AUC, while the change in AUC…

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