20,211 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Bogang Wu, Win Thant, Elena Bitman et al. · 2026 · Journal for ImmunoTherapy of Cancer
ABSTRACT Background Immune exclusion inhibits anti-tumor immunity and response to immunotherapy, but its mechanisms remain poorly defined. In triple-negative breast cancer (TNBC), an aggressive and generally immune-rich subtype, an…
View details →Kağan Kırcaburun, Pınar Özdemir · 2026 · Behavioral Sciences
The rapid integration of generative artificial intelligence (GAI) tools into academic and professional contexts has raised concerns regarding unethical use and the potential development of problematic usage patterns. Drawing on personality and moral psychology frameworks, the present study examined the associations between antagonistic personality traits (narcissism, Machiavellianism, and psychopathy) and problematic (i.e., addictive) GAI use (PGAIU), as well as the chain mediating effect of moral disengagement and unethical GAI use (UGAIU). Data were collected from an adult sample (N = 491; 5
View details →Sandra Heskamp, Otto C. Boerman, Janneke D.M. Molkenboer‐Kuenen et al. · 2014 · Molecular Pharmaceutics
Bevacizumab and cetuximab are approved for the treatment of cancer. However, in advanced colorectal cancer, addition of cetuximab to chemotherapy with bevacizumab did not improve survival. The reason for the lack of activity remains…
View details →Takahiro Ogawa, Rune Shibata, Keiji Komatsu et al. · 2025 · International Journal of Implant Dentistry
PURPOSE: Despite decades of clinical success with microrough implant surfaces, persistent challenges-particularly the biological trade-off between osteoblast proliferation and differentiation-highlight the need for novel surface design strategies. This review investigates the potential of meso-scale topography (10-500 μm) as a promising and underexplored dimension in implant surface engineering, situated between macro-level implant geometry and conventional microroughness. METHODS: A systematic review, supplemented by a targeted literature search, was conducted to evaluate the biological and m
View details →Özgür Atılgan, Franz W. Kellermanns · 2025 · Family Business Review
We investigate how negative types of intra-family conflicts (i.e., status conflict and relationship conflict) influence the family firm leader’s socioemotional wealth importance (SEWi). Based on 159 matched responses from family firm…
View details →Bekir Enes Koca, Sümeyye Sarıtaş, Mikhaël Bechelany et al. · 2025 · International Journal of Molecular Sciences
Polyphenols are bioactive molecules that occur naturally in plants and exhibit a diverse array of properties, including antioxidant, anti-inflammatory, and anti-obesity effects, all of which have been supported by numerous studies. They are categorized into four main groups: flavonoids, phenolic acids, stilbenes, and lignans. Polyphenols demonstrate a wide range of health-promoting effects throughout human life, from the womb to old age. They can exert these effects by modulating signaling pathways, regulating gut microbiota, influencing gene expression, and regulating epigenetic pathways. Thi
View details →Haisheng Zhang, Jiawei Li, Haijing Yan et al. · 2025 · Advanced Materials
Proton exchange membrane water electrolysis (PEMWE) is a promising blueprint for the industrial production of green hydrogen in the short term, but its large-scale deployment is extremely constrained by the high cost and low storage of…
View details →Yohsuke Ohtsubo, Miyu Higuchi · 2022 · Letters on Evolutionary Behavioral Science
This study aimed at replicating a previously reported pattern: costly apologies are perceived as more sincere than non-costly apologies even when the transgression was unintentional, while costly apologies do not foster forgiveness more than non-costly apologies when the transgression was unintentional. We conducted a vignette study with a 2 (apology cost: costly vs. non-costly) × 3 (intention: no vs. ambiguous vs. malicious intention) between-participants factorial design. We failed to replicate the aforementioned pattern. Instead, we found that costly apologies promote not only perceived sin
View details →Gustavo Jimenez‐Maggiora, Arndt‐Peter Schulz, Michael Donohue et al. · 2024 · The Journal of Prevention of Alzheimer s Disease
BACKGROUND: The Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN) studies were conducted between 2014 and 2023, with enrollment completed in 2017 and final study results reported in 2023. The study screening process involved the collection of initial clinical, cognitive, neuroimaging, and genetic measures to determine eligibility. Once randomized, enrolled participants were assessed every four weeks over a 4.5-year follow-up period during which longitudinal clinical, cognitive, and neuroimaging measures wer
View details →Tongbo Zhu, Zhiying Wang, Lynn M. McMullen et al. · 2021 · Microorganisms
The locus of heat resistance (LHR) confers resistance to extreme heat, chlorine and oxidative stress in Escherichia coli. This study aimed to determine the function of the LHR in maintaining bacterial cell envelope homeostasis, the regulation of the genes comprising the LHR and the contribution of the LHR to alkaline pH response. The presence of the LHR did not affect the activity of the Cpx two-component regulatory system in E. coli, which was measured to quantify cell envelope stress. The LHR did not alter E. coli MG1655 growth rate in the range of pH 6.9 to 9.2. However, RT-qPCR results ind
View details →Christian Basil Omeh, Musa Adekunle Ayanwale, Lindelani Mnguni et al. · 2025 · Journal of New Approaches in Educational Research
Abstract Despite the increasing emphasis on computational literacy in higher education, we observed that many undergraduate students particularly in developing contexts struggle to master fundamental programming skills and develop critical thinking. Conventional instructional approaches often lack interactivity and personalized scaffolding, which are essential for teaching abstract programming concepts. In response to this challenge, we examined the effect of artificial intelligence (AI)-assisted problem-based learning (PBL) on students’ programming skills, critical thinking, and problem-solvi
View details →Patrick Golletz, Sissel Damsbo Jensen, Madeline Collignon et al. · 2025 · Journal of Oral Microbiology
Introduction: Coaggregation may reduce the abundance of bacteria in physiological fluids, such as saliva, as aggregated bacteria are cleared more easily than planktonic cells. This study aimed to identify Lactobacillus strains that…
View details →Lucia Scisciola, Manuela Giovanna Basilicata, Marta Belmonte et al. · 2026 · Nutrients
BACKGROUND: The heart depends on a continuous and flexible energy supply from fatty acids, glucose, and other substrates. Emerging evidence shows that gut microbiota-derived metabolites-such as trimethylamine-N-oxide (TMAO), short-chain fatty acids (SCFAs), secondary bile acids, indoles, phenylacetylglutamine (PAGln), and branched-chain amino acids-modulate cardiac metabolism and function. Although clinical evidence linking these metabolites to cardiovascular outcomes is expanding, most data remain associative, with limited causal or interventional proof. METHODS: A comprehensive narrative rev
View details →Marek Franěk, Jan Petružálek · 2025 · Scientific Reports
A number of eye-tracking studies have shown that viewing natural environments is associated with reduced eye movement activity compared with viewing built environments. This has been linked to the cognitive benefits of viewing nature and…
View details →Toshiaki Taoka, Rintaro Ito, Rei Nakamichi et al. · 2026 · Japanese Journal of Radiology
Diffusion tensor image analysis along the perivascular space (DTI-ALPS) was originally developed and defined as a noninvasive diffusion MRI method intended to evaluate glymphatic function and is now widely used in neuroimaging research. However, accumulating evidence suggests that the biological meaning of the ALPS index is more complex than initially assumed as a simple marker of glymphatic function. The ALPS index does not directly measure whole-brain fluid transport but rather reflects localized directional diffusivity based on the Brownian motion of water molecules. Its value is strongly i
View details →Chrysanthi Melanou, Maik Beege · 2026 · Education Sciences
Generative artificial intelligence (AI) is increasingly used in higher education as an interactive tutoring partner rather than a passive information tool. While AI offers opportunities to support learning, concerns remain regarding cognitive offloading, reduced engagement, and unreflective use. Although instructional scaffolding is a well-established design principle for supporting complex learning, its role in shaping cognitive and metacognitive processes in AI-supported settings remains underexplored. This quasi-experimental pre–post study examined how varying levels of scaffolding influenc
View details →Lei Yuan, Zhe Zhao, Hongxiang Peng et al. · 2026 · Cardiovascular Diabetology
BACKGROUND: The C-reactive protein-triglyceride-glucose index (CTI) has been proposed as a novel biomarker for insulin resistance and inflammation. However, its role in the progression trajectory of cardiometabolic multimorbidity (CMM) remains unclear. We aimed to investigate the involvement of the CTI in the CMM progression trajectory. METHODS: This prospective study included 266,049 individuals from the UK Biobank, who were free of cardiometabolic diseases (CMD) at baseline. CMM was defined as the presence of two or more CMDs, including type 2 diabetes (T2D), coronary heart disease (CHD), an
View details →Ngoc Anh Pham, The Anh Phan · 2025 · Journal Of Vacation Marketing
In the fast-paced world of TikTok, travel influencers craft immersive experiences that captivate followers and inspire travel intentions. This study explores how an influencer's persona—through interaction, attractiveness, and…
View details →Simone Taddeo, Andrea Regoli, O. Weber et al. · 2026 · Business Strategy and the Environment
ABSTRACT This study investigates the financial consequences of greenwashing, operationalized as the misalignment between ESG disclosure and actual ESG performance. While prior research has explored the reputational and ethical dimensions…
View details →Annefleur C. Langedijk, Floris van den Dungen, Lisette M. Harteveld et al. · 2025 · Human Vaccines & Immunotherapeutics
The European Medicines Agency has authorized two interventions to prevent lower respiratory tract disease due to respiratory syncytial virus (RSV-LRTD) in infants: nirsevimab, a monoclonal antibody, and bivalent stabilized prefusion F…
View details →Michael Harrison Storandt, Frank A. Sinicrope · 2026 · BMJ Oncology
The treatment paradigm for deficient mismatch repair (dMMR) colorectal cancer (CRC) has evolved substantially in recent years. Universal mismatch repair testing and broad use of next-generation sequencing have increased the detection of…
View details →Yang Fu, Jie Liu, Zeming Mo et al. · 2026 · MedComm
ABSTRACT Melanoma is the most aggressive skin malignant tumor, typically exhibiting a high mutation burden and potentially harboring mutations in NRAS, BRAF, or NF1. To enhance survival rates, these driver alterations can achieve significant antitumor activity through targeted therapy. In the past decade, BRAF inhibitors combined with MEK inhibitors significantly improved the prognosis of BRAF mutation melanoma. Nevertheless, researchers have attempted various strategies to block the NRAS signaling pathway, NRAS mutation in melanoma is still considered to be untargetable. In recent years, MEK
View details →Sarah Ancheta, Leah C. Dorman, Guillaume Le Treut et al. · 2026 · PLoS Computational Biology
Single-cell RNA sequencing is revolutionizing our understanding of cell state dynamics, allowing researchers to capture and quantify the transcriptomic profile of a single cell at a specific timepoint. Among the computational techniques used to predict cellular trajectories, RNA velocity has emerged as a predominant tool for modeling transcriptional dynamics. RNA velocity leverages the mRNA maturation process to generate velocity vectors that predict the likely future state of a cell, offering insights into cellular differentiation, aging, and disease progression. Although this technique has s
View details →Batist Geldhof, Jolien Pattyn, Sam Noppen et al. · 2026 · Plant Stress
Abstract Developing leaves undergo a vast array of age-related changes as they mature. These include physiological, hormonal and morphological changes that determine their adaptation plasticity towards adverse conditions. Waterlogging…
View details →Chang Hu, Wenying Huang, W. W. Zhang et al. · 2026 · BMC Psychiatry
BACKGROUND: Suicidal ideation is an emerging issue among athletes, posing significant risks to their mental health. The mechanisms linking psychological strain to suicidal ideation remain unclear. This study addresses this gap by examining…
View details →HASAN F. SHABBIR, Yanwen Chen, Jing Sun et al. · 2026 · International Journal of Molecular Sciences
Since their initial discovery in 2003, carbon quantum dots (CDs) have attracted significant attention due to their unique optical properties and potential biomedical applications. This review critically examines the past 20 years of research on CDs, with a particular focus on cytotoxicity studies from the last decade. CDs, typically less than 10 nm in size, have been synthesized from various organic and inorganic precursors using multiple methods, including hydrothermal, microwave, and chemical reduction techniques. Their properties can be finely tuned by modifying synthesis parameters and inc
View details →Nic Glewwe, Evan M. Dastin-van Rijn, Cathy S. Chen et al. · 2026 · Neuropsychopharmacology
Cognitive flexibility can be defined as the ability to adaptively shift between choices or strategies based on environmental feedback. Flexibility is disrupted in numerous neuropsychiatric conditions. Individual differences in the computations supporting cognitive flexibility may reveal mechanisms of neuropsychiatric risk and resilience. One critical variable well known to influence individual differences in neuropsychiatric risk is sex. While previous research has identified sex differences in value based decision making in mice, whether sex reflects a major source of variation in cognitive f
View details →Ariadna Tibau, Edward R. Scheffer Cliff, Alejandra Romano et al. · 2025 · EClinicalMedicine
Background: The accelerated approval pathway allows the FDA to approve drugs for serious conditions based on promising surrogate measures, with confirmatory studies required later. If subsequent testing shows an unfavorable benefit-risk profile, the indication may be withdrawn. This study aimed to identify factors associated with the withdrawal of drug indications following accelerated approval. Methods: In this retrospective cohort study, we identified FDA-approved drugs for solid and hematologic cancers from 1992 to 2022 and extracted factors present at the time of accelerated approval, incl
View details →Rafael Cabral, Ricardo Santos, José A.F.O. Correia et al. · 2025 · Sensors
The automated inspection of civil infrastructure with Unmanned Aerial Vehicles (UAVs) is hampered by the challenge of accurately segmenting multi-damage in high-resolution imagery. While foundational models like the Segment Anything Model (SAM) offer data-efficient segmentation, their effectiveness is constrained by prompting strategies, especially for geometrically complex defects. This paper presents a comprehensive comparative analysis of deep learning strategies to identify an optimal deep learning pipeline for segmenting cracks, efflorescences, and exposed rebars. It systematically evalua
View details →Shangkai Gao, Léa Décarie-Spain, Cindy Gu et al. · 2026 · Comprehensive physiology
Glucagon-like peptide-1 (GLP-1) is a nutrient-responsive hormone classically associated with glucose homeostasis and food intake control, yet its receptor is broadly expressed throughout the central nervous system (CNS) in circuits governing complex cognitive processes. Here, we synthesize emerging evidence from preclinical models and human studies demonstrating that GLP-1 receptor (GLP-1R) signaling modulates multiple cognitive domains, including reward and motivational processes relevant to obesity and substance use disorder, affective-related behaviors, and learning and memory. We propose a
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