Negative / Null Result ReportOpen accessMedicine
Malte L Schmieding, Marvin Kopka, Myrto Bolanaki et al. · 2025 · Journal of Medical Internet Research
BACKGROUND: Symptom checker apps (SCAs) are layperson-facing tools that advise on whether and where to seek care, or possible diagnoses. Previous research has primarily focused on evaluating the accuracy, safety, and usability of their recommendations. However, studies examining SCAs' impact on clinical care, including the patient-physician interaction and satisfaction with care, remain scarce. OBJECTIVE: This study aims to evaluate the effects of an SCA on satisfaction with the patient-physician interaction in acute care settings. Additionally, we examined its influence on patients' anxiety a
View details →Negative / Null Result ReportOpen accessMedicine
Steven D. Nathan, Victoria Lacasse, Heidi Bell et al. · 2024 · Pulmonary Circulation
The PERFECT study, a randomized, controlled, double-blind study of inhaled treprostinil in patients with COPD and associated pulmonary hypertension (PH-COPD) was a negative trial that was terminated early. The reason(s) for the negative…
View details →Negative / Null Result ReportOpen accessMedicine
Jason E. Pope, Ajay Antony, Erika Petersen et al. · 2024 · Pain and Therapy
INTRODUCTION: Drawbacks of fixed-output spinal cord stimulation (SCS) screening trials may lead to compromised trial outcomes and poor predictability of long-term success. Evoked compound action potential (ECAP) dose-controlled closed-loop…
View details →Negative / Null Result ReportOpen accessMedicine
Sandra Heskamp, Otto C. Boerman, Janneke D.M. Molkenboer‐Kuenen et al. · 2014 · Molecular Pharmaceutics
Bevacizumab and cetuximab are approved for the treatment of cancer. However, in advanced colorectal cancer, addition of cetuximab to chemotherapy with bevacizumab did not improve survival. The reason for the lack of activity remains…
View details →Negative / Null Result ReportOpen accessEngineering
Takahiro Ogawa, Rune Shibata, Keiji Komatsu et al. · 2025 · International Journal of Implant Dentistry
PURPOSE: Despite decades of clinical success with microrough implant surfaces, persistent challenges-particularly the biological trade-off between osteoblast proliferation and differentiation-highlight the need for novel surface design strategies. This review investigates the potential of meso-scale topography (10-500 μm) as a promising and underexplored dimension in implant surface engineering, situated between macro-level implant geometry and conventional microroughness. METHODS: A systematic review, supplemented by a targeted literature search, was conducted to evaluate the biological and m
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Özgür Atılgan, Franz W. Kellermanns · 2025 · Family Business Review
We investigate how negative types of intra-family conflicts (i.e., status conflict and relationship conflict) influence the family firm leader’s socioemotional wealth importance (SEWi). Based on 159 matched responses from family firm…
View details →Negative / Null Result ReportOpen accessMedicine
Bekir Enes Koca, Sümeyye Sarıtaş, Mikhaël Bechelany et al. · 2025 · International Journal of Molecular Sciences
Polyphenols are bioactive molecules that occur naturally in plants and exhibit a diverse array of properties, including antioxidant, anti-inflammatory, and anti-obesity effects, all of which have been supported by numerous studies. They are categorized into four main groups: flavonoids, phenolic acids, stilbenes, and lignans. Polyphenols demonstrate a wide range of health-promoting effects throughout human life, from the womb to old age. They can exert these effects by modulating signaling pathways, regulating gut microbiota, influencing gene expression, and regulating epigenetic pathways. Thi
View details →Negative / Null Result ReportOpen accessEnergy
Haisheng Zhang, Jiawei Li, Haijing Yan et al. · 2025 · Advanced Materials
Proton exchange membrane water electrolysis (PEMWE) is a promising blueprint for the industrial production of green hydrogen in the short term, but its large-scale deployment is extremely constrained by the high cost and low storage of…
View details →Negative / Null Result ReportOpen accessPsychology
Yohsuke Ohtsubo, Miyu Higuchi · 2022 · Letters on Evolutionary Behavioral Science
This study aimed at replicating a previously reported pattern: costly apologies are perceived as more sincere than non-costly apologies even when the transgression was unintentional, while costly apologies do not foster forgiveness more than non-costly apologies when the transgression was unintentional. We conducted a vignette study with a 2 (apology cost: costly vs. non-costly) × 3 (intention: no vs. ambiguous vs. malicious intention) between-participants factorial design. We failed to replicate the aforementioned pattern. Instead, we found that costly apologies promote not only perceived sin
View details →Negative / Null Result ReportOpen accessMedicine
Gustavo Jimenez‐Maggiora, Arndt‐Peter Schulz, Michael Donohue et al. · 2024 · The Journal of Prevention of Alzheimer s Disease
BACKGROUND: The Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN) studies were conducted between 2014 and 2023, with enrollment completed in 2017 and final study results reported in 2023. The study screening process involved the collection of initial clinical, cognitive, neuroimaging, and genetic measures to determine eligibility. Once randomized, enrolled participants were assessed every four weeks over a 4.5-year follow-up period during which longitudinal clinical, cognitive, and neuroimaging measures wer
View details →Negative / Null Result ReportOpen accessChemistry
Tongbo Zhu, Zhiying Wang, Lynn M. McMullen et al. · 2021 · Microorganisms
The locus of heat resistance (LHR) confers resistance to extreme heat, chlorine and oxidative stress in Escherichia coli. This study aimed to determine the function of the LHR in maintaining bacterial cell envelope homeostasis, the regulation of the genes comprising the LHR and the contribution of the LHR to alkaline pH response. The presence of the LHR did not affect the activity of the Cpx two-component regulatory system in E. coli, which was measured to quantify cell envelope stress. The LHR did not alter E. coli MG1655 growth rate in the range of pH 6.9 to 9.2. However, RT-qPCR results ind
View details →Negative / Null Result ReportOpen accessEngineering
Tuğba Özer, Sakda Jampasa, Atchara Lomae et al. · 2026 · Analytical Chemistry
High Resolution Image Download MS PowerPoint Slide Herein, we present a potentiometric biosensor based on amine magnetic beads functionalized with electrostatically neutral peptide nucleic acids (PNA) for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A screen-printed carbon electrode was modified with a plasticized polymeric membrane. A SARS-CoV-2 specific peptide nucleic acid probe was designed and synthesized. We exploited the advantage of neutral PNAs to remove the negatively charged DNA probes that cause fouling due to the attraction of positively charged b
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
António Afonso, José Alves, João Jalles et al. · 2026 · Scottish Journal of Political Economy
ABSTRACT We examine how geopolitical risks (GPR) affect fiscal (FS) and external sustainability (ES) across 27 European Union economies over 2001Q4–2022Q3. We apply a two‐step strategy: first, estimating time‐varying FS and ES coefficients…
View details →Negative / Null Result ReportOpen accessComputer Science
Sebastian Schorcht, Fabian Anton Müller, Nils Frederik Buchholtz · 2026 · ZDM
Abstract Large Language Models (LLMs) are increasingly discussed as tools for supporting mathematical problem solving. However, existing research predominantly evaluates LLM performance in terms of correctness, while the mathematics educational quality of AI-generated worked-out solutions remains largely unexplored. This study investigates how the mathematics educational quality (a set of quality criteria relating to teaching and learning mathematics) of AI-generated problem solutions can be influenced by model choice and prompt engineering. Four LLMs (Gemini 1.5 Pro (Advanced), Claude 3.5 Son
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Elias Sabri, Agustín Mangiarotti, Rumiana Dimova · 2026 · Nature Communications
Biomolecular condensates, essential for cellular organization, possess mesoscale properties largely governed by hydrophobicity, influencing molecule partitioning and material characteristics like viscosity, surface tension, and hydration. While hydrophobicity's role is increasingly recognized, its impact on membrane-condensate interactions remains unexplored. Here, we combine hyperspectral imaging of an environment-sensitive dye and phasor analysis, to quantitatively map the local dielectric permittivity of both condensates and their environment with pixel resolution. This robust method senses
View details →Negative / Null Result ReportOpen accessHealth Professions
Rachel O’Neill · 2025 · International Journal of Cultural Studies
Medical doctors are central to existing networks for wellness content on Instagram in and beyond the UK, yet remain overlooked within scholarship concerned with this terrain. Taking a case study approach, this article examines three such figures prominent in the UK context. In doing so, it challenges existing conceptualisations of the 'wellness influencer' and argues for an expanded understanding of the category, one that does not assume its representatives are 'lay' persons without recognised expertise in health and well-being. The analysis developed demonstrates that credentials cannot resol
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Ruiyi Tian, Xiaoyu Zong, Duo Ren et al. · 2026 · Nature Medicine
Abstract Incidence of early-onset cancer is rising globally in recent generations, which underscores the need to elucidate the influence of emerging generational risk factors. Systemic and organ-specific aging reflects the cumulative impact of exposures and may provide an integrative and complementary approach to understand early-onset cancer risk. Here among 154,169 young adults from the United Kingdom Biobank, systemic aging measured by PhenoAge increased across birth cohorts, with 23% s.d. increase for those born 1965–1974 versus 1950–1954, and was associated with early-onset solid cancer r
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Luyanda Majenge, Sakhile Mpungose, Simiso Msomi · 2025 · Energies
The transition of South Africa from coal-dependent energy systems to renewable energy alternatives presents economic and environmental trade-off complexities that require empirical investigation. This study employed threshold-switching dynamic models, NARDL analysis, and threshold Granger causality tests to investigate nonlinear relationships between renewable energy generation, economic growth, and carbon dioxide emissions in South Africa from 1980 to 2023. The threshold-switching dynamic models revealed critical structural breakpoints: a 56.4% renewable energy threshold for carbon dioxide em
View details →Negative / Null Result ReportOpen accessEngineering
Fhysmélia Firmino de Albuquerque, Rodrigo M. Iost, Frank N. Crespilho · 2025 · ACS Measurement Science Au
The development of enzyme-based bioelectronic devices, including biosensors and biomimetic systems, has significantly advanced with the introduction of innovative materials such as hydrogels, deep eutectic solvents (DES), and ionic liquids (ILs). These materials offer unique advantages in enhancing biodevice performance, particularly in enzyme stabilization, biocompatibility, and electrochemical sensitivity. Hydrogels, known for their high water content and flexibility, provide an ideal matrix for enzyme immobilization in biological applications but are limited by low ionic conductivity. DES,
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Xiangdong Ji, Yang Chen · 2026 · Nuclear Physics B
Momentum current density (MCD) $T^{ij}$ is a general physics concept describing the momentum conservation through momentum flow generated from both the kinetic motion of particles and the interacting forces among them. It has been suggested by M. Polyakov et al. that the MCD in the nucleon, characterized by the form factor $C/D$ of the QCD energy-momentum tensor, can be interpreted as the pressure and shear forces between adjacent parts of the system because the nucleon interior approximates a continuous medium. While intuitively appealing, we find that the interpretation is hard to justify fr
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Tamara Evstafyeva, Nils Peter Siemonsen, William E. East · 2026 · Physical review. D/Physical review. D.
We reinvestigate the stability properties of ultracompact spinning boson stars with a stable light ring using fully nonlinear 3+1 and 2+1 numerical relativity simulations and two different formulations of the Einstein equations. We find no…
View details →Negative / Null Result ReportOpen accessDecision Sciences
Pablo Ruiz‐Palomino, Juliana Toro‐Arias, María del Pilar Rodríguez‐Córdoba et al. · 2025 · Business Ethics the Environment & Responsibility
ABSTRACT A supportive ethical culture (EC) can encourage moral behavior among employees and help them avoid wrongdoing. One option for fostering EC is ethics training; its longer‐term effectiveness, however, has rarely been examined,…
View details →Negative / Null Result ReportOpen accessMedicine
Lion Stammen, Eva J I Hoeijmakers, Thomas G. Flohr et al. · 2025 · European Radiology
OBJECTIVES: To evaluate diagnostic image quality (IQ) for pulmonary embolism detection in photon-counting detector CT (PCD-CT) with significantly reduced contrast media (CM) dose vs conventional energy-integrating detector CT (EID-CT), using optimized and individualized CM protocols. MATERIALS AND METHODS: Consecutive CT pulmonary angiography (CTPA) scans performed on the EID-CT (Jan 2024-Mar 2024) with an individualized kilovoltage (kV) and total body weight (TBW) adapted CM protocol, and on the PCD-CT (Aug 2023-Feb 2024) with a TBW adapted CM protocol matching the 70 kV EID-CT protocol, were
View details →Negative / Null Result ReportOpen accessMedicine
Jijuan Zhang, Hancheng Yu, Tingting Geng et al. · 2025 · BMC Medicine
BACKGROUND: Accelerated aging is a dynamic process, yet few studies examined the association of changes in accelerated aging with cardiovascular disease (CVD) and mortality. This study aims to evaluate this association in three prospective…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
George Yumnam, Parul R. Raghuvanshi, J. D. Budai et al. · 2025 · Cell Reports Physical Science
We provide experimental evidence for the absence of a magnetic moment in bulk RuO 2 , a candidate altermagnetic material, by using a combination of Mössbauer spectroscopy, nuclear forward scattering, inelastic X-ray and neutron scattering,…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
M. Rossi, Stefania Salvadori, Á. Skúladóttir et al. · 2025 · The Astrophysical Journal
Abstract The elusive properties of the first (Population III or Pop III) stars can be indirectly unveiled by uncovering their true descendants. To this end, we exploit our data-calibrated model for the best-studied ultrafaint dwarf galaxy (UFD), Boötes I, which tracks the chemical evolution (from carbon to zinc) of individual stars from their formation to the present day. We explore the chemical imprint of Pop III supernovae (SNe), with different explosion energies and masses, showing that they leave distinct chemical signatures in their descendants. We find that UFDs are strongly affected by
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Chan Seok Lim, Jisun Lee, Jisun Lee et al. · 2025 · Nature Communications
SUMMARY We report the cryo-EM structures of clusters of TNF receptor family proteins, TNFR1 and BAFFR. The receptor-ligand complexes were anchored to a flat lipid layer to mimic the membrane-bound state. We observed that the TNFα-TNFR1…
View details →Negative / Null Result ReportOpen accessEngineering
Fengxiang Liu, Shipeng Ning, Xia Wang et al. · 2025 · Science Advances
Cancer stem cells (CSCs) and myeloid-derived suppressor cells (MDSCs) contribute to chemoresistance and immunosuppression, constraining chemoimmunotherapy outcomes. Differentiation therapy, aiming to mature CSCs and MDSCs, shows great promise. However, its efficacy is hindered by limited accessibility in hypoxic deep tumor regions. Inspired by the apoptotic body (ApoBD)-mediated deep tumor penetration, we design a pulsatile sequential drug release system with a core-shell structure. The reversible acid-responsive shell protonates and swells in lysosomes to release doxorubicin, inducing lysosom
View details →Negative / Null Result ReportOpen accessMedicine
Alexander N. Klishko, Jonathan Harnie, Claire E. Hanson et al. · 2025 · The Journal of Physiology
It has been suggested that during locomotion, the nervous system controls movement by activating groups of muscles, or muscle synergies. Analysis of muscle synergies can reveal the organization of spinal locomotor networks and how it…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Nurcan Kilinc‐Ata, Alia Al-Fori · 2026 · Journal of risk and financial management
The intersection of financial innovation and environmental sustainability offers important opportunities for low- and middle-income (LMI) countries. This study examines the association between FinTech investment, geopolitical-economic uncertainty, urbanization, economic development, and carbon dioxide (CO2) emissions in LMI countries. CO2 emissions per capita are used as an environmental outcome indicator rather than as a direct measure of green finance. Using a panel dataset covering 2010–2021, the study applies fixed-effects panel regressions as the main empirical approach and reports one-st
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