Negative / Null Result ReportOpen accessMaterials Science
L L Sun, Yisa Zhao, Xiyu Caomeng et al. · 2026 · ChemistryOpen
Traditional blending electrospinning has a series of issues during implementation, and the corresponding monolithic nanofibers can always be updated through the intentional design of core-sheath nanostructures. In this study, a modified coaxial electrospinning approach was employed to refine the electrospinning process by eliminating abnormal phenomena, while simultaneously imparting core-sheath nanostructures and improved transdermal finasteride (FIN) delivery performance. Using an electrospinnable ethylcellulose (EC) solution containing FIN as the core fluid and an unspinnable polyvinylpyrro
View details →Negative / Null Result ReportOpen accessMedicine
Edoardo Cipolletta, Tatiana Zverkova Sandström, D. Rozza et al. · 2026 · JAMA Internal Medicine
Importance: Gout is associated with increased cardiovascular risk. Whether achieving a target serum urate level lower than 6 mg/dL with urate-lowering treatment (ULT) would reduce cardiovascular risk in patients with gout is unknown. Objectives: To evaluate the association between achieving a serum urate treatment target lower than 6 mg/dL and cardiovascular events among patients with gout who were newly prescribed ULT. Design, Setting, and Participants: This new-user cohort study using emulated target trial framework with up to 5-year follow-up was performed using primary care data from the C
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Chang‐Wei Bai, Yi-Jiao Sun, Xin-Tong Huang et al. · 2026 · Nature Communications
Heterogeneous Fenton-like systems activated by peroxymonosulfate represent promising platforms for organic wastewater treatment but are significantly hampered by competing adsorption and catalytic oxidation processes at identical active…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Amina Hamdouni · 2025 · International Journal of Financial Studies
This study examines the association between Saudi banks’ internal adoption of AI-enabled FinTech-related digital tools and their financial performance, sustainability performance, and financial stability over the period 2015–2024. Using a panel dataset of 10 banks, the analysis investigates how the adoption of AI-driven technologies—such as machine-learning credit assessment, robo-advisory systems, and automated compliance tools—is related to market performance (Tobin’s Q), accounting performance (ROA and ROE), financial stability (Z-Score), and sustainability outcomes measured by both Bloombe
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Avilash Singh Yadav, Lilan Hong, Patrick M. Klees et al. · 2026 · Current Biology
Nature exhibits organs of various shapes and forms, ranging from smooth to undulated morphologies. How cells coordinate their growth to produce smoothly shaped leaves and leaf-like organs such as sepals remains unclear. We identified a mutant, as2-7D, that exhibits ectopic expression of ASYMMETRIC LEAVES 2 (AS2) on the outer epidermis. Our analysis reveals that ectopic AS2 expression causes the outer epidermis of as2-7D sepals to buckle during early stages of sepal development. Buckling is caused by conflicting cell growth directions and unequal tissue stiffness across the epidermal layers. Ov
View details →Negative / Null Result ReportOpen accessPsychology
Christian Greiner, Vincent Besch, Marissa Bouchard-Boivin et al. · 2025 · PLoS ONE
The concept of epistemic trust is gaining traction in the mental health field. Epistemic trust is thought to play a foundational role as a resilience factor against the development and maintenance of psychopathology by fostering social learning. The primary aim of this study was to validate the French-language version of the Epistemic Trust, Mistrust and Credulity Questionnaire (ETMCQ). We further sought to replicate previously reported associations with key developmental and psychological factors (childhood trauma, mentalizing and attachment) and test for epistemic trust's potential mediating
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Kasper Skytte Andersen, Kai Zhao, Alexander de Linde Agerskov et al. · 2025 · Nature Communications
Understanding species-level abundance dynamics in complex microbial communities is key to managing microbial ecosystems, yet it remains a major challenge. In wastewater treatment plants (WWTPs), the presence and abundance of…
View details →Negative / Null Result ReportOpen accessComputer Science
Thevin Senath, Kumuthu Athukorala, Ransika Costa et al. · 2025 · Natural Language Processing Journal
In this paper, we address the challenge of recipe personalization through ingredient substitution. We make use of Large Language Models (LLMs) to build an ingredient substitution system designed to predict plausible substitute ingredients within a given recipe context. Given that the use of LLMs for this task has been barely done, we carry out an extensive set of experiments to determine the best LLM, prompt, and the fine-tuning setups. We further experiment with methods such as multi-task learning, two-stage fine-tuning, and Direct Preference Optimization (DPO). The experiments are conducted
View details →Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
Sadek Ahmed, Khaled M. Attallah, Marwa Eid Sayyed · 2026 · AAPS PharmSciTech
Abstract This research focuses on creating a novel Brijaluronic-based terpesomal system capable of transporting quercetin (QER) efficiently to the brain. The vesicles were fabricated through an ethanol-injection method and then refined using a structured optimization approach in Design-Expert® software. The influence of three main formulation parameters: terpene-to-drug ratio, surfactant type, and hyaluronic acid amount were evaluated. The optimization process was designed to maximize EE%, minimize VS, and maintain ZP within an acceptable stability range. The optimal formula hit a desirability
View details →Negative / Null Result ReportOpen accessMedicine
Gabriela-Florentina Tapos, Ioan-Alexandru Cîmpeanu, Iasmina-Alexandra Predescu et al. · 2026 · Diseases
BACKGROUND/OBJECTIVES: Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide and increasingly are recognized as a continuum of interconnected conditions rather than isolated entities. METHODS: A structured narrative literature search was performed in PubMed, Scopus, and Google Scholar for publications from 2015 to 2025 using combinations of different keywords: "cardiovascular disease spectrum", "multi-omics", "precision cardiology", "machine learning", and "artificial intelligence in cardiology". RESULTS: Evidence was synthesized across seven major cluste
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Daniel S. Borrus, Raghav Sehgal, Judith Armstrong et al. · 2026 · Aging Cell
ABSTRACT Epigenetic clocks have emerged as potential biomarkers of aging due to their association with morbidity and mortality. They have recently gained traction as outcome measurements for anti‐aging interventions. However, as the number of new epigenetic clocks continues to grow, different clocks may not agree on the effect of an intervention. This raises the question of when researchers can trust epigenetic clock results. In this study, we find that when extending previously published single‐clock intervention studies to include additional clock models, no additional clocks reach statistic
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Elizabeth Demers, Victor Xiaoqi Wang, Kean Wu · 2026 · Accounting Horizons
In 2020, the SEC issued amendments to Regulation S-K requiring filers to provide discussions of their human capital (HC) management practices. We investigate how firms respond during the first two years under this principles-based…
View details →Negative / Null Result ReportOpen accessMedicine
Shivani Baisiwala, Elisa Fazzari, Matthew Li et al. · 2026 · Cell Reports
A major obstacle to identifying effective therapies for the aggressive brain tumor glioblastoma is the lack of human-specific, immunocompetent models that reflect the human tumor microenvironment. To address this, we developed the…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Susana Pereira Bastos · 2026 · University of Vienna
The presence of Indians in Mozambique since the second half of the 19th century is closely linked with the socio-economic and political transformations of the Swahili coast, as well as with the migratory movements between India and Austral Africa which began in 1860, namely with the wave of Gujarati “passengers” who paid their own passage, first to South Africa, later also to Delagoa Bay (Lourenco Marques). Based on the family life histories of the main Indian (Hindu, Sunni and Ismaili) family businesses of Mozambique, we intend to illustrate how the consolidation of a transnational migratory
View details →Negative / Null Result ReportOpen accessEngineering
Lianpeng Dai, Xin Zhao, Yishan Pan et al. · 2026 · Journal of Rock Mechanics and Geotechnical Engineering
Strainburst is a type of severe dynamic hazard frequently encountered in underground excavation, involving violent rock ejection. It is caused by the release of elastic strain energy stored in the surrounding rocks. Hence, the burst energy…
View details →Negative / Null Result ReportOpen accessMedicine
Qiaojuan Jane Su, James R. Ashenhurst, Wanwan Xu et al. · 2026 · Nature
The development of glucagon-like peptide 1 (GLP1) receptor agonists, including semaglutide and tirzepatide, has transformed the clinical management of overweight and obesity. However, substantial inter-person variability exists in both…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Gonzalo Morrás, G. Pratten, P. Schmidt · 2026 · The Astrophysical Journal Letters
Abstract The observation of gravitational waves (GWs) from merging black holes and neutron stars provides a unique opportunity to discern information about their astrophysical environment. Two signatures that are considered powerful tracers to distinguish between different binary formation channels are general relativistic spin-induced orbital precession and orbital eccentricity. Both effects leave characteristic imprints in the GW signal that can be extracted from observations. To date, neither precession nor eccentricity has been confidently discerned in merging neutron star–black hole binar
View details →Negative / Null Result ReportOpen accessComputer Science
Husna Husna, Khalid Abdullah Al Muzaini, Maryam Rashid Saleh Al Tamimi et al. · 2026 · Ar-Rayyan Journal of Islamic Education
The increasing availability of educational data has opened new opportunities for improving instructional decision-making through learning analytics. However, its application in Islamic Religious Education (IRE) remains limited, particularly in predicting students’ academic achievement and learning behavior. This study aims to develop a learning analytics model capable of identifying learning patterns and predicting students’ performance in IRE. A quantitative research design employing Educational Data Mining (EDM) techniques was conducted using learning management system (LMS) data from 512 se
View details →Negative / Null Result ReportOpen accessMedicine
Mitali Tyagi, Eric de Hoog, Matthew Grega et al. · 2026 · Cell
Abstract Intracellular neurofibrillary tangles that consist of misfolded tau protein 1 cause neurodegeneration in Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Tau pathology spreads cell-to-cell 2 but the exact mechanisms of tau release and intercellular transmission remain poorly defined. Tau is released from neurons as free protein or in extracellular vesicles (EVs) 3–5 but the role of these different release mechanisms in intercellular tau transmission is unclear. Here, we show that the neuronal gene Arc is critical for packaging tau into EVs. Brain EVs purified from human tau
View details →Negative / Null Result ReportOpen accessSocial Sciences
Jeremy Bowles, Kevin Croke, Horacio Larreguy et al. · 2025 · American Political Science Review
Exposure to misinformation can affect citizens’ beliefs, political preferences, and compliance with government policies. However, little is known about how to durably reduce susceptibility to misinformation, particularly in the Global South. We evaluate an intervention in South Africa that encouraged individuals to consume biweekly fact-checks—as text messages or podcasts—via WhatsApp for six months. Sustained exposure to these fact-checks induced substantial internalization of fact-checked content, while increasing participants’ ability to discern new political and health misinformation upon
View details →Negative / Null Result Report
Gabriela Yamazaki de Campos, Raquel Amorim Oliveira, Patrícia Kellen Martins Oliveira-Brito et al. · 2020 · PeerJ
Background The macrophage lineage is characterized by plasticity due to the acquisition of distinct functional phenotypes, and two major subsets are evaluated; classical M1 activation (strong microbicidal activity) and alternative M2…
View details →Negative / Null Result Report
Joshua Hascher, Nitisha Desai, Ian Krajbich · 2021 · Judgment and Decision Making
Abstract A core principle in decision science is that people choose according to their subjective values. These values are often measured using unincentivized scales with arbitrary units (e.g., from 0 to 10) or using incentivized…
View details →Negative / Null Result Report
Behrooz Ghorbani, Song Mei, Theodor Misiakiewicz et al. · 2021 · Journal of Statistical Mechanics: Theory and Experiment
Abstract For a certain scaling of the initialization of stochastic gradient descent (SGD), wide neural networks (NN) have been shown to be well approximated by reproducing kernel Hilbert space (RKHS) methods. Recent empirical work showed…
View details →Negative / Null Result Report
Kärt Simre, Oivi Uibo, Aleksandr Peet et al. · 2019 · Acta Paediatrica
Abstract Aim Our aim was to compare the presence of various common viruses (rhinovirus, enterovirus, adenovirus, Epstein–Barr virus, cytomegalovirus, norovirus, parechovirus) in stool and nasal swab samples as well as virus‐specific…
View details →Negative / Null Result Report
Heido Trofimov, Nicolas Bellouin, Velle Toll · 2020 · Journal of Geophysical Research: Atmospheres
Abstract Aerosols offset a poorly quantified fraction of anthropogenic greenhouse gas warming, and the aerosol impact on clouds is the most uncertain mechanism of anthropogenic climate forcing. Here observations of a relatively weak…
View details →Negative / Null Result Report
Yumeng Zhang, Premsai Kumar, Jacob J. Adashek et al. · 2022 · Cells
Modulating the cyclooxygenase 2 (COX-2) pathway has improved responses to immune checkpoint inhibitors (ICIs) in certain solid tumors, such as melanoma. Little is known about COX-2 inhibition in response to ICIs in metastatic renal cell…
View details →Negative / Null Result Report
Howard Cooke, Rianne Appel-Meulenbroek, Theo Arentze · 2019 · International Journal of Strategic Property Management
This paper seeks to understand whether the alignment process between business strategy and Corporate Real Estate (CRE) between 2007 and 2014 was dynamic. It investigated the financial data of 230 UK companies by means of a distributed time…
View details →Negative / Null Result Report
Vikram Sharma, Tanujit Dey, Kesavan Sankaramangalam et al. · 2019 · Journal of the American Heart Association
Background Troponin elevation occurs commonly in the setting of transcatheter aortic valve replacement (TAVR). There is a lack of information on the extent of troponin elevation post TAVR that is prognostically significant. We assessed the…
View details →Negative / Null Result Report
Robin-Tobias Jauss, Sophia Schließke, Rami Abou Jamra · 2022 · Genes
Routine diagnostics is biased towards genes and variants with satisfactory evidence, but rare disorders with only little confirmation of their pathogenicity might be missed. Many of these genes can, however, be considered relevant,…
View details →Negative / Null Result Report
Paul C. Moorehead, Nicholas J. Barrowman, Janelle Cyr et al. · 2017 · Pediatric Critical Care Medicine
Objective: There are no proven methods to predict the risk of clinically significant bleeding in the PICU. A retrospective study identified platelet count as a risk marker for clinically significant bleeding. We conducted a study to…
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