20,211 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
M Berg · 2026 · Acta Dermato Venereologica
Only in Sweden is skin disease reputedly caused by working at visual display units (VDUs) a considerable problem. In the present work facial skin complaints in VDU-exposed persons have been studied by means of epidemiological, clinical and…
View details →Katherine L. Ford, Michael B. Sawyer, Sunita Ghosh et al. · 2024 · ESMO Open
•Patients were able to increase and sustain dietary protein intake from preintervention levels.•Over one-half of patients in the 2.0 g/kg/day group maintained or gained MM with a 12-week targeted nutrition intervention.•This work…
View details →Adam La Caze, Stephen B. Duffull · 2010 · Journal of Clinical Pharmacy and Therapeutics
WHAT IS KNOWN AND OBJECTIVE: The importance of statistical power is widely recognized from a pre-trial perspective, and when interpreting results that are not statistically significant. It is less well recognized that poor power can lead…
View details →Susan Rowell, Eric N. Meier, Tatiana Hoyos Gomez et al. · 2024 · The Journal of Trauma: Injury, Infection, and Critical Care
BACKGROUND: In the prehospital tranexamic acid (TXA) for traumatic brain injury (TBI) trial, TXA administered within 2 hours of injury in the out-of-hospital setting did not reduce mortality in all patients with moderate/severe traumatic…
View details →Emanuela Colombo, Rosaria Pascente, Daniela Triolo et al. · 2020 · Molecules
Astrocytes greatly participate to inflammatory and neurotoxic reactions occurring in neurodegenerative diseases and are valuable pharmacological targets to support neuroprotection. Here we used human astrocytes generated from reprogrammed fibroblasts as a cellular model to study the effect of the compound Laquinimod and its active metabolite de-Laquinimod on astrocyte functions and the astrocyte-neuron interaction. We show that human iAstrocytes expressed the receptor for the inflammatory mediator IL1 and responded to it via nuclear translocation of NFκB, an event that did not occur if cells w
View details →Brian Premchand, Liyuan Liang, Kok Soon Phua et al. · 2024 · NeuroSci
Detecting stress is important for improving human health and potential, because moderate levels of stress may motivate people towards better performance at cognitive tasks, while chronic stress exposure causes impaired performance and health risks. We propose a Brain-Computer Interface (BCI) system to detect stress in the context of high-pressure work environments. The BCI system includes an electroencephalogram (EEG) headband with dry electrodes and an electrocardiogram (ECG) chest belt. We collected EEG and ECG data from 40 participants during two stressful cognitive tasks: the Cognitive Vig
View details →Isabel O. Gallegos, Chen Shani, Weiyan Shi et al. · 2026 · PNAS Nexus
Abstract As generative AI enables the creation and dissemination of information at massive scale and speed, it is increasingly important to understand how people perceive AI-generated content. One prominent policy proposal requires explicitly labeling AI-generated content to increase transparency and encourage critical thinking about the information, but prior research has not yet tested the effects of such labels. To address this gap, we conducted a survey experiment (N=1,601) on a diverse sample of Americans, presenting participants with an AI-generated message about several public policies
View details →Chris Kent, Adam A. Scaife, Nick Dunstone et al. · 2025 · npj Climate and Atmospheric Science
Abstract Machine learning weather models trained on observed atmospheric conditions can outperform conventional physics-based models at short- to medium-range (1–14 day) forecast timescales. Here we take the machine learning model ACE2, trained to predict 6-hourly steps in atmospheric evolution and which can remain stable over long forecast periods, and assess it from a seasonal forecasting perspective (1–3 month lead time). Applying persisted sea surface temperature (SST) and sea-ice anomalies centred on 1 st November each year, we initialise a lagged ensemble of seasonal predictions covering
View details →Jiayi Liu, Weichen Hong, Zhendong Sun et al. · 2026 · Frontiers in Immunology
The proposal of the gut-lung axis has profoundly reshaped our understanding of the mechanisms underlying respiratory diseases. As a crucial component of this axis, the gut microbiota plays a central role in pulmonary immune regulation through inter-organ communication mediated by metabolic products. However, a systematic integration of mechanisms explaining how gut microbes achieve precise cross-organ immune regulation remains elusive. Existing research predominantly focuses on descriptive observations, such as the association between early-life microbiota dysbiosis and an increased risk of as
View details →Peter A. Merkel, Michael George, Huibin Yue et al. · 2025 · ACR Open Rheumatology
OBJECTIVE: This study aimed to report the safety of avacopan, an oral selective complement C5a receptor antagonist, using pooled data from clinical trials in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis…
View details →Mukhlis Mukhlis, Ahmad Nabriz, Muhammad Eissawy Abu El Yazid et al. · 2026 · Integrated Education Journal
This study aims to comparatively analyze the perspectives, policies, implementation, and challenges of multicultural education in developed and developing countries. A qualitative approach was employed using library research, drawing on scholarly journal articles, academic books, educational policy documents, and relevant previous studies. Data were analyzed through comparative content analysis to identify patterns of similarities, differences, challenges, and implementation strategies across the two contexts. The findings indicate that developed countries generally demonstrate more systematic
View details →Claire Henderson, Yasuhiro Kotera, Brynmor Lloyd‐Evans et al. · 2026 · World Psychiatry
Social inclusion means being able to participate in activities valued within one's community or wider society as one would wish. People with severe mental illness (i.e., psychoses, bipolar disorder, and severe depression) experience some…
View details →Bethan Cracknell Daniels, Neil M. Ferguson, Ilaria Dorigatti · 2025 · Nature Medicine
Dengue is the most common arboviral infection, causing substantial morbidity and mortality globally. The licensing of Qdenga, a second-generation vaccine developed by Takeda Pharmaceuticals, is therefore timely, but the potential public health impact of vaccination across transmission settings needs to be evaluated. To address this, we characterized Qdenga's efficacy profile using mathematical models calibrated to published clinical trial data and estimated the public health impact of routine vaccine use. We find that efficacy against both virologically confirmed dengue and hospitalization dep
View details →Lisa S. Rotenstein, A. Jay Holmgren, Robert Thombley et al. · 2026 · JAMA
Importance: Artificial intelligence (AI)-enabled scribes have been proposed to reduce electronic health record (EHR) burden and improve clinician satisfaction. There is limited evidence about their associated results across multiple sites…
View details →Pradeep Kumar Singh, Jennifer A. Rybak, Ryan J Schuck et al. · 2024 · Science Advances
Receptor tyrosine kinases (RTKs) regulate many cellular functions and are important targets in pharmaceutical development, particularly in cancer treatment. EGFR and EphA2 are two key RTKs that are associated with oncogenic phenotypes.…
View details →Yuting Tan, Rui Xue, Yuwei Pan et al. · 2026 · Signal Transduction and Targeted Therapy
The dynamic interplay between neoplastic cells and the host has been increasingly recognized as important players in the pathogenesis of cancer cachexia, a syndrome affecting ~50-80% of cancer patients with various incidences of different types of malignancies. Despite its prevalence, a comprehensive understanding of cancer cachexia progression, with a holistic view at the cross-organismal, cellular and molecular levels, remains elusive. In this review, we undertake an in-depth exploration of the relevant target organs and their regulatory roles in cancer cachexia, with a particular focus on m
View details →Newton Cao, Warda Merchant, Laurent Gautron · 2024 · Scientific Reports
The communication between intestinal Glucagon like peptide 1 (GLP-1)-producing cells and the peripheral nervous system has garnered renewed interest considering the availability of anti-obesity and anti-diabetic approaches targeting GLP-1…
View details →Yimao Wu, Kaiyu Zhang, 夏新亚 et al. · 2026 · BMC Medicine
BACKGROUND: Breast cancer is the most commonly diagnosed malignancy in women worldwide, and its marked heterogeneity together with the complexity of the tumor microenvironment contributes to substantial variability in therapeutic…
View details →Rickard Strandberg, Fredrik Åberg, Juho Asteljoki et al. · 2025 · BMJ
OBJECTIVE: To develop and validate a novel risk prediction model for incident major adverse liver outcomes (MALO) in a primary care setting. DESIGN: Population based cohort study. SETTING: Sweden, with validation in Finland and the UK.…
View details →Liangsuo Ma, Larry Keen, Joel L. Steinberg et al. · 2024 · NeuroImage
• Resting- state fMRI data were acquired from 34 healthy participants. • Effective connectivities (ECs) associated with HRV and heart rate were investigated. • Regression DCM and ICA were used to identify most relevant network nodes. • ECs…
View details →Rishi Chanderraj, Brian Bartek, Kathleen A. Stringer et al. · 2026 · Journal of Clinical Investigation
BACKGROUNDSepsis encompasses considerable biological and clinical heterogeneity. Previously, 2 phenotypes ("hyperinflammatory" and "hypoinflammatory") have been consistently identified within sepsis via latent class analysis. These phenotypes differ in their biological features, clinical outcomes, and therapeutic responses to interventions. Prior studies of sepsis heterogeneity have focused primarily on the host response. Here, we investigate the potential influence of the causative pathogen on sepsis heterogeneity and pathobiology.METHODSWe performed a retrospective observational analysis of
View details →Denis A. Zadkov, Nikita MARTYUSHEV, Boris V. Malozyomov et al. · 2026 · Mathematics
In this study, a comprehensive mathematical method for modeling the operational reliability of mine hoisting equipment under conditions of incomplete and heavily censored data is developed. The analyzed dataset includes 259 observations collected over a five-year period for six critical components, with the overall level of censoring reaching 62% and exceeding 70% for long life mechanical subsystems. Considering right, left, and interval censoring, the paper proposes a unified statistical procedure that combines empirical estimation of failure rates with parametric identification using Weibull
View details →Anonymous, G. Baltus, Sarah Caudill et al. · 2026 · Physical review. D/Physical review. D.
We perform a search for binary black hole mergers with one sub-solar mass (SSM) black hole and a primary component above $\sim 2 M_\odot$ in data from the second observing run (O2) of the LIGO-Virgo detectors. Our analysis extends the parameter space explored by previous LIGO-Virgo Collaboration searches for binaries containing SSM components into a region of parameter space motivated by broad mass distributions of primordial black holes (PBHs) exhibiting a peak around $[2-3] M^{}_\odot$, which can arise from the reduction of the equation of state during the QCD phase transition in the early U
View details →Aras Fahrettin Korkmaz, Fatih Ekinci, Şehmus Altaş et al. · 2025 · Biology
This study presents a novel approach for classifying Discomycetes species using deep learning and explainable artificial intelligence (XAI) techniques. The EfficientNet-B0 model achieved the highest performance, reaching 97% accuracy, a 97% F1-score, and a 99% AUC, making it the most effective model. MobileNetV3-L followed closely, with 96% accuracy, a 96% F1-score, and a 99% AUC, while ShuffleNet also showed strong results, reaching 95% accuracy and a 95% F1-score. In contrast, the EfficientNet-B4 model exhibited lower performance, achieving 89% accuracy, an 89% F1-score, and a 93% AUC. These
View details →Francesco D’Eugenio, Ignas Juodžbalis, Xihan Ji et al. · 2025 · Monthly Notices of the Royal Astronomical Society
ABSTRACT We present a ‘Little Red Dot’ (LRD) broad-line active galactic nucleus (AGN) at $z=5.077 $, observed with NIRSpec/MSA (micro-shutter assembly) and NIRSpec/IFU (integral-field unit) by the JADES (JWST Advanced Deep Extragalactic Survey) and BlackTHUNDER (Black holes in THe early Universe aNd their DensE surRoundings) surveys. Combining spatially resolved and high-resolution spectroscopy, we characterize its central engine, host, and environment. H$\alpha $ has multiple components, including two broad Gaussians, yielding a black-hole mass $\log (M_{\bullet }/{\rm M}_\odot) = 7.65 $, whi
View details →Nikolaos P.E. Kadoglou, Konstantinos G. Moulakakis, George Mantas et al. · 2022 · Angiology
Arterial stiffness and its valid index, the cardio-ankle vascular index (CAVI), have emerged as predictors of adverse cardiovascular outcomes. We investigated the relationship of the CAVI with significant carotid stenosis (> 50%) and the…
View details →Anna Kuehne, Barbara Hauer, Bonita Brodhun et al. · 2018 · Eurosurveillance
Background Germany has a low tuberculosis (TB) incidence. A relevant and increasing proportion of TB cases is diagnosed among asylum seekers upon screening. Aim: We aimed to assess whether cases identified by screening asylum seekers had…
View details →Jiajia Du, Zhiyong Huang, Erlei Zhang · 2024 · Frontiers in Immunology
Background Immunotherapy based on immune checkpoint inhibitors (ICIs) has become the first-line treatment for unresectable hepatocellular carcinoma (uHCC). However, only a small portion of patients are responsive to ICIs. It is important…
View details →Olive Lennon, Deirdre Phelan, Deborah Wallace et al. · 2019 · Physiotherapy Research International
Abstract Background and Purpose Evidence‐based practice (EBP), which integrates clinical reasoning skills, research evidence, and patient preference, has become standard in curricula for health care professional programs. Students however…
View details →Robert Pontius · 2018 · Land
The Verified Carbon Standard (VCS) recommends the Figure of Merit (FOM) as a possible metric to confirm models that simulate deforestation baselines for Reducing Emissions from Deforestation and forest Degradation (REDD). The FOM ranges…
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