19,810 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Charlie Curtsinger, Emery D. Berger · 2013 · ACM SIGARCH Computer Architecture News
Researchers and software developers require effective performance evaluation. Researchers must evaluate optimizations or measure overhead. Software developers use automatic performance regression tests to discover when changes improve or…
View details →Evan A. Valdes, James H. Liu, Matt N Williams · 2022 · Asian Journal Of Social Psychology
The status‐legitimacy hypothesis proposes that those who are most disadvantaged by unequal social systems are even more likely than members of more advantaged groups to provide ideological support for the very social system that is responsible for their disadvantages. Li, Yang, Wu, and Kou (2020, Personality and Social Psychology Bulletin ) sought to expand the generalizability of this hypothesis by testing it in China, addressing inconsistencies surrounding the empirical support for this hypothesis by postulating that the construct of status should be separated into an objective and subjectiv
View details →Jacqueline Ramı́rez, Tae Won Kim, Wanqing Liu et al. · 2013 · Pharmacogenetics and Genomics
XK469 (NSC 697887) is a selective topoisomerase II β inhibitor eliminated mainly by aldehyde oxidase I (AOX1). We performed a candidate gene study to investigate whether AOX1 genetic variation contributes to interindividual variability in…
View details →Lu Zhao, Caroline Mwaliko, Evans Atoni et al. · 2019 · Frontiers in Microbiology
Globally, mosquitoes are known to be competent vectors to various arboviruses that cause serious and debilitating diseases to humans and animals. Conversely, mosquitoes harbor a wide array of insect specific viruses (ISVs) that are generally neglected. Extensive characterization of these ISVs is important in understanding their persistence infection effect on host behavior and arbovirus transmission. Herein, we report first time isolation of Tanay virus (TANAV) isolate YN15_103_01 in Anopheles sinensis mosquitoes from Yunnan Province, China. Phylogenetically, the isolate’s nucleotide identity
View details →R. Garrett, Daniel Sude, Paolo Riva · 2019 · Political Communication
Research suggests that ostracism could promote endorsement of partisan falsehoods. Socially excluded individuals are uniquely attentive to distinctions between in-groups and out-groups, and act in ways intended to promote group belonging,…
View details →George Gitonga Inoti · 2014 · Journal of Finance and Accounting
This study sought to determine whether acquisitions enhance corporate financial performance. The general objective of the study was to assess the effects of acquisitions on the financial performance of the acquiring companies in Kenya. The…
View details →Selina Banda, Florence Phiri, Jack Kaale et al. · 2023
Bloom’s Taxonomy is crucial in any teaching and learning environment because it determines direction for a course of study. This study assessed application of Bloom’s Taxonomy in courses of study offered in colleges in Lusaka District. Objectives were: Assess the application of Bloom’s Taxonomy in setting learning outcomes for the courses; Assess reflection of Bloom’s Taxonomy in activities set for course participants; Ascertain significance attached to Bloom’s Taxonomy in courses of study designed for participants. The study employed a mixed methodology, in particular employing a descriptive
View details →Neil A. Duncan, Sabina B. Bruehlmann, Christopher Hunter et al. · 2012 · Computer Methods in Biomechanics & Biomedical Engineering
Designing biomaterials to mimic and function within the complex mechanobiological conditions of connective tissues requires a detailed understanding of the micromechanical environment of the cell. The objective of our study was to measure…
View details →Christos Koros, Athina‐Maria Simitsi, Dimitra Papadimitriou et al. · 2020 · Journal of Parkinson s Disease
BACKGROUND: Blood uric acid level represents an emerging biomarker in Parkinson's disease (PD). Whether uric acid levels change in genetic forms of PD is just beginning to be explored. OBJECTIVE: The aim of the present study was to assess differences in serum uric acid level among PD patients harboring the p.A53T mutation in the alpha-synuclein gene, idiopathic PD, and healthy controls. METHODS: Longitudinal 5-year serum uric acid measurement data of 369 de novo idiopathic PD patients and 174 age- and gender-matched healthy controls have been downloaded from the Parkinson's Progression Markers
View details →Canan Kop Bozbay, Ahmet Akdag, Helin Atan et al. · 2020 · Animal Bioscience
OBJECTIVE: The objectives of this study were to compare the effects of normal and low protein content (PC) of starter diet supplemented or not with blends of branched-chain amino acids (BCAAs) on growth performance of broilers under summer conditions and to investigate whether these effects altered some quality traits and the characteristics of gastrointestinal tract. METHODS: A total of 768 mixed-sex broiler chicks (Ross 308, one-d-old) with an average initial body weight (BW) of 47.6±1.03 g were allocated into six treatments with four replications in 2×3 factorial arrangement. Factors were:
View details →Nicolas Laverde, Christian Grévisse, Sandra Ximena Jaramillo-Rincón et al. · 2025 · Computational and Structural Biotechnology Journal
Effective communication is crucial for trust-building, accurate information gathering, and clinical decision-making in healthcare. Despite its emphasis in medical curricula, traditional training methods, such as role-playing with…
View details →Rachel Charlton, Anita McGrogan, Julia Snowball et al. · 2017 · Drug Safety
Electronic healthcare data have several advantages over prospective observational studies, but the sensitivity of data on neurodevelopmental outcomes and its comparability with data generated through other methodologies is unknown. The…
View details →Patrick R.J. Fortuna, Helle Bielefeldt‐Ohmann, Dmitry A. Ovchinnikov et al. · 2018 · Stem Cells and Development
Horses are susceptible to a number of neurotropic viruses, including West Nile virus (WNV), which is a pathogen of global significance in both horses and humans. However, there are no in vitro models with which to study infectious…
View details →Colleen Lacey, Lisa Ohlhauser, Jodie R. Gawryluk · 2019 · Frontiers in Neurology
Background Clarifying the neuropathology of depression as a symptom of Parkinson's disease (PD) has been the goal of recent neuroimaging studies; however, results have been conflicting and lack replication. The purpose of the current study was to replicate recent methods that have used diffusion tensor imaging (DTI) to compare individuals with PD with and without depression and to extend previous findings to allow for a better understanding of the results. Methods Thirty-seven participants with de novo PD were retrieved from the Parkinson's Progression Marker's Initiative (PPMI) and were separ
View details →Abby E. Davis, Kaitlin R. Deutsch, Alondra M. Torres et al. · 2021 · Scientific Reports
Flowers can be transmission platforms for parasites that impact bee health, yet bees share floral resources with other pollinator taxa, such as flies, that may be hosts or non-host vectors (i.e., mechanical vectors) of parasites. Here, we assessed whether the fecal-orally transmitted gut parasite of bees, Crithidia bombi, can infect Eristalis tenax flower flies. We also investigated the potential for two confirmed solitary bee hosts of C. bombi, Osmia lignaria and Megachile rotundata, as well as two flower fly species, Eristalis arbustorum and E. tenax, to transmit the parasite at flowers. We
View details →Charles M. Reigeluth, Peter Honebein · 2020 · Revista de Educación a Distancia (RED)
La mayoría de los investigadores que diseñan experiencias innovadoras de aprendizaje digital y luego realizan investigaciones que investigan la utilidad de esas experiencias de aprendizaje, no aplican completamente la teoría de la…
View details →Wilhelmiina Hämäläinen · 2010 · Työväentutkimus Vuosikirja
Analyzing statistical dependencies is a fundamental problem in all empirical science. Dependencies help us understand causes and effects, create new scientific theories, and invent cures to problems. Nowadays, large amounts of data is…
View details →Karen R. Gouze, John V. Lavigne, Joyce Hopkins et al. · 2012 · Infant Mental Health Journal
Temperamental negative affectivity (NA) and effortful control (EC) have long been of interest to psychologists, but sensory regulation (SR) has received less attention. Using confirmatory factor analysis, the present study reexamined the…
View details →Newton Cao, Warda Merchant, Laurent Gautron · 2024 · Scientific Reports
The communication between intestinal Glucagon like peptide 1 (GLP-1)-producing cells and the peripheral nervous system has garnered renewed interest considering the availability of anti-obesity and anti-diabetic approaches targeting GLP-1…
View details →Denis A. Zadkov, Nikita MARTYUSHEV, Boris V. Malozyomov et al. · 2026 · Mathematics
In this study, a comprehensive mathematical method for modeling the operational reliability of mine hoisting equipment under conditions of incomplete and heavily censored data is developed. The analyzed dataset includes 259 observations collected over a five-year period for six critical components, with the overall level of censoring reaching 62% and exceeding 70% for long life mechanical subsystems. Considering right, left, and interval censoring, the paper proposes a unified statistical procedure that combines empirical estimation of failure rates with parametric identification using Weibull
View details →Peter A. Merkel, Michael George, Huibin Yue et al. · 2025 · ACR Open Rheumatology
OBJECTIVE: This study aimed to report the safety of avacopan, an oral selective complement C5a receptor antagonist, using pooled data from clinical trials in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis…
View details →Bethan Cracknell Daniels, Neil M. Ferguson, Ilaria Dorigatti · 2025 · Nature Medicine
Dengue is the most common arboviral infection, causing substantial morbidity and mortality globally. The licensing of Qdenga, a second-generation vaccine developed by Takeda Pharmaceuticals, is therefore timely, but the potential public health impact of vaccination across transmission settings needs to be evaluated. To address this, we characterized Qdenga's efficacy profile using mathematical models calibrated to published clinical trial data and estimated the public health impact of routine vaccine use. We find that efficacy against both virologically confirmed dengue and hospitalization dep
View details →Lisa S. Rotenstein, A. Jay Holmgren, Robert Thombley et al. · 2026 · JAMA
Importance: Artificial intelligence (AI)-enabled scribes have been proposed to reduce electronic health record (EHR) burden and improve clinician satisfaction. There is limited evidence about their associated results across multiple sites…
View details →Susan Rowell, Eric N. Meier, Tatiana Hoyos Gomez et al. · 2024 · The Journal of Trauma: Injury, Infection, and Critical Care
BACKGROUND: In the prehospital tranexamic acid (TXA) for traumatic brain injury (TBI) trial, TXA administered within 2 hours of injury in the out-of-hospital setting did not reduce mortality in all patients with moderate/severe traumatic…
View details →Pradeep Kumar Singh, Jennifer A. Rybak, Ryan J Schuck et al. · 2024 · Science Advances
Receptor tyrosine kinases (RTKs) regulate many cellular functions and are important targets in pharmaceutical development, particularly in cancer treatment. EGFR and EphA2 are two key RTKs that are associated with oncogenic phenotypes.…
View details →Katherine L. Ford, Michael B. Sawyer, Sunita Ghosh et al. · 2024 · ESMO Open
•Patients were able to increase and sustain dietary protein intake from preintervention levels.•Over one-half of patients in the 2.0 g/kg/day group maintained or gained MM with a 12-week targeted nutrition intervention.•This work…
View details →Rickard Strandberg, Fredrik Åberg, Juho Asteljoki et al. · 2025 · BMJ
OBJECTIVE: To develop and validate a novel risk prediction model for incident major adverse liver outcomes (MALO) in a primary care setting. DESIGN: Population based cohort study. SETTING: Sweden, with validation in Finland and the UK.…
View details →Yuting Tan, Rui Xue, Yuwei Pan et al. · 2026 · Signal Transduction and Targeted Therapy
The dynamic interplay between neoplastic cells and the host has been increasingly recognized as important players in the pathogenesis of cancer cachexia, a syndrome affecting ~50-80% of cancer patients with various incidences of different types of malignancies. Despite its prevalence, a comprehensive understanding of cancer cachexia progression, with a holistic view at the cross-organismal, cellular and molecular levels, remains elusive. In this review, we undertake an in-depth exploration of the relevant target organs and their regulatory roles in cancer cachexia, with a particular focus on m
View details →Claire Henderson, Yasuhiro Kotera, Brynmor Lloyd‐Evans et al. · 2026 · World Psychiatry
Social inclusion means being able to participate in activities valued within one's community or wider society as one would wish. People with severe mental illness (i.e., psychoses, bipolar disorder, and severe depression) experience some…
View details →M Berg · 2026 · Acta Dermato Venereologica
Only in Sweden is skin disease reputedly caused by working at visual display units (VDUs) a considerable problem. In the present work facial skin complaints in VDU-exposed persons have been studied by means of epidemiological, clinical and…
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