Laquinimod Modulates Human Astrocyte Function and Dampens Astrocyte-Induced Neurotoxicity during Inflammation
Emanuela Colombo; Rosaria Pascente; Daniela Triolo; Claudia Bassani; Anthea De Angelis; Francesca Ruffini; Linda Ottoboni; Gıancarlo Comı · 2020 · Molecules
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Astrocytes greatly participate to inflammatory and neurotoxic reactions occurring in neurodegenerative diseases and are valuable pharmacological targets to support neuroprotection. Here we used human astrocytes generated from reprogrammed fibroblasts as a cellular model to study the effect of the compound Laquinimod and its active metabolite de-Laquinimod on astrocyte functions and the astrocyte-neuron interaction. We show that human iAstrocytes expressed the receptor for the inflammatory mediator IL1 and responded to it via nuclear translocation of NFκB, an event that did not occur if cells w
Abstract by Emanuela Colombo; Rosaria Pascente; Daniela Triolo; Claudia Bassani; Anthea De Angelis; Francesca Ruffini; Linda Ottoboni; Gıancarlo Comı, Molecules (2020) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/molecules25225403