Negative / Null Result ReportOpen accessMedicine
Mark B. Stoddard, Hui Li, Shuyi Wang et al. · 2015 · mBio
UNLABELLED: Hepatitis C virus (HCV) infection is characterized by persistent replication of a complex mixture of viruses termed a "quasispecies." Transmission is generally associated with a stringent population bottleneck characterized by infection by limited numbers of "transmitted/founder" (T/F) viruses. Characterization of T/F genomes of human immunodeficiency virus type 1 (HIV-1) has been integral to studies of transmission, immunopathogenesis, and vaccine development. Here, we describe the identification of complete T/F genomes of HCV by single-genome sequencing of plasma viral RNA from a
View details →Negative / Null Result ReportMedicine
Jinling Li, Carol J. Cardona · 2010 · Avian Diseases
Mutations in a wild duck isolate of avian influenza virus were detected in isolates shed by chickens within 1 day after inoculation. The newly adapted virus was transmitted to naïve chickens in direct contact and sharing food and water.…
View details →Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
Michael Schütt, Konstantinos Stamatopoulos, Hannah Batchelor et al. · 2022 · European Journal of Pharmaceutical Sciences
The performance of colon-targeted solid dosage forms is commonly assessed using standardised pharmacopeial dissolution apparatuses like the USP II or the miniaturised replica, the mini-USP II. However, these fail to replicate the hydrodynamics and shear stresses in the colonic environment, which is crucial for the tablet's drug release process. In this work, computer simulations are used to create a digital twin of a dissolution apparatus and to develop a method to create a digital twin of a tablet that behaves realistically. These models are used to investigate the drug release profiles and s
View details →Negative / Null Result ReportOpen accessPsychology
Ana R. Sepúlveda, Dimitra Anastasiadou, Yolanda de Pellegrin et al. · 2016 · Men and Masculinities
The aim of this study was to examine the factor structure of the Male Body Attitudes Scale (MBAS) among a sample of 212 adolescent males by conducting a confirmatory factor analysis. The data revealed that while muscularity and low body fat factors were appropriate for the male sample, the height factor was not supported. The composite MBAS-Spanish version (MBAS-S) and its two factors had high internal consistency and were not significantly related to the traditionally used measure of body image (Eating Disorder Inventory–Body Dissatisfaction [BD]), confirming that this subscale only appears t
View details →Negative / Null Result ReportOpen accessNeuroscience
Brett Mercier, Dylan Wiwad, Paul K. Piff et al. · 2020 · Collabra Psychology
Does belief in free will increase support for economic inequality? Five studies using diverse measures and methods tested this question. Study 1 finds belief in free will is associated with increased support for inequality. Study 2 manipulates belief in free will and does not find evidence that this changes support for inequality. Studies 3 and 4 find that people are more willing to support inequality in a hypothetical universe where free will exists compared to one where it does not (dz = 0.10–0.13), indicating that people believe the existence of free will justifies inequality. However, a be
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Klaus Grobys · 2021 · International Review of Financial Analysis
Recent research shows that the vast majority of scientific studies published in leading finance journals fails scientific replication (Hou, Xue, and Zhang, 2020; Harvey, Liu, and Zhu; 2016). This study argues that p-hacking, publication pressure and the selection bias from leading finance journals are perhaps not the underlying root cause for this issue. This study shows that standard methodologies often used in finance research are inevitably sample-specific due to the very nature of financial markets. While the consensus of earlier research postulates a rejection of the time-honored Levy hyp
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Thomas Perneger, Angèle Gayet-Ageron · 2023 · JAMA
Importance Many randomized clinical trials yield statistically nonsignificant results. Such results are difficult to interpret within the dominant statistical framework. Objective To estimate the strength of evidence in favor of the null…
View details →Negative / Null Result ReportOpen accessMedicine
Gen Suzuki, Hideya Yamazaki, Norihiro Aibe et al. · 2019 · In Vivo
BACKGROUND/AIM: To evaluate the predictive factors in older patients with localized esophageal cancer treated with definitive radiotherapy. PATIENTS AND METHODS: We retrospectively analyzed patients aged ≥75 years who were treated with…
View details →Negative / Null Result ReportOpen accessMedicine
Mary A.M. Rogers, Kathleen Ward, Tanya R. Gure et al. · 2011 · Diabetes Care
OBJECTIVE: The goals of this study were to examine trajectories of blood pressure (BP) in adults with diabetes and investigate the association of trajectory patterns with mortality. RESEARCH DESIGN AND METHODS: A nonconcurrent longitudinal…
View details →Negative / Null Result ReportOpen accessMedicine
Lucy Brazil, Angela Swampillai, Ka Man Mak et al. · 2020 · Neuro-Oncology Advances
BACKGROUND: Effective treatment for patients at least 70 years with newly diagnosed glioblastoma remains challenging and alternatives to conventional cytotoxics are appealing. Autophagy inhibition has shown promising efficacy and safety in small studies of glioblastoma and other cancers. METHODS: We conducted a randomized phase II trial to compare radiotherapy with or without hydroxychloroquine (2:1 allocation). Patients aged at least 70 years with newly diagnosed high-grade glioma deemed suitable for short-course radiotherapy with an ECOG performance status of 0-1 were included. Radiotherapy
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Jose Ruiz, Saravana Kanagavelu, Claudia Flores et al. · 2016 · Frontiers in Cellular and Infection Microbiology
Recognition of Gram-negative bacteria by toll-like receptor (TLR)4 induces MyD88 and TRIF mediated responses. We have shown that TRIF-dependent responses play an important role in intestinal defense against Gram-negative enteropathogens. In the current study, we examined underlying mechanisms of how systemic TRIF activation enhances intestinal immune defense against Gram-negative bacteria. First we confirmed that the protective effect of poly I:C against enteric infection of mice with Yersinia enterocolitica was dependent on TLR3-mediated TRIF signaling by using TLR3-deficient mice. This prote
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Diego Chemello, Luís Eduardo Paim Rohde, Kátia Gonçalves dos Santos et al. · 2010 · EP Europace
AIMS: We investigated whether the combination of beta(1)-Gly389Arg and GNB3 C825T, two genetic polymorphisms strictly related to adrenergic system modulation, could act as predictors of appropriate therapies in patients with heart failure…
View details →Negative / Null Result ReportOpen accessMedicine
Etsuro Ogata, Masafumi Fukagawa, Hideki Hirakata et al. · 2016 · Clinical and Experimental Nephrology
BACKGROUND: Calcium (Ca)-based phosphate (P) binders, compared to non-Ca-based P binders, contribute to vascular calcification, which is associated with cardiovascular events. METHODS: The LANDMARK study is a multicenter, randomized, open-label, parallel comparative study of lanthanum carbonate (LC) and calcium carbonate (CC) in hemodialysis patients. Stable hemodialysis patients with intact parathyroid hormone ≤240 pg/mL meeting ≥1 of the following criteria (age >65 years, postmenopause, diabetes mellitus) were randomized into the LC and CC groups. LC group patients initially received LC 750
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Annelise Mennicke, Heather M. Bush, Candace J. Brancato et al. · 2021 · Journal of Family Violence
Abstract Youth who witness parental intimate partner violence (IPV) are at increased risk of teen dating violence (DV). This analysis of secondary data investigated whether a bystander intervention program, Green Dot, was effective at…
View details →Negative / Null Result ReportOpen accessMedicine
Lijun Lu, Youqing Deng, Renshi Xu · 2024 · Frontiers in Neurology
Amyotrophic lateral sclerosis (ALS) is a debilitating motor neurological disorder for which there is still no cure. The disease seriously jeopardizes the health and lifespan of adult populations. The authors extensively retrieved the current literature about clinical and experimental ALS treatments. Based on them, this review primarily focused on summarizing the current potential clinical usage and trialing therapeutics of ALS. Currently, the clinical ALS treatments have focused primarily on relieving symptoms to improve the quality of life yet. There are a number of therapeutic approaches suc
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Micah J. McCauley, Ioulia Rouzina, Jasmine Li et al. · 2020 · Viruses
Retroviral nucleocapsid (NC) proteins are nucleic acid chaperones that play distinct roles in the viral life cycle. During reverse transcription, HIV-1 NC facilitates the rearrangement of nucleic acid secondary structures, allowing the transactivation response (TAR) RNA hairpin to be transiently destabilized and annealed to a complementary RNA hairpin. In contrast, during viral assembly, NC, as a domain of the group-specific antigen (Gag) polyprotein, binds the genomic RNA and facilitates packaging into new virions. It is not clear how the same protein, alone or as part of Gag, performs such d
View details →Negative / Null Result ReportOpen accessMedicine
Robert S. Wallis · 2014 · Open Forum Infectious Diseases
OBJECTIVES: There is increasing interest in the potential role of adjunctive anti-inflammatory therapy to accelerate tuberculosis (TB) treatment. Sputum culture conversion is an important biomarker predictor of durable TB cure. METHODS:…
View details →Negative / Null Result ReportOpen accessMedicine
Mark Seow Khoon Chong, Jing Lim, Junwei Goh et al. · 2014 · Molecular Pharmaceutics
In spite of recognized limitations in capturing species-specific responses and high costs, rodent models remain commonly used in prostate cancer metastasis research, due largely to the lack of available alternatives. We aim to develop an…
View details →Negative / Null Result ReportOpen accessNeuroscience
Aung Naing, Alain P. Algazi, Gerald S. Falchook et al. · 2022 · Cancer
BACKGROUND: Targeting programmed cell death protein 1 (PD-1) and indoleamine 2,3-dioxygenase (IDO1) pathways is an appealing option for cancer treatment. METHODS: The open-label, phase 1/2 ECHO-203 study evaluated the safety, tolerability,…
View details →Negative / Null Result Report
Adélaïde Doussau, Paul Perez, Maryse Puntous et al. · 2013 · Transfusion
Background During on‐pump cardiac surgery, hemorrhagic complications occur frequently. Fresh‐frozen plasma ( FFP ) is widely transfused to provide coagulation factors. Yet, no randomized clinical trial has demonstrated its benefits on…
View details →Negative / Null Result ReportOpen accessMedicine
Charanpreet Singh, Sanjay Jain, Veena Dhawan et al. · 2020 · Archives of Endocrinology and Metabolism
OBJECTIVE: We conducted a study to examine the association of endothelial dysfunction and oxidative stress with uric acid levels in patients of metabolic syndrome. METHODS: One hundred and two patients of Metabolic Syndrome (International Diabetes Federation definition) were included in the study. Anthropometric measurements, serum uric acid levels, fasting blood sugar levels and lipid levels, as well as malondialdehyde and reactive nitrogen intermediates were measured after an 8-hour fasting period. Flow mediated vasodilation (FMD) of the brachial artery was measured and endothelial dysfuncti
View details →Negative / Null Result ReportOpen accessMedicine
Jie Wu, Jianan Ren, Qinjie Liu et al. · 2019 · Frontiers in Immunology
Background: Continuous veno–venous hemofiltration (CVVH) could influence immunomodulation by cytokine removal. Damage-associated molecular patterns (DAMPs) are released by injured cells and have roles in sepsis. We investigated if the magnitude of DAMPs removal was associated with mortality in patients with sepsis undergoing CVVH. Methods: We conducted a prospective, observational study on patients acquiring CVVH at department of surgery, Jinling Hospital. Circulating levels of DAMPs (mitochondrial DNA [mtDNA]; nuclear DNA [nDNA]; heat shock protein [HSP]70) and cytokines were measured at the
View details →Negative / Null Result ReportOpen accessMedicine
Sarita Depani, Kondwani Joseph Banda, Simon Bailey et al. · 2015 · Pediatric Blood & Cancer
BACKGROUND: We previously reported a 28-day treatment protocol for children with endemic Burkitt lymphoma (BL) which included four doses of cyclophosphamide (CPM), intrathecal methotrexate and hydrocortisone (IT MTX/HC) at Queen Elizabeth…
View details →Negative / Null Result ReportOpen accessMedicine
Moonkyoo Kong, Yu Jin Lim, Youngkyong Kim · 2018 · PubMed
Background: We conducted this study to contribute to resolving some controversial issues on management of nasopharyngeal carcinoma. Methods: Thirty-two patients with stage III-IVB nasopharyngeal carcinoma were included in this…
View details →Negative / Null Result ReportMedicine
Aerlyn G. Dawn, Naomi Lawrence · 2013 · Dermatologic Surgery
BACKGROUND: Squamous cell carcinomas (SCCs) generally have been reported to be more prevalent on the lips than basal cell carcinomas (BCCs), but in our experience, BCCs of the lips are common, particularly in women. OBJECTIVES: To…
View details →Negative / Null Result ReportEngineering
Lukas Koedijk, Ana Oprescu · 2022
The EU Green Deal mirrors the societal concern regarding climate change. In the software industry this means reducing the energy consumption of a program. This can be done by looking both at the hardware and the software used. We take a…
View details →Negative / Null Result ReportOpen accessMedicine
Shao-rui Hao, Yan Ren, Shan-yan Zhang et al. · 2020 · Journal of Zhejiang University SCIENCE B
BACKGROUND: Currently, there are no drugs that have been proven to be effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Because of its broad antiviral activity, interferon (IFN) should be evaluated as a…
View details →Negative / Null Result ReportOpen accessMedicine
Tarek Mohamed Ashoor, Ahmad Mahmoud Hasseb, Ibrahim M. Esmat · 2020 · Korean journal of anesthesiology
Background: Nebulized heparin has been effectively used in the management of many pulmonary diseases. However, its effect on mechanically ventilated patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD) has never…
View details →Negative / Null Result ReportOpen accessMedicine
Louise Katherine Bartolac, Jenna Lowe, George Koustas et al. · 2015 · Journal of Reproduction and Development
The aim of this study was to determine the optimum conditions for vitrifying in vitro produced day 7 porcine embryos using different vitrification devices and blastocoele collapse methods. Firstly embryos were collapsed by micro-pipetting,…
View details →Negative / Null Result ReportOpen accessMedicine
Botao Ning, Sheng Ye, Yi Lyu et al. · 2020 · Translational Pediatrics
BACKGROUND: Sepsis has always been a challenge in pediatric intensive care unit (PICU) with poor prognosis. In order to evaluate the effect between routine continuous renal replacement therapy (CRRT) and high-volume hemofiltration (HVHF)…
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