19,808 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Mark Seow Khoon Chong, Jing Lim, Junwei Goh et al. · 2014 · Molecular Pharmaceutics
In spite of recognized limitations in capturing species-specific responses and high costs, rodent models remain commonly used in prostate cancer metastasis research, due largely to the lack of available alternatives. We aim to develop an…
View details →Aung Naing, Alain P. Algazi, Gerald S. Falchook et al. · 2022 · Cancer
BACKGROUND: Targeting programmed cell death protein 1 (PD-1) and indoleamine 2,3-dioxygenase (IDO1) pathways is an appealing option for cancer treatment. METHODS: The open-label, phase 1/2 ECHO-203 study evaluated the safety, tolerability,…
View details →Adélaïde Doussau, Paul Perez, Maryse Puntous et al. · 2013 · Transfusion
Background During on‐pump cardiac surgery, hemorrhagic complications occur frequently. Fresh‐frozen plasma ( FFP ) is widely transfused to provide coagulation factors. Yet, no randomized clinical trial has demonstrated its benefits on…
View details →Charanpreet Singh, Sanjay Jain, Veena Dhawan et al. · 2020 · Archives of Endocrinology and Metabolism
OBJECTIVE: We conducted a study to examine the association of endothelial dysfunction and oxidative stress with uric acid levels in patients of metabolic syndrome. METHODS: One hundred and two patients of Metabolic Syndrome (International Diabetes Federation definition) were included in the study. Anthropometric measurements, serum uric acid levels, fasting blood sugar levels and lipid levels, as well as malondialdehyde and reactive nitrogen intermediates were measured after an 8-hour fasting period. Flow mediated vasodilation (FMD) of the brachial artery was measured and endothelial dysfuncti
View details →Piers Forster, Tristram Walsh, Chris Smith et al. · 2026 · Earth system science data
Abstract. In a rapidly changing climate, evidence-based decision-making benefits from up-to-date and timely information. We track twelve key sets of indicators of the state of the climate system, closely following Intergovernmental Panel on Climate Change (IPCC) Sixth Assessment report (AR6) methods, to produce our fourth annual publication. One of the indicators, the Earth's energy imbalance (EEI) provides a crucial integrative measure of the overall heating of the planet and the pace of climate change – this has more than doubled since the 1976–1995 period. A newly added indicator of tempera
View details →Onurcan Yılmaz, Hasan G. Bahçekapılı · 2015 · PLoS ONE
Scientific and religious thinking compete with each other on several levels. For example, activating one generally weakens the other. Since priming religion is known to increase moral behaviour and moral sensitivity, priming science might be expected to have the opposite effect. However, it was recently demonstrated that, on the contrary, science priming increases moral sensitivity as well. The present set of studies sought to replicate this effect and test two explanations for it. Study 1 used a sentence unscrambling task for implicitly priming the concept of science but failed to replicate i
View details →Michael S. Vitevitch, Gavin J. D. Mullin · 2021 · Brain Sciences
Cognitive network science is an emerging approach that uses the mathematical tools of network science to map the relationships among representations stored in memory to examine how that structure might influence processing. In the present study, we used computer simulations to compare the ability of a well-known model of spoken word recognition, TRACE, to the ability of a cognitive network model with a spreading activation-like process to account for the findings from several previously published behavioral studies of language processing. In all four simulations, the TRACE model failed to retr
View details →Wesley Myers, Kristin M. Lloyd, Jillian J. Turanovic et al. · 2018 · Journal of Contemporary Criminal Justice
There is a growing “replication crisis” in the social and behavioral sciences, where original research across a wide array of substantive areas has failed to replicate when conducted by others. This problem highlights the importance of…
View details →Chloe Wittenberg, Ziv Epstein, Gabrielle Péloquin-Skulski et al. · 2025 · PNAS Nexus
Abstract Recent advancements in generative AI have raised widespread concern about the use of this technology to spread audio and visual misinformation. In response, there has been a major push among policymakers and technology companies to label AI-generated media appearing online. It remains unclear, however, what types of labels are most effective for this purpose. Here, we evaluate two (potentially complementary) strategies for labeling AI-generated content online: (i) a process-based approach, aimed at clarifying how content was made and (ii) a harm-based approach, aimed at highlighting c
View details →Mboneye Anselme, Huafeng He, Chengyang Lai et al. · 2025 · Journal of Translational Medicine
In the realm of cellular biochemistry, mitochondria have been increasingly recognized for their critical role in both cellular metabolism and the etiology of various diseases. Mitochondrial transporters (MTs) are essential for maintaining…
View details →Filippo Laganà, Danilo Pratticò, Marco F. Quattrone et al. · 2026 · Eng—Advances in Engineering
Defects in printed circuit boards (PCBs), if not detected promptly, may persist over time until they cause the failure of critical components. Traditional monitoring methods, which are limited to simulations or superficial measurements, obstruct predictive maintenance and real-time fault detection. To address these issues and enhance real-time diagnostics of thermal anomalies in PCBs, this work proposes an integrated system that combines infrared thermography (IRT), artificial intelligence (AI) algorithms, and Taguchi–ANOVA statistical techniques. IR thermography was employed to identify therm
View details →Patrick Vermersch, Laura Airas, Thomas Berger et al. · 2025 · Frontiers in Immunology
Background: Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS), characterized by inflammation and neurodegeneration. The pathophysiology of MS, especially its progressive forms, involves various cellular components, including microglia, the primary resident immune cells of the CNS. This review discusses the role of microglia in neuroinflammation, tissue repair, and neural homeostasis, as well as their involvement in MS and explores potential therapeutic strategies targeting microglial function. Methods: A literature search conducted in August 202
View details →Josef Biber, Catharina Gandor, Elvir Bećirović et al. · 2025 · Pharmacology & Therapeutics
Gene therapy is an innovative medical approach that offers new treatment options for congenital and acquired diseases by transferring, correcting, inactivating or regulating genes to supplement, replace or modify a gene function. The approval of voretigene neparvovec (Luxturna), a gene therapy for RPE65-associated retinopathy, has marked a milestone for the field of retinal gene therapy, but has also helped to accelerate the development of gene therapies for genetic diseases affecting other organs. Voretigene neparvovec is a vector based on adeno-associated virus (AAV) that delivers a function
View details →Qiyao Zhang, Zhen Cao, Shangcheng Yan et al. · 2025 · Journal of Translational Medicine
Pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC), is notorious for its aggressive nature and dismal prognosis, ranking as a leading cause of cancer-related mortality worldwide. Despite advancements in surgical…
View details →Roberta Fida, Irene Skovgaard‐Smith, Claudio Barbaranelli et al. · 2024 · Human Relations
While considerable attention has been devoted to understanding how individual characteristics influence unethical actions, far less research has examined the role of social and organisational processes. We introduce the concept of organisational moral disengagement (OrgMD), drawing on Bandura’s moral agency theory, to explain how unethicality may be fostered in organisations. OrgMD is a multilevel construct, capturing perceptions of the mechanisms through which morality can be suspended in an organisation allowing unethical practices to flourish. Using four empirical studies, we validated OrgM
View details →Ruixia Zhang, Yi Fan, Hongjing Mao et al. · 2025 · Communications Medicine
The brain age gap (BAG) is a neuroimaging-derived marker of accelerated brain aging. However, its clinical application faces challenges due to model inaccuracies and unclear links to disease mechanisms. This study investigates the clinical…
View details →Galina Stoyancheva, Nikolina Mihaylova, Maria Gerginova et al. · 2025 · International Journal of Molecular Sciences
The human endometrium, previously considered a sterile environment, is now recognized as a low-biomass but biologically active microbial niche critical to reproductive health. Advances in sequencing technologies, particularly shotgun metagenomics, have provided unprecedented insights into the taxonomic and functional complexity of the endometrial microbiome. While 16S rRNA sequencing has delineated the distinction between Lactobacillus-dominant and non-dominant microbial communities, shotgun metagenomics has revealed additional diversity at the species and strain level, uncovering microbial si
View details →Gregor Bieri, Karishma J.B. Pratt, Yasuhiro Fuseya et al. · 2026 · Cell
Blood factors transfer the benefits of exercise to the aged brain independent of physical activity. Here, we show that the liver-derived exercise factor (exerkine) glycosylphosphatidylinositol (GPI)-specific phospholipase D1 (GPLD1), a GPI-degrading enzyme, reverses aging- and Alzheimer's-related memory loss by targeting the brain vasculature. GPLD1 has the potential to cleave over 100 putative GPI-anchored proteins, necessitating the identification of downstream targets that mediate cognitive rejuvenation for translational application. We identified GPI-anchored tissue-nonspecific alkaline ph
View details →Sadek Ahmed, Osama Saher, Heba Attia et al. · 2026 · Frontiers in Pharmacology
Introduction: Vaginal candidiasis remains a recurrent fungal infection affecting millions of women worldwide, necessitating innovative local delivery systems to overcome poor drug solubility and mucosal barriers. This study introduces Dual-Functional Hybrid Cationic PEGylated Proniosomes (DHCPP) as a smart nano-platform designed to boost the vaginal delivery of Fenticonazole Nitrate (FTN). Methods: DHCPP systems were fabricated via the coacervation phase separation method and optimized using a full 2 3 factorial design, achieving a high desirability value of 0.931. The optimized DHCPP exhibite
View details →Sofia Ammassari, Duncan McDonnell, Annika Werner et al. · 2026 · European Journal of Political Research
Abstract Do young women and men join political parties for different reasons? To investigate, we theorize the following: first, women will be more attracted by social incentives and men by material ones, while purposive incentives will be…
View details →Jie Wu, Jianan Ren, Qinjie Liu et al. · 2019 · Frontiers in Immunology
Background: Continuous veno–venous hemofiltration (CVVH) could influence immunomodulation by cytokine removal. Damage-associated molecular patterns (DAMPs) are released by injured cells and have roles in sepsis. We investigated if the magnitude of DAMPs removal was associated with mortality in patients with sepsis undergoing CVVH. Methods: We conducted a prospective, observational study on patients acquiring CVVH at department of surgery, Jinling Hospital. Circulating levels of DAMPs (mitochondrial DNA [mtDNA]; nuclear DNA [nDNA]; heat shock protein [HSP]70) and cytokines were measured at the
View details →Sarita Depani, Kondwani Joseph Banda, Simon Bailey et al. · 2015 · Pediatric Blood & Cancer
BACKGROUND: We previously reported a 28-day treatment protocol for children with endemic Burkitt lymphoma (BL) which included four doses of cyclophosphamide (CPM), intrathecal methotrexate and hydrocortisone (IT MTX/HC) at Queen Elizabeth…
View details →Moonkyoo Kong, Yu Jin Lim, Youngkyong Kim · 2018 · PubMed
Background: We conducted this study to contribute to resolving some controversial issues on management of nasopharyngeal carcinoma. Methods: Thirty-two patients with stage III-IVB nasopharyngeal carcinoma were included in this…
View details →Aerlyn G. Dawn, Naomi Lawrence · 2013 · Dermatologic Surgery
BACKGROUND: Squamous cell carcinomas (SCCs) generally have been reported to be more prevalent on the lips than basal cell carcinomas (BCCs), but in our experience, BCCs of the lips are common, particularly in women. OBJECTIVES: To…
View details →Lukas Koedijk, Ana Oprescu · 2022
The EU Green Deal mirrors the societal concern regarding climate change. In the software industry this means reducing the energy consumption of a program. This can be done by looking both at the hardware and the software used. We take a…
View details →Shao-rui Hao, Yan Ren, Shan-yan Zhang et al. · 2020 · Journal of Zhejiang University SCIENCE B
BACKGROUND: Currently, there are no drugs that have been proven to be effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Because of its broad antiviral activity, interferon (IFN) should be evaluated as a…
View details →Tarek Mohamed Ashoor, Ahmad Mahmoud Hasseb, Ibrahim M. Esmat · 2020 · Korean journal of anesthesiology
Background: Nebulized heparin has been effectively used in the management of many pulmonary diseases. However, its effect on mechanically ventilated patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD) has never…
View details →Louise Katherine Bartolac, Jenna Lowe, George Koustas et al. · 2015 · Journal of Reproduction and Development
The aim of this study was to determine the optimum conditions for vitrifying in vitro produced day 7 porcine embryos using different vitrification devices and blastocoele collapse methods. Firstly embryos were collapsed by micro-pipetting,…
View details →Botao Ning, Sheng Ye, Yi Lyu et al. · 2020 · Translational Pediatrics
BACKGROUND: Sepsis has always been a challenge in pediatric intensive care unit (PICU) with poor prognosis. In order to evaluate the effect between routine continuous renal replacement therapy (CRRT) and high-volume hemofiltration (HVHF)…
View details →Penghao Ye, Senmao Xia, Yu Xiong et al. · 2020 · International Journal of Environmental Research and Public Health
Thermal power generation based on coal-fired power plants has the advantages of stability and controllability and has been the largest source of electricity supply in China. Coal-fired power plants, however, are also accompanied by high…
View details →