Negative / Null Result ReportOpen accessSocial Sciences
Richard Fendler, Craig Ruff, Milind Shrikhande · 2018 · Online Learning
Much of the e-education literature suggests that there is no significant difference in aggregate student learning outcomes between online and face-to-face instruction. In this study, we develop a model that forecasts the grade that individual students would have most likely earned in the alternate class setting. Students for whom the difference between the actual grade received in one class format (for example, online) and the forecasted grade in the other class setting (for example, face-to-face) is one full letter grade or higher are called “jumpers.” Our findings indicate that jumpers are n
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Soumik Barman, Francesco Borriello, Byron Brook et al. · 2022 · ACS Chemical Biology
) cells, and germinal center (GC) B cells along with the IgG2c-skewed humoral response in vivo. Dual-loaded cGAMP/CL075-PSs did not outperform admixed cGAMP-PS and CL075-PS in vivo. These data validate an optimally designed adjuvantation…
View details →Negative / Null Result ReportSocial Sciences
Kitae Sohn, Illoong Kwon · 2016 · The Singapore Economic Review
Trust was found to promote entrepreneurship in the US. We investigated whether this was true in a developing country, Indonesia. We failed to replicate this; this failure was true whether trust was estimated at the individual or community…
View details →Negative / Null Result ReportOpen accessMedicine
Caterina Peraldo‐Neia, Giuliana Cavalloni, Elisabetta Fenocchio et al. · 2018 · PLoS ONE
The association of anti-EGFR to gemcitabine and oxaliplatin (GEMOX) chemotherapy did not improve survival in biliary tract carcinoma (BTC) patients. Multiple mechanisms might be involved in the resistance to anti-EGFR. Here, we explored the mutation profile of EGFR extracellular domain (ECD), of tyrosine kinase domain (TKD), and its amplification status. EGFR mutational status of exons 12, 18-21 was analyzed in 57 tumors by Sanger sequencing. EGFR amplification was evaluated in 37 tumors by Fluorescent In Situ Hybridization (FISH). Kaplan-Meier curves were calculated using the log-rank test. S
View details →Negative / Null Result ReportOpen accessSocial Sciences
Sara Vitoria-Estruch, Ángel Romero‐Martínez, Marisol Lila et al. · 2018 · International Journal of Environmental Research and Public Health
Proactively aggressive individuals have been shown to present a different pattern of autonomic nervous system (ANS) dysregulation from that of individuals characterized by reactive violence. Although attempts have been made to classify intimate partner violence (IPV) perpetrators based on ANS reactivity to acute stress, subsequent studies have failed to replicate this classification. Notably, the proposed classification neglected the role of chronic alcohol abuse in ANS dysregulation and the fact that this dysregulation entails an abnormal stress response. The aim of the present study was to a
View details →Negative / Null Result ReportOpen accessComputer Science
Julio Cesar Munguía Mondragón, Paula Branco, Guy-Vincent Jourdan et al. · 2025 · Applied Intelligence
Globally, cyberattacks are growing and mutating each month. Intelligent Intrusion Network Detection Systems are developed to analyze and detect anomalous traffic to face these threats. A way to address this is by using network flows, an…
View details →Negative / Null Result ReportOpen accessPsychology
Terence J. Lyons, Merle Spriggs, Leevi Kerkelä et al. · 2026 · Nature Communications
Psychedelics have robust effects on acute brain function and long-term behavior but whether they also cause enduring functional and anatomical brain changes is largely unknown. In an exploratory, placebo-controlled, within-subjects, electroencephalography (EEG), and magnetic resonance imaging (MRI) study in 28 healthy, entirely psychedelic-naive participants, anatomical and functional brain changes are detected from one-hour to one-month after a single high-dose (25 mg) of psilocybin. Increases in cognitive flexibility, psychological insight, and well-being are seen at one-month. Diffusion ten
View details →Negative / Null Result ReportOpen accessNeuroscience
Hye-Won Yang, Danyeong Kim, YoungSoon Yang et al. · 2025 · International Journal of Molecular Sciences
TREM2 (triggering receptor expressed on myeloid cells 2) is a membrane-bound receptor primarily expressed on microglia in the central nervous system (CNS). TREM2 plays a crucial role in regulating immune responses, phagocytosis, lipid metabolism, and inflammation. Mutations in the TREM2 gene have been linked to various neurodegenerative diseases, including Alzheimer’s disease (AD), frontotemporal dementia (FTD), Parkinson’s disease (PD), and Nasu–Hakola disease (NHD). These mutations are suggested to impair microglial activation and reduce the ability to clear amyloid aggregates, leading to ex
View details →Negative / Null Result ReportOpen accessMedicine
Cecília Rodrigues Silva, José Eduardo Dutra de Oliveira, Rui Augusto Hudari Gonçalves de Souza et al. · 2026 · Archivos Latinoamericanos de Nutrición
Eleven diabetic patients: 5, type 1 and 6, type 2 received a low-fiber diet (I) during 1 week and during the next 7 days the same diet, enriched with 40 g of fiber (30.6% insoluble and 11.7% soluble components) from rice bran (II) per day.…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Luiz Carlos Vieira, Morgan L. Handojo, Claus O. Wilke · 2025 · Scientific Reports
Protein language models (pLMs) can offer deep insights into evolutionary and structural properties of proteins. While larger models, such as the 15 billion parameter model ESM-2, promise to capture more complex patterns in sequence space, they also present practical challenges due to their high dimensionality and high computational cost. We systematically evaluated the performance of various ESM-style models across multiple biological datasets to assess the impact of model size on transfer learning via feature extraction. Surprisingly, we found that larger models do not necessarily outperform
View details →Negative / Null Result ReportOpen accessMedicine
Ömer Aydın, Enis Karaarslan, Fatih Safa Erenay et al. · 2026 · Turkish Journal of Engineering
DeepSeek v3, developed in China, was released in December 2024, followed by Alibaba’s Qwen 2.5 Max in January 2025 and Qwen3 235B in April 2025. These free and open-source models offer significant potential for academic writing and content…
View details →Negative / Null Result ReportOpen accessMedicine
Stefano Fiorucci, Ginevra Urbani, Eleonora Distrutti et al. · 2025 · Pharmaceuticals
The Farnesoid-X-receptor (FXR) is a bile sensor involved in the regulation of bile acid homeostasis, fibrosis, inflammation, and metabolism. Obeticholic acid (OCA), a semisynthetic derivative of chenodeoxycholic acid (CDCA), initially named 6-ethyl-CDCA or INT-747, is the first in a class of FXR ligands that have been approved for clinical use for the treatment of patients with primary biliary cholangitis (PBC) who are unresponsive or intolerant to ursodeoxycholic acid. In this narrative review, we will examine the current status and future perspective of clinical use of OCA. Based on results
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Joop Schaye, Evgenii Chaikin, Matthieu Schaller et al. · 2026 · Monthly Notices of the Royal Astronomical Society
ABSTRACT We present the COLIBRE galaxy formation model and the COLIBRE suite of cosmological hydrodynamical simulations. COLIBRE includes new models for radiative cooling, dust grains, star formation, stellar mass loss, turbulent diffusion, pre-supernova stellar feedback, supernova feedback, supermassive black holes, and active galactic nucleus (AGN) feedback. The multiphase interstellar medium is explicitly modelled without a pressure floor. Hydrogen and helium are tracked in non-equilibrium, with their contributions to the free electron density included in metal-line cooling calculations. Th
View details →Negative / Null Result ReportOpen accessPsychology
Joon Soo Lim, Nalae Hong, Erika J. Schneider · 2025 · Computers in Human Behavior
As generative artificial intelligence (GenAI) becomes more integrated into corporate communication, its role in crisis messaging raises critical questions about audience perception and trust. Drawing on theories of machine heuristics, this…
View details →Negative / Null Result ReportOpen accessPsychology
Joyce S. Pang, Hiram Ring, Kate Y Huang et al. · 2026 · Journal of Personality Assessment
Implicit motives have a clear relation to observed behavior but are time-consuming to measure. Automating the content coding of implicit motives has been a pursuit since the 1960s, but has not been widely adopted due to limitations with…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
M. Bernert, T.O.S.J. Bosman, T. Lunt et al. · 2025 · Nuclear Materials and Energy
Power exhaust is a crucial issue for future fusion reactors. Divertor detachment and the required power dissipation fractions of about 95% are foreseen to be achieved by impurity seeding. In a tokamak, at high seeding levels the radiation often concentrates in a small region inside the confined plasma near the X-point. In early observations the so-called X-point radiator (XPR) often led to back-transitions to L-mode or disruptions. In metal tokamaks or with higher available heating power, these regimes can be stabilized and are now established on AUG, JET, TCV, KSTAR and WEST. The XPR is a col
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Ihsen Abid · 2025 · Engineering Technology & Applied Science Research
Saudi Arabia, as one of the world’s leading oil producers, faces critical challenges in transitioning to sustainable economic growth. The heavy reliance on oil exports, coupled with rapid urbanization and environmental degradation, underscores the urgent need for green growth strategies tailored to the Kingdom’s unique socioeconomic and environmental context. This study aims to investigate the factors influencing the Green Growth Index (GGI), which measures sustainable economic growth, and analyze the short-term and long-term relationships between key variables such as environmental technology
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Carlo Russo, Mariarosaria Simeone, Maria Angela Perito · 2020 · Sustainability
In this paper, we investigated educated millennials’ evaluation of credence attributes in food products containing genetically modified organisms (GMO products). Our goal is to assess whether beliefs about GMO products are determined by scientific knowledge alone or if they are affected by other factors such as trust in information providers and use of social media. The focus on millennials is motivated by the increasing relevance of this social group in the public debate and by their extensive use of social media. We surveyed a sample of 215 Italian college students, confronting them with que
View details →Negative / Null Result ReportOpen accessEnergy
Adeyemi Ogundipe, Opeyemi Akınyemi, Oluwatomisin Ogundipe · 2016 · Covenant University Repository (Covenant University)
The study examines the relationship between electricity consumption and economic development using an extended neoclassical model for the period 1970-2013. The study incorporates the uniqueness of the Nigerian economy by controlling for…
View details →Negative / Null Result ReportAgricultural and Biological Sciences
Muhammad Bilal, Muhammad Aslam Mirza, Muhammad Kaleem et al. · 2016 · Journal of Animal Physiology and Animal Nutrition
The response of broiler chickens to 3 levels of sunflower meal and 2 levels of NSP-ase enzyme combination (with and without) was investigated in 3 × 2 factorial arrangement under complete randomized design (CRD). A total of 240 Hubbard…
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Weitao Zhou, Xiaoyong Li, Daochao Huang et al. · 2015 · Current Alzheimer Research
It is reported that 7,8-dihydroxyflavone (DHF), a TrkB agonist, has beneficial effects on neuronal excitotoxicity, stroke, and Parkinson disease in animal models by enhancing axon regeneration, muscle reinnervation and neuromuscular…
View details →Negative / Null Result ReportOpen accessEngineering
Federico Serpe, Carlo Massimo Casciola, Giancarlo Ruocco et al. · 2024 · International Journal of Bioprinting
Microfluidics is rapidly revolutionizing the scientific panorama, providing unmatched high-throughput platforms that find application in numerous areas of physics, chemistry, biology, and materials science. Recently, microfluidic chips have been proposed, in combination with bioactive materials, as promising tools for spinning cell-laden fibers with on-demand characteristics. However, cells encapsulated in filaments produced via microfluidic spinning technology are confined in a quasi-three-dimensional (3D) environment that fails to replicate the intricate 3D architecture of biological tissues
View details →Negative / Null Result ReportOpen accessMedicine
Louisa Chan, Christine T. H. Bui, Chris Ka Pun Mok et al. · 2016 · Scientific Reports
Novel avian H7N9 virus emerged in China in 2013 resulting in a case fatality rate of around 39% and continues to pose zoonotic and pandemic risk. Amino acid substitutions in PB2 protein were shown to influence the pathogenicity and transmissibility of H7N9 following experimental infection of ferrets and mice. In this study, we evaluated the role of amino acid substitution PB2-627K or compensatory changes at PB2-591K and PB2-701N, on the tropism and replication competence of H7N9 viruses for human and swine respiratory tracts using ex vivo organ explant cultures. Recombinant viruses of A/Shangh
View details →Negative / Null Result ReportMedicine
Kenneth H. Mayer, Douglas Krakower · 2012 · Annals of Internal Medicine
During the past 2 years, several pivotal clinical trials have proven that the use of antiretrovirals by HIV-infected and at-risk uninfected persons can decrease the probability of HIV being transmitted sexually. The initial…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Satoru Taniguchi, Kohei Ninomiya, Itaru Kushima et al. · 2019 · Psychiatry and Clinical Neurosciences
AIMS: Recent studies have revealed that the interplay between polygenic risk scores (PRS) and large copy number variants (CNV; >500kb) is essential for the etiology of schizophrenia (SCZ). To replicate previous findings, including those for smaller CNV (>10kb), the PRS between SCZ patients with and without CNV were compared. METHODS: The PRS were calculated for 724 patients with SCZ and 1178 healthy controls (HC), genotyped using array-based comparative genomic hybridization and single nucleotide polymorphisms chips, and comparisons were made between cases and HC, or between subjects with and
View details →Negative / Null Result ReportPsychology
Caitlin Mills, Jennifer Wu, Sidney K. D’Mello · 2017 · Discourse Processes
We investigated how affective states influence expository text comprehension and whether text valence moderates the effects (i.e., mood congruency). In Experiment 1 participants were randomly assigned to a happy or sad affective state…
View details →Negative / Null Result ReportOpen accessPsychology
Tobias Kopp, Marco Baumgartner, Steffen Kinkel · 2023 · International Journal of Human-Computer Studies
An appropriate level of human-robot trust is widely acknowledged as a crucial factor for successful human-robot interaction (HRI). Previous research has addressed anthropomorphic design but mostly neglected linguistic framing as a means to…
View details →Negative / Null Result ReportArts and Humanities
Chris Skurka, Rainer Romero‐Canyas, Helen H. Joo et al. · 2021 · Human Communication Research
Abstract There is much need to verify the robustness of published findings in the field of communication—particularly regarding the effects of persuasive emotional appeals about social issues. To this end, we present the results from a…
View details →Negative / Null Result ReportNeuroscience
Lidia Y. X. Wong, Stephen J. Gray, David A. Gallo · 2018 · Cognitive Neuroscience
We report 4 experiments aiming to replicate and extend the finding that anodal transcranial direct current stimulation (tDCS) over dorsolateral prefrontal cortex after encoding and just prior to retrieval improves accuracy on an episodic…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Cheng Peng, Martijn den Dekker, Andrés Cárdenas et al. · 2018 · Environmental Health Perspectives
BACKGROUND: Epigenetic variability is hypothesized as a regulatory pathway through which prenatal exposures may influence child development and health. OBJECTIVE: We sought to examine the associations of residential proximity to roadways at birth and epigenome-wide DNA methylation. We also assessed associations of differential methylation with child cognitive outcomes. METHODS: We estimated residential proximity to roadways at birth using a geographic information system (GIS) and cord blood methylation using Illumina's HumanMethylation450-array in 482 mother-child pairs in Project Viva. We ide
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