Negative / Null Result ReportOpen accessMedicine
Pau Ribó-Molina, Stefan van Nieuwkoop, Anna Z. Mykytyn et al. · 2024 · mSphere
ABSTRACT Human metapneumovirus (HMPV), a member of the Pneumoviridae family, causes upper and lower respiratory tract infections in humans. In vitro studies with HMPV have mostly been performed in monolayers of undifferentiated epithelial cells. In vivo studies in cynomolgus macaques and cotton rats have shown that ciliated epithelial cells are the main target of HMPV infection, but these observations cannot be studied in monolayer systems. Here, we established an organoid-derived bronchial culture model that allows physiologically relevant studies on HMPV. Inoculation with multiple prototype
View details →Negative / Null Result ReportOpen accessMedicine
Gongxun Zhong, Shufang Fan, Masato Hatta et al. · 2019 · Journal of Virology
Bats are reservoirs for several severe zoonotic pathogens. The genomes of influenza A viruses of the H17N10 and H18N11 subtypes have been identified in bats, but no live virus has been isolated. The characterization of artificially…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Lyndsay Gavin, Jenna McChesney, Anson Tong et al. · 2022 · Technology Mind and Behavior
The spread of misinformation has generated confusion and uncertainty about how to behave with respect to protective actions during the COVID-19 pandemic, such as social distancing and getting vaccinated. garnered significant press…
View details →Negative / Null Result ReportOpen accessMedicine
Melissa K. Crocker, Paul B. Kaplowitz · 2010 · Clinical Endocrinology
OBJECTIVE: Thyroid hormones are involved in metabolic regulation, but the degree to which they affect body weight and body mass index (BMI) in children is unclear. We examined the effect of hypo- and hyperthyroidism on weight and BMI at…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Annie Gott, Clare Andrews, María Larriva et al. · 2018 · PeerJ
) found that a marker of biological age predicted the strength of the stress response even in individuals of the same chronological age. Specifically, birds that had experienced greater developmental telomere attrition (DTA) showed a lower peak corticosterone (CORT) response to an acute stressor, and more rapid recovery of CORT levels towards baseline. Here, we performed a follow-up study using the same capture-handling-restraint stressor in a separate cohort of starlings that had been subjected to a developmental manipulation of food availability and begging effort. We measured the CORT respo
View details →Negative / Null Result ReportOpen accessMedicine
Akio Kôyama, Toshiro Fujita, Fumitake Gejyo et al. · 2015 · BMC Nephrology
BACKGROUND: Evidence increasingly points to the importance of chronic hypoxia in the tubulointerstitium as a final common pathway to end-stage renal disease (ESRD). Beraprost sodium (BPS) is an orally active prostacyclin (PGI2) analogue demonstrating prevention of the progression of chronic kidney disease (CKD) in various animal models by maintaining renal blood flow and attenuating renal ischemic condition. METHODS: This multicenter, randomized, double-blind, placebo-controlled, phase II trial was designed to determine the recommended dose of the sustained-release form of BPS (TRK-100STP 120
View details →Negative / Null Result ReportBusiness, Management and Accounting
Noel D. Campbell, David Mitchell, Tammy M. Rogers · 2013 · Journal of Entrepreneurship and Public Policy
Purpose The purpose of this paper is to provide a robustness check of the relationship between entrepreneurial activity and economic freedom. As a deliberate “robustness check,” the authors estimated various spatial measures of…
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Travis J. Matics, Nadia Khan, Priti Jani et al. · 2019 · Pediatric Critical Care Medicine
Objectives: The Fragility Index measures the number of events on which the statistical significance of a result depends and has been suggested as an adjunct statistical assessment for interpretation of trial results. This study aimed to…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Haotian Zhang, Wen‐Yong Guo, Wenting Wang · 2023 · Ecology and Evolution
How to effectively obtain species-related low-dimensional data from massive environmental variables has become an urgent problem for species distribution models (SDMs). In this study, we will explore whether dimensionality reduction on environmental variables can improve the predictive performance of SDMs. We first used two linear (i.e., principal component analysis (PCA) and independent components analysis) and two nonlinear (i.e., kernel principal component analysis (KPCA) and uniform manifold approximation and projection) dimensionality reduction techniques (DRTs) to reduce the dimensionali
View details →Negative / Null Result ReportOpen accessNeuroscience
Takatsugu Aihara, Takeshi OGAWA, Takeaki Shimokawa et al. · 2017 · PLoS ONE
Humans often utilize past experience to solve difficult problems. However, if past experience is insufficient to solve a problem, solvers may reach an impasse. Insight can be valuable for breaking an impasse, enabling the reinterpretation or re-representation of a problem. Previous studies using between-subjects designs have revealed a causal relationship between the anterior temporal lobes (ATLs) and non-verbal insight, by enhancing the right ATL while inhibiting the left ATL using transcranial direct current stimulation (tDCS). In addition, neuroimaging studies have reported a correlation be
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Jiaying Liu, Weixi Zhang, Chao Teng et al. · 2024 · Frontiers in Microbiology
Introduction: Enhancing the planning of the forest-agricultural composite model and increasing the efficiency with which forest land is utilized could benefit from a thorough understanding of the impacts of intercropping between forests and agriculture on soil physicochemical properties and microbial communities. Methods: intercrop soils, along with their corresponding monocrops, were used in this study's llumina high-throughput sequencing analysis to determine the composition and diversity of soil bacterial and fungal communities. Results: The findings indicated that intercropping considerabl
View details →Negative / Null Result ReportOpen accessMedicine
Dipender Gill, Marios Arvanitis, Paul Carter et al. · 2020 · Royal Society Open Science
Angiotensin-converting enzyme 2 (ACE2) and serine protease TMPRSS2 have been implicated in cell entry for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). The expression of ACE2 and TMPRSS2 in the lung epithelium might have implications for the risk of SARS-CoV-2 infection and severity of COVID-19. We use human genetic variants that proxy angiotensin-converting enzyme (ACE) inhibitor drug effects and cardiovascular risk factors to investigate whether these exposures affect lung ACE2 and TMPRSS2 gene expression and circ
View details →Negative / Null Result ReportOpen accessMedicine
Natalie A. Prow, Marcus G. Mah, Joshua M. Deerain et al. · 2018 · Journal of General Virology
Liao ning virus (LNV) was first isolated in 1996 from mosquitoes in China, and has been shown to replicate in selected mammalian cell lines and to cause lethal haemorrhagic disease in experimentally infected mice. The first detection of…
View details →Negative / Null Result ReportOpen accessComputer Science
Tianjiao Cao, Jiahao Lyu, Weichao Zeng et al. · 2024
Scene text detection has seen the emergence of high-performing methods that excel on academic benchmarks. However, these detectors often fail to replicate such success in real-world scenarios. We uncover two key factors contributing to…
View details →Negative / Null Result ReportSocial Sciences
Kitae Sohn, Illoong Kwon · 2016 · The Singapore Economic Review
Trust was found to promote entrepreneurship in the US. We investigated whether this was true in a developing country, Indonesia. We failed to replicate this; this failure was true whether trust was estimated at the individual or community…
View details →Negative / Null Result ReportOpen accessPsychology
Emilou Noser, Jessica Schoch, Ulrike Ehlert · 2018 · PLoS ONE
Research has indicated that men's facial width-to-height ratio (fWHR) is part of an evolved system of social dominance, aggression, and power. fWHR has been linked to antisocial behavior, measured by self-reported aggression, but recent studies have failed to replicate this finding. To overcome these inconsistencies, influencing factors such as social status have to be taken into account in order to explain the relationship between fWHR and aggression. In particular, income has been shown to be an important influencing factor in this relationship. Furthermore, previous findings suggested that
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Joop Schaye, Evgenii Chaikin, Matthieu Schaller et al. · 2026 · Monthly Notices of the Royal Astronomical Society
ABSTRACT We present the COLIBRE galaxy formation model and the COLIBRE suite of cosmological hydrodynamical simulations. COLIBRE includes new models for radiative cooling, dust grains, star formation, stellar mass loss, turbulent diffusion, pre-supernova stellar feedback, supernova feedback, supermassive black holes, and active galactic nucleus (AGN) feedback. The multiphase interstellar medium is explicitly modelled without a pressure floor. Hydrogen and helium are tracked in non-equilibrium, with their contributions to the free electron density included in metal-line cooling calculations. Th
View details →Negative / Null Result ReportOpen accessPsychology
Joyce S. Pang, Hiram Ring, Kate Y Huang et al. · 2026 · Journal of Personality Assessment
Implicit motives have a clear relation to observed behavior but are time-consuming to measure. Automating the content coding of implicit motives has been a pursuit since the 1960s, but has not been widely adopted due to limitations with…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Sara Vitoria-Estruch, Ángel Romero‐Martínez, Marisol Lila et al. · 2018 · International Journal of Environmental Research and Public Health
Proactively aggressive individuals have been shown to present a different pattern of autonomic nervous system (ANS) dysregulation from that of individuals characterized by reactive violence. Although attempts have been made to classify intimate partner violence (IPV) perpetrators based on ANS reactivity to acute stress, subsequent studies have failed to replicate this classification. Notably, the proposed classification neglected the role of chronic alcohol abuse in ANS dysregulation and the fact that this dysregulation entails an abnormal stress response. The aim of the present study was to a
View details →Negative / Null Result ReportOpen accessMedicine
Stefano Fiorucci, Ginevra Urbani, Eleonora Distrutti et al. · 2025 · Pharmaceuticals
The Farnesoid-X-receptor (FXR) is a bile sensor involved in the regulation of bile acid homeostasis, fibrosis, inflammation, and metabolism. Obeticholic acid (OCA), a semisynthetic derivative of chenodeoxycholic acid (CDCA), initially named 6-ethyl-CDCA or INT-747, is the first in a class of FXR ligands that have been approved for clinical use for the treatment of patients with primary biliary cholangitis (PBC) who are unresponsive or intolerant to ursodeoxycholic acid. In this narrative review, we will examine the current status and future perspective of clinical use of OCA. Based on results
View details →Negative / Null Result ReportOpen accessPsychology
Terence J. Lyons, Merle Spriggs, Leevi Kerkelä et al. · 2026 · Nature Communications
Psychedelics have robust effects on acute brain function and long-term behavior but whether they also cause enduring functional and anatomical brain changes is largely unknown. In an exploratory, placebo-controlled, within-subjects, electroencephalography (EEG), and magnetic resonance imaging (MRI) study in 28 healthy, entirely psychedelic-naive participants, anatomical and functional brain changes are detected from one-hour to one-month after a single high-dose (25 mg) of psilocybin. Increases in cognitive flexibility, psychological insight, and well-being are seen at one-month. Diffusion ten
View details →Negative / Null Result ReportOpen accessMedicine
Ömer Aydın, Enis Karaarslan, Fatih Safa Erenay et al. · 2026 · Turkish Journal of Engineering
DeepSeek v3, developed in China, was released in December 2024, followed by Alibaba’s Qwen 2.5 Max in January 2025 and Qwen3 235B in April 2025. These free and open-source models offer significant potential for academic writing and content…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Luiz Carlos Vieira, Morgan L. Handojo, Claus O. Wilke · 2025 · Scientific Reports
Protein language models (pLMs) can offer deep insights into evolutionary and structural properties of proteins. While larger models, such as the 15 billion parameter model ESM-2, promise to capture more complex patterns in sequence space, they also present practical challenges due to their high dimensionality and high computational cost. We systematically evaluated the performance of various ESM-style models across multiple biological datasets to assess the impact of model size on transfer learning via feature extraction. Surprisingly, we found that larger models do not necessarily outperform
View details →Negative / Null Result ReportOpen accessSocial Sciences
Richard Fendler, Craig Ruff, Milind Shrikhande · 2018 · Online Learning
Much of the e-education literature suggests that there is no significant difference in aggregate student learning outcomes between online and face-to-face instruction. In this study, we develop a model that forecasts the grade that individual students would have most likely earned in the alternate class setting. Students for whom the difference between the actual grade received in one class format (for example, online) and the forecasted grade in the other class setting (for example, face-to-face) is one full letter grade or higher are called “jumpers.” Our findings indicate that jumpers are n
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Ihsen Abid · 2025 · Engineering Technology & Applied Science Research
Saudi Arabia, as one of the world’s leading oil producers, faces critical challenges in transitioning to sustainable economic growth. The heavy reliance on oil exports, coupled with rapid urbanization and environmental degradation, underscores the urgent need for green growth strategies tailored to the Kingdom’s unique socioeconomic and environmental context. This study aims to investigate the factors influencing the Green Growth Index (GGI), which measures sustainable economic growth, and analyze the short-term and long-term relationships between key variables such as environmental technology
View details →Negative / Null Result Report
Christoph Alexander Rüst, Romuald Lepers, Thomas Rosemann et al. · 2014 · SpringerPlus
Abstract This study investigated the change in sex differences across years in ultra-distance swimming performances at the 36-km ‘Maratona del Golfo Capri-Napoli’ race held from 1954 to 2013. Changes in swimming performance of 662 men and…
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Jacques Demongeot, Hervé Seligmann · 2020 · Scientific Reports
Abstract Ribosomal RNAs are complex structures that presumably evolved by tRNA accretions. Statistical properties of tRNA secondary structures correlate with genetic code integration orders of their cognate amino acids. Ribosomal RNA…
View details →Negative / Null Result ReportOpen accessComputer Science
Julio Cesar Munguía Mondragón, Paula Branco, Guy-Vincent Jourdan et al. · 2025 · Applied Intelligence
Globally, cyberattacks are growing and mutating each month. Intelligent Intrusion Network Detection Systems are developed to analyze and detect anomalous traffic to face these threats. A way to address this is by using network flows, an…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
M. Bernert, T.O.S.J. Bosman, T. Lunt et al. · 2025 · Nuclear Materials and Energy
Power exhaust is a crucial issue for future fusion reactors. Divertor detachment and the required power dissipation fractions of about 95% are foreseen to be achieved by impurity seeding. In a tokamak, at high seeding levels the radiation often concentrates in a small region inside the confined plasma near the X-point. In early observations the so-called X-point radiator (XPR) often led to back-transitions to L-mode or disruptions. In metal tokamaks or with higher available heating power, these regimes can be stabilized and are now established on AUG, JET, TCV, KSTAR and WEST. The XPR is a col
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Soumik Barman, Francesco Borriello, Byron Brook et al. · 2022 · ACS Chemical Biology
) cells, and germinal center (GC) B cells along with the IgG2c-skewed humoral response in vivo. Dual-loaded cGAMP/CL075-PSs did not outperform admixed cGAMP-PS and CL075-PS in vivo. These data validate an optimally designed adjuvantation…
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