Negative / Null Result ReportOpen accessImmunology and Microbiology
Sergio Cleto, Camila Eleutério Rodrigues, Ceila María Sant’Ana Malaque et al. · 2016 · PLoS ONE
BACKGROUND: Leptospirosis is a health problem worldwide. Its most severe form is a classic model of sepsis, provoking acute respiratory distress syndrome (ARDS) and acute kidney injury (AKI), with associated mortality that remains unacceptably high. We previously demonstrated that early initiation of sustained low-efficiency dialysis (SLED) followed by daily SLED significantly decreases mortality. However, the mode of clearance can also affect dialysis patient outcomes. Therefore, the objective of this study was to compare the effects of SLED with traditional (diffusive) clearance, via hemodia
View details →Negative / Null Result ReportOpen accessMedicine
Anthony Bentley, Samantha Gillard, Michael Spino et al. · 2013 · PharmacoEconomics
BACKGROUND: Patients with β-thalassaemia major experience chronic iron overload due to regular blood transfusions. Chronic iron overload can be treated using iron-chelating therapies such as desferrioxamine (DFO), deferiprone (DFP) and…
View details →Negative / Null Result ReportOpen accessMedicine
Melvin L.K. Chua, Grace Kusumawidjaja, Patricia Gan et al. · 2016 · OncoTargets and Therapy
BACKGROUND: Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor with high relapse rate. In this study, we aimed to determine if dose-escalated (DE) radiotherapy improved tumor control and survival in GBM patients.…
View details →Negative / Null Result Report
Paweł Mateusz Nowak, Edyta Sekuła, Paweł Kościelniak · 2020 · Chromatographia
Abstract The choice between capillary electrophoresis (CE) and high-performance liquid chromatography (HPLC) is not easy and depends on many factors. An attempt to facilitate this choice is this work, in which both techniques have been…
View details →Negative / Null Result ReportOpen accessMedicine
Juan José Yepes-Núñez, Anita Rajasekhar, Maryam Rahman et al. · 2020 · Blood Advances
The impact of pharmacologic prophylaxis for venous thromboembolism in patients undergoing neurosurgical intervention remains uncertain. We reviewed the efficacy and safety of pharmacologic compared with nonpharmacologic thromboprophylaxis…
View details →Negative / Null Result ReportOpen accessMedicine
Kogieleum Naidoo, Santhanalakshmi Gengiah, Nonhlanhla Yende‐Zuma et al. · 2022 · EClinicalMedicine
Background HIV-TB treatment integration reduces mortality. Operational implementation of integrated services is challenging. This study assessed the impact of quality improvement (QI) for HIV-TB integration on mortality within primary…
View details →Negative / Null Result Report
Tom Burns · 2010 · The Psychiatrist
Summary UK mental healh services have been distinguished by their continuity of care but recently there has been a move to separating consultant responsibility for in-patient and out-patient care. Local examples of the success of this…
View details →Negative / Null Result ReportOpen accessMedicine
Sergio Luis‐Lima, Tomás H. Higuera Linares, Laura Henríquez-Gómez et al. · 2019 · Journal of Clinical Medicine
Type 2 diabetes mellitus represents 30-50% of the cases of end stage renal disease worldwide. Thus, a correct evaluation of renal function in patients with diabetes is crucial to prevent or ameliorate diabetes-associated kidney disease. The reliability of formulas to estimate renal function is still unclear, in particular, those new equations based on cystatin-C or the combination of creatinine and cystatin-C. We aimed to assess the error of the available formulas to estimate glomerular filtration rate in diabetic patients. We evaluated the error of creatinine and/or cystatin-C based formulas
View details →Negative / Null Result Report
David Curtis · 2014 · The Psychiatric Bulletin
Summary In the Oxford Community Treatment Order Evaluation Trial (OCTET), patients were randomised either to be made subject to a community treatment order (CTO) or to be managed with Section 17 leave and discharge. No differences in…
View details →Negative / Null Result Report
Rezzy Eko Caraka, Yusra Yusra, Toni Toharudin et al. · 2021 · Sustainability
Background and objectives: The impacts of COVID-19 are like two sides of one coin. During 2020, there were many research papers that proved our environmental and climate conditions were improving due to lockdown or large-scale restriction…
View details →Negative / Null Result Report
Rachael Storo, Cole Easson, Mahmood Shivji et al. · 2021 · Frontiers in Microbiology
Profiles of symbiotic microbial communities (“microbiomes”) can provide insight into the natural history and ecology of their hosts. Using high throughput DNA sequencing of the 16S rRNA V4 region, microbiomes of five shark species in South…
View details →Negative / Null Result ReportDentistry
Cristina Neves Girao Salgado Soares, Flávia Lucisano Botelho do Amaral, Marcelo Ferraz Mesquita et al. · 2017 · PubMed
This in vitro study evaluated the efficacy of toothpastes containing abrasive and chemical whitening agents in reducing the extrinsic discoloration of dental enamel. Sixty slabs of dentin from human teeth were sealed so that only the…
View details →Negative / Null Result ReportOpen accessMedicine
Yan Tong, Peter Jezzard, Thomas W. Okell et al. · 2020 · Magnetic Resonance in Medicine
PURPOSE: To improve the labeling efficiency of pseudo-continuous arterial spin labeling (PCASL) at 7T using parallel transmission (pTx). METHODS: maps were acquired in the labeling plane for tagging pulse design. Complex weights of the labeling pulses for each of the 8 transmit channels were calculated to produce a homogenous radiofrequency (RF) -shimmed labeling across the ROIs. Variable-Rate Selective Excitation (VERSE) pulses were also implemented as a part of the labeling pulse train. Whole-brain perfusion-weighted images were acquired under conditions of RF shimming, VERSE with RF shimmin
View details →Negative / Null Result Report
Falko Dahm, Hassan Syed, Sebastian Tomescu et al. · 2022 · Arthroscopy
Purpose The purpose of this study was to investigate biomechanical differences of medial patellofemoral ligament (MPFL) reconstruction, medial quadriceps tendon femoral ligament (MQTFL) reconstruction, and a combination of these techniques…
View details →Negative / Null Result ReportOpen accessDentistry
Georgia Verardi, Maximiliano Sérgio Cenci, Tamires Timm Maske et al. · 2016 · Brazilian Oral Research
Oral rehabilitation with osseointegrated implants is a way to restore esthetics and masticatory function in edentulous patients, but bacterial colonization around the implants may lead to mucositis or peri-implantitis and consequent implant loss. Peri-implantitis is the main complication of oral rehabilitation with dental implants and, therefore, it is necessary to take into account the potential effects of antiseptics such as chlorhexidine (CHX), chloramine T (CHT), triclosan (TRI), and essential oils (EO) on bacterial adhesion and on biofilm formation. To assess the action of these substance
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Takeshi Kuroda, Naohito Tanabe, Daisuke Kobayashi et al. · 2012 · BMC Nephrology
BACKGROUND: The kidney is a major target organ for systemic amyloidosis that often affects the kidney including proteinura, and elevated serum creatinine (Cr). The correlation between amount of amyloid deposits and clinical parameters is not known. The aim of this study was to clarify correlation the amyloid area in all renal biopsy specimen and clinical parameters. METHODS: Fifty-eight patients with an established diagnosis of AL amyloidosis participated in the study. All patients showed amyloid deposits in renal biopsies. We retrospectively investigated the correlation between clinical data
View details →Negative / Null Result Report
W. Roether, J. E. Lupton · 2011 · Ocean Science
Abstract. Observations of tritium and 3He in the Tyrrhenian Sea, 1987–2009, confirm the enhanced vertical mixing of intermediate waters into the deep waters that has been noted and associated with the Eastern Mediterranean Transient in…
View details →Negative / Null Result Report
Remco van Dijk, Sem J. Aronson, Dirk R. de Waart et al. · 2017 · Scientific Reports
Abstract We aimed to identify potent biliverdin reductase (BVRA) inhibitors as a novel concept for the treatment of severe unconjugated hyperbilirubinemia. 1280 FDA-approved compounds were screened in vitro for their ability to inhibit…
View details →Negative / Null Result Report
Nadia A. Abdelmegeed Abdelwahed, Bahadur Ali Soomro, Naimatullah Shah · 2022 · Management of Environmental Quality: An International Journal
Purpose The study investigates the intention to adopt climate change and the pro-environmental behaviours among the residents of a developing country (Pakistan) through the theory of planned behaviour (TPB). Design/methodology/approach…
View details →Negative / Null Result Report
Yukari Kobayashi, Jennifer A. Tremmel, Yuhei Kobayashi et al. · 2015 · Journal of the American Heart Association
Background Although a myocardial bridge ( MB ) is often regarded as a benign coronary variant, recent studies have associated MB with focal myocardial ischemia. The physiological consequences of MB on ventricular function during stress…
View details →Negative / Null Result ReportOpen accessMedicine
Lily R. Aleksandrova, Yu Tian Wang, Anthony G. Phillips · 2017 · Chronic Stress
The prevailing hypothesis of ketamine's unique antidepressant effects implicates N-methyl-d-aspartate receptor (NMDAR) inhibition-dependent enhancement of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated transmission,…
View details →Negative / Null Result ReportOpen accessMedicine
Arran T. Reader, Victoria S. Trifonova, H. Henrik Ehrsson · 2021 · European Journal of Neuroscience
Body ownership refers to the distinct sensation that our observed body belongs to us, which is believed to stem from multisensory integration. This is commonly shown through the rubber hand illusion (RHI), which induces a sense of ownership over a false limb. Whilst the RHI may interfere with object-directed action and alter motor cortical activity, it is not yet clear whether a sense of ownership over an artificial hand has functional consequences for movement production per se. As such, we performed two motion-tracking experiments (n = 117) to examine the effects of the RHI on the reaction t
View details →Negative / Null Result ReportOpen accessMedicine
Thi Yen Loan Le, Hilda A. Pickett, Andrian Yang et al. · 2019 · Scientific Reports
We have previously reported a subpopulation of mesenchymal stromal cells (MSCs) within the platelet-derived growth factor receptor-alpha (PDGFRα)/CD90 co-expressing cardiac interstitial and adventitial cell fraction. Here we further characterise PDGFRα/CD90-expressing cardiac MSCs (PDGFRα + cMSCs) and use human telomerase reverse transcriptase (hTERT) over-expression to increase cMSCs ability to repair the heart after induced myocardial infarction. hTERT over-expression in PDGFRα + cardiac MSCs (hTERT + PDGFRα + cMSCs) modulates cell differentiation, proliferation, survival and angiogenesis re
View details →Negative / Null Result ReportOpen accessNeuroscience
Megan Willis, Andrea I. Costantino, Michael A. Nitsche et al. · 2019 · Frontiers in Neuroscience
There has been increasing interest in the utility of transcranial electrical stimulation as a tool to enhance cognitive abilities. In the domain of face perception, enhancements have been reported for both transcranial direct current stimulation (tDCS) and high-frequency transcranial random noise stimulation (tRNS) targeting the occipitotemporal cortex. In a series of two experiments, we attempted to replicate these findings for face identity perception, and extend on previous studies, to determine if similar enhancements are also observed for object and facial expression perception. In Experi
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Santiago López‐Miranda, Daniel Berdejo, Elisa Pagán et al. · 2020 · Journal of the Science of Food and Agriculture
Abstract BACKGROUND The antimicrobial activity of essential oils and their constituents has led to increasing interest in using them as natural preservative agents. However, their high sensitivity to light and oxygen, their volatility and…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Cristian Vasco · 2013 · Americanae (AECID Library)
Con datos de la “Encuesta de condiciones de vida (ecv) 2005-2006”, este artículo analiza el impacto de la migración internacional y las remesas en la iniciativa emprendedora en el Ecuador rural. Los resultados sugieren que ni la migración…
View details →Negative / Null Result ReportOpen accessEngineering
Seong Ki Yoo, Simon L. Cotton, Young Jin Chun et al. · 2017 · IEEE Antennas and Wireless Propagation Letters
This letter investigates the first-order characteristics of dynamic off-body communications channels at 60 GHz. In particular, we have studied signal propagation from a chest-worn millimeter-wave transmitter as an adult male walked toward and then away from a hypothetical base station. The mobile line-of-sight (LOS) and non-LOS (NLOS) channel measurements have been conducted in a diverse range of environments, including a hallway, an open office, an anechoic chamber, and an outdoor car park. In this study, we have decomposed the received signal into its path loss, large-scale, and small-scale
View details →Negative / Null Result ReportOpen accessDecision Sciences
J. van Wolferen, Yoel Inbar, Marcel Zeelenberg · 2013 · Judgment and Decision Making
Abstract In this paper we test two hypotheses regarding magical thinking about the perceived likelihood of future events. The first is that people believe that those who “tempt fate” by failing to take necessary precautions are more likely to suffer negative outcomes. The second is the “protection effect”, where reminding people of precautions they have taken leads them to see related risks as less likely. To this end, we describe the results from three attempted direct replications of a protection effect experiment reported in Tykocinski (2008) and two replications of a tempting fate experime
View details →Negative / Null Result ReportOpen accessNeuroscience
Ellen Bialystok · 2020 · Journal of Multilingual Theories and Practices
The controversy over whether bilingualism has consequences for mind and brain shows no sign of abating. A steady stream of research reporting both positive results supporting the claim for beneficial effects of bilingualism and null…
View details →Negative / Null Result ReportPsychology
Shayne B. Piasta, Jessica A. R. Logan, Cynthia M. Zettler‐Greeley et al. · 2022 · Journal of Learning Disabilities
Preschool-age children identified as at risk for later reading difficulties can benefit from supplemental, small-group emergent literacy intervention. As such interventions become commercially available and marketed to preschool programs,…
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