e-ISSN: Pending

Browse the failure-mode index

21 real negative results, null findings, and replication failures in Ophthalmology · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessOphthalmology

Severe ocular and adnexal complications in dengue hemorrhagic fever: A report of 29 eyes

V S Vijitha, Tarjani Vivek Dave, Somasheila I Murthy et al. · 2021 · Indian Journal of Ophthalmology

Purpose: To describe a series of sight-threatening ocular and adnexal involvement associated with dengue hemorrhagic fever and their treatment options. Methods: Retrospective, interventional, non-comparative case series. Medical records of patients who presented with ocular symptoms attributed to dengue hemorrhagic fever were reviewed. Demography, presenting features, and treatment outcomes were recorded. Outcome measures assessed included globe salvage, vision salvage, and visual improvement. The outcome was deemed as favorable if vision salvage was possible and unfavorable if the vision was

View details →
Negative / Null Result ReportOpen accessOphthalmology

Effects of preoperative doses of betamethasone acetate 0.1% on dry eye control after cataract surgery

Saeed Shokoohi-Rad, Seyedeh Zeinab Hashemi Javaheri, Fatemeh Zare Malekabad et al. · 2020 · Indian Journal of Ophthalmology

Purpose: The aim of the present study was to compare the effects of the preoperative doses of betamethasone acetate 0.1% and placebo on controlling dry eye after cataract surgery. Methods: This randomized triple-blind clinical trial was conducted on 62 patients. For the purpose of the study, the participants were assigned into two groups of betamethasone (n = 28) and placebo (n = 34). The groups were administered with drops A or B three days before the operation, four times a day. These drops contained either betamethasone 0.1% or normal saline (placebo). Postoperative follow-up was performed

View details →
Negative / Null Result ReportOpen accessOphthalmology

Decreased levels of interleukin-6 level in tears and clinical changes in subjects with moderate-to-severe infection corneal ulcers treated with platelet-rich fibrin lysate eye drops

Jehan Fauzi Rakhmandani, Indra Tri Mahayana, Felicia Widyaputri et al. · 2023 · Taiwan Journal of Ophthalmology

PURPOSE: To assess the change of interleukin-6 (IL-6) levels in tears and ocular clinical parameters in corneal ulcer patients with moderate-to-severe infection after adjunctive therapy with platelet-rich fibrin (PRF) lysate-eyedrops compared with autologous serum eyedrops. MATERIALS AND METHODS: This study was a randomized double-blind controlled trial, which compared two groups of patients at Dr. Sardjito Hospital, Yogyakarta. A total of 42 patients (42 eyes) were divided into the control group (21 patients) and the intervention group (21 patients). All patients received antibacterial/antifu

View details →
Negative / Null Result ReportOpen accessOphthalmology

Influence of bar reader colour and contrast when reading

Fiona J. Rowe, Laura Tremarco · 2010 · British and Irish Orthoptic Journal

Aim: To identify the effect of using different coloured bars on reading time for the bar reading task, along with an assessment of subject experience with different colour bars. Methods: Inclusion criteria were: visual acuity better than 0.5 logMAR, presence of binocular single vision, and ability to understand and perform bar reading. Measurements were taken of visual acuity, near point of convergence, interpupillary distance, Bagolini glasses and prism fusion range. Bar reading was timed and undertaken with and without five coloured bars for N5 and N12 print. Results: Forty subjects were rec

View details →
Negative / Null Result ReportOpen accessOphthalmology

The Effects of Implantable Collamer Lens ICL Implantation in High Myopia Patients’ Mental Health

Lin Y, Luo S, Lu Q et al. · 2024 · Clinical Ophthalmology

Ye Lin, Shuke Luo, Qiang Lu, Xueke Pan Department of Ophthalmology, The Second People’s Hospital of Foshan, Foshan, Guangdong Province, People’s Republic of ChinaCorrespondence: Shuke Luo, Department of Ophthalmology, The Second People’s Hospital of Foshan, Foshan, Guangdong Province, 528000, People’s Republic of China, Tel +86 13679830510, Email 542377993@qq.comPurpose: To investigate the psychological changes in patients pre and post implantable collamer lens (ICL, EVO) implantation surgery in the posterior chamber.Patients and methods: Self-rating anxiety scale (SAS) and self-rating depress

View details →
Negative / Null Result ReportOpen accessOphthalmology

The measurement of intraocular pressure over positive soft contact lenses by rebound tonometry

Fabrizio Zeri, Mario De Cusatis, Luigi Lupelli et al. · 2016 · Journal of Optometry

Purpose: To investigate if the accuracy of intraocular pressure (IOP) measurements using rebound tonometry over disposable hydrogel (etafilcon A) contact lenses (CL) is affected by the positive power of the CLs. Methods: The experimental group comprised 26 subjects, (8 male, 18 female). IOP measurements were undertaken on the subjects’ right eyes in random order using a Rebound Tonometer (ICare). The CLs had powers of +2.00 D and +6.00 D. Measurements were taken over each contact lens and also before and after the CLs had been worn. Results: The IOP measure obtained with both CLs was significa

View details →
Negative / Null Result ReportOpen accessOphthalmology

Efficacy of two vertically integrated teaching–learning methods – The ocular basic science workshop versus lecture in enhancing knowledge and skills of ocular examination techniques and underlying principles in second clinical year medical students: A prospective interventional study

Anika Amritanand, Danica Lyngwa, Nimmy Thomas et al. · 2021 · TNOA Journal of Ophthalmic Science and Research

Purpose: The purpose of the study was to compare the efficacy of two vertically integrated teaching–learning methods, a peer-led ocular basic science workshop (OBSW) versus lecture by ophthalmology faculty, in enhancing the underlying basic science knowledge and examination skills of ophthalmic clinical tests among second clinical year medical students. Design: This was a prospective, interventional comparative study. Students were randomly assigned to peer-led OBSW and interactive lecture-based method of teaching by a faculty. Change in knowledge was assessed using pre and post multiple-choic

View details →
Negative / Null Result ReportOpen accessOphthalmology

Comparison of 12-month therapeutic effect of conbercept and ranibizumab for diabetic macular edema: a real-life clinical practice study

Yule Xu, Ao Rong, Wei Xu et al. · 2017 · BMC Ophthalmology

Abstract Background To compare the efficacy of intravitreal conbercept and ranibizumab in the treatment of diabetic macular edema (DME) in a real-life clinical practice. Methods This was a retrospective study. Among 62 Chinese patients with DME, 32 patients (36 eyes) received intravitreal conbercept (IVC) injections and 30 patients (32 eyes) received intravitreal ranibizumab (IVR) injections, once a month for 3 months followed by as needed therapy. All participants had at least 12 months of follow-up. We compared the changes in best-corrected visual acuity (BCVA) letter score and central retin

View details →
Negative / Null Result ReportOpen accessOphthalmology

Comparison of intravitreal injection of ranibizumab, steroids, and pars plana vitrectomy for chronic persistent nonimproving diabetic macular edema with nontractional epiretinal membrane

Mahmoud F. Abdelaal, Soheir M. Esmat, Mohamed A. Salah Eldein et al. · 2026 · Delta Journal of Ophthalmology

Purpose This study aimed to compare the anatomical and functional outcomes of pars plana vitrectomy (PPV), intravitreal ranibizumab (IVR), and intravitreal triamcinolone acetonide (IVTA) injection in chronic persistent diabetic macular edema (DME) with nontractional epiretinal membrane (NT-ERM). Patients and methods This is a randomized prospective study that included 52 patients having chronic DME with NT-ERM who were divided into three groups: PPV with internal limiting membrane peeling group, IVR group, and IVTA group. The patients were evaluated by optical coherence tomography angiography

View details →
Negative / Null Result ReportOpen accessOphthalmology

Comparison of microbiology and visual outcomes of patients undergoing small-gauge and 20-gauge vitrectomy for endophthalmitis

Almeida DRP, Chin EK, Shah SS et al. · 2016 · Clinical Ophthalmology

David RP Almeida,1 Eric K Chin,2,3 Shaival S Shah,3 Benjamin Bakall,3 Karen M Gehrs,3 H Culver Boldt,3 Stephen R Russell,3 James C Folk,3 Vinit B Mahajan3,41VitreoRetinal Surgery PA, Minneapolis, MN, 2Retina Consultants of Southern California, Riverside, CA, 3Vitreoretinal Service, Department of Ophthalmology and Visual Sciences, 4Omics Laboratory, University of Iowa, Iowa City, IA, USABackground: The role of pars plana vitrectomy (PPV) for endophthalmitis has evolved over recent decades but the literature is lacking on comparisons between small-gauge and 20-gauge vitrectomy.Objective: To eval

View details →
Negative / Null Result ReportOpen accessOphthalmology

Risk factors for opaque bubble layer in femtosecond-laser-assisted laser in situ keratomileusis (an Egyptian study)

Ahmed S Abdel-Wanes, Abelrahman G Salman, Azza M.A Said et al. · 2020 · Journal of the Egyptian Ophthalmological Society

Aim To determine the risk factors responsible for opaque bubble layer (OBL) formation in femtosecond-laser-assisted in situ keratomileusis (FSL-LASIK). Patients and methods A retrospective, comparative study was carried out from January 2015 to January 2017 in El-Watany Eye Hospital. Two hundred eyes who were eligible for FSL-laser-assisted in situ keratomileusis (FSL was done using FS200, wavelight, Germany SR/1025-1-380) were classified into two groups. Group I: the study group with OBL formation during surgery (100 eye) and group (II): the control group without OBL formation during surgery

View details →
Negative / Null Result ReportOpen accessOphthalmology

Clinical Application of Foldable Capsular Vitreous Bodies in the Treatment of Severe Ocular Trauma and Silicone Oil Dependent Eyes

Hao Jiang, Chao Xue, Yanlin Gao et al. · 2022 · Journal of Ophthalmology

Purpose. This study aimed to assess the application of a foldable capsular vitreous body (FCVB) in the treatment of severe ocular trauma and silicone oil (SO) dependent eyes. Methods. A retrospective analysis was performed on the clinical application of FCVB in the treatment of severe ocular trauma and SO dependent eyes. The results of best-corrected visual acuity and intraocular pressure (IOP) evaluation, B-scan ultrasonography or color Doppler ultrasonography, ultrasound biomicroscopy, and anterior segment photography were recorded during follow-up. A paired t-test was used to compare the di

View details →
Negative / Null Result ReportOpen accessOphthalmology

Can Tinted Lenses Be Used to Manipulate Pupil Size and Visual Performance When Wearing Multifocal Contact Lenses?

Park HM, Ryu YU, Park IJ et al. · 2020 · Clinical Optometry

Hyung Min Park, 1 Young Uk Ryu, 2 In Jee Park, 1 Byoung Sun Chu 1 1School of Optometry and Vision Science, Daegu Catholic University, Gyeongsan-si, Republic of Korea; 2Department of Physical Therapy, Daegu Catholic University, Gyeongsan-si, Republic of KoreaCorrespondence: Byoung Sun ChuSchool of Optometry and Vision Science, Daegu Catholic University, 13-13 Hayang-ro, Hayang-eup, Gyeongsan-si, Gyeongsangbuk-do 38430, Republic of KoreaTel +82-53-850-2553Fax +82-53-359-6793Email bschu@cu.ac.krBackground: The purpose of this study is to investigate the effect of wearing neutral density (ND) filt

View details →
Negative / Null Result ReportOpen accessOphthalmology

Effect of donor graft thickness on clinical outcomes after descemet stripping automated endothelial keratoplasty

Sepehr Feizi, Mohammad Ali Javadi · 2019 · Journal of Ophthalmic & Vision Research

Purpose: To evaluate the effects of donor graft thickness on postoperative best spectacle-corrected visual acuity (BSCVA), refractive outcomes, endothelial cell density (ECD) and function, intraocular pressure (IOP), and postoperative complications after Descemet stripping automated endothelial keratoplasty (DSAEK). Methods: This retrospective, interventional case series enrolled 77 eyes of 64 patients who underwent DSAEK with or without simultaneous cataract surgery. Clinical outcomes, including BSCVA, refraction, keratometric astigmatism, IOP, and ECD were assessed at the final follow-up exa

View details →
Negative / Null Result ReportOpen accessOphthalmology

Association between visual status and mental health status in Thai rural elderly: a community-based study

Pear Pongsachareonnont, Nopphawan Uramphorn, Nuchanad Hounnaklang · 2018 · International Journal of Ophthalmology

AIM: To evaluate the association between visual impairment (VI) and mental health or social engagement in older adults living in rural Thailand. METHODS: Data for this cross-sectional study were drawn from a community survey conducted in 2015 in Saraburi Province, Thailand. Participants were 327 adults aged ≥50y. VI was assessed using presenting distance visual acuity. Mental health and social engagement were evaluated in face-to-face interviews using validated questionnaires. After determining the prevalence of VI and relevant sociodemographic characteristics, multivariate regression analysis

View details →
Negative / Null Result ReportOpen accessOphthalmology

Microkeratome versus manually dissected donor tissue for Descemet stripping endothelial keratoplasty: A randomized prospective study

Ritu Mali, Smruti R. Priyadarshini, Srikant K. Sahu et al. · 2024 · Indian Journal of Ophthalmology

Purpose: To compare the visual outcomes, postoperative complications, and graft asymmetry between precut and manually dissected donor tissues for Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet stripping endothelial keratoplasty (DSEK) procedures, respectively. Methods: Seventy eyes of 70 patients undergoing DSEK/DSAEK at a tertiary eyecare center in eastern India were included in this prospective randomized control study. The 70 eyes were divided equally into two groups. Group A (n = 35) and Group B (n = 35) underwent DSEK and DSAEK procedures, respectively. the ope

View details →
Negative / Null Result ReportOpen accessOphthalmology

The sick body is not associated with the sicker eye

Neoh Yee Ling, Tan Ee Ling, Syed Mudassar Imran Bukhari et al. · 2015 · Journal of Clinical Ophthalmology and Research

Introduction: Systemic diseases such as hypertension and diabetes mellitus (DM) have been identified as the risk factor for glaucoma. However, there is minimal knowledge on the impact of systemic diseases on severity of glaucoma. This study aimed to determine the association between systemic disease and systemic treatment and severity of glaucoma. Materials and Methods: A cross-sectional study was conducted involving 298 primary open-angle glaucoma (POAG; 169 high tension glaucoma (HTG) and 129 normal tension glaucoma (NTG)) patients presented at the eye clinic of two tertiary hospitals in Mal

View details →
Negative / Null Result ReportOpen accessOphthalmology

Biosafety of a 3D-printed intraocular lens made of a poly(acrylamide-co-sodium acrylate) hydrogel in vitro and in vivo

Jia-Wen Li, Yi-Jian Li, Xi-Su Hu et al. · 2020 · International Journal of Ophthalmology

AIM: To assess the biosafety of a poly(acrylamide-co-sodium acrylate) hydrogel (PAH) as a 3D-printed intraocular lens (IOL) material. METHODS: The biosafety of PAH was first evaluated in vitro using human lens epithelial cells (LECs) and the ARPE19 cell line, and a cell counting kit-8 (CCK-8) assay was performed to investigate alterations in cell proliferation. A thin film of PAH and a conventional IOL were intraocularly implanted into the eyes of New Zealand white rabbits respectively, and a sham surgery served as control group. The anterior segment photographs, intraocular pressure (IOP), bl

View details →
Negative / Null Result ReportOpen accessOphthalmology

Effect of transportation on the quality of the donor corneal buttons

Rini Saha, Gautam Singh Parmar, Ashok Kumar et al. · 2018 · Journal of Clinical Ophthalmology and Research

The aim of this study is to see the effect of transportation on corneoscleral buttons and to correlate them with the weight of ice used during transportation. This is a prospective cross-sectional study. A total of 119 corneas were graded using slit-lamp examination and specular microscopy before and after transportation. Groups were made based on the weight of ice used during transportation and the number of hours of storage in McCarey-Kaufman (MK) media. The overall median percentage of endothelial cell loss (ECL) was 11.33%. The median percentage of ECL was significantly more with <500 g of

View details →
Negative / Null Result ReportOpen accessOphthalmology

Comparison of surgical outcomes between initial trabeculectomy and Ex-PRESS in terms of achieving an intraocular pressure below 15 and 18 mmHg: a retrospective comparative study

Shunsuke Nakakura, Ryo Asaoka · 2022 · Eye and Vision

Abstract Background To evaluate the postoperative outcomes of initial trabeculectomy (Trab) and Ex-PRESS (EX) in terms of achieving an intraocular pressure (IOP) below 15 and 18 mmHg. Methods This study retrospectively analyzed 64 and 54 cases of Trab and EX, respectively, performed by the same surgeon with uniform management from April 2018 to March 2019. Surgical success was defined as 5 < IOP < 15 mmHg (criterion 1) and 5 < IOP < 18 mmHg (criterion 2) without additional glaucoma medication, needling, and bleb reconstruction 2 months after surgery. Survival analysis with Cox regression was p

View details →
Negative / Null Result ReportOpen accessOphthalmology

A case of bilateral macular hole in a young HIV-positive patient

Jemal Zeberga Shifa, Alemayehu Mekonnen Gezmu, Gezahen Negusse Ayane et al. · 2019 · The Pan-American Journal of Ophthalmology

A 22-year-old female patient was diagnosed to have HIV and treated by highly active antiretroviral therapy (HAART) since 2012 had developed a reduction of vision in both eyes secondary to cataract. The cataract was extracted from both eyes with no immediate postoperative complication. During follow-up, it was recognized that she had had bilateral Stage 3 macular hole in both eyes. The visual acuity in both eyes was 6/60 which did not improve with application of pinhole. Pars plana vitrectomy was done and sealed the macular hole in the left eye. The visual acuity remained the same in both eyes

View details →