11,287 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Brian A. Boone, Mazen S. Zenati, Melissa E. Hogg et al. · 2015 · JAMA Surgery
IMPORTANCE: Quality assessment is an important instrument to ensure optimal surgical outcomes, particularly during the adoption of new surgical technology. The use of the robotic platform for complex pancreatic resections, such as the…
View details →Andrew McArdle, Ortensia Vito, Harsita Patel et al. · 2021 · New England Journal of Medicine
BACKGROUND: Evidence is urgently needed to support treatment decisions for children with multisystem inflammatory syndrome (MIS-C) associated with severe acute respiratory syndrome coronavirus 2. METHODS: We performed an international…
View details →Carlo Catassi, Debby Kryszak, Bushra Bhatti et al. · 2010 · Annals of Medicine
BACKGROUND: The natural history and the possible changes of celiac disease (CD) prevalence over time are still unclear. OBJECTIVES: 1) To establish whether loss of tolerance to gluten may occur at any age; 2) to investigate possible…
View details →Jens‐Ulrik Stæhr Jensen, Lars Hein, Bettina Lundgren et al. · 2011 · Critical Care Medicine
OBJECTIVE: For patients in intensive care units, sepsis is a common and potentially deadly complication and prompt initiation of appropriate antimicrobial therapy improves prognosis. The objective of this trial was to determine whether a…
View details →Lawrence Fisher, Russell E. Glasgow, Lisa A. Strycker · 2010 · Diabetes Care
OBJECTIVE: To clarify previous findings that diabetes distress is related to glycemic control and self-management whereas measures of depression are not, using both binary and continuous measures of depression. RESEARCH DESIGN AND METHODS:…
View details →Alessandro Doria, Andrzej T. Gałecki, Cathie Spino et al. · 2020 · New England Journal of Medicine
BACKGROUND: Higher serum urate levels are associated with an increased risk of diabetic kidney disease. Lowering of the serum urate level with allopurinol may slow the decrease in the glomerular filtration rate (GFR) in persons with type 1…
View details →James Y. Lau, Yuanyuan Yu, Raymond S. Tang et al. · 2020 · New England Journal of Medicine
BACKGROUND: It is recommended that patients with acute upper gastrointestinal bleeding undergo endoscopy within 24 hours after gastroenterologic consultation. The role of endoscopy performed within time frames shorter than 24 hours has not…
View details →C. Thanasas, George N. Papadimitriou, Charalambos Charalambidis et al. · 2011 · The American Journal of Sports Medicine
BACKGROUND: Chronic lateral elbow epicondylitis is a tendinosis with angiofibrolastic degeneration of the wrist extensors' origin. Healing of this lesion is reported with the use of autologous blood as well as with platelet-rich plasma…
View details →Joeli Marrero, Kyu Y. Rhee, Dirk Schnappinger et al. · 2010 · Proceedings of the National Academy of Sciences
Metabolic adaptation to the host niche is a defining feature of the pathogenicity of Mycobacterium tuberculosis (Mtb). In vitro, Mtb is able to grow on a variety of carbon sources, but mounting evidence has implicated fatty acids as the…
View details →D. Robert Siemens, Sanoj Punnen, James M.W. Wong et al. · 2010 · BMC Medical Education
BACKGROUND: An observed decrease of physician scientists in medical practice has generated much recent interest in increasing the exposure of research programs in medical school. The aim of this study was to review the experience and attitudes regarding research by medical students in Canada. METHODS: An anonymous, cross-sectional, self-report questionnaire was administered to second and fourth year students in three medical schools in Ontario between February and May of 2005. Questions were primarily closed-ended and consisted of Likert scales. Descriptive and correlative statistics were used
View details →Robert F. Spetzler, Cameron G. McDougall, Felipe C Albuquerque et al. · 2013 · Journal of neurosurgery
OBJECT: The authors report the 3-year results of the Barrow Ruptured Aneurysm Trial (BRAT). The objective of this ongoing randomized trial is to compare the safety and efficacy of microsurgical clip occlusion and endovascular coil…
View details →Joachim von Pawel, Robert M. Jotte, David R. Spigel et al. · 2014 · Journal of Clinical Oncology
PURPOSE: Amrubicin, a third-generation anthracycline and potent topoisomerase II inhibitor, showed promising activity in small-cell lung cancer (SCLC) in phase II trials. This phase III trial compared the safety and efficacy of amrubicin…
View details →Ji Young Bang, Udayakumar Navaneethan, Muhammad K. Hasan et al. · 2018 · Gut
OBJECTIVE: Although lumen-apposing metal stents (LAMS) are increasingly used for drainage of walled-off necrosis (WON), their advantage over plastic stents is unclear. We compared efficacy of LAMS and plastic stents for WON drainage.…
View details →Ralph Peterli, Yves Borbély, Béatrice Kern et al. · 2013 · Annals of Surgery
In Brief Objective: Laparoscopic sleeve gastrectomy (LSG) has been proposed as an effective alternative to the current standard procedure, laparoscopic Roux-en-Y gastric bypass (LRYGB). Prospective data comparing both procedures are rare.…
View details →Anand Rohatgi, Marit Westerterp, Arnold von Eckardstein et al. · 2021 · Circulation
Low high-density lipoprotein cholesterol (HDL-C) characterizes an atherogenic dyslipidemia that reflects adverse lifestyle choices, impaired metabolism, and increased cardiovascular risk. Low HDL-C is also associated with increased risk of…
View details →Aung Ko Win, Joanne Young, Noralane M. Lindor et al. · 2012 · Journal of Clinical Oncology
PURPOSE: To determine whether cancer risks for carriers and noncarriers from families with a mismatch repair (MMR) gene mutation are increased above the risks of the general population. PATIENTS AND METHODS: We prospectively followed a…
View details →Sung Soo Ahn, Myeong‐Jin Kim, Joon Seok Lim et al. · 2010 · Radiology
PURPOSE: To determine the added value of hepatobiliary phase images in gadoxetic acid-enhanced magnetic resonance (MR) imaging in the evaluation of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Institutional review board approved…
View details →Petros Aristodemou, Nathaniel E. Knox Cartwright, J M Sparrow et al. · 2010 · Journal of Cataract & Refractive Surgery
PURPOSE: To assess how intraocular lens (IOL) formula choice affects refractive outcomes after cataract surgery using IOLMaster biometry. SETTING: Department of Ophthalmology, Gloucestershire Hospitals NHS Foundation Trust, Cheltenham,…
View details →The INIS Collaborative Group · 2011 · New England Journal of Medicine
BACKGROUND: Neonatal sepsis is a major cause of death and complications despite antibiotic treatment. Effective adjunctive treatments are needed. Newborn infants are relatively deficient in endogenous immunoglobulin. Meta-analyses of…
View details →Jane Warwick, Emanuela Falaschetti, Kenneth Rockwood et al. · 2015 · BMC Medicine
BACKGROUND: Treatment for hypertension with antihypertensive medication has been shown to reduce stroke, cardiovascular events, and mortality in older adults, but there is concern that such treatment may not be appropriate in frailer older adults. To investigate whether there is an interaction between effect of treatment for hypertension and frailty in older adults, we calculated the frailty index (FI) for all available participants from the HYpertension in the Very Elderly Trial (HYVET) study, a double-blind, placebo-controlled study of antihypertensives in people with hypertension aged 80 an
View details →William G. Lindsley, Terri Pearce, Judith B. Hudnall et al. · 2012 · Journal of Occupational and Environmental Hygiene
The question of whether influenza is transmitted to a significant degree by aerosols remains controversial, in part, because little is known about the quantity and size of potentially infectious airborne particles produced by people with…
View details →Mihai Gheorghiade, Michael Böhm, Stephen J. Greene et al. · 2013 · JAMA
IMPORTANCE: Hospitalizations for heart failure (HHF) represent a major health burden, with high rates of early postdischarge rehospitalization and mortality. OBJECTIVE: To investigate whether aliskiren, a direct renin inhibitor, when added…
View details →Alice G. Cheng, Molly McAdow, Hwan Keun Kim et al. · 2010 · PLoS Pathogens
The bacterial pathogen Staphylococcus aureus seeds abscesses in host tissues to replicate at the center of these lesions, protected from host immune cells via a pseudocapsule. Using histochemical staining, we identified prothrombin and fibrin within abscesses and pseudocapsules. S. aureus secretes two clotting factors, coagulase (Coa) and von Willebrand factor binding protein (vWbp). We report here that Coa and vWbp together are required for the formation of abscesses. Coa and vWbp promote the non-proteolytic activation of prothrombin and cleavage of fibrinogen, reactions that are inhibited wi
View details →Yan Wang, Fabiana Quagliarini, Viktoria Gusarova et al. · 2013 · Proceedings of the National Academy of Sciences
Angiopoietin-like protein (ANGPTL)8 (alternatively called TD26, RIFL, Lipasin, and Betatrophin) is a newly recognized ANGPTL family member that has been implicated in both triglyceride (TG) and glucose metabolism. Hepatic overexpression of…
View details →Rolf Jorde, Monica Sneve, Peter A. Torjesen et al. · 2010 · Nutrition Journal
BACKGROUND: In meta-analyses supplementation with vitamin D appears to reduce incidence of fractures, and in cross-sectional studies there is a positive association between serum 25-hydroxyvitamin D (25(OH)D) levels and bone mineral density (BMD). However, the effect of supplementation with high doses of vitamin D on BMD is more uncertain and could in theory have both positive and negative effects. METHODS: The study was a one year, double blind placebo-controlled intervention trial performed at the University Hospital of North Norway. 421 subjects, 21 - 70 years old, were included and 312 com
View details →Julie Agel, Todd Rockwood, David Klossner · 2016 · Clinical Journal of Sport Medicine
OBJECTIVE: To present data on the rate of anterior cruciate ligament (ACL) injury in 15 collegiate sports from 2004 to 2005 through 2012 to 2013 updating the 1988-1989 to 2003-2004 data. DESIGN: Prospectively designed descriptive…
View details →Luis Paz‐Ares, Y Chen, Niels Reinmuth et al. · 2022 · ESMO Open
•Durvalumab plus EP showed sustained OS benefit over EP with a well-tolerated safety profile after median follow-up >3 years.•Three times more patients were estimated to be alive at 3 years when treated with durvalumab plus EP versus EP…
View details →Lucy van Dorp, Damien Richard, Cedric Tan et al. · 2020 · Nature Communications
COVID-19 is caused by the coronavirus SARS-CoV-2, which jumped into the human population in late 2019 from a currently uncharacterised animal reservoir. Due to this recent association with humans, SARS-CoV-2 may not yet be fully adapted to its human host. This has led to speculations that SARS-CoV-2 may be evolving towards higher transmissibility. The most plausible mutations under putative natural selection are those which have emerged repeatedly and independently (homoplasies). Here, we formally test whether any homoplasies observed in SARS-CoV-2 to date are significantly associated with inc
View details →Justin Beardsley, Marcel Wolbers, Freddie Kibengo et al. · 2016 · New England Journal of Medicine
BACKGROUND: Cryptococcal meningitis associated with human immunodeficiency virus (HIV) infection causes more than 600,000 deaths each year worldwide. Treatment has changed little in 20 years, and there are no imminent new anticryptococcal…
View details →Biren B. Kamdar, Lauren M. King, Nancy A. Collop et al. · 2013 · Critical Care Medicine
OBJECTIVES: To determine if a quality improvement intervention improves sleep and delirium/cognition. DESIGN: Observational, pre-post design. SETTING: A tertiary academic hospital in the United States. PATIENTS: 300 medical ICU patients.…
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