Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Zhenhan Deng, Xueqin Gao, Hajime Utsunomiya et al. · 2022 · Bone Reports
Background and aims: Previous work has shown that oral losartan can enhance microfracture-mediated cartilage repair in a rabbit osteochondral defect injury model. In this study, we aimed to determine whether oral losartan would have a detrimental effect on articular cartilage and bone homeostasis in the uninjured sides. Methods: New Zealand rabbits were divided into 4 groups including normal uninjured (Normal), contralateral uninjured side of osteochondral defect (Defect), osteochondral defect plus microfracture (Microfracture) and osteochondral defect plus microfracture and losartan oral admi
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Daniele Faria Miguel, Maria Teresa Terreri, Rosa Maria Rodrigues Pereira et al. · 2020 · Advances in Rheumatology
Abstract Background Urinary parameters, anti-dsDNA antibodies and complement tests were explored in patients with childhood-Systemic Lupus Erythematosus (cSLE) early-onset lupus nephritis (ELN) from a large multicenter cohort study. Methods Clinical and laboratory features of cSLE cases with kidney involvement at presentation, were reviewed. Disease activity parameters including SLEDAI-2 K scores and major organ involvement at onset and follow up, with accrued damage scored by SLICC-DI, during last follow up, were compared with those without kidney involvement. Autoantibodies, renal function a
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Xingtao Ge, Xinghua Ge, Chen Wang et al. · 2022 · BMC Musculoskeletal Disorders
Abstract Background A safe and effective technique for anterolateral portal placement in elbow arthroscopy is significant. We compared the outcomes of patients who underwent elbow arthroscopy using different ultrasound-assisted techniques. Methods From May 2016 to June 2021 a retrospective analysis on all patients who underwent elbow arthroscopy in our department was performed. Patients were separated into three groups: non-ultrasound; preoperative ultrasound; and intraoperative ultrasound. The minimum follow-up period was 1 year. Nerve injuries, visual analog scale (VAS), Mayo elbow-performan
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Enas M Shahine, Tarek S Shafshak · 2014 · Egyptian Rheumatology and Rehabilitation
Objective The aim of this study was to compare the effects of bilateral arm training with auditory cueing (BATRAC) versus control intervention on motor performance of the upper extremity (UE) and to explore the central neurophysiological mechanism underlying this effect in moderately impaired chronic stroke patients. Design This was a randomized-controlled clinical trial. Materials and Methods Overall, 76 chronic stroke patients (mean age = 50.2 ± 6.2 years), 6-67 months after the onset of the first stroke were enrolled. They received either BATRAC (with both UE trained simultaneously in symme
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Akif Albayrak, Baris Ozkul, Mehmet Bulent Balioglu et al. · 2016 · Journal of Craniovertebral Junction and Spine
Study Design: Retrospective cohort study. Purpose: Facet joints are considered a common source of chronic low-back pain. To determine whether pathogens related to the facet joint arthritis have any effect on treatment failure. Materials and Methods: Facet joint injection was applied to 94 patients treated at our hospital between 2011 and 2012 (mean age 59.5 years; 80 women and 14 men). For the purpose of analysis, the patients were divided into two groups. Patients who only had facet hypertrophy were placed in group A (47 patients, 41 women and 6 men, mean age 55.3 years) and patients who had
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Andrea Buonsenso, Domenico Di Fonza, Gloria Di Claudio et al. · 2025 · Journal of Functional Morphology and Kinesiology
Objectives : The lat pulldown machine is one of the most versatile pieces of equipment for back strengthening, allowing variations in grip and load. However, there are significant gaps in the literature regarding the relationship between exercise modality and specific muscle activation. Methods : This study examined the electromyographic (EMG) activity of major back muscles during seven lat pulldown exercise variants that differed in grip type, width, and trunk inclination. Forty male subjects, with at least 5 years of resistance training experience, performed five repetitions of lat pulldown
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
A. Guermazi, G. Kalsi, J. Niu et al. · 2017 · BMC Musculoskeletal Disorders
Abstract Background To determine effects of allogeneic human chondrocytes expressing TGF-β1 (TG-C) on structural progression of MRI features of knee osteoarthritis over a 1 year period. Methods This phase II randomized controlled trial of TG-C included patients with moderate to advanced osteoarthritis. Patients were randomized to receive an intraarticular 3:1 mixture of non-transduced allogeneic human chondrocytes and TG-C or placebo. 3 T MRI was acquired for all patients at baseline and follow-up (3, 6 and 12 months). MRIs were assessed using the WORMS system including cartilage damage, bone
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Feng-Hang Chang, Alan M. Jette, Mary D. Slavin et al. · 2018 · BMC Musculoskeletal Disorders
Abstract Background The intent of this study was to examine and compare the ability to detect change of two patient reported outcome (PRO) instruments that use a computerized adaptive test (CAT) approach to measurement. The Patient Reported Outcomes Measurement Information System (PROMIS®) Physical Function scale is a generic PRO, while the Osteoarthritis Computerized Adaptive Test (OA-CAT) is an osteoarthritis-specific PRO. Methods This descriptive, longitudinal study was conducted in a community setting, involving individuals from the greater Boston area. Inclusion criteria: age > 50, self-r
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Hak Jun Kim, Eui Dong Yeo, Im Joo Rhyu et al. · 2017 · BMC Musculoskeletal Disorders
Abstract Background Malalignment of the ankle joint has been found after trauma, by neurological disorders, genetic predisposition and other unidentified factors, and results in asymmetrical joint loading. For a medial open wedge supramalleolar osteotomy(SMO), there are some debates as to whether concurrent fibular osteotomy should be performed. We assessed the changes in motion of ankle joint and plantar pressure after supramalleolar osteotomy without fibular osteotomy. Methods Ten lower leg specimens below the knee were prepared from fresh-frozen human cadavers. They were harvested from five
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Tobias Wollersheim, Julius J. Grunow, Niklas M. Carbon et al. · 2019 · Journal of Cachexia, Sarcopenia and Muscle
Abstract Background Early mobilization improves physical independency of critically ill patients at hospital discharge in a general intensive care unit (ICU)‐cohort. We aimed to investigate clinical and molecular benefits or detriments of early mobilization and muscle activating measures in a high‐risk ICU‐acquired weakness cohort. Methods Fifty patients with a SOFA score ≥9 within 72 h after ICU admission were randomized to muscle activating measures such as neuromuscular electrical stimulation or whole‐body vibration in addition to early protocol‐based physiotherapy (intervention) or early p
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Andrew P. McBride, Thibault Lafosse, Alex N. Karanja et al. · 2025 · BMC Musculoskeletal Disorders
Abstract Background Long term studies have shown the Latarjet procedure to be successful in preventing re-dislocation in primary and recurrent anterior inferior shoulder instability. It provides stability through the sling effect of the conjoint tendon and the bone block. It is unclear whether augmentation with capsular repair provides an added benefit or leads to restricted range of external rotation. The primary aim of this study is to evaluate the effect of capsular repair in the open Latarjet procedure on rotational range of active external rotation in 90 degrees abduction (RoM-ER90). The
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Takuya Tajima, Nami Yamaguchi, Makoto Nagasawa et al. · 2019 · BMC Musculoskeletal Disorders
Abstract Background Bone tunnel enlargement following primary anterior cruciate ligament (ACL) reconstruction with soft tissue graft might be a severe disadvantage for revision surgery. The postoperative rehabilitation protocol including the non-weight-bearing periods were different depending on the surgeon or institute. To determine the relationship between femoral bone tunnel enlargement and the postoperative non-weight-bearing period after double-bundle ACL reconstruction with hamstring grafts. Methods Forty-two patients who underwent primary double-bundle ACL reconstruction with hamstring
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Talia Golan, Ravit Geva, Donald Richards et al. · 2018 · Journal of Cachexia, Sarcopenia and Muscle
Abstract Background Cachexia is a formidable clinical challenge in pancreatic cancer. We assessed LY2495655 (antimyostatin antibody) plus standard‐of‐care chemotherapy in pancreatic cancer using cachexia status as a stratifier. Methods In this randomized, phase 2 trial, patients with stage II–IV pancreatic cancer were randomized to 300 mg LY2495655, 100 mg LY2495655, or placebo, plus physician‐choice chemotherapy from a prespecified list of standard‐of‐care regimens for first and later lines of care. Investigational treatment was continued during second‐line treatment. The primary endpoint was
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Natalia Pereira Machado, Eliana Nogueira, Karen Oseki et al. · Revista Brasileira de Reumatologia
ABSTRACT Objectives: Innate immunity is involved in the physiopathology of ankylosing spondylitis (AS), with the participation of Gram-negative bacteria, modulation of human leukocyte antigen (HLA) B27 and the involvement of pattern recognition receptors, such as Toll-like receptors (TLRs). The aim of this study was to investigate the clinical characteristics and frequency of TLR4 polymorphisms (Asp299Gly and Thr 399Ile) in a cohort of Brazilian patients with AS. Methods: A cross-sectional study was carried out involving 200 patients with a diagnosis of AS and a healthy control group of 200 in
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Hye‐Sun Park, Sang Ho Park, Yeseul Seong et al. · 2024 · Journal of Cachexia, Sarcopenia and Muscle
Abstract Background The association between the adiponectin‐to‐leptin ratio (A/L ratio) and the risk of incident chronic kidney disease (CKD) is poorly understood. This study aimed to investigate the association between A/L ratio and the risk of incident CKD and to examine whether such a relationship varied according to sex and body composition. Methods In this prospective community‐based cohort, participants with normal kidney function were analysed (N = 5192). The association between the A/L ratio at baseline and the risk of incident CKD, defined as two or more occasions with an estimated gl
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Jenny Brouwer, Radboud J. E. M. Dolhain, Johanna M. W. Hazes et al. · 2019 · ACR Open Rheumatology
Objective Subfertility, a time to pregnancy (TTP) longer than 12 months, is present in 40% of female patients with rheumatoid arthritis (RA) who are actively trying to conceive. Because patients with RA appear to reach menopause at a younger age, diminished ovarian function may explain the reduced fertility. Serum anti‐Müllerian hormone (AMH) levels are the best proxy to measure ovarian function. Our objectives were to study AMH levels in female patients with RA and determine the association of preconception serum AMH levels with TTP. Methods A post hoc analysis was performed before conception
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Gulsen Ozen, Michael O'Rorke, Paul Romitti et al. · 2026 · ACR Open Rheumatology
Objective The aim of this study was to develop and validate International Classification of Diseases (ICD) code–based algorithms for identifying systemic sclerosis (SSc) cases within electronic health record (EHR) data and to evaluate algorithm performance. Methods We identified patients with at least one ICD, Ninth Revision (ICD‐9)/ICD‐10 code for SSc in a large multicenter EHR dataset (TriNetX Research Network). A random sample of patients underwent detailed medical record review to confirm SSc diagnosis (gold standard). All ICD‐9/10 codes assigned during inpatient or outpatient encounters a
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Yan-Tao Ma, Yu-Lin Dong, Bo Wang et al. · 2023 · BMC Musculoskeletal Disorders
Abstract Background Latent and active myofascial trigger points (MTrPs) in knee-associated muscles may play a key role in pain management among patients with knee osteoarthritis (KOA). The aim of this study was to investigate the effect of dry needling treatment on pain intensity, disability, and range of motion (ROM) in patients with KOA. Methods This randomized, single-blinded, clinical trial was carried out for 6 weeks of treatment and 6-month follow-up. A total of 98 patients met the entry criteria and were randomly assigned to the dry needling latent and active myofascial trigger point (M
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Nicola Manta, Laura Mangiavini, Cristiana Balbino et al. · 2021 · BMC Musculoskeletal Disorders
Abstract Background Suction drainage is commonly applied after total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA) to reduce hematoma, swelling and to favor surgical wound healing. However, its efficacy remains controversial; thus, the purpose of this study is to evaluate drainage efficiency in the management of postoperative bleeding in TKA and UKA. Methods The cohort comprised 134 clinical records of patients affected by knee osteoarthritis (OA) who underwent either TKA or UKA. All the patients were subdivided into 2 groups: the first one with drainage and the second o
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Mohamed A. Mortada, Haidy E. Zidan, Noha A. Abdelsalam et al. · 2020 · Egyptian Rheumatology and Rehabilitation
Abstract Background Impaired deoxyribonucleic acid (DNA) repair may induce an autoimmune response in susceptible individuals. The association between DNA repair gene XRCC1 Arg399Gln gene polymorphism and susceptibility of systemic lupus erythematosus (SLE) is controversial. This study aimed to detect the association of XRCC1 Arg399Gln gene polymorphism with SLE and its clinical manifestations in the Egyptian population. Results A significant association was found between weight loss and genotype GG (P = 0.048); however, genotype AG was significantly associated with high serum creatinine and lo
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Takuji Yokoe, Takuya Tajima, Shuichi Kawagoe et al. · 2022 · BMC Musculoskeletal Disorders
Abstract Background A number of studies have evaluated risk factors for lateral ankle sprain (LAS) or chronic lateral ankle instability (CLAI). However, the definitive risk factors for LAS or CLAI remain controversial. The purpose of this study was to evaluate whether the contralateral healthy ankles of subjects with ipsilateral mechanical lateral ankle laxity (group I) show greater lateral ankle laxity in comparison to the healthy ankles of bilateral healthy controls (group B). Methods From March 2020, anterior talofibular ligament (ATFL) lengths of young adult volunteers were cross-sectional
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Jeremy C Heard, Yunsoo A Lee, Nicholas D D'Antonio et al. · 2024 · Journal of Craniovertebral Junction and Spine
Objectives: To evaluate the (1) 90-day surgical outcomes and (2) 1-year revision rate of robotic versus nonrobotic lumbar fusion surgery. Methods: Patients >18 years of age who underwent primary lumbar fusion surgery at our institution were identified and propensity-matched in a 1:1 fashion based on robotic assistance during surgery. Patient demographics, surgical characteristics, and surgical outcomes, including 90-day surgical complications and 1-year revisions, were collected. Multivariable regression analysis was performed. Significance was set to P < 0.05. Results: Four hundred and fiftee
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Alexander C. Lehn, Cullen O'Gorman, Sarah Olson et al. · 2017 · Tremor and Other Hyperkinetic Movements
Background: Orthostatic tremor (OT) was first described in 1977. It is characterized by rapid tremor of 13–18 Hz and can be recorded in the lower limbs and trunk muscles. OT remains difficult to treat, although some success has been reported with deep brain stimulation (DBS). Case Report: We report a 68-year-old male with OT who did not improve significantly after bilateral thalamic stimulation. Discussion: Although some patients were described who improved after DBS surgery, more information is needed about the effect of these treatment modalities on OT, ideally i
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