Effects of oral losartan administration on homeostasis of articular cartilage and bone in a rabbit model
Zhenhan Deng; Xueqin Gao; Hajime Utsunomiya; Justin W. Arner; Joseph J. Ruzbarsky; Matthieu Huard; Sudheer Ravuri; Marc J. Philippon · 2022 · Bone Reports
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background and aims: Previous work has shown that oral losartan can enhance microfracture-mediated cartilage repair in a rabbit osteochondral defect injury model. In this study, we aimed to determine whether oral losartan would have a detrimental effect on articular cartilage and bone homeostasis in the uninjured sides. Methods: New Zealand rabbits were divided into 4 groups including normal uninjured (Normal), contralateral uninjured side of osteochondral defect (Defect), osteochondral defect plus microfracture (Microfracture) and osteochondral defect plus microfracture and losartan oral admi
Abstract by Zhenhan Deng; Xueqin Gao; Hajime Utsunomiya; Justin W. Arner; Joseph J. Ruzbarsky; Matthieu Huard; Sudheer Ravuri; Marc J. Philippon, Bone Reports (2022) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1016/j.bonr.2022.101526