Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Yutong Chen, Yi Ding, Shanliang Jin et al. · 2024 · Frontiers in Endocrinology
PurposeThis research aimed to assess the correlation between the Adjusted Body Shape Index (ABSI) and the presence of abdominal aortic calcification (AAC) among middle-aged and older American adults.MethodsEmploying a cross-sectional design, this study analyzed data from the 2013-2014 National Health and Nutrition Examination Survey (NHANES), focusing on 3077 participants aged 40 and above. AAC detection was conducted using dual-energy X-ray absorptiometry (DXA). ABSI was determined based on waist circumference (WC), weight, and height data. The association between ABSI and AAC was examined th
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Hania Szajewska, Agnieszka Szypowska, Lidia Groele et al. · 2021 · BMJ Open Diabetes Research & Care
Introduction The gut microbiota may be relevant in the development of type 1 diabetes (T1D). We examined the effects of Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12 on beta-cell function in children with newly diagnosed T1D.Research design and methods Children aged 8–17 years with newly (within 60 days) diagnosed T1D were enrolled in a double-blind, randomised controlled trial in which they received L. rhamnosus GG and B. lactis Bb12 at a dose of 109 colony-forming units or placebo, orally, once daily, for 6 months. The follow-up was for 12 months. The primary outcome measure was
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Camila Viecceli, Camila Viecceli, Ana Carolina Viana Mattos et al. · 2022 · Frontiers in Endocrinology
ObjectiveThe first-line treatment for Cushing’s disease is transsphenoidal surgery, after which the rates of remission are 60 to 80%, with long-term recurrence of 20 to 30%, even in those with real initial remission. Drug therapies are indicated for patients without initial remission or with surgical contraindications or recurrence, and ketoconazole is one of the main available therapies. The objective of this study was to evaluate the safety profile of and the treatment response to ketoconazole in Cushing’s disease patients followed up at the endocrinology outpatient clinic of a Brazilian uni
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Yea Eun Kang, Sorim Choung, Ju Hee Lee et al. · 2017 · Endocrinology and Metabolism
BackgroundSlit2 is a new secreted protein from adipose tissue that improves glucose hemostasis in mice; however, there is no study about the serum levels and precise role of Slit2 in human. The aim of this study is to explore the serum level of Slit2 in human, and to identify the role of Slit2 in diabetes mellitus (DM).MethodsThe participants of this study consist of 38 subjects with newly diagnosed DM, and 75 healthy subjects as a control group. Serum Slit2 levels were measured using an enzyme-linked immunosorbent assay. Relationship between circulating Slit2 and diabetic related factors was
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Chaoyu Pang, Yongzheng Li, Ming Shi et al. · 2024 · Frontiers in Endocrinology
BackgroundCXC chemokine receptor 4 (CXCR4) is associated with the progression and metastasis of numerous malignant tumors. However, its relationship with Gastroenteropancreatic Neuroendocrine Neoplasms Grade 3 (GEP-NENs G3) is unclear. The aim of this study was to characterize the expression of CXCR4 in GEP-NENS and to explore the clinical and prognostic value of CXCR4.MethodsThis study retrospectively collected clinical and pathological data from patients with GEP-NENs who receiving surgery in Qilu Hospital of Shandong University from January 2013 to April 2021, and obtained the overall survi
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Runsheng Zhao, Kaiyu Fan, Weiqing Wan · 2023 · BMC Endocrine Disorders
Abstract Background To prevent thyroid storm and ensure surgical safety, it is imperative to regulate excessive thyroid hormone levels in patients with thyrotropin-secreting pituitary adenomas (TSHoma) prior to surgery. Somatostatin analogues (SSAs), such as octreotide, have showed efficacy in shrinking tumors, which may facilitate surgical resection. This retrospective study aimed to investigate the effect of shortterm preoperative octreotide treatment on the surgical outcome of TSHoma. Methods A total of 65 TSHoma patients from January 2010 to July 2019 were included in the study. Of these,4
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Pei Wang, Pei Wang, Zhizhong Dong et al. · 2024 · Frontiers in Endocrinology
BackgroundActive surveillance has been an option for patients with low-risk papillary thyroid carcinoma (PTC). However, whether delayed surgery leads to an increased risk of local tumor metastasis remain unclear. We sought to investigate the impact of observation time on central lymph node metastasis (CLNM) and multifocal disease in patients with low-risk PTC.MethodsPatients who were diagnosed with asymptomatic low-risk PTC, and with a pathological maximum tumor size ≤1.5 cm by were included. The patients were classified into observation group and immediate surgery group, and subgroup analyses
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Maiko Miyamoto, Aika Miya, Akinobu Nakamura et al. · 2026 · Journal of Diabetes Investigation
ABSTRACT Aims/Introduction We aimed to explore the short‐term effects of tofogliflozin on the insulin secretory capacity of people with type 2 diabetes. Materials and Methods We performed a multicenter, prospective, randomized, active‐controlled, open‐label, parallel‐group comparison study of people with type 2 diabetes aged 20–89 years, with hemoglobin A1c (HbA1c) 6.5%–9.0%, not previously treated with antihyperglycemic agents. The participants were randomly assigned to a group that received 20 mg tofogliflozin per day or a group that received 500 mg metformin per day for 4 weeks. Fasting blo
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Pannipa Suwannasom, Tasalak Thonghong, Krit Leemasawat et al. · 2024 · Journal of Diabetes Investigation
Abstract Aims/Introduction Individuals with diabetes are at high risk of developing cardiovascular events. The present study investigated the predictive value of the cardio‐ankle vascular index (CAVI) when added to the Systematic Coronary Risk Evaluation 2‐Diabetes (SCORE2‐Diabetes) risk algorithm to predict cardiovascular events in the Asian population. Materials and Methods The SCORE2‐Diabetes risk was assessed in 1,502 patients with diabetes, aged 40–69 years. Then, we further stratified each 10‐year risk category with a CAVI value of 9.0. The primary outcomes (composite of all causes of de
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Sailimai Man, Yuan Ma, Cheng Jin et al. · 2020 · Journal of Diabetes Research
Background. Studies suggest an association between H. pylori infection and extragastrointestinal disease. Limited studies provided conflicting results on the association between H. pylori infection and diabetes. The present study was aimed at examining the association between H. pylori infection and diabetes in a large health checkup population in China. Methods. A cross-sectional study was conducted; participants who attended health checkups at Beijing MJ Health Screening Center during 2017-2018 were included. H. pylori infection was diagnosed by 13C-urea breath test. Multivariate logistic re
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Yina Piao, Mengxia Jin · 2026 · Therapeutic Advances in Endocrinology and Metabolism
Background: Stress-induced hyperglycemia ratio (SHR) has shown strong correlations with diabetes risk. However, its relationship with gestational diabetes mellitus (GDM) remains an area of limited research. Objective: Based on the National Health and Nutrition Examination Survey (NHANES) database, this cross-sectional study aims to explore the association between SHR and GDM. Methods: The study included 461 pregnant women from NHANES between 1999 and 2016. Logistic regression analysis was performed to investigate the relation between SHR and GDM, as well as the weighted tertiles of SHR. Strati
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Yoriko Heianza, Lu Qi, Marly Augusto Cardoso et al. · 2020 · BMJ Open Diabetes Research & Care
Exposure to different air pollutants has been linked to type 2 diabetes mellitus, but the evidence for the association between air pollutants and gestational diabetes mellitus (GDM) has not been systematically evaluated. We systematically retrieved relevant studies from PubMed, Embase, and the Web of Science, and performed stratified analyses and regression analyses. Thirteen studies were analyzed, comprising 1 547 154 individuals from nine retrospective studies, three prospective studies, and one case–control study. Increased exposure to particulate matter ≤2.5 µm in diameter (PM2.5) was not
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Nuria Valdés, Nuria Valdés, Ana Romero et al. · 2024 · Frontiers in Endocrinology
IntroductionHistorically, Multiple Endocrine Neoplasia type 1 (MEN1)-related pituitary adenomas (PAs) were considered more aggressive and treatment-resistant than sporadic PAs. However, recent studies suggest similarities in their behavior. This study aimed to evaluate the long-term outcomes of MEN1 PAs and identify predictive factors.MethodsNationwide multicenter retrospective cohort study of MEN1-related PAs with a minimum 1-year follow-up, collecting patient demographics, germline MEN1 pathogenic variants (PV), PA size, secretory profile, radiological characteristics, treatments, and outcom
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Maysa S. Campos, José B. Volpon, João Paulo B. Ximenez et al. · 2022 · Frontiers in Endocrinology
ObjectiveTo investigate the effects of vibration therapy on fracture healing in diabetic and non-diabetic rats.Methods148 rats underwent fracture surgery and were assigned to four groups: (1) SHAM: weight-matched non-diabetic rats, (2) SHAM+VT: non-diabetic rats treated with vibration therapy (VT), (3) DM: diabetic rats, and (4) DM+VT: diabetic rats treated with VT. Thirty days after diabetes induction with streptozotocin, animals underwent bone fracture, followed by surgical stabilization. Three days after bone fracture, rats began VT. Bone healing was assessed on days 14 and 28 post-fracture
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Peipei Liu, Guoqing Dong, Mingzhu Li et al. · 2026 · Frontiers in Endocrinology
ObjectiveTo investigate the association between estrogen receptor β (ERβ) gene RsaI (rs1256049) and AluI (rs4986938) polymorphisms and the risk of idiopathic central precocious puberty (ICPP) in girls, and to provide potential molecular genetic references for early risk prediction and individualized management of ICPP.MethodsA total of 100 girls with ICPP from the Pediatric Endocrinology Clinic and Inpatient Ward of Shenzhen Maternity & Child Healthcare Hospital were enrolled, and 100 agematched healthy girls undergoing routine physical examinations during the same period served as controls. T
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Xingquan Zhao, Qian Zhang, Shengyun Chen et al. · 2025 · BMJ Open Diabetes Research & Care
Introduction The effects of different glucose metabolic states and diabetes-controlled status on asymptomatic carotid atherosclerosis has not been well investigated. Herein, we aimed to investigate the association of different diabetes status with asymptomatic carotid plaques and carotid intima–media thickness (CIMT).Research design and methods 4752 participants aged over 40 years, free of stroke or myocardial infarction, from the China National Stroke Screen Survey programme were enrolled. Carotid plaque and CIMT were assessed using duplex ultrasonography. Logistic regression analysis was use
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Takehiro Sugiyama, Takashi Furuno, Yuichi Ichinose et al. · 2024 · Journal of Diabetes Investigation
ABSTRACT Aims/Introduction A recent US Food and Drug Administration report highlighted concerns over nitrosamine (7‐nitroso‐3‐(trifluoromethyl)‐5,6,7,8‐tetrahydro[1,2,4] triazolo‐[4,3‐a]pyrazine [NTTP]) impurities in sitagliptin, prompting investigations into its safety profile. The present study aimed to determine if the use of NTTP‐contaminated sitagliptin, in comparison with other dipeptidyl peptidase‐4 (DPP‐4) inhibitors, is associated with an increased cancer risk. Materials and Methods This retrospective cohort study secondarily used the National Database of Health Insurance Claims and S
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Sofya Ilmer, Rubab Sohail, Sharon Hyman · 2026 · Frontiers in Endocrinology
IntroductionThis retrospective chart review investigated the relationship between 25-hydroxyvitamin D levels and the initial clinical and biochemical presentation of type 1 diabetes mellitus (T1DM) in children under 18 years of age, specifically: (1) presence or absence of diabetic ketoacidosis and the severity of diabetic ketoacidosis (DKA) - among those with DKA, and (2) beta-cell function.MethodsThis study included 99 children with new-onset Type 1 Diabetes Mellitus (T1DM). Patients were diagnosed at our pediatric endocrinology practice at Northwell Health between June 2023 and February 202
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Mahdieh Hosseinzadeh, Niloufar Saber, Sakineh Shab Bidar et al. · 2024 · BMC Endocrine Disorders
Abstract Background Type 2 diabetes mellitus (T2DM) is often linked to chronic inflammation, which can be influenced by both lifestyle and dietary choices. However, the relationship between the inflammatory potential of diet and lifestyle factors and the risk of developing T2DM remains unclear. The present study aimed to investigate the associations of the empirical dietary inflammatory index (EDII), dietary inflammatory score (DIS), and lifestyle inflammatory score (LIS) with the risk of T2DM among Iranian adults. Methods The current study was conducted on 5714 individuals from Yazd Health St
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Sung Hye Kong · 2026 · Endocrinology and Metabolism
For decades, vitamin D has been a cornerstone of preventive medicine. However, recent large-scale randomized controlled trials have failed to replicate the broad benefits previously observed in epidemiological studies, particularly with respect to fracture and fall prevention in vitamin D-replete populations. Moreover, growing evidence suggesting an increased fall risk associated with high-dose bolus administration has necessitated a re-evaluation of safety assumptions. This review synthesizes these discordant findings to propose a framework grounded in precision medicine. We explore the ‘dive
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