A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke
New England Journal of Medicine · 2014
All failures in Medicine
Negative / Null Result Reports in Medicine
11,264 indexed negative / null result reports in Medicine — real published studies, so you can learn what already failed before you repeat it.
Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile
New England Journal of Medicine · 2013
Stenting versus Endarterectomy for Treatment of Carotid-Artery Stenosis
New England Journal of Medicine · 2010
Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus
New England Journal of Medicine · 2010
Spironolactone for Heart Failure with Preserved Ejection Fraction
New England Journal of Medicine · 2014
10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer
New England Journal of Medicine · 2016
Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma
JAMA · 2015
Endovascular Therapy after Intravenous t-PA versus t-PA Alone for Stroke
New England Journal of Medicine · 2013
Diuretic Strategies in Patients with Acute Decompensated Heart Failure
New England Journal of Medicine · 2011
Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care
New England Journal of Medicine · 2012
Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients
New England Journal of Medicine · 2014
Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: The lupus nephritis assessment with rituximab study
Arthritis & Rheumatism · 2012
Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer's Disease
The Journal of Prevention of Alzheimer s Disease · 2022
Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19
JAMA · 2020
Early Versus Delayed Initiation of Concurrent Palliative Oncology Care: Patient Outcomes in the ENABLE III Randomized Controlled Trial
Journal of Clinical Oncology · 2015
High versus Low Blood-Pressure Target in Patients with Septic Shock
New England Journal of Medicine · 2014
Validation of Digital Visual Analog Scale Pain Scoring With a Traditional Paper-based Visual Analog Scale in Adults
JAAOS Global Research and Reviews · 2018
Prostate Cancer Screening in the Randomized Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial: Mortality Results after 13 Years of Follow-up
JNCI Journal of the National Cancer Institute · 2012
Adaptive Servo-Ventilation for Central Sleep Apnea in Systolic Heart Failure
New England Journal of Medicine · 2015
RIBBON-1: Randomized, Double-Blind, Placebo-Controlled, Phase III Trial of Chemotherapy With or Without Bevacizumab for First-Line Treatment of Human Epidermal Growth Factor Receptor 2–Negative, Locally Recurrent or Metastatic Breast Cancer
Journal of Clinical Oncology · 2011
Randomized Trial of Benznidazole for Chronic Chagas’ Cardiomyopathy
New England Journal of Medicine · 2015
5-Year Outcomes After Left Atrial Appendage Closure
Journal of the American College of Cardiology · 2017
Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19
JAMA · 2021
Aspirin in Patients Undergoing Noncardiac Surgery
New England Journal of Medicine · 2014
Effect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss at 5 Years Among Patients With Morbid Obesity
JAMA · 2018
Gemcitabine Plus Bevacizumab Compared With Gemcitabine Plus Placebo in Patients With Advanced Pancreatic Cancer: Phase III Trial of the Cancer and Leukemia Group B (CALGB 80303)
Journal of Clinical Oncology · 2010
Phase III Randomized Clinical Trial Comparing Tremelimumab With Standard-of-Care Chemotherapy in Patients With Advanced Melanoma
Journal of Clinical Oncology · 2013
Prednisolone or Pentoxifylline for Alcoholic Hepatitis
New England Journal of Medicine · 2015
Multiple Human Papilloma Virus Infections and Their Impact on the Development of High-Risk Cervical Lesions
Acta Cytologica · 2015
Impact of Remote Telemedical Management on Mortality and Hospitalizations in Ambulatory Patients With Chronic Heart Failure
Circulation · 2011
Long-Term Results of Stenting versus Endarterectomy for Carotid-Artery Stenosis
New England Journal of Medicine · 2016
Short- Versus Long-Term Duration of Dual-Antiplatelet Therapy After Coronary Stenting
Circulation · 2012
Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China
BioMed Research International · 2014
Myeloablative Versus Reduced-Intensity Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndromes
Journal of Clinical Oncology · 2017
High-Frequency Oscillation for Acute Respiratory Distress Syndrome
New England Journal of Medicine · 2013
Once-Only Sigmoidoscopy in Colorectal Cancer Screening: Follow-up Findings of the Italian Randomized Controlled Trial--SCORE
JNCI Journal of the National Cancer Institute · 2011
Reversible Cerebral Vasoconstriction Syndromes
Archives of Neurology · 2011
Effect of Prehospital Induction of Mild Hypothermia on Survival and Neurological Status Among Adults With Cardiac Arrest
JAMA · 2013
Long-Term Update of US GI Intergroup RTOG 98-11 Phase III Trial for Anal Carcinoma: Survival, Relapse, and Colostomy Failure With Concurrent Chemoradiation Involving Fluorouracil/Mitomycin Versus Fluorouracil/Cisplatin
Journal of Clinical Oncology · 2012
SEARCH: A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial of Sorafenib Plus Erlotinib in Patients With Advanced Hepatocellular Carcinoma
Journal of Clinical Oncology · 2014
Effect of Mechanical Thrombectomy Without vs With Intravenous Thrombolysis on Functional Outcome Among Patients With Acute Ischemic Stroke
JAMA · 2021
IMpower150 Final Overall Survival Analyses for Atezolizumab Plus Bevacizumab and Chemotherapy in First-Line Metastatic Nonsquamous NSCLC
Journal of Thoracic Oncology · 2021
Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial
The Lancet · 2021
Conservative Oxygen Therapy during Mechanical Ventilation in the ICU
New England Journal of Medicine · 2019
Phase III trial of chemoradiotherapy with temozolomide plus nivolumab or placebo for newly diagnosed glioblastoma with methylated MGMT promoter
Neuro-Oncology · 2022
Low-Dose Dopamine or Low-Dose Nesiritide in Acute Heart Failure With Renal Dysfunction
JAMA · 2013
Interventions to Prevent Perinatal Depression
JAMA · 2019
Research Pearls: The Significance of Statistics and Perils of Pooling. Part 1: Clinical Versus Statistical Significance
Arthroscopy The Journal of Arthroscopic and Related Surgery · 2017
Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117)
Molecular Psychiatry · 2017
Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation
Thorax · 2011