Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Frank Dudbridge · 2013 · PLoS Genetics
Polygenic scores have recently been used to summarise genetic effects among an ensemble of markers that do not individually achieve significance in a large-scale association study. Markers are selected using an initial training sample and used to construct a score in an independent replication sample by forming the weighted sum of associated alleles within each subject. Association between a trait and this composite score implies that a genetic signal is present among the selected markers, and the score can then be used for prediction of individual trait values. This approach has been used to
View details →DOI: 10.1371/journal.pgen.1003348Cited by 1,639 Negative / Null Result ReportOpen accessSocial Sciences
Richard Klein, Michelangelo Vianello, Fred Hasselman et al. · 2018 · Advances in Methods and Practices in Psychological Science
We conducted preregistered replications of 28 classic and contemporary published findings, with protocols that were peer reviewed in advance, to examine variation in effect magnitudes across samples and settings. Each protocol was…
View details →DOI: 10.1177/2515245918810225Cited by 1,021 Negative / Null Result ReportSocial Sciences
Tyler W. Watts, Greg J. Duncan, Haonan Quan · 2018 · Psychological Science
We replicated and extended Shoda, Mischel, and Peake's (1990) famous marshmallow study, which showed strong bivariate correlations between a child's ability to delay gratification just before entering school and both adolescent achievement…
View details →DOI: 10.1177/0956797618761661Cited by 525 Negative / Null Result ReportPsychology
Christopher J. Soto · 2019 · Psychological Science
The Big Five personality traits have been linked to dozens of life outcomes. However, metascientific research has raised questions about the replicability of behavioral science. The Life Outcomes of Personality Replication (LOOPR) Project…
View details →DOI: 10.1177/0956797619831612Cited by 486 Negative / Null Result ReportOpen accessNeuroscience
Mante S. Nieuwland, Stephen Politzer‐Ahles, Evelien Heyselaar et al. · 2018 · eLife
Do people routinely pre-activate the meaning and even the phonological form of upcoming words? The most acclaimed evidence for phonological prediction comes from a 2005 Nature Neuroscience publication by DeLong, Urbach and Kutas, who observed a graded modulation of electrical brain potentials (N400) to nouns and preceding articles by the probability that people use a word to continue the sentence fragment (‘cloze’). In our direct replication study spanning 9 laboratories (N=334), pre-registered replication-analyses and exploratory Bayes factor analyses successfully replicated the noun-results
View details →DOI: 10.7554/elife.33468Cited by 303 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Federico Innocenti, Gregory M. Cooper, Ian B. Stanaway et al. · 2011 · PLoS Genetics
The discovery of expression quantitative trait loci ("eQTLs") can help to unravel genetic contributions to complex traits. We identified genetic determinants of human liver gene expression variation using two independent collections of primary tissue profiled with Agilent (n = 206) and Illumina (n = 60) expression arrays and Illumina SNP genotyping (550K), and we also incorporated data from a published study (n = 266). We found that ∼30% of SNP-expression correlations in one study failed to replicate in either of the others, even at thresholds yielding high reproducibility in simulations, and
View details →DOI: 10.1371/journal.pgen.1002078Cited by 210 Negative / Null Result ReportOpen accessPsychology
David Zendle, Paul Cairns · 2019 · PLoS ONE
Loot boxes are items in video games that contain randomised contents and can be purchased with real-world money. Similarities between loot boxes and forms of gambling have led to questions about their legal status, and whether they should be regulated as gambling. Previous research has suggested a link between the amount that gamers spend on loot boxes and their problem gambling: The more individuals spent on loot boxes, the more severe their problem gambling. However, the generalisability of prior work may be limited by both the self-selected nature of the sample under test, and the fact that
View details →DOI: 10.1371/journal.pone.0213194Cited by 173 Negative / Null Result ReportOpen accessPsychology
Christine R. Harris, Noriko Coburn, Doug Rohrer et al. · 2013 · PLoS ONE
Bargh et al. (2001) reported two experiments in which people were exposed to words related to achievement (e.g., strive, attain) or to neutral words, and then performed a demanding cognitive task. Performance on the task was enhanced after exposure to the achievement related words. Bargh and colleagues concluded that better performance was due to the achievement words having activated a "high-performance goal". Because the paper has been cited well over 1100 times, an attempt to replicate its findings would seem warranted. Two direct replication attempts were performed. Results from the first
View details →DOI: 10.1371/journal.pone.0072467Cited by 167 Negative / Null Result ReportOpen accessImmunology and Microbiology
Alexander M. Aiken, Calum Davey, James Hargreaves et al. · 2015 · International Journal of Epidemiology
BACKGROUND: Helminth (worm) infections cause morbidity among poor communities worldwide. An influential study conducted in Kenya in 1998-99 reported that a school-based drug-and-educational intervention had benefits regarding worm…
View details →DOI: 10.1093/ije/dyv127Cited by 140 Negative / Null Result ReportNeuroscience
Min-Sun Kim, Yuan Yuan · 2015 · Episteme
Abstract In “Normativity and Epistemic Intuitions” (NEI), Weinberg, Nichols and Stich famously argue from empirical data that East Asians and Westerners have different intuitions about Gettier-style cases. We attempted to replicate their…
View details →DOI: 10.1017/epi.2015.17Cited by 118 Negative / Null Result ReportOpen accessSocial Sciences
Tobias Wingen, Jana Berkessel, Birte Englich · 2019 · Social Psychological and Personality Science
In the current psychological debate, low replicability of psychological findings is a central topic. While the discussion about the replication crisis has a huge impact on psychological research, we know less about how it impacts public trust in psychology. In this article, we examine whether low replicability damages public trust and how this damage can be repaired. Studies 1–3 provide correlational and experimental evidence that low replicability reduces public trust in psychology. Additionally, Studies 3–5 evaluate the effectiveness of commonly used trust-repair strategies such as informati
View details →DOI: 10.1177/1948550619877412Cited by 118 Negative / Null Result ReportOpen accessDecision Sciences
Charles R. Ebersole, Maya B. Mathur, Erica Baranski et al. · 2020 · Advances in Methods and Practices in Psychological Science
Replication studies in psychological science sometimes fail to reproduce prior findings. If these studies use methods that are unfaithful to the original study or ineffective in eliciting the phenomenon of interest, then a failure to…
View details →DOI: 10.1177/2515245920958687Cited by 103 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Christian Garm, María Moreno‐Villanueva, Alexander Bürkle et al. · 2012 · Aging Cell
Exogenous and endogenous damage to DNA is constantly challenging the stability of our genome. This DNA damage increase the frequency of errors in DNA replication, thus causing point mutations or chromosomal rearrangements and has been…
View details →DOI: 10.1111/acel.12019Cited by 99 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
R. Anand, Kartik Shah, Hengyao Niu et al. · 2011 · Nucleic Acids Research
DNA sequences that form secondary structures or bind protein complexes are known barriers to replication and potential inducers of genome instability. In order to determine which helicases facilitate DNA replication across these barriers,…
View details →DOI: 10.1093/nar/gkr836Cited by 91 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Anne J. M. R. Geijsen, Stefanie Brezina, Pekka Keski‐Rahkonen et al. · 2019 · International Journal of Cancer
Colorectal cancer is known to arise from multiple tumorigenic pathways; however, the underlying mechanisms remain not completely understood. Metabolomics is becoming an increasingly popular tool in assessing biological processes. Previous metabolomics research focusing on colorectal cancer is limited by sample size and did not replicate findings in independent study populations to verify robustness of reported findings. Here, we performed a ultrahigh performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) screening on EDTA plasma from 268 colorectal cancer
View details →DOI: 10.1002/ijc.32146Cited by 81 Negative / Null Result ReportOpen accessMedicine
Andrés Cárdenas, Sabrina Faleschini, Andrea P. Cortés Hidalgo et al. · 2019 · Clinical Epigenetics
BACKGROUND: Maternal mood disorders and their treatment during pregnancy may have effects on the offspring epigenome. We aim to evaluate associations of maternal prenatal antidepressant use, anxiety, and depression with cord blood DNA methylation across the genome at birth and test for persistence of associations in early and mid-childhood blood DNA. METHODS: A discovery phase was conducted in Project Viva, a prospective pre-birth cohort study with external replication in an independent cohort, the Generation R Study. In Project Viva, pregnant women were recruited between 1999 and 2002 in East
View details →DOI: 10.1186/s13148-019-0653-xCited by 73 Negative / Null Result ReportOpen accessMedicine
Ignácio F. Mata, Dora Yearout, Victoria Álvarez et al. · 2011 · Movement Disorders
Recent genome-wide association studies of Parkinson's disease have nominated 3 new susceptibility loci (PARK16-18) and confirmed 2 known risk genes (MAPT and SNCA) in populations of European ancestry. We sought to replicate these findings.…
View details →DOI: 10.1002/mds.23642Cited by 70 Negative / Null Result Report
Andrew C. Chang, Phillip Li · 2017 · American Economic Review
We attempted to replicate 67 macroeconomic papers using author-provided data and code files by following a preanalysis plan. Excluding 6 papers that used confidential data, we obtained data and code replication files for 29 of 35 papers…
View details →DOI: 10.1257/aer.p20171034Cited by 64 Negative / Null Result ReportOpen accessMedicine
Shannon Rhodes, Janet S. Sinsheimer, Yvette Bordelon et al. · 2010 · Annals of Human Genetics
In the investigation of disease aetiology, the genome-wide association study (GWAS) provides a hypothesis-free investigation of the broader human genome and, as with all scientific investigations, replication is essential to validate any…
View details →DOI: 10.1111/j.1469-1809.2010.00616.xCited by 63 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Charles R. Dunlop, Yann Wallez, Timothy Isaac Johnson et al. · 2020 · British Journal of Cancer
BACKGROUND: Personalised medicine strategies may improve outcomes in pancreatic ductal adenocarcinoma (PDAC), but validation of predictive biomarkers is required. Having developed a clinical trial to assess the ATR inhibitor, AZD6738, in combination with gemcitabine (ATRi/gem), we investigated ATM loss as a predictive biomarker of response to ATRi/gem in PDAC. METHODS: Through kinase inhibition, siRNA depletion and CRISPR knockout of ATM, we assessed how ATM targeting affected the sensitivity of PDAC cells to ATRi/gem. Using flow cytometry, immunofluorescence and immunoblotting, we investigate
View details →DOI: 10.1038/s41416-020-1016-2Cited by 63 Negative / Null Result ReportOpen accessPsychology
Thomas Mangin, Nathalie André, Abdelrhani Benraïss et al. · 2021 · Psychology of sport and exercise
The ego-depletion effect refers to a temporary failure of self-control exertion after first performing an effortful task. This phenomenon has experienced a replication crisis in the past few years. In the present series of experiments, we…
View details →DOI: 10.1016/j.psychsport.2021.102033Cited by 59 Negative / Null Result ReportOpen accessMathematics
Lincoln Colling, Dénes Szűcs, Damiano De Marco et al. · 2020 · Advances in Methods and Practices in Psychological Science
The attentional spatial-numerical association of response codes (Att-SNARC) effect (Fischer, Castel, Dodd, & Pratt, 2003)—the finding that participants are quicker to detect left-side targets when the targets are preceded by small numbers and quicker to detect right-side targets when they are preceded by large numbers—has been used as evidence for embodied number representations and to support strong claims about the link between number and space (e.g., a mental number line). We attempted to replicate Experiment 2 of Fischer et al. by collecting data from 1,105 participants at 17 labs. Acr
View details →DOI: 10.1177/2515245920903079Cited by 58 Negative / Null Result ReportOpen accessPsychology
Warren Tierney, Jay H. Hardy, Charles R. Ebersole et al. · 2020 · Journal of Experimental Social Psychology
How can we maximize what is learned from a replication study? In the creative destruction approach to replication, the original hypothesis is compared not only to the null hypothesis, but also to predictions derived from multiple alternative theoretical accounts of the phenomenon. To this end, new populations and measures are included in the design in addition to the original ones, to help determine which theory best accounts for the results across multiple key outcomes and contexts. The present pre-registered empirical project compared the Implicit Puritanism account of intuitive work and sex
View details →DOI: 10.1016/j.jesp.2020.104060Cited by 56 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Zhuan Li, Yohei Yamauchi, Maki Kamakura et al. · 2011 · Journal of Virology
Tankyrase 1 is a poly(ADP-ribose) polymerase (PARP) which localizes to multiple subcellular sites, including telomeres and mitotic centrosomes. Poly(ADP-ribosyl)ation of the nuclear mitotic apparatus (NuMA) protein by tankyrase 1 during…
View details →DOI: 10.1128/jvi.05897-11Cited by 55 Negative / Null Result ReportOpen accessPsychology
Michael Bang Petersen, Lasse Laustsen · 2018 · Political Psychology
Animal models of conflict behavior predict that an organism's behavior in a conflict situation is influenced by physical characteristics related to abilities to impose costs on adversaries. Stronger and larger organisms should be more…
View details →DOI: 10.1111/pops.12505Cited by 55 Negative / Null Result ReportOpen accessMedicine
János Kálmán, Loes M. Olde Loohuis, Annabel Vreeker et al. · 2021 · The British Journal of Psychiatry
BACKGROUND: Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools. AIMS: To examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics. METHOD: Genome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of on
View details →DOI: 10.1192/bjp.2021.102Cited by 50 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Kristin M. Burkart, Tamar Sofer, Stephanie J. London et al. · 2018 · American Journal of Respiratory and Critical Care Medicine
Abstract Rationale Lung function and chronic obstructive pulmonary disease (COPD) are heritable traits. Genome-wide association studies (GWAS) have identified numerous pulmonary function and COPD loci, primarily in cohorts of European ancestry. Objectives Perform a GWAS of COPD phenotypes in Hispanic/Latino populations to identify loci not previously detected in European populations. Methods GWAS of lung function and COPD in Hispanic/Latino participants from a population-based cohort. We performed replication studies of novel loci in independent studies. Measurements and Main Results Among 11,
View details →DOI: 10.1164/rccm.201707-1493ocCited by 49 Negative / Null Result ReportMedicine
Larisa I. Labzin, Keng Yih Chew, Kathrin Eschke et al. · 2023 · Science Signaling
Macrophages are key cellular contributors to the pathogenesis of COVID-19, the disease caused by the virus SARS-CoV-2. The SARS-CoV-2 entry receptor ACE2 is present only on a subset of macrophages at sites of SARS-CoV-2 infection in…
View details →DOI: 10.1126/scisignal.abq1366Cited by 46 Negative / Null Result ReportOpen accessSocial Sciences
Adam K. Fetterman, Kai Sassenberg · 2015 · PLoS ONE
Scientists are dedicating more attention to replication efforts. While the scientific utility of replications is unquestionable, the impact of failed replication efforts and the discussions surrounding them deserve more attention. Specifically, the debates about failed replications on social media have led to worry, in some scientists, regarding reputation. In order to gain data-informed insights into these issues, we collected data from 281 published scientists. We assessed whether scientists overestimate the negative reputational effects of a failed replication in a scenario-based study. Sec
View details →DOI: 10.1371/journal.pone.0143723Cited by 46 Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Frederick F. Lang, Nam Tran, Vinay K. Puduvalli et al. · 2017 · Journal of Clinical Oncology
2002 Background: DNX-2401 is a replication-competent, tumor-selective, oncolytic adenovirus with enhanced infectivity that causes durable tumor control by killing tumor cells and eliciting antitumor immunity. To increase immune activation,…
View details →DOI: 10.1200/jco.2017.35.15_suppl.2002Cited by 44 