Negative / Null Result ReportOpen accessMedicine
Ruby Yu, Grace Leung, Jean Woo · 2021 · International Journal of Environmental Research and Public Health
(1) Objective: This study examined the effects of a combined intervention of Brainastic computerized cognitive training (CCT) preceded by physical exercise (PE) for improving frailty status and cognitive function in older adults. (2) Methods: Older adults aged 50 years or older attending elderly centers, without frailty/history of cognitive impairment, were randomly allocated into either a 12-week (i) multi-domain CCT + PE (n = 117), (ii) two-domain CCT + PE (n = 116) or (iii) video watching + PE (i.e., control, n = 114). Brainastic is an online application for cognitive training through video
View details →DOI: 10.3390/ijerph18041396Cited by 40 Negative / Null Result ReportOpen accessMedicine
Yuri Chaves Martins, Graziela Maria Zaniní, John A. Frangos et al. · 2012 · PLoS ONE
BACKGROUND: Low nitric oxide (NO) bioavailability plays a role in the pathogenesis of human as well as of experimental cerebral malaria (ECM) caused by Plasmodium berghei ANKA (PbA). ECM is partially prevented by administration of the NO-donor dipropylenetriamine NONOate (DPTA-NO) at high concentration (1 mg/mouse), which also induces major side effects such as a sharp drop in blood pressure. We asked whether alternative strategies to improve NO bioavailability with minor side effects would also be effective in preventing ECM. METHODOLOGY/PRINCIPAL FINDINGS: Mice were infected with PbA and pro
View details →DOI: 10.1371/journal.pone.0032048Cited by 40 Negative / Null Result ReportOpen accessMedicine
Wilhelmina G. Melsen, Anne Marie G. A. de Smet, Jan Kluytmans et al. · 2011 · British journal of surgery
BACKGROUND: Selective digestive decontamination (SDD) and selective oropharyngeal decontamination (SOD) are effective in improving survival in patients under intensive care. In this study possible differential effects in surgical and…
View details →DOI: 10.1002/bjs.7703Cited by 40 Negative / Null Result Report
Johannes Claßen, Stefan Pischinger, Sascha Krysmon et al. · 2020 · International Journal of Engine Research
The progression of emission legislation has intensified the efforts of the automotive industry to develop improved exhaust gas after-treatment systems. The requirement to fulfill Euro 6d-TEMP in real-world driving scenarios, the already…
View details →DOI: 10.1177/1468087420935221Cited by 40 Negative / Null Result ReportOpen accessMedicine
Junjie Ding, Nguyễn Thụy Thương Thương, Toi Van Pham et al. · 2020 · Clinical Pharmacology & Therapeutics
The most effective antituberculosis drug treatment regimen for tuberculous meningitis is uncertain. We conducted a randomized controlled trial comparing standard treatment with a regimen intensified by rifampin 15 mg/kg and levofloxacin for the first 60 days. The intensified regimen did not improve survival or any other outcome. We therefore conducted a nested pharmacokinetic/pharmacodynamic study in 237 trial participants to define exposure-response relationships that might explain the trial results and improve future therapy. Rifampin 15 mg/kg increased plasma and cerebrospinal fluid (CSF) e
View details →DOI: 10.1002/cpt.1783Cited by 40 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Theocharis Ispoglou, D. A. O’Kelly, Athanasia Angelopoulou et al. · 2015 · The Journal of Strength and Conditioning Research
Mouth rinsing with carbohydrate (CHO) solutions during cycling time trials results in performance enhancements; however, most studies have used approximately 6% CHO solutions. Therefore, the purpose of this study was to compare the…
View details →DOI: 10.1519/jsc.0000000000000882Cited by 39 Negative / Null Result ReportOpen accessMedicine
Cissy Kityo, Alexander J. Szubert, Abraham Siika et al. · 2018 · PLoS Medicine
BACKGROUND: In sub-Saharan Africa, individuals infected with HIV who are severely immunocompromised have high mortality (about 10%) shortly after starting antiretroviral therapy (ART). This group also has the greatest risk of morbidity and mortality associated with immune reconstitution inflammatory syndrome (IRIS), a paradoxical response to successful ART. Integrase inhibitors lead to significantly more rapid declines in HIV viral load (VL) than all other ART classes. We hypothesised that intensifying standard triple-drug ART with the integrase inhibitor, raltegravir, would reduce HIV VL fast
View details →DOI: 10.1371/journal.pmed.1002706Cited by 39 Negative / Null Result ReportOpen accessMedicine
Ruben A. Mesa, Jean‐Jacques Kiladjian, Srđan Verstovšek et al. · 2013 · Haematologica
Prior to Janus kinase inhibitors, available therapies for myelofibrosis were generally supportive and did not improve survival. This analysis compares efficacy outcomes of patients with myelofibrosis in the control arms (placebo [n=154]…
View details →DOI: 10.3324/haematol.2013.087650Cited by 39 Negative / Null Result Report
Ahuva Y. Segal, Tracey L. Sletten, Erin E. Flynn-Evans et al. · 2016 · Journal of Biological Rhythms
While previous studies have demonstrated short-wavelength sensitivity to the acute alerting effects of light during the biological night, fewer studies have assessed the alerting effect of light during the daytime. This study assessed the…
View details →DOI: 10.1177/0748730416659953Cited by 38 Negative / Null Result ReportOpen accessMedicine
Matthijs Kant, Wilton A. van Klei, Markus W. Hollmann et al. · 2025 · JAMA
Importance: Intraoperative hypotension is associated with adverse postoperative outcomes, but whether a proactive strategy to prevent intraoperative hypotension improves outcomes is uncertain. Objective: To determine whether intraoperative…
View details →DOI: 10.1001/jama.2025.18007Cited by 38 Negative / Null Result Report
E. Gautier, J. Savarino, J. Erbland et al. · 2016 · Climate of the Past
Abstract. Current volcanic reconstructions based on ice core analysis have significantly improved over the past few decades by incorporating multiple-core analyses with a high temporal resolution from different parts of the polar regions…
View details →DOI: 10.5194/cp-12-103-2016Cited by 38 Negative / Null Result ReportOpen accessNursing
Tatiana Galvão, Bethany H. Brown, Peter Hecker et al. · 2011 · Cardiovascular Research
AIMS: The impact of a high-fat diet on the failing heart is unclear, and the differences between polyunsaturated fatty acids (PUFA) and saturated fat have not been assessed. Here, we compared a standard low-fat diet to high-fat diets…
View details →DOI: 10.1093/cvr/cvr258Cited by 37 Negative / Null Result ReportOpen accessPsychology
Victoria Whitelock, Suzanne Higgs, Jeffrey M. Brunstrom et al. · 2018 · Appetite
Focusing attention on food during a meal has been shown to reduce later snack consumption. We report the results of two studies that aimed to replicate this effect and to elucidate the underlying mechanisms. We hypothesised that focused attention during a lunchtime meal would improve visual memory and/or memory for the satiating effects of the meal, and that this would reduce later food intake. In Study 1, participants (N = 108, 52.8% female, BMI M = 25.75 kg/m2) were randomly allocated to eat a fixed lunchtime meal while listening to instructions that encouraged them to pay attention to the s
View details →DOI: 10.1016/j.appet.2018.06.002Cited by 37 Negative / Null Result ReportOpen accessPhysics and Astronomy
K. Masuda, Joshua N. Winn · 2017 · The Astronomical Journal
Abstract We revisit the null result of the Hubble Space Telescope search for transiting planets in the globular cluster 47 Tucanae, in the light of improved knowledge of planet occurrence from the Kepler mission. Gilliland and co-workers…
View details →DOI: 10.3847/1538-3881/aa647cCited by 37 Negative / Null Result ReportOpen accessMedicine
Silvia Tietz, Marcel Zwahlen, Neda Haghayegh Jahromi et al. · 2016 · European Journal of Immunology
Considering the 3R rules of animal experimentation, we asked if refined scoring of experimental autoimmune encephalomyelitis (EAE) in mice improves documentation of clinical EAE allowing to perform a more powerful statistical analysis.…
View details →DOI: 10.1002/eji.201546272Cited by 36 Replication FailureOpen accessMedicine
John Lowe, David Gillespie, Ali F. Aboklaish et al. · 2024 · The Lancet Respiratory Medicine
BACKGROUND: Systematic reviews have reported conflicting evidence on whether macrolide antibiotics reduce rates of chronic lung disease of prematurity (CLD) in at-risk preterm infants born at less than 30 weeks' gestation, including in those colonised with pulmonary Ureaplasma spp. Since an adequately powered trial has been lacking, we aimed to assess if the macrolide azithromycin improved survival without the development of physiologically defined moderate or severe CLD in preterm infants. METHODS: AZTEC was a multicentre, double-blind, randomised, placebo-controlled trial conducted in 28 ter
View details →DOI: 10.1016/s2213-2600(24)00079-1Cited by 36 Negative / Null Result Report
Dhayana Dallmeier, Martin G. Larson, Na Wang et al. · 2012 · Journal of the American Heart Association
Background Prior studies have reported conflicting findings with regard to the association of biomarkers in the prediction of incident type 2 diabetes. We evaluated 12 biomarkers as possible diabetes predictors in the F ramingham H eart S…
View details →DOI: 10.1161/jaha.112.000869Cited by 35 Negative / Null Result ReportOpen accessMedicine
Xiaodong Huang, Xiaozhong Chen, Chong Zhao et al. · 2020 · Frontiers in Oncology
Purpose: To explore the efficacy of concomitant chemotherapy in intensity-modulated radiotherapy(IMRT) to treat stage II nasopharyngeal carcinoma (NPC). Methods and Materials: In this randomized phase 2 study (registered with ClinicalTrials.gov, (NCT01187238)), eligible patients with stage II (2010 UICC/AJCC) NPC were randomly assigned to either IMRT alone (RT group) or IMRT combined with concurrent cisplatin (40 mg/m2, weekly) (CCRT group). The primary endpoint was overall survival (OS). The second endpoints included local failure-free survival (LFFS), regional failure-free survival (RFFS), d
View details →DOI: 10.3389/fonc.2020.01314Cited by 35 Negative / Null Result ReportOpen accessMathematics
Xinwu Qian, Lijun Sun, Satish V. Ukkusuri · 2021 · Scientific Reports
Improved mobility not only contributes to more intensive human activities but also facilitates the spread of communicable disease, thus constituting a major threat to billions of urban commuters. In this study, we present a multi-city investigation of communicable diseases percolating among metro travelers. We use smart card data from three megacities in China to construct individual-level contact networks, based on which the spread of disease is modeled and studied. We observe that, though differing in urban forms, network layouts, and mobility patterns, the metro systems of the three cities
View details →DOI: 10.1038/s41598-021-83878-7Cited by 35 Negative / Null Result ReportOpen accessMedicine
Joseph Rigdon, Sanjay Basu · 2019 · BMJ Open
OBJECTIVES: We aimed to test whether or not adding (1) nutrition predictor variables and/or (2) using machine learning models improves cardiovascular death prediction versus standard Cox models without nutrition predictor variables.…
View details →DOI: 10.1136/bmjopen-2019-032703Cited by 35 Negative / Null Result ReportOpen accessMedicine
Luke Hodgson, Jo Congleton, Richard Venn et al. · 2018 · Clinical Medicine
ABSTRACT The Royal College of Physicians (RCP) recently published the National Early Warning Score 2 (NEWS2), aiming to improve safety for patients with hypercapnic respiratory failure by suggesting a separate oxygen saturation (SpO2)…
View details →DOI: 10.7861/clinmedicine.18-5-371Cited by 35 Negative / Null Result ReportOpen accessMedicine
Michael Stewart, Raj K. Maturi, Vincent Chen et al. · 2014 · Clinical ophthalmology
AIMS: To determine if intravitreal bevacizumab combined with the dexamethasone intravitreal implant 0.7 mg improves visual acuity and macular thickness more than bevacizumab monotherapy in eyes with macular edema due to branch and central…
View details →DOI: 10.2147/opth.s60159Cited by 35 Negative / Null Result ReportOpen accessMedicine
Felicia C. Goldstein, Angela F. Caveney, Vicki Hertzberg et al. · 2016 · Journal of Neurotrauma
A Phase III, double-blind, placebo-controlled trial (ProTECT III) found that administration of progesterone did not reduce mortality or improve functional outcome as measured by the Glasgow Outcome Scale Extended (GOSE) in subjects with…
View details →DOI: 10.1089/neu.2015.4313Cited by 34 Negative / Null Result Report
Stephanie Seneff, Robert Davidson, Jingjing Liu · 2012 · Entropy
Autism is a condition characterized by impaired cognitive and social skills, associated with compromised immune function. The incidence is alarmingly on the rise, and environmental factors are increasingly suspected to play a role. This…
View details →DOI: 10.3390/e14112227Cited by 34 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Tugba Nilay Kulaksız, Şükran Nazan Koşar, Süleyman Bulut et al. · 2016 · Nutrients
The carbohydrate (CHO) concentration of a mouth rinsing solution might influence the CHO sensing receptors in the mouth, with consequent activation of brain regions involved in reward, motivation and regulation of motor activity. The purpose of the present study was to examine the effects of maltodextrin mouth rinsing with different concentrations (3%, 6% and 12%) after an overnight fast on a 20 km cycling time trial performance. Nine recreationally active, healthy males (age: 24 ± 2 years; V ˙ O 2 m a x : 47 ± 5 mL·kg(-1)·min(-1)) participated in this study. A double-blind, placebo-controlled
View details →DOI: 10.3390/nu8050269Cited by 34 Negative / Null Result Report
Timothy J. Layton, Andrew M. Ryan · 2015 · Health Services Research
Objective To evaluate the effects of the size of financial bonuses on quality of care and the number of plan offerings in the Medicare Advantage Quality Bonus Payment Demonstration. Data Sources Publicly available data from CMS from 2009…
View details →DOI: 10.1111/1475-6773.12409Cited by 32 Negative / Null Result Report
Mikhail Ponomarenko, Dmitry Rasskazov, Olga Arkova et al. · 2015 · BioMed Research International
The use of biomedical SNP markers of diseases can improve effectiveness of treatment. Genotyping of patients with subsequent searching for SNPs more frequent than in norm is the only commonly accepted method for identification of SNP…
View details →DOI: 10.1155/2015/359835Cited by 32 Negative / Null Result Report
Shuichi Matsuda, Hideki Mizu‐uchi, Shingo Fukagawa et al. · 2010 · Knee Surgery, Sports Traumatology, Arthroscopy
Abstract A prospective study was performed to compare the clinical and radiological results of mobile‐ and fixed‐bearing total knee arthroplasty with specific attention to rotational alignment and range of motion. Sixty‐one knees were…
View details →DOI: 10.1007/s00167-010-1143-zCited by 32 Negative / Null Result ReportOpen accessComputer Science
J. M. Górriz, R. Martin-Clemente, F. Segovia et al. · 2026 · Information Fusion
As a technique that can compactly represent complex patterns, machine learning has significant potential for predictive inference in multi-source and heterogeneous information fusion scenarios. K-fold cross-validation (CV) is the most common approach for ascertaining the likelihood that a machine learning outcome is generated by chance and frequently outperforms conventional hypothesis testing. This improvement arises from measures directly obtained from machine learning classifications, such as accuracy, that do not have a parametric description. To approach a frequentist analysis within fusi
View details →DOI: 10.1016/j.inffus.2026.104404Cited by 32 Negative / Null Result ReportMedicine
Taro Oshikiri, Hodaka Numasaki, Junya Oguma et al. · 2021 · Annals of Surgery
OBJECTIVE: To clarify whether routine thoracic duct (TD) resection improves the prognosis of patients with esophageal cancer after radical esophagectomy. SUMMARY OF BACKGROUND DATA: Although TD resection can cause nutritional disadvantage…
View details →DOI: 10.1097/sla.0000000000005340Cited by 31 