Negative / Null Result ReportOpen accessMedicine
Pradeesh Sivapalan, Charlotte Suppli Ulrik, Thérèse Lapperre et al. · 2021 · European Respiratory Journal
Background Combining the antibiotic azithromycin and hydroxychloroquine induces airway immunomodulatory effects, with the latter also having in vitro antiviral properties. This may improve outcomes in patients hospitalised for coronavirus…
View details →DOI: 10.1183/13993003.00752-2021Cited by 48 Negative / Null Result Report
Jacob Schewe, Anders Levermann · 2012 · Environmental Research Letters
Abstract Indian monsoon rainfall is vital for a large share of the world’s population. Both reliably projecting India’s future precipitation and unraveling abrupt cessations of monsoon rainfall found in paleorecords require improved…
View details →DOI: 10.1088/1748-9326/7/4/044023Cited by 48 Negative / Null Result ReportOpen accessComputer Science
Zongyao Li, Kazuhiro Kitajima, Kenji Hirata et al. · 2021 · EJNMMI Research
Abstract Background To improve the diagnostic accuracy of axillary lymph node (LN) metastasis in breast cancer patients using 2-[ 18 F]FDG-PET/CT, we constructed an artificial intelligence (AI)-assisted diagnosis system that uses deep-learning technologies. Materials and methods Two clinicians and the new AI system retrospectively analyzed and diagnosed 414 axillae of 407 patients with biopsy-proven breast cancer who had undergone 2-[ 18 F]FDG-PET/CT before a mastectomy or breast-conserving surgery with a sentinel lymph node (LN) biopsy and/or axillary LN dissection. We designed and trained a
View details →DOI: 10.1186/s13550-021-00751-4Cited by 47 Negative / Null Result ReportOpen accessMedicine
Christoph Rochlitz, Martin Bigler, Roger von Moos et al. · 2016 · BMC Cancer
BACKGROUND: Adding bevacizumab to chemotherapy improves response rates and progression-free survival (PFS) in metastatic breast cancer (mBC). We aimed to demonstrate decreased toxicity with metronomic chemotherapy/bevacizumab compared with paclitaxel/bevacizumab. METHODS: This multicenter, randomized phase III trial compared bevacizumab with either paclitaxel (arm A) or daily oral capecitabine-cyclophosphamide (arm B) as first-line treatment in patients with HER2-negative advanced breast cancer. The primary endpoint was the incidence of selected grade 3-5 adverse events (AE) including: febrile
View details →DOI: 10.1186/s12885-016-2823-yCited by 46 Negative / Null Result ReportOpen accessMedicine
L. Kavalieris, P.J. O’Sullivan, James M. Suttie et al. · 2015 · BMC Urology
BACKGROUND: Hematuria can be symptomatic of urothelial carcinoma (UC) and ruling out patients with benign causes during primary evaluation is challenging. Patients with hematuria undergoing urological work-ups place significant clinical and financial burdens on healthcare systems. Current clinical evaluation involves processes that individually lack the sensitivity for accurate determination of UC. Algorithms and nomograms combining genotypic and phenotypic variables have largely focused on cancer detection and failed to improve performance. This study aimed to develop and validate a model inc
View details →DOI: 10.1186/s12894-015-0018-5Cited by 46 Negative / Null Result ReportOpen accessPsychology
Adele Wang, S. Katherine Nelson, Kristin Layous et al. · 2017 · PLoS ONE
Interventions rarely have a universal effect on all individuals. Reasons ranging from participant characteristics, context and fidelity of intervention completion could cause some people to respond more positively than others. Understanding these individual differences in intervention response may provide clues to the mechanisms behind the intervention, as well as inform future designs to make interventions maximally beneficial for all. Here we focus on an intervention designed to improve adolescent wellbeing, and explore potential moderators using a representative and well-powered sample. 16-
View details →DOI: 10.1371/journal.pone.0187601Cited by 44 Negative / Null Result ReportOpen accessMedicine
Ilaria Salvato, Antonio Marchini · 2024 · Cancers
Despite decades of research and the best up-to-date treatments, grade 4 Glioblastoma (GBM) remains uniformly fatal with a patient median overall survival of less than 2 years. Recent advances in immunotherapy have reignited interest in utilizing immunological approaches to fight cancer. However, current immunotherapies have so far not met the anticipated expectations, achieving modest results in their journey from bench to bedside for the treatment of GBM. Understanding the intrinsic features of GBM is of crucial importance for the development of effective antitumoral strategies to improve pat
View details →DOI: 10.3390/cancers16071276Cited by 44 Negative / Null Result ReportOpen accessMedicine
Joshua T. Kantrowitz, Christoph U. Correll, Rakesh Jain et al. · 2023 · The International Journal of Neuropsychopharmacology
BACKGROUND: Schizophrenia is a disabling disorder that profoundly affects functioning and quality of life. While available antipsychotics have improved outcomes for patients with schizophrenia, they are relatively ineffective for negative and cognitive symptoms and are associated with a range of troublesome side effects. A significant unmet medical need for more effective and better-tolerated therapies remains. METHODS: A roundtable consisting of 4 experts in the treatment of patients with schizophrenia convened to discuss the current treatment landscape, unmet needs from patient and societal
View details →DOI: 10.1093/ijnp/pyad011Cited by 44 Negative / Null Result ReportOpen accessMedicine
Anouk Wouters, Gerda Croiset, Nienke R. Schripsema et al. · 2017 · Advances in Health Sciences Education
Medical schools seek ways to improve their admissions strategies, since the available methods prove to be suboptimal for selecting the best and most motivated students. In this multi-site cross-sectional questionnaire study, we examined the value of (different) selection procedures compared to a weighted lottery procedure, which includes direct admission based on top pre-university grade point averages (≥8 out of 10; top-pu-GPA). We also considered whether students had participated in selection, prior to being admitted through weighted lottery. Year-1 (pre-clinical) and Year-4 (clinical) stude
View details →DOI: 10.1007/s10459-016-9745-yCited by 43 Negative / Null Result ReportOpen accessMedicine
Miles Piper, Benjamin Van Court, Adam Mueller et al. · 2021 · Clinical Cancer Research
PURPOSE: Metastasis remains a major hurdle in treating aggressive malignancies such as pancreatic ductal adenocarcinoma (PDAC). Improving response to treatment, therefore, requires a more detailed characterization of the cellular…
View details →DOI: 10.1158/1078-0432.ccr-21-2767Cited by 43 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Mariama Jaiteh, Ismael Rodríguez‐Espigares, Jana Selent et al. · 2020 · PLoS Computational Biology
Rational drug design for G protein-coupled receptors (GPCRs) is limited by the small number of available atomic resolution structures. We assessed the use of homology modeling to predict the structures of two therapeutically relevant GPCRs and strategies to improve the performance of virtual screening against modeled binding sites. Homology models of the D2 dopamine (D2R) and serotonin 5-HT2A receptors (5-HT2AR) were generated based on crystal structures of 16 different GPCRs. Comparison of the homology models to D2R and 5-HT2AR crystal structures showed that accurate predictions could be obta
View details →DOI: 10.1371/journal.pcbi.1007680Cited by 43 Negative / Null Result ReportOpen accessNeuroscience
Mürşide Değirmenci, Yılmaz Kemal Yüce, Matjaž Perc et al. · 2023 · Frontiers in Human Neuroscience
In recent studies, in the field of Brain-Computer Interface (BCI), researchers have focused on Motor Imagery tasks. Motor Imagery-based electroencephalogram (EEG) signals provide the interaction and communication between the paralyzed patients and the outside world for moving and controlling external devices such as wheelchair and moving cursors. However, current approaches in the Motor Imagery-BCI system design require effective feature extraction methods and classification algorithms to acquire discriminative features from EEG signals due to the non-linear and non-stationary structure of EEG
View details →DOI: 10.3389/fnhum.2023.1223307Cited by 43 Negative / Null Result ReportOpen accessMedicine
Jing Wang, Ting Xu, Lirong Wu et al. · 2022 · JTO Clinical and Research Reports
IntroductionDurvalumab after concurrent chemoradiation (CCRT) for NSCLC improves survival, but only in a subset of patients. We investigated the effect of severe radiation-induced lymphopenia (sRIL) on survival in these…
View details →DOI: 10.1016/j.jtocrr.2022.100391Cited by 42 Negative / Null Result ReportOpen accessMedicine
Bertrand Sauneuf, Benoît Champigneulle, Alexis Soummer et al. · 2013 · Critical Care
INTRODUCTION: The overall outcome of septic shock has been recently improved. We sought to determine whether this survival gain extends to the high-risk subgroup of patients with cirrhosis. METHODS: Cirrhotic patients with septic shock admitted to a medical intensive care unit (ICU) during two consecutive periods (1997-2004 and 2005-2010) were retrospectively studied. RESULTS: Forty-seven and 42 cirrhotic patients presented with septic shock in 1997-2004 and 2005-2010, respectively. The recent period differed from the previous one by implementation of adjuvant treatments of septic shock includ
View details →DOI: 10.1186/cc12687Cited by 42 Negative / Null Result ReportOpen accessSocial Sciences
Rachel Hayes, Daniel Titheradge, Kate Allen et al. · 2019 · British Journal of Educational Psychology
BACKGROUND: Teaching is a stressful occupation with poor retention. The Incredible Years® Teacher Classroom Management (TCM) programme is a training programme that research has demonstrated may be an effective intervention for improving…
View details →DOI: 10.1111/bjep.12284Cited by 41 Negative / Null Result ReportOpen accessMedicine
Henrik Falconer, Ulrika Joneborg, Kamilla Krawiec et al. · 2020 · Gynecologic Oncology
OBJECTIVE: Ultra-radical surgery to achieve complete resection in advanced epithelial ovarian cancer (EOC) has been widely accepted without strong supporting data. Our objective was to assess overall survival after a structured shift to an ultra-radical upfront surgical treatment algorithm and to investigate changes in the distribution of primary treatments after this shift. PATIENTS AND METHODS: In this population-based cohort study, all women with suspected EOC in the Stockholm-Gotland region of Sweden reported to the Swedish Quality Registry for Gynecologic Cancer (SQRGC) and National Cance
View details →DOI: 10.1016/j.ygyno.2020.07.009Cited by 41 Negative / Null Result ReportOpen accessMedicine
Eleni Karakike, Brendon P. Scicluna, Maria Roumpoutsou et al. · 2022 · Critical Care
BACKGROUND: Clarithromycin may act as immune-regulating treatment in sepsis and acute respiratory dysfunction syndrome. However, clinical evidence remains inconclusive. We aimed to evaluate whether clarithromycin improves 28-day mortality among patients with sepsis, respiratory and multiple organ dysfunction syndrome. METHODS: We conducted a multicenter, randomized, clinical trial in patients with sepsis. Participants with ratio of partial oxygen pressure to fraction of inspired oxygen less than 200 and more than 3 SOFA points from systems other than the respiratory function were enrolled betw
View details →DOI: 10.1186/s13054-022-04055-4Cited by 41 Negative / Null Result ReportOpen accessMedicine
Wenshu Tang, Cario W. S. Lo, Wei Ma et al. · 2024 · Cell & Bioscience
BACKGROUND: Glioma is a highly heterogeneous brain tumor categorized into World Health Organization (WHO) grades 1-4 based on its malignancy. The suppressive immune microenvironment of glioma contributes significantly to unfavourable patient outcomes. However, the cellular composition and their complex interplays within the glioma environment remain poorly understood, and reliable prognostic markers remain elusive. Therefore, in-depth exploration of the tumor microenvironment (TME) and identification of predictive markers are crucial for improving the clinical management of glioma patients. RE
View details →DOI: 10.1186/s13578-024-01218-4Cited by 41 Negative / Null Result Report
Johannes Claßen, Stefan Pischinger, Sascha Krysmon et al. · 2020 · International Journal of Engine Research
The progression of emission legislation has intensified the efforts of the automotive industry to develop improved exhaust gas after-treatment systems. The requirement to fulfill Euro 6d-TEMP in real-world driving scenarios, the already…
View details →DOI: 10.1177/1468087420935221Cited by 40 Negative / Null Result ReportOpen accessMedicine
Michael Huang, Kenneth G. Lucas · 2010 · Sarcoma
Ewing sarcoma (ES) is the second most common type of primary bone malignancy in children and young adults. Survival rates for localized ES have improved to upwards of 70% with aggressive chemotherapy and local control. On the other hand, there has been little improvement in survival rates for patients with metastatic or recurrent ES. Herein we review the different current therapeutic approaches available, including the different upfront and salvage chemotherapy regimens, the role for stem cell transplantation, and potential use of immunotherapy.
View details →DOI: 10.1155/2011/863210Cited by 40 Negative / Null Result ReportOpen accessMedicine
Ruby Yu, Grace Leung, Jean Woo · 2021 · International Journal of Environmental Research and Public Health
(1) Objective: This study examined the effects of a combined intervention of Brainastic computerized cognitive training (CCT) preceded by physical exercise (PE) for improving frailty status and cognitive function in older adults. (2) Methods: Older adults aged 50 years or older attending elderly centers, without frailty/history of cognitive impairment, were randomly allocated into either a 12-week (i) multi-domain CCT + PE (n = 117), (ii) two-domain CCT + PE (n = 116) or (iii) video watching + PE (i.e., control, n = 114). Brainastic is an online application for cognitive training through video
View details →DOI: 10.3390/ijerph18041396Cited by 40 Negative / Null Result ReportOpen accessMedicine
Yuri Chaves Martins, Graziela Maria Zaniní, John A. Frangos et al. · 2012 · PLoS ONE
BACKGROUND: Low nitric oxide (NO) bioavailability plays a role in the pathogenesis of human as well as of experimental cerebral malaria (ECM) caused by Plasmodium berghei ANKA (PbA). ECM is partially prevented by administration of the NO-donor dipropylenetriamine NONOate (DPTA-NO) at high concentration (1 mg/mouse), which also induces major side effects such as a sharp drop in blood pressure. We asked whether alternative strategies to improve NO bioavailability with minor side effects would also be effective in preventing ECM. METHODOLOGY/PRINCIPAL FINDINGS: Mice were infected with PbA and pro
View details →DOI: 10.1371/journal.pone.0032048Cited by 40 Negative / Null Result ReportOpen accessMedicine
Junjie Ding, Nguyễn Thụy Thương Thương, Toi Van Pham et al. · 2020 · Clinical Pharmacology & Therapeutics
The most effective antituberculosis drug treatment regimen for tuberculous meningitis is uncertain. We conducted a randomized controlled trial comparing standard treatment with a regimen intensified by rifampin 15 mg/kg and levofloxacin for the first 60 days. The intensified regimen did not improve survival or any other outcome. We therefore conducted a nested pharmacokinetic/pharmacodynamic study in 237 trial participants to define exposure-response relationships that might explain the trial results and improve future therapy. Rifampin 15 mg/kg increased plasma and cerebrospinal fluid (CSF) e
View details →DOI: 10.1002/cpt.1783Cited by 40 Negative / Null Result ReportOpen accessMedicine
Wilhelmina G. Melsen, Anne Marie G. A. de Smet, Jan Kluytmans et al. · 2011 · British journal of surgery
BACKGROUND: Selective digestive decontamination (SDD) and selective oropharyngeal decontamination (SOD) are effective in improving survival in patients under intensive care. In this study possible differential effects in surgical and…
View details →DOI: 10.1002/bjs.7703Cited by 40 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Theocharis Ispoglou, D. A. O’Kelly, Athanasia Angelopoulou et al. · 2015 · The Journal of Strength and Conditioning Research
Mouth rinsing with carbohydrate (CHO) solutions during cycling time trials results in performance enhancements; however, most studies have used approximately 6% CHO solutions. Therefore, the purpose of this study was to compare the…
View details →DOI: 10.1519/jsc.0000000000000882Cited by 39 Negative / Null Result ReportOpen accessMedicine
Cissy Kityo, Alexander J. Szubert, Abraham Siika et al. · 2018 · PLoS Medicine
BACKGROUND: In sub-Saharan Africa, individuals infected with HIV who are severely immunocompromised have high mortality (about 10%) shortly after starting antiretroviral therapy (ART). This group also has the greatest risk of morbidity and mortality associated with immune reconstitution inflammatory syndrome (IRIS), a paradoxical response to successful ART. Integrase inhibitors lead to significantly more rapid declines in HIV viral load (VL) than all other ART classes. We hypothesised that intensifying standard triple-drug ART with the integrase inhibitor, raltegravir, would reduce HIV VL fast
View details →DOI: 10.1371/journal.pmed.1002706Cited by 39 Negative / Null Result ReportOpen accessMedicine
Ruben A. Mesa, Jean‐Jacques Kiladjian, Srđan Verstovšek et al. · 2013 · Haematologica
Prior to Janus kinase inhibitors, available therapies for myelofibrosis were generally supportive and did not improve survival. This analysis compares efficacy outcomes of patients with myelofibrosis in the control arms (placebo [n=154]…
View details →DOI: 10.3324/haematol.2013.087650Cited by 39 Negative / Null Result Report
Ahuva Y. Segal, Tracey L. Sletten, Erin E. Flynn-Evans et al. · 2016 · Journal of Biological Rhythms
While previous studies have demonstrated short-wavelength sensitivity to the acute alerting effects of light during the biological night, fewer studies have assessed the alerting effect of light during the daytime. This study assessed the…
View details →DOI: 10.1177/0748730416659953Cited by 38 Negative / Null Result ReportOpen accessMedicine
Matthijs Kant, Wilton A. van Klei, Markus W. Hollmann et al. · 2025 · JAMA
Importance: Intraoperative hypotension is associated with adverse postoperative outcomes, but whether a proactive strategy to prevent intraoperative hypotension improves outcomes is uncertain. Objective: To determine whether intraoperative…
View details →DOI: 10.1001/jama.2025.18007Cited by 38 Negative / Null Result Report
E. Gautier, J. Savarino, J. Erbland et al. · 2016 · Climate of the Past
Abstract. Current volcanic reconstructions based on ice core analysis have significantly improved over the past few decades by incorporating multiple-core analyses with a high temporal resolution from different parts of the polar regions…
View details →DOI: 10.5194/cp-12-103-2016Cited by 38 