Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jie Shen, Gary N. Landis, John Tower · 2016 · The Journals of Gerontology Series A
The Gompertz equation describes survival in terms of initial mortality rate (parameter a), indicative of health, and age-dependent acceleration in mortality rate (parameter b), indicative of aging. Gompertz parameters were analyzed for…
View details →DOI: 10.1093/gerona/glw005Cited by 32 Negative / Null Result ReportOpen accessPsychology
on behalf of the Pediatric Imaging Neurocognition Genetics study, John D. Eicher, Angela Montgomery et al. · 2015 · Brain Imaging and Behavior
Dyslexia and language impairment (LI) are complex traits with substantial genetic components. We recently completed an association scan of the DYX2 locus, where we observed associations of markers in DCDC2, KIAA0319, ACOT13, and FAM65B with reading-, language-, and IQ-related traits. Additionally, the effects of reading-associated DYX3 markers were recently characterized using structural neuroimaging techniques. Here, we assessed the neuroimaging implications of associated DYX2 and DYX3 markers, using cortical volume, cortical thickness, and fractional anisotropy. To accomplish this, we examin
View details →DOI: 10.1007/s11682-015-9392-6Cited by 31 Negative / Null Result ReportOpen accessMedicine
Manuel Blesa, Paola Galdi, Gemma Sullivan et al. · 2020 · Frontiers in Neurology
Preterm birth is closely associated with cognitive impairment and generalized dysconnectivity of neural networks inferred from water diffusion MRI (dMRI) metrics. Peak width of skeletonized mean diffusivity (PSMD) is a metric derived from histogram analysis of mean diffusivity across the white matter skeleton, and it is a useful biomarker of generalized dysconnectivity and cognition in adulthood. We calculated PSMD and five other histogram based metrics derived from diffusion tensor imaging (DTI) and neurite orientation and dispersion imaging (NODDI) in the newborn, and evaluated their accurac
View details →DOI: 10.3389/fneur.2020.00235Cited by 31 Negative / Null Result ReportOpen accessDentistry
Gerlig Widmann, Alexander Bischel, Andreas Stratis et al. · 2017 · Dentomaxillofacial Radiology
OBJECTIVES: The objective of this study was to determine how iterative reconstruction technology (IRT) influences contrast and spatial resolution in ultralow-dose dentomaxillofacial CT imaging. METHODS: A polymethyl methacrylate phantom with various inserts was scanned using a reference protocol (RP) at CT dose index volume 36.56 mGy, a sinus protocol at 18.28 mGy and ultralow-dose protocols (LD) at 4.17 mGy, 2.36 mGy, 0.99 mGy and 0.53 mGy. All data sets were reconstructed using filtered back projection (FBP) and the following IRTs: adaptive statistical iterative reconstructions (ASIRs) (ASIR
View details →DOI: 10.1259/dmfr.20160452Cited by 30 Negative / Null Result Report
Arjen Alink, Hunar Abdulrahman, Richard N. Henson · 2018 · Nature Communications
Abstract Inferring neural mechanisms from functional magnetic resonance imaging (fMRI) is challenging because the fMRI signal integrates over millions of neurons. One approach is to compare computational models that map neural activity to…
View details →DOI: 10.1038/s41467-018-05957-0Cited by 29 Negative / Null Result ReportOpen accessMaterials Science
Qi Li, Rongchao Jin · 2017 · Nanotechnology Reviews
Abstract Silicon nanoparticles (NPs) have long been regarded as a promising alternative for commercial organic dyes and typical quantum dots (e.g. CdSe) for applications in light emitting, bio-imaging, sensing, etc. The photoluminescence…
View details →DOI: 10.1515/ntrev-2017-0145Cited by 29 Negative / Null Result ReportNeuroscience
Tong He, Ru Kong, Avram J. Holmes et al. · 2018
In recent years, deep learning has transformed the field of machine learning. In the field of neuroimaging, there are increasing interests in adopting deep learning techniques. However, deep neural networks (DNNs) usually need large…
View details →DOI: 10.1109/prni.2018.8423958Cited by 28 Negative / Null Result ReportMedicine
Christopher J. Green, Jeffrey M P Holly, Antony Bayer et al. · 2014 · Journal of Alzheimer s Disease
BACKGROUND: The increasing incidence of cognitive impairment and dementia in an aging population poses a significant burden on healthcare. Consequently, identifying modifiable physiological factors which may influence the onset of…
View details →DOI: 10.3233/jad-132183Cited by 27 Negative / Null Result ReportOpen accessEnvironmental Science
Anthony Laybros, Daniel Schläpfer, Jean‐Baptiste Féret et al. · 2019 · Remote Sensing
Imaging spectroscopy is a promising tool for airborne tree species recognition in hyper-diverse tropical canopies. However, its widespread application is limited by the signal sensitivity to acquisition parameters, which may require new training data in every new area of application. This study explores how various pre-processing steps may improve species discrimination and species recognition under different operational settings. In the first experiment, a classifier was trained and applied on imaging spectroscopy data acquired on a single date, while in a second experiment, the classifier wa
View details →DOI: 10.3390/rs11070789Cited by 26 Negative / Null Result ReportOpen accessMedicine
Xiaozhun Huang, Lin Xu, Teng Ma et al. · 2021 · Frontiers in Oncology
BACKGROUND: Nivolumab and pembrolizumab disrupt the programmed cell death-1 immune checkpoint and display promising efficacy and safety results in advanced hepatocellular carcinoma (HCC). However, the benefits remain limited. The preliminary results of lenvatinib (LEN) combined with immune checkpoint inhibitors (ICIs) reveal that the combinations were well-tolerated and encouraging. This study aimed to analyze the safety and efficacy of LEN plus ICIs in a real-world cohort of patients with advanced HCC. METHOD: Between June 4, 2017, and June 30, 2019, 16 patients received LEN plus nivolumab, a
View details →DOI: 10.3389/fonc.2021.751159Cited by 26 Negative / Null Result ReportOpen accessMedicine
Noha Mahmoud Youssef, Azza Mohammed Abdelmohsen, Ahmed Atteya Ashour et al. · 2026 · PubMed
BACKGROUND: Chronic ankle instability (CAI) is a common sequence of ankle sprain. Conservative treatment of CAI is currently accepted as a primary mean of managing the condition and preventing of recurrence. OBJECTIVES: The purpose of the…
View details →DOI: 10.82161/1vv8-sf51Cited by 25 Negative / Null Result ReportOpen accessMedicine
Lucius S. Fekonja, Ziqian Wang, Dogu Baran Aydogan et al. · 2021 · Frontiers in Oncology
Tumors infiltrating the motor system lead to significant disability, often caused by corticospinal tract injury. The delineation of the healthy-pathological white matter (WM) interface area, for which diffusion magnetic resonance imaging (dMRI) has shown promising potential, may improve treatment outcome. However, up to 90% of white matter (WM) voxels include multiple fiber populations, which cannot be correctly described with traditional metrics such as fractional anisotropy (FA) or apparent diffusion coefficient (ADC). Here, we used a novel fixel-based along-tract analysis consisting of cons
View details →DOI: 10.3389/fonc.2020.622358Cited by 25 Negative / Null Result ReportOpen accessNeuroscience
David R. Roalf, Martijn Figee, Desmond J. Oathes · 2024 · Translational Psychiatry
Although neuroimaging has been widely applied in psychiatry, much of the exuberance in decades past has been tempered by failed replications and a lack of definitive evidence to support the utility of imaging to inform clinical decisions. There are multiple promising ways forward to demonstrate the relevance of neuroimaging for psychiatry at the individual patient level. Ultra-high field magnetic resonance imaging is developing as a sensitive measure of neurometabolic processes of particular relevance that holds promise as a new way to characterize patient abnormalities as well as variability
View details →DOI: 10.1038/s41398-024-02781-7Cited by 25 Negative / Null Result ReportOpen accessMedicine
Meryem A. Yücel, Robert Luke, Rickson C. Mesquita et al. · 2025 · Communications Biology
As data analysis pipelines grow more complex in brain imaging research, understanding how methodological choices affect results is essential for ensuring reproducibility and transparency. This is especially relevant for functional Near-Infrared Spectroscopy (fNIRS), a rapidly growing technique for assessing brain function in naturalistic settings and across the lifespan, yet one that still lacks standardized analysis approaches. In the fNIRS Reproducibility Study Hub (FRESH) initiative, we asked 38 research teams worldwide to independently analyze the same two fNIRS datasets. Despite using dif
View details →DOI: 10.1038/s42003-025-08412-1Cited by 24 Negative / Null Result ReportOpen accessEngineering
Suribabu Conety Ravi, Neelakantan Thurvas Renganathan, Sivakumar Perumal et al. · 2019 · Drinking water engineering and science
Abstract. Pressure-driven analysis (PDA) of water distribution networks necessitates an assessment of the supplying capacity of a network within the minimum and required pressure ranges. Pressure-deficient conditions happen due to the uncertainty of nodal demands, failure of electromechanical components, diversion of water, aging of pipes, permanent increase in the demand at certain supply nodes, fire demand, etc. As the demand-driven analysis (DDA) solves the governing equations without any bound on pressure head, it fails to replicate the real scenario, particularly when the network experien
View details →DOI: 10.5194/dwes-12-1-2019Cited by 24 Negative / Null Result ReportOpen accessSocial Sciences
Sue Lim, Ralf Schmälzle, Gary Bente · 2025 · Computers in Human Behavior Artificial Humans
Interactions with artificial intelligence (AI) based agents can positively influence human behavior and judgment. However, studies to date focus on text-based conversational agents (CA) with limited embodiment, restricting our understanding of how social influence principles, such as physical similarity, apply to AI agents (i.e., artificial social influence). We address this gap by leveraging latest advances in AI (large language models) and combining them with immersive virtual reality (VR). Specifically, we built VR-ECAs, or embodied conversational agents that can engage in turn-taking conve
View details →DOI: 10.1016/j.chbah.2025.100172Cited by 24 Negative / Null Result ReportOpen accessPsychology
Marlou Poppelaars, Anna Lichtwarck‐Aschoff, Roy Otten et al. · 2021 · Frontiers in Psychology
Depressive symptoms and disorders are major public health concerns, affecting many adolescents and young adults. Despite extensive research, depression prevention programs for youth show limited effectiveness. Moreover, the maximal potential of youth psychotherapy — on which depression prevention programs are based — may have been reached. Commercial video games may offer an engaging alternative vehicle for youth to practice emotional and social skills vital to mental health. The current study investigated the potential for the commercial video game Journey to prevent the exacerbation of depre
View details →DOI: 10.3389/fpsyg.2020.575962Cited by 24 Failed Experiment ReportOpen accessMedicine
Kui Yang, Elizabeth Wills, Joel D. Baines · 2011 · Journal of Virology
Herpesvirus genomic DNA is cleaved from concatemers that accumulate in infected cell nuclei. Genomic DNA is inserted into preassembled capsids through a unique portal vertex. Extensive analyses of viral mutants have indicated that intact…
View details →DOI: 10.1128/jvi.00857-11Cited by 23 Negative / Null Result ReportEngineering
John Keane, Wei Zhang, Chris H. Kim · 2010
We present an array-based system to accurately study variations in ROSC aging. Microsecond measurements for minimal BTI recovery, and frequency shift measurement resolution ranging down to the error floor of 0.07% are achieved with three…
View details →DOI: 10.1109/iedm.2010.5703293Cited by 23 Negative / Null Result ReportOpen accessMedicine
Ping‐Hong Yeh, Sara M. Lippa, Tracey A. Brickell et al. · 2022 · Brain Communications
Abstract The purpose of this study was to analyze quantitative diffusion tensor imaging measures across the spectrum of traumatic brain injury severity and evaluate their trajectories in military service members. Participants were 96 U.S. military service members and veterans who had sustained a mild traumatic brain injury [including complicated mild traumatic brain injury (n = 16) and uncomplicated mild traumatic brain injury (n = 68)], moderate-severe traumatic brain injury (n = 12), and controls (with or without orthopaedic injury, n = 39). All participants had been scanned at least twice,
View details →DOI: 10.1093/braincomms/fcac132Cited by 23 Negative / Null Result ReportOpen accessEngineering
Michael Schütt, Connor O’Farrell, Konstantinos Stamatopoulos et al. · 2022 · Pharmaceutics
The performance of solid oral dosage forms targeting the colon is typically evaluated using standardised pharmacopeial dissolution apparatuses. However, these fail to replicate colonic hydrodynamics. This study develops a digital twin of the Dynamic Colon Model; a physiologically representative in vitro model of the human proximal colon. Magnetic resonance imaging of the Dynamic Colon Model verified that the digital twin robustly replicated flow patterns under different physiological conditions (media viscosity, volume, and peristaltic wave speed). During local contractile activity, antegrade
View details →DOI: 10.3390/pharmaceutics14010184Cited by 23 Negative / Null Result ReportOpen accessMedicine
Duncan G.J. Green, Jinhee Kim, Stephen J. Kish et al. · 2021 · Journal of Psychiatry and Neuroscience
Background: Upregulation of the endocannabinoid enzyme fatty acid amide hydrolase (FAAH) has been linked to abnormal activity in frontoamygdalar circuits, a hallmark of posttraumatic stress disorder. We tested the hypothesis that FAAH…
View details →DOI: 10.1503/jpn.200010Cited by 21 Negative / Null Result ReportSocial Sciences
Holger Hopp, Teresa Kieseier, Jenny Jakisch et al. · 2021 · Multilingua
Abstract This paper reports findings of a project on pedagogical translanguaging (PTL) among 128 fourth-grade students learning English as a foreign language (EFL) in German primary schools. Over a period of six months, 20% of lesson time…
View details →DOI: 10.1515/multi-2020-0164Cited by 21 Negative / Null Result ReportOpen accessMedicine
Hidehiko Okazawa, Tetsuya Tsujikawa, Yoshifumi Higashino et al. · 2019 · EJNMMI Research
Accurate attenuation correction (AC) is one of the most important issues to be addressed in quantitative brain PET/MRI imaging. Atlas-based MRI AC (AB-MRAC), one of the representative MRAC methods, has been used to estimate the skull attenuation in brain scans. The zero echo time (ZTE) pulse sequence is also expected to provide a better MRAC estimation in brain PET scans. The difference in quantitative measurements of cerebral blood flow (CBF) using H215O-PET/MRI was compared between the two MRAC methods, AB and ZTE. Twelve patients with cerebrovascular disease (4 males, 43.2 ± 11.7 years) und
View details →DOI: 10.1186/s13550-019-0494-9Cited by 21 Negative / Null Result ReportOpen accessNeuroscience
Shan-Chuan Teng, Yunn-Wen Lien · 2022 · PLoS ONE
Mind wandering has been argued to be beneficial for breaking through mental impasses, which leads to better creative performance upon a second attempt (i.e., the incubation effect). However, the evidence is inconsistent. Different from the propensity for mind wandering that has been the focus of past studies, in this study we further examined the role of diversity (i.e., non-repetitiveness of mind wandering respective to its content) and types of mind wandering along the dimensions of intentionality and awareness during incubation when engaging in a 0-back task (a mind wandering-prone conditio
View details →DOI: 10.1371/journal.pone.0267187Cited by 21 Negative / Null Result ReportOpen accessNeuroscience
Takatsugu Aihara, Takeshi OGAWA, Takeaki Shimokawa et al. · 2017 · PLoS ONE
Humans often utilize past experience to solve difficult problems. However, if past experience is insufficient to solve a problem, solvers may reach an impasse. Insight can be valuable for breaking an impasse, enabling the reinterpretation or re-representation of a problem. Previous studies using between-subjects designs have revealed a causal relationship between the anterior temporal lobes (ATLs) and non-verbal insight, by enhancing the right ATL while inhibiting the left ATL using transcranial direct current stimulation (tDCS). In addition, neuroimaging studies have reported a correlation be
View details →DOI: 10.1371/journal.pone.0184749Cited by 19 Negative / Null Result ReportOpen accessPsychology
Terence J. Lyons, Merle Spriggs, Leevi Kerkelä et al. · 2026 · Nature Communications
Psychedelics have robust effects on acute brain function and long-term behavior but whether they also cause enduring functional and anatomical brain changes is largely unknown. In an exploratory, placebo-controlled, within-subjects, electroencephalography (EEG), and magnetic resonance imaging (MRI) study in 28 healthy, entirely psychedelic-naive participants, anatomical and functional brain changes are detected from one-hour to one-month after a single high-dose (25 mg) of psilocybin. Increases in cognitive flexibility, psychological insight, and well-being are seen at one-month. Diffusion ten
View details →DOI: 10.1038/s41467-026-71962-3Cited by 19 Negative / Null Result ReportOpen accessMedicine
Yasir Almuhanna · 2025 · Journal of Clinical Medicine
Wound healing is a complex and multistage process that incorporates precise cellular and molecular coordination. The presence of biofilms in chronic wounds adversely affects the wound healing process, as it prolongs the closure of the wound, thus sustaining chronic inflammation. Current data suggest that biofilms are present in almost all chronic wounds, which leads to significant challenges in diagnosis and treatment. Traditional detection methods, such as cultures and light microscopy, often fail to detect biofilms; however, sophisticated molecular and imaging techniques are constrained by t
View details →DOI: 10.3390/jcm14228121Cited by 18 Negative / Null Result ReportOpen accessImmunology and Microbiology
Micah J. McCauley, Ioulia Rouzina, Jasmine Li et al. · 2020 · Viruses
Retroviral nucleocapsid (NC) proteins are nucleic acid chaperones that play distinct roles in the viral life cycle. During reverse transcription, HIV-1 NC facilitates the rearrangement of nucleic acid secondary structures, allowing the transactivation response (TAR) RNA hairpin to be transiently destabilized and annealed to a complementary RNA hairpin. In contrast, during viral assembly, NC, as a domain of the group-specific antigen (Gag) polyprotein, binds the genomic RNA and facilitates packaging into new virions. It is not clear how the same protein, alone or as part of Gag, performs such d
View details →DOI: 10.3390/v12050484Cited by 18 Negative / Null Result ReportOpen accessMedicine
Stijntje Dijk, Claudia Wollny, Jörg Barkhausen et al. · 2025 · JAMA
Importance: Given the widespread use of medical imaging, evaluating the effectiveness of interventions to improve appropriateness is crucial for optimizing health care resources and patient outcomes. Objective: To assess the effects of…
View details →DOI: 10.1001/jama.2024.27853Cited by 18 