Negative / Null Result ReportMedicine
Tang, Mi, Xue et al. · 2026 · Annals of medicine
The impact of prior SARS-CoV-2 infection on the clinical course of recurrent pulmonary tuberculosis (TB) remains poorly defined. This study aimed to compare clinical features, radiographic evolution, and outcomes in recurrent TB patients…
View details →DOI: 10.1080/07853890.2026.2683160 Negative / Null Result ReportOpen accessInfectious and parasitic diseases
Amira Al Balakosy, Mostafa Alfishawy, Omnia Elnabawy et al. · 2021 · Afro-Egyptian Journal of Infectious and Endemic Diseases
Background and study aim: Epidemiological data reported lower death rates of COVID-19 cases in countries with higher & recent coverage by measles containing vaccines. In this study we aim to identify measles IgG titer in COVID-19 patients & correlate it with disease severity. Patients and Method: This is a Cross-sectional study where 78 patients admitted to Ain Shams University Quarantine hospitals with positive PCR for SARS-CoV-2 were enrolled. All patients underwent quantification of serum measles IgG titer. Then classified according to the COVID-19 severity into mild, moderate and
View details →DOI: 10.21608/aeji.2021.72615.1144 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Asher Shafrir, Asher Shafrir, Asher Shafrir et al. · 2022 · Frontiers in Pharmacology
Background and Aims: There is conflicting evidence regarding the association between proton pump inhibitors (PPI) and the risk of acquisition and severity of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.Aim: To evaluate the association between PPI exposure and infection and development of severe disease in patients infected with SARS-CoV2in a large population-based historical cohort.Methods: Data were extracted from a health maintenance organization database in Israel that insures over 1,200,000 individuals from across the country. All patients who underwent SARS-CoV-2 testi
View details →DOI: 10.3389/fphar.2022.791074 Negative / Null Result ReportOpen accessMedicine
Kendall Kling, Patrick Janulis, A. Demonbreun et al. · 2023 · Frontiers in Immunology
Background Understanding the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination will enable accurate counseling and inform evolving vaccination strategies. Little is known about antibody response…
View details →DOI: 10.3389/fimmu.2022.1048776 Negative / Null Result ReportOpen accessMedicine
Khaliq O, Maharaj N, David M et al. · 2026 · Laboratory medicine
Introduction The COVID-19 pandemic led to rapid global vaccine deployment, especially among high-risk groups, such as individuals living with HIV. Data are limited, however, on the immunologic effects of SARS-CoV-2…
View details →DOI: 10.1093/labmed/lmag014 Negative / Null Result ReportOpen accessMicrobiology
Miao Jiang, Pekka Kolehmainen, Laura Kakkola et al. · 2021 · Microbiology Spectrum
ABSTRACT The primary target organ of coronavirus disease 2019 (COVID-19) infection is the respiratory tract. Currently, there is limited information on the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to infect and regulate innate immunity in human immune cells and lung epithelial cells. Here, we compared the ability of four Finnish isolates of SARS-CoV-2 from COVID-19 patients to replicate and induce interferons (IFNs) and other cytokines in different human cells. All isolates failed to replicate in dendritic cells, macrophages, monocytes, and lymphocytes, and no in
View details →DOI: 10.1128/spectrum.00774-21 Negative / Null Result ReportOpen accessMedicine
Pienkos S, Swank Z, Hamlin RE et al. · 2025 · Open forum infectious diseases
Plasma samples obtained approximately 3 ( n = 100) and 12 months ( n = 78) after acute SARS-CoV-2 infection were tested for S1, spike, and N antigens. There were no significant differences in plasma proteins or single-cell protein…
View details →DOI: 10.1093/ofid/ofaf515 Negative / Null Result ReportOpen accessMedicine
Lu J, Ahmad A, Chomont N et al. · 2026 · Frontiers in immunology
Due to persistent immune dysfunction, People with HIV (PWH) are at increased risk of more severe infections with SARS-CoV-2 and hospitalizations. In several countries, they were listed as a priority group for receiving anti-SARS-CoV-2…
View details →DOI: 10.3389/fimmu.2026.1829485 Negative / Null Result Report
A. Hunt, H. Nasr, H. Willmott et al. · 2022 · British Journal of Surgery
Abstract Aim A retrospective case-control study comparing Surgical Site Infections (SSIs) following primary hip and knee arthroplasty before and during the SARS-CoV-2 pandemic across East Sussex NHS Trust (ESHT). The aim of this study was…
View details →DOI: 10.1093/bjs/znac040.017 Negative / Null Result ReportMedicine
Brindisi, Gori, Pignataro et al. · 2026 · Journal of clinical medicine
Background: The relationship between allergic status, SARS-CoV-2 infection, Long COVID, and post-restriction respiratory outcomes in children remains incompletely understood. This study aimed to explore the associations between allergic…
View details →DOI: 10.3390/jcm15103982 Negative / Null Result Report
Wang L, Wu S, Zeng G et al. · 2026 · Preprint
Abstract Objectives To investigate the seroconversion rate and dynamics of serum IgG antibodies following Coronavirus Disease 2019(COVID-19) vaccination in children. Methods A total of 3561 children aged 3–17 years who were hospitalized at…
View details →DOI: 10.21203/rs.3.rs-9332864/v1 Negative / Null Result ReportOpen accessComputer applications to medicine. Medical informatics
Carolina Biliotti, Nicolò Fraccaroli, Michelangelo Puliga et al. · 2025 · Journal of Medical Internet Research
BackgroundAs the spread of the SARS-CoV-2 virus coincided with lockdown measures, it is challenging to distinguish public reactions to lockdowns from responses to COVID-19 itself. Beyond the direct impact on health, lockdowns may have worsened public sentiment toward politics and the economy or even heightened dissatisfaction with health care, imposing a significant cost on both the public and policy makers. ObjectiveThis study aims to analyze the causal effect of COVID-19 lockdown policies on various dimensions of sentiment and uncertainty, using the Italian lockdown of February 2020 as a qua
View details →DOI: 10.2196/64667 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Mudit Agarwal, Piyush Ranjan, Upendra Baitha et al. · 2020 · Frontiers in Pharmacology
Hydroxychloroquine has gained much attention as one of the candidate drugs that can be repurposed as a prophylactic agent against SARS-CoV-2, the agent responsible for the COVID-19 pandemic. Due to high transmissibility and presence of asymptomatic carriers and presymptomatic transmission, there is need for a chemoprophylactic agent to protect the high-risk population. In this review, we dissect the currently available evidence on hydroxychloroquine prophylaxis from a clinical and pharmacological point of view. In vitro studies on Vero cells show that hydroxychloroquine effectively inhibits SA
View details →DOI: 10.3389/fphar.2020.593099 Negative / Null Result ReportMedicine
Zember, Turkbey, Chu et al. · 2026 · Pediatric radiology
Radiologic findings associated with SARS-CoV-2 infection have been well described since its emergence. However, long-term clinical and radiologic complications of pediatric SARS-CoV-2 infection are less defined, including radiologic…
View details →DOI: 10.1007/s00247-026-06701-3 Failed Experiment ReportOpen accessMedicine
Lorenzo Porta, Sih-Shiang Huang, Chen Wei et al. · 2022 · PLoS ONE
Objectives While corticosteroids have been hypothesized to exert protective benefits in patients infected with SARS-CoV-2, data remain mixed. This study sought to investigate the outcomes of methylprednisone administration in an Italian cohort of hospitalized patients with confirmed SARS-CoV-2 infection. Methods Patients with confirmatory testing for SARS-CoV-2 were retrospectively enrolled from a tertiary university hospital in Milan, Italy from March 1st to April 30th, 2020 and divided into two groups by administration of corticosteroids. Methylprednisolone was administered to patients not r
View details →DOI: 10.1371/journal.pone.0266901 Negative / Null Result ReportOpen accessMedicine
Simson Tarigan, Gita Sekarmila, Apas et al. · 2024 · PLoS ONE
Developing intranasal vaccines against pandemics and devastating airborne infectious diseases is imperative. The superiority of intranasal vaccines over injectable systemic vaccines is evident, but developing effective intranasal vaccines presents significant challenges. Fusing a protein antigen with the catalytic domain of cholera toxin (CTA1) and the two-domain D of staphylococcal protein A (DD) has significant potential for intranasal vaccines. In this study, we constructed two fusion proteins containing CTA1, tandem repeat linear epitopes of the SARS-CoV-2 spike protein (S14P5 or S21P2), a
View details →DOI: 10.1371/journal.pone.0306153 Negative / Null Result ReportOpen accessPublic aspects of medicine
Jonas Radermacher, Steffen Thiel, Aimo Kannt et al. · 2025 · BMC Public Health
Abstract Background The COVID-19 pandemic has profoundly affected daily life and posed significant challenges for politics, the economy, and the education system. To better prepare for such situations and implement effective measures, it is crucial to accurately assess, monitor, and forecast the progression of a pandemic. This study examines the potential of integrating wastewater surveillance data to enhance an autoregressive COVID-19 forecasting model for Germany and its federal states. Methods First, we explore the cross-correlations between SARS-CoV-2 viral RNA load measured in wastewater
View details →DOI: 10.1186/s12889-025-24149-2 Negative / Null Result ReportOpen accessDiseases of the genitourinary system. Urology
Manisha Ghate, Pallavi Shidhaye, Shraddha Gurav et al. · 2022 · Journal of the International Association of Providers of AIDS Care
Background : We aimed to determine the anti-SARS-CoV-2 IgG antibodies among people living with HIV (PLHIV) in Pune, India. Methods : This cross-sectional study was conducted between March 2021 and June 2021. Demographic and clinical information related to coronavirus disease 2019 (COVID-19) were recorded on structured questionnaires. Blood samples were collected and tested for anti-SARS-CoV-2 IgG antibodies using commercial ELISA. Results : Of the 405 HIV infected individuals enrolled in the study, 223(55.1%) were females. Mean age and CD4 count of participants were 42 years (SD: 10) and 626 c
View details →DOI: 10.1177/23259582221077943 Negative / Null Result ReportOpen accessInfectious and parasitic diseases
Watheq Thabet Taher, Amen A. Bawazir, Talal A. Sallam et al. · 2023 · BMC Infectious Diseases
Abstract Background Healthcare workers (HCWs) are at a higher risk of contracting COVID-19 due to their close contact with infected patients. However, the true burden of COVID-19 among HCWs in Yemen is unknown due to the inadequate availability of healthcare and the subclinical nature of the disease. This study aims to estimate the seroprevalence of SARS-CoV-2 infection among HCWs in two Yemeni governorates and identify associated factors using a cross-sectional design. Method A total of 404 HCWs were surveyed from June 2022 to September 2022 in Lahj and AL-Dhalea hospitals. A self-administere
View details →DOI: 10.1186/s12879-023-08760-5 Negative / Null Result ReportOpen accessSurgery
René Hage, Macé M. Schuurmans · 2022 · Transplantology
Introduction: We report on characteristics and lung function outcomes among lung transplant recipients (LTRs) after COVID-19 with infections occurring in the first year of the coronavirus pandemic prior to introduction of the vaccines. Methods: This was a retrospective study of 18 LTRs who tested positive for SARS-CoV-2 between 1 February 2020 and 1 March 2021. The mean age was 49.9 (22–68) years; 12 patients (67%) were male. Two patients died due to severe COVID-19. Results: During the study period, there were 18 lung transplant recipients with a community-acquired SARS-CoV-2 infection. In th
View details →DOI: 10.3390/transplantology3040028 Negative / Null Result Report
Sines BJ, Hagan RS, Jiang X et al. · 2026 · Preprint
ABSTRACT Background Corticosteroids reduce mortality in severe COVID-19 requiring oxygen or invasive mechanical ventilation, yet emerging data suggest that SARS-CoV-2-associated acute lung injury is biologically heterogeneous and that…
View details →DOI: 10.64898/2026.06.08.26355201 Negative / Null Result ReportOpen accessMedicine
Haddad A, Zabari Parnis E, Stein N et al. · 2026 · Vaccines
Background/Objective : The emergence of the COVID-19 pandemic has raised significant concerns regarding its impact on immune-mediated diseases, particularly with respect to disease induction and exacerbation. We aimed to investigate the…
View details →DOI: 10.3390/vaccines14040289 Negative / Null Result ReportOpen accessMedicine
Hoffmann K, Michalak M, Jarząb M et al. · 2026 · Frontiers in public health
Introduction Six years after the emergence of SARS-CoV-2, vaccination remains still central to preventing severe COVID-19. The aim was to determine the impact of the vaccine type and number of doses on the course of COVID-19 infection…
View details →DOI: 10.3389/fpubh.2026.1750819 Negative / Null Result ReportOpen accessMedicine
Sueiro-Benavides RA, Leiro-Vidal JM, Rodríguez-González JA et al. · 2026 · International journal of molecular sciences
The redox mechanisms of RAW 264.7 macrophages exposed to 2.45 GHz RF-EMF at subthermal specific absorption rates and to lipopolysaccharide (LPS) and/or the SARS-CoV-2 spike protein (CSP) were investigated. To this end, cellular responses…
View details →DOI: 10.3390/ijms27093813 Negative / Null Result Report
Yu D, Song Z, Liu Y et al. · 2024 · Preprint
Abstract Background Ursodeoxycholic acid (UDCA) was reported to reduce susceptibility to SARS-CoV-2 infection by downregulating farnesoid X receptor (FXR) -ACE2 signaling. However, we found a different story in real-world clinical studies.…
View details →DOI: 10.21203/rs.3.rs-4837114/v1 Failed Experiment Report
Wickenhagen A, Flagg M, Port J et al. · 2024 · Preprint
The emergence of the Omicron lineage represented a major genetic drift in SARS-CoV-2 evolution. This was associated with phenotypic changes including evasion of pre-existing immunity and decreased disease severity. Continuous evolution…
View details →DOI: 10.1101/2024.06.13.598902 Negative / Null Result ReportOpen accessMedicine
Hertereau L, Barthe M, Lamghari N et al. · 2026 · JID innovations : skin science from molecules to population health
The distribution of receptors and cellular factors across tissues determines differential susceptibility of cells to viral infection. For severe acute respiratory syndrome coronavirus 2, viral spike and nucleocapsid proteins have been…
View details →DOI: 10.1016/j.xjidi.2025.100447 Negative / Null Result ReportMedicine
Schilter KF, Kapoor S, Smith BA et al. · 2024 · Laboratory medicine
Objective The aim of this study was to compare the performance of direct amplification of viral nucleic acid from transport medium to extracted nucleic acid for polymerase chain reaction (PCR), sequencing, and genotyping applications.…
View details →DOI: 10.1093/labmed/lmad075 Negative / Null Result ReportMedicine
Agergaard J, Gunst JD, Schiøttz-Christensen B et al. · 2023 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Objectives Knowledge is limited on how changing SARS-CoV-2 variants may translate into different characteristics and affect the prognosis of patients with long COVID, especially following Omicron variants. We compared long-term prognosis…
View details →DOI: 10.1016/j.ijid.2023.10.022 Negative / Null Result ReportOpen accessMedicine
Figueiredo RR, de Azevedo AA, Figueiredo GMR et al. · 2026 · Brazilian journal of otorhinolaryngology
Objectives COVID-19 is a respiratory disease caused by the coronavirus SARS-CoV-2. Previous studies reported cases of tinnitus following COVID infection, most of them mild and with similar characteristics to other forms of tinnitus. Our…
View details →DOI: 10.1016/j.bjorl.2026.101857 