A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
1894 results for "Mpro" · page 10 of 64
Naiyue Hu, Chenghang Du, Wanqing Zhang et al. · 2022 · Agronomy
Grain yield and quality of wheat are both important components for food security. Great effort has been made in the genetic improvement of wheat grain yield in China. However, wheat grain quality (i.e., protein concentration and protein…
Christina Thunberg, Mari S. Messel, Liisa Raud et al. · 2020 · Scientific Reports
Abstract The ability to cancel an already initiated response is central to flexible behavior. While several different behavioral and neural markers have been suggested to quantify the latency of the stopping process, it remains unclear if…
Maria Fortunata Lofiego, Francesca Piazzini, Francesca Pia Caruso et al. · 2024 · Journal of Translational Medicine
BACKGROUND: Glioblastoma multiforme (GBM) is a highly aggressive primary brain tumor, that is refractory to standard treatment and to immunotherapy with immune-checkpoint inhibitors (ICI). Noteworthy, melanoma brain metastases (MM-BM), that share the same niche as GBM, frequently respond to current ICI therapies. Epigenetic modifications regulate GBM cellular proliferation, invasion, and prognosis and may negatively regulate the cross-talk between malignant cells and immune cells in the tumor milieu, likely contributing to limit the efficacy of ICI therapy of GBM. Thus, manipulating the tumor
Beau J. Fenner, Jonathan F. Russell, Arlene V. Drack et al. · 2023 · Frontiers in Medicine
Introduction X-linked retinoschisis (XLRS) is an inherited retinal disease (IRD) caused by pathogenic mutations in the retinoschisin gene, RS1 . Affected individuals develop retinal layer separation, leading to loss of visual acuity (VA). Several XLRS gene therapy trials have been attempted but none have met their primary endpoints. An improved understanding of XLRS natural history and clinical outcomes may better inform future trials. Here, we report the long-term functional and structural outcomes of XLRS and the relevance of RS1 genotypes to the visual prognosis of affected individuals. Met
Amit Walia, Matthew Shew, Jordan Varghese et al. · 2023 · JAMA Otolaryngology–Head & Neck Surgery
Importance: Cochlear implantation produces remarkable results in postlingual deafness, although auditory outcomes vary. Electrocochleography (ECochG) has emerged as a valuable tool for assessing the cochlear-neural substrate and evaluating…
Caterina Peraldo‐Neia, Giuliana Cavalloni, Elisabetta Fenocchio et al. · 2018 · PLoS ONE
The association of anti-EGFR to gemcitabine and oxaliplatin (GEMOX) chemotherapy did not improve survival in biliary tract carcinoma (BTC) patients. Multiple mechanisms might be involved in the resistance to anti-EGFR. Here, we explored the mutation profile of EGFR extracellular domain (ECD), of tyrosine kinase domain (TKD), and its amplification status. EGFR mutational status of exons 12, 18-21 was analyzed in 57 tumors by Sanger sequencing. EGFR amplification was evaluated in 37 tumors by Fluorescent In Situ Hybridization (FISH). Kaplan-Meier curves were calculated using the log-rank test. S
Margarida Arrobas, João V. Decker, Bruna L. Feix et al. · 2021 · Soil Use and Management
Abstract Soil conditioners, such as biochar and zeolites, may play an important role in agriculture if they increase nutrient use efficiency, in particular, that of phosphorus (P), due to the depletion of phosphate rocks from which…
Marta Arroyo‐Izaga, Concepción Martínez de la Pera, Laura Ansotegui et al. · 2026 · Archivos Latinoamericanos de Nutrición
The objective of this study was to determine whether a short training program, using real foods, would decreased their portion-size estimation errors after training. 90 student volunteers (20.18+/-0.44 y old) of the University of the…
Stijntje Dijk, Claudia Wollny, Jörg Barkhausen et al. · 2025 · JAMA
Importance: Given the widespread use of medical imaging, evaluating the effectiveness of interventions to improve appropriateness is crucial for optimizing health care resources and patient outcomes. Objective: To assess the effects of…
Lijun Lu, Youqing Deng, Renshi Xu · 2024 · Frontiers in Neurology
Amyotrophic lateral sclerosis (ALS) is a debilitating motor neurological disorder for which there is still no cure. The disease seriously jeopardizes the health and lifespan of adult populations. The authors extensively retrieved the current literature about clinical and experimental ALS treatments. Based on them, this review primarily focused on summarizing the current potential clinical usage and trialing therapeutics of ALS. Currently, the clinical ALS treatments have focused primarily on relieving symptoms to improve the quality of life yet. There are a number of therapeutic approaches suc
Caitlin E. Hill, Danika M. Brodak, Mary Bartlett Bunge · 2012 · Journal of Neurotrauma
Several recent studies suggest that predegenerated nerves (PDNs) or dissociated PDNs (dPDNs) can improve behavioral and histological outcomes following transplantation into the injured rat spinal cord. In the current study we tested the…
Michael K. Urban, Kristy M. Labib, Shane C. Reid et al. · 2018 · HSS Journal®: The Musculoskeletal Journal of Hospital for Special Surgery
Background The treatment of postoperative pain is a challenge after posterior spinal fusions. Pain management using predominantly opioids is often associated with multiple adverse effects, while multimodal postoperative analgesia may…
Saranya Chitturi, Venkata Gopich, Talatam et al. · 2013 · Der pharmacia lettre
Recently, many studies have been oriented towards improving methods and efficiency of recovery from different fruit industry wastes. The investigations carried out were mainly aimed at evaluating Pectin content, Protease activity, Protein…
Bente Silnes Tandberg, Kathrine Frey Frøslie, Trond Markestad et al. · 2019 · Acta Paediatrica
Abstract Aim The aim was to compare growth in very premature infants cared for in a single‐family room (SFR) and an open‐bay (OB) unit. We recorded duration of parental presence and skin‐to‐skin contact as proxies for parental involvement…
Melissa B. Gilkey, Brigid K. Grabert, Jennifer Heisler-MacKinnon et al. · 2022 · PEDIATRICS
BACKGROUND AND OBJECTIVES: US health departments routinely conduct in-person quality improvement (QI) coaching to strengthen primary care clinics' vaccine delivery systems, but this intervention achieves only small, inconsistent…
Daniel Rasbash, Kevin Joseph Dillman, Jukka Heinonen et al. · 2023 · Sustainability
Electrification is considered key to decarbonizing the transport sector. While electric vehicles (EVs) lack tailpipe emissions, battery and electricity production can lead to significant emissions. This study analysed whether EVs can effectively mitigate GHG emissions in North America, by calculating two GHG breakeven indicators for EVs and comparing them to internal combustion engine vehicles (ICEVs). EV life cycle emissions were compared to those of ICEVs in Canada, Mexico, and the USA. In addition, this study considered potential national electricity grids evolutions and improvements in bat
Johan P. Mackenbach, Marina Karanikolos, Jamie Lopez Bernal et al. · 2015 · Scandinavian Journal of Public Health
Background: The upturn of life expectancy in Central and Eastern Europe in the 1990s, after a period of stagnation or even decline, is one of the main events in European population history of the late 20th century, but has not been…
Nalinie Joharatnam‐Hogan, William Wilson, Kai Keen Shiu et al. · 2020 · Cancers
Background: Despite notable advances in the management of metastatic colorectal cancer (mCRC) over the last two decades, treatment intent in the vast majority of patients remains palliative due to technically unresectable disease, extensive disease, or co-morbidities precluding major surgery. Up to 30% of individuals with mCRC are considered potentially suitable for primary or metastasis-directed multimodal therapy, including surgical resection, ablative techniques, or stereotactic radiotherapy (RT), with the aim of improving survival outcomes. We reviewed the potential benefits of multimodal
IREC, CSIC–UCLM–JCCM, Ciudad Real, Spain, Ainhoa Mateo-Moriones, Rafael Villafuerte et al. · 2012 · Animal Biodiversity and Conservation
This work evaluates the effectiveness of fox control as a method to improve the survival of red–legged partridge (Alectoris rufa). We radio–tracked 89 adult partridges and their chicks (62 few days old chicks and 46 over one–month–old chicks) and monitored their nests (N = 45) on two hunting estates in northern Spain over two years. Generalist predators (red fox, Vulpes vulpes, and magpie, Pica pica) were selectively controlled on one half of each estate during the first year, and on the other half in the second year. We estimated the effect of predator control on survival rates. Predator cont
Pate, KM, Pohlmeyer, C, Walker-Sperling, V et al. · 2015 · Journal of the International AIDS Society
Introduction Sensitive assays are needed for detection of residual HIV in patients with undetectable plasma viral loads to determine if eradication strategies are effective. The gold standard quantitative viral outgrowth assay (QVOA) underestimates the magnitude of the viral reservoir, while sensitive PCR-based assays lack the ability to distinguish replication competent from defective virus. We sought to determine whether xenograft of leukocytes from HIV-1 infected patients with undetectable plasma viral loads into severely immunocompromised mice would result in viral amplification and measur
A.R.J.V. Vossen, H.H. van der Zee, N. Davelaar et al. · 2018 · Journal of the European Academy of Dermatology and Venereology
Abstract Background Treatment with apremilast has recently demonstrated clinically meaningful improvement in moderate hidradenitis suppurativa ( HS ). Objective To evaluate the change in expression of inflammatory markers in lesional skin…
Luigi Aurisicchio, Gennaro Ciliberto · 2011 · Cancers
Therapeutic vaccination against cancer is an important approach which, when combined with other therapies, can improve long-term control of cancer. In fact, the induction of adaptive immune responses against Tumor Associated Antigens (TAAs) as well as innate immunity are important factors for tumor stabilization/eradication. A variety of immunization technologies have been explored in last decades and are currently under active evaluation, such as cell-based, protein, peptide and heat-shock protein-based cancer vaccines. Genetic vaccines are emerging as promising methodologies to elicit immune
Jingran Zhang, Wukui Wang, Lei Gao et al. · 2022 · Atmosphere
Air pollution caused by coal burning not only increases the cost of environmental pollution but also harms human health. It is urgent for China to change the practice of coal-fired central heating. Therefore, the effectiveness and…
Jorge G. Ruiz, Allen D. Andrade, Ramanakumar Anam et al. · 2013 · The Diabetes Educator
Purpose The purpose of this study was to investigate whether computer-based programmed instruction (CPI) with a dynamic avatar (DA) improves retention of medication information better than text (controls) or better than CPI with text…
Barbora Weinbergerová, Tomáš Kabut, Iva Kocmanová et al. · 2020 · Scientific Reports
Invasive fungal disease (IFD) early diagnosis improves hematological patient survival. Non-culture-based methods may reduce diagnostic time to identify IFD. As complex data on the value of 1,3-β-D-glucan (BDG) from bronchoalveolar lavage fluid (BALF) compared to serum for the most frequent invasive pulmonary aspergillosis (IPA) diagnosis are scarce, particularly including evaluation of potential factors adversely affecting BDG assay, we provided prospective single-center analysis evaluating 172 episodes of pulmonary infiltrates with BDG detection in BALF and serum samples collected in parallel
Mireia M. Ginesta, Zamira V. Díaz‐Riascos, Juli Busquets et al. · 2016 · Oncology Letters
Early detection of pancreatic and periampullary neoplasms is critical to improve their clinical outcome. The present authors previously demonstrated that DNA hypermethylation of adenomatous polyposis coli (APC), histamine receptor H2…
Rachel Murchison, Catherine Gooday, Ketan Dhatariya · 2014 · Journal of the American Podiatric Medical Association
Medication to aid weight loss and weight loss surgery are becoming more commonly available for people with diabetes. As a result of profound weight loss, diabetes may go into remission and many biochemical and physical parameters improve.…
Brian Premchand, Liyuan Liang, Kok Soon Phua et al. · 2024 · NeuroSci
Detecting stress is important for improving human health and potential, because moderate levels of stress may motivate people towards better performance at cognitive tasks, while chronic stress exposure causes impaired performance and health risks. We propose a Brain-Computer Interface (BCI) system to detect stress in the context of high-pressure work environments. The BCI system includes an electroencephalogram (EEG) headband with dry electrodes and an electrocardiogram (ECG) chest belt. We collected EEG and ECG data from 40 participants during two stressful cognitive tasks: the Cognitive Vig
Angeliki Argyriadou, Athanasios Ι. Gelasakis, Georgios Banos et al. · 2020 · Journal of the Hellenic Veterinary Medical Society
The objective of the study was twofold: (i) to review the genetics of production and resilience traits of indigenous Greek small ruminant breeds as well as the evolution of national breeding programs, and (ii) explore innovative and…
Olive Lennon, Deirdre Phelan, Deborah Wallace et al. · 2019 · Physiotherapy Research International
Abstract Background and Purpose Evidence‐based practice (EBP), which integrates clinical reasoning skills, research evidence, and patient preference, has become standard in curricula for health care professional programs. Students however…