19,803 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Ruella Rouf, Sara M. Karaba, Jenny Dao et al. · 2011 · Microbiology
The environmental bacterium Stenotrophomonas maltophilia is increasingly described as a multidrug-resistant pathogen of humans, being associated with pneumonia, among other diseases. But the degree to which S. maltophilia is capable of…
View details →Boshu Ru, Dingcheng Li, Yueqi Hu et al. · 2019 · IEEE Transactions on NanoBioscience
Serendipitous drug usage refers to the unexpected relief of comorbid diseases or symptoms when taking medication for a different known indication. Historically, serendipity has contributed significantly to identifying many new drug…
View details →Tsai‐Ling Liao, Ching‐Heng Lin, Hsin‐Hua Chen et al. · 2017 · Journal of the American Heart Association
Background Accumulating evidence suggests an increased risk of stroke after herpes zoster ( HZ ). This risk is elevated in immunocompromised patients. The incidence of HZ in Asia is higher than in Western countries. However, the…
View details →Richard A. Brown, Susan E. Ramsey, Christopher W. Kahler et al. · 2011 · Journal of Studies on Alcohol and Drugs
OBJECTIVE: A previous pilot study found positive outcomes among alcohol-dependent individuals with elevated depressive symptoms who received cognitive-behavioral treatment for depression (CBT-D; n = 19) compared with a relaxation training…
View details →Claus Neurohr, Nikolaus Kneidinger, Alessandro Ghiani et al. · 2021 · American Journal of Transplantation
Long-term survival after lung transplantation is limited by chronic allograft dysfunction. The aim of this study was to investigate the effect of locally augmented immunosuppression with liposomal cyclosporine A for inhalation (L-CsA-i)…
View details →Shane Esola, Brian Wisner, Prashanth A. Vanniamparambil et al. · 2018 · Applied Sciences
The research presented in this article aims to demonstrate how acoustic emission (AE) monitoring can be implemented in an industrial setting to assist with part qualification, as mandated by related industry standards. The combined structural and nondestructive evaluation method presented departs from the traditional pass/fail criteria used for part qualification, and contributes toward a multi-dimensional assessment by taking advantage of AE data recorded during structural testing. To demonstrate the application of this method, 16 composite fixed-wing-aircraft spars were tested using a struct
View details →Marlou Poppelaars, Anna Lichtwarck‐Aschoff, Roy Otten et al. · 2021 · Frontiers in Psychology
Depressive symptoms and disorders are major public health concerns, affecting many adolescents and young adults. Despite extensive research, depression prevention programs for youth show limited effectiveness. Moreover, the maximal potential of youth psychotherapy — on which depression prevention programs are based — may have been reached. Commercial video games may offer an engaging alternative vehicle for youth to practice emotional and social skills vital to mental health. The current study investigated the potential for the commercial video game Journey to prevent the exacerbation of depre
View details →Ying Shen, Yuanlong Yan, Yunqiang Liu et al. · 2013 · Human Molecular Genetics
AZFc deletions cause a significant phenotypic heterogeneity with respect to spermatogenesis; however, the reason for this is poorly understood. Recently, testis-specific protein Y-encoded 1 (TSPY1) copy number variation (CNV) was…
View details →Giorgio Aicardi · 2013 · Rejuvenation Research
Despite decades of research, there is no cure for Alzheimer disease (AD), and current pharmacological treatments only partially mask the symptoms while the disease progresses within the brain. AD is associated with impaired clearance of…
View details →Juliana Abagsonema Abane, Ronald Adamtey, Virceta Owusu Ayim · 2022 · Future Business Journal
Abstract There is mixed evidence that low levels of productivity at the local government level are not common with organizations with strong cultures as these are less prone to any externalities. The paper investigated the link between organizational culture and employee productivity from the perspectives of employees of the Sekondi-Takoradi Metropolitan Assembly (STMA) in Ghana. The study used the quantitative approach with descriptive and cross-sectional designs. The simple random and stratified sampling techniques were used to select 132 respondents from the STMA using a self-administered s
View details →Karam Khateeb, Zhaojie Yao, Viktor Kharazia et al. · 2019
Ischemic stroke is a major cause of disability among adults worldwide. Despite its prevalence, few effective treatment options exist to alleviate sensory and motor dysfunctions that result from stroke. In the past, rodent models of stroke…
View details →Masaru Sekijima, Hiroshi Takeda, Katsuaki Yasunaga et al. · 2010 · Journal of Radiation Research
We investigated the mechanisms by which radiofrequency (RF) fields exert their activity, and the changes in both cell proliferation and the gene expression profile in the human cell lines, A172 (glioblastoma), H4 (neuroglioma), and IMR-90…
View details →Eamonn P. Culligan, Julian R. Marchesi, Colin Hill et al. · 2014 · Frontiers in Microbiology
In the current study, a number of salt-tolerant clones previously isolated from a human gut metagenomic library were screened using Phenotype MicroArray (PM) technology to assess their functional capacity. PM's can be used to study gene function, pathogenicity, metabolic capacity and identify drug targets using a series of specialized microtitre plate assays, where each well of the microtitre plate contains a different set of conditions and tests a different phenotype. Cellular respiration is monitored colorimetrically by the reduction of a tetrazolium dye. One clone, SMG 9, was found to be po
View details →Tiffany A. Greenwood, John R. Kelsoe · 2013 · PLoS ONE
The use of clinical features to define subtypes of a disorder may aid in gene identification for complex diseases. In particular, clinical subtypes of mania may distinguish phenotypic subgroups of bipolar subjects that may also differ genetically. To assess this possibility, we performed a genome-wide association study using genotype data from the Bipolar Genome Study (BiGS) and subjects that were categorized as having either irritable or elated mania during their most severe episode. A bipolar case-only analysis in the GAIN bipolar sample identified several genomic regions that differed betwe
View details →Trisha Harjani, Melisa-Sinem Basol, Jon Roozenbeek et al. · 2023 · Journal of Trial and Error
Although the spread of misinformation is a pervasive and disruptive global problem, extant research is skewed towards “WEIRD” countries leaving questions about how to tackle misinformation in the developing world with different media and consumption patterns unanswered. We report the results of a game-based intervention against misinformation in India. The game is based on the mechanism of psychological inoculation; borrowed from the medical context, inoculation interventions aim to pre-emptively neutralize falsehoods and help audiences spot and resist misinformation strategies. Though the eff
View details →Arthur Wickenhagen, Meaghan Flagg, Julia R. Port et al. · 2025 · Nature Communications
The emergence of the Omicron lineage represented a major genetic drift in SARS-CoV-2 evolution. This was associated with phenotypic changes including evasion of pre-existing immunity and decreased disease severity. Continuous evolution within the Omicron lineage raised concerns of potential increased transmissibility and/or disease severity. To address this, we evaluate the fitness and pathogenesis of contemporary Omicron variants XBB.1.5, XBB.1.16, EG.5.1, and JN.1 in the upper (URT) and lower respiratory tract (LRT). We compare in vivo infection in Syrian hamsters with infection in primary h
View details →Nathalie Charlier, Andrew D. Davidson, Kai Dallmeier et al. · 2010 · Journal of General Virology
Chimeric yellow fever virus 17D (YFV-17D) and dengue virus type 2 (DENV2) carrying the surface proteins of Modoc virus (MODV), a not-known-vector (NKV) flavivirus, replicated efficiently in mammalian (Vero-B) and mosquito (C6/36) cells,…
View details →Jongwook Choi, Yuwen Zhang · 2020 · Numerical Heat Transfer Part A Applications
The oscillatory flow and the heat transfer in two-dimensional pulsating heat pipes (PHPs) with multi-turns were simulated using OpenFOAM. The volume of fluid method was used for the phase change, and the behavior of the working fluid was…
View details →Suribabu Conety Ravi, Neelakantan Thurvas Renganathan, Sivakumar Perumal et al. · 2019 · Drinking water engineering and science
Abstract. Pressure-driven analysis (PDA) of water distribution networks necessitates an assessment of the supplying capacity of a network within the minimum and required pressure ranges. Pressure-deficient conditions happen due to the uncertainty of nodal demands, failure of electromechanical components, diversion of water, aging of pipes, permanent increase in the demand at certain supply nodes, fire demand, etc. As the demand-driven analysis (DDA) solves the governing equations without any bound on pressure head, it fails to replicate the real scenario, particularly when the network experien
View details →Bo Xi, Yue Shen, Kathleen H. Reilly et al. · 2012 · Clinical Endocrinology
OBJECTIVE: Recent genome-wide association studies have identified a few single nucleotide polymorphisms (SNPs), which are associated with body mass index (BMI)/obesity. This study aimed to examine the identified associations among a…
View details →Ariel White, Anton Strezhnev, Christopher Lucas et al. · 2018 · Journal of Experimental Political Science
Abstract Prior research demonstrates that responses to surveys can vary depending on the race, gender, or ethnicity of the investigator asking the question. We build upon this research by empirically testing how information about…
View details →Sjirk Geerts, Pieter Willem Botha, Vernon Visser et al. · 2013 · South African Journal of Botany
The legumes (Fabaceae) Genista monspessulana and Spartium junceum are major invaders in several other parts of the world, but not yet so in South Africa. We determine their current distributions in South Africa at different spatial scales, assess population structure (soil seed banks and size at reproduction) evaluate current management activities, and provide recommendations for control (including assessing the feasibility of nation-wide eradication). G. monspessulana occurs at nine localities in three quarter-degree cells, covering a total of 22.7 ha. S. junceum is much more widespread, occu
View details →Franca E. Dupuy, Adam R. Clarke, Robert J. Barry et al. · 2013 · Clinical EEG and Neuroscience
This study further investigated electroencephalogram (EEG) differences between girls with the Combined and Inattentive types of attention-deficit/hyperactivity disorder (AD/HD). We selected subjects with widely separated scores on…
View details →María Valdés Hernández, Lucia Ballerini, Andreas Glatz et al. · 2019 · Brain Imaging and Behavior
Brain iron deposits (IDs) are indicative of microvessel dysfunction which may predispose to small vessel disease (SVD) brain damage and worsen cognition later in life. Visible perivascular spaces in the centrum semiovale (CSO-PVS) are SVD features linked with microvessel dysfunction. We examined possible associations of CSO-PVS volume and count with brain IDs and cognitive abilities in 700 community-dwelling individuals from the Lothian Birth Cohort 1936 who underwent detailed cognitive testing and multimodal brain MRI at mean age 72.7 years. Brain IDs were assessed automatically followed by m
View details →Ryan Smith, Claire A. Lavalley, S Taylor et al. · 2023 · Journal of Psychiatry and Neuroscience
BACKGROUND: Decision-making under approach-avoidance conflict (AAC; e.g., sacrificing quality of life to avoid feared outcomes) may be affected in multiple psychiatric disorders. Recently, we used a computational (active inference) model…
View details →Kaye M. Reid–Lombardo, Brooke L. Fridley, William R. Bamlet et al. · 2011 · Cancer Epidemiology Biomarkers & Prevention
BACKGROUND: Recent reports support an association between chronic inflammation and progression to pancreatic cancer (PC). METHODS: This case-control, candidate gene association study evaluated 1,354 Caucasian patients with pancreatic…
View details →Odis Johnson · 2012 · Review of Educational Research
Since 1976, the U.S. Department of Housing and Urban Development (HUD) has relocated low-income children of color from public housing communities to less racially and economically isolated neighborhoods in an effort to improve their…
View details →Fumitaka Furuoka · 2016 · Applied Economics Letters
This article proposes a new unit root test to analyse unemployment hysteresis. The test is able to incorporate cross-sectional dependence, unattended nonlinearity and unknown structural breaks in the time-series data. This study used data…
View details →Brahim Aı̈ssani, Kui Zhang, Howard W. Wiener · 2015 · Frontiers in Genetics
We evaluated the association of 56 candidate SNPs identified in two published genome-wide association studies (GWAS) of uterine leiomyoma (UL), or fibroids, with the risk and tumor size in the multi-ethnic uterine fibroid study (NIEHS-UFS). The selected SNPs were genotyped in 916 premenopausal women of African American (AA) and European American (EA) descents and their association with the outcomes was evaluated in race-stratified models and in meta-analysis of risk in NIEHS-UFS and discovery and replication GWAS in the Japanese population. We report moderate associations of variant rs4954368
View details →John G. McCabe, Daniel A. Krauss · 2011 · Behavioral Sciences & the Law
An intervention designed to correct affective and cognitive biases was tested in the context of a civil commitment hearing of a sexually violent predator. Potential differences between a college student mock jury sample and a more…
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