Negative / Null Result ReportOpen accessNeuroscience
Ashley M. Brouillette, Gülin Öz, Christopher M. Gómez · 2015 · Disease Markers
Neurodegenerative diseases, including the spinocerebellar ataxias (SCA), would benefit from the identification of reliable biomarkers that could serve as disease subtype-specific and stage-specific indicators for the development and monitoring of treatments. We analyzed the cerebrospinal fluid (CSF) level of tau, α-synuclein, DJ-1, and glial fibrillary acidic protein (GFAP), proteins previously associated with neurodegenerative processes, in patients with the autosomal dominant SCA1, SCA2, and SCA6, and the sporadic disease multiple system atrophy, cerebellar type (MSA-C), compared with age-ma
View details →Negative / Null Result ReportMedicine
Kazunari Misawa, Yoshinari Mochizuki, Munetoshi Sakai et al. · 2019 · British journal of surgery
BACKGROUND: A survival benefit of extensive intraoperative peritoneal lavage (EIPL) has been reported in patients with gastric cancer with positive peritoneal cytology. The hypothesis of this study was that EIPL may reduce peritoneal…
View details →Negative / Null Result Report
Carl J. Rothfels, Anne K. Johnson, Michael D. Windham et al. · 2014 · TAXON
Abstract Here we present the first nuclear phylogeny for Cystopteridaceae (Polypodiales), using the single‐copy locus gapCp “ short ”. This phylogeny corroborates broad results from plastid data in demonstrating strong support for the…
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Prayut Jain, Shashi Jain · 2019 · Risks
The Hierarchical risk parity (HRP) approach of portfolio allocation, introduced by Lopez de Prado (2016), applies graph theory and machine learning to build a diversified portfolio. Like the traditional risk-based allocation methods, HRP…
View details →Negative / Null Result ReportAgricultural and Biological Sciences
Nanike Esterhuizen, Susana Clusella‐Trullas, Corné E. van Daalen et al. · 2014 · Journal of Experimental Biology
The influence of thermal history on temperature-dependent flight performance was investigated in an invasive agricultural pest insect, Ceratitis capitata (Diptera: Tephritidae). Flies were exposed to one of four developmental acclimation…
View details →Negative / Null Result ReportOpen accessPsychology
Rebecca Treiman, Brett Kessler, Tatiana Cury Pollo et al. · 2016 · Scientific Studies of Reading
Learning the orthographic forms of words is important for both spelling and reading. To determine whether some methods of scoring children's early spellings predict later spelling performance better than do other methods, we analyzed data…
View details →Negative / Null Result ReportOpen accessEngineering
Guy E. Blelloch, Girija Narlikar · 2018 · Figshare
This work compares three algorithms for the three dimensional N-body problem, the Barnes-Hut algorithm, Greengard's Fast Multipole Method(FMM), and the Parallel Multipole Tree Algorithm (PMTA) to determine which of the algorithms performs…
View details →Negative / Null Result ReportOpen accessDentistry
Gerlig Widmann, Alexander Bischel, Andreas Stratis et al. · 2017 · Dentomaxillofacial Radiology
OBJECTIVES: The objective of this study was to determine how iterative reconstruction technology (IRT) influences contrast and spatial resolution in ultralow-dose dentomaxillofacial CT imaging. METHODS: A polymethyl methacrylate phantom with various inserts was scanned using a reference protocol (RP) at CT dose index volume 36.56 mGy, a sinus protocol at 18.28 mGy and ultralow-dose protocols (LD) at 4.17 mGy, 2.36 mGy, 0.99 mGy and 0.53 mGy. All data sets were reconstructed using filtered back projection (FBP) and the following IRTs: adaptive statistical iterative reconstructions (ASIRs) (ASIR
View details →Negative / Null Result ReportOpen accessSocial Sciences
Imad Bou Akl, Fatima Ghaddar, Ramzi Sabra et al. · 2011 · The Journal of Clinical Pharmacology
The purpose of this study was to formulate evidence-based recommendations on whether to deliver the team-based learning (TBL)-designed clinical pharmacology course at the American University of Beirut Faculty of Medicine (AUBFM) during the…
View details →Negative / Null Result ReportOpen accessMedicine
Marika Fallenius, Markus B. Skrifvars, Matti Reinikainen et al. · 2017 · Scandinavian Journal of Trauma Resuscitation and Emergency Medicine
BACKGROUND: Intensive care scoring systems are widely used in intensive care units (ICU) around the world for case-mix adjustment in research and benchmarking. The aim of our study was to investigate the usefulness of common intensive care scoring systems in predicting mid-term mortality in patients with spontaneous intracerebral hemorrhage (ICH) treated in intensive care units (ICU). METHODS: We performed a retrospective observational study including adult patients with spontaneous ICH treated in Finnish ICUs during 2003-2012. We used six-month mortality as the primary outcome of interest. We
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
S. Heirbaut, Xiaoping Jing, Barbara Stefańska et al. · 2022 · Journal of Dairy Science
Data on metabolic profiles of blood sampled at d 3, 6, 9, and 21 in lactation from 117 lactations (99 cows) were used for unsupervised k-means clustering. Blood metabolic parameters included -hydroxybutyrate (BHB), nonesterified fatty acids, glucose, insulin-like growth factor-1 (IGF-1) and insulin. Clustering relied on the average and range of the 5 blood parameters of all 4 sampling days. The clusters were labeled as imbalanced (n = 42) and balanced (n = 72) metabolic status based on the values of the blood parameters. Various random forest models were built to predict the metabolic cluster
View details →Negative / Null Result ReportDentistry
Chia Wen Tsai, Wen Shin Chang, Kuo Cheng Lin et al. · 2014 · PubMed
Interleukin-10 (IL10) is an immunosuppressive cytokine which may facilitate carcinogenesis by down-regulating interferon-gamma production and supporting tumor escape from the immune response. Polymorphisms within the promoter of IL10 gene…
View details →Negative / Null Result ReportMedicine
Davide Ferrari, Massimo Locatelli · 2020 · International Journal for Vitamin and Nutrition Research
Abstract. The world is currently overwhelmed by a novel coronavirus disease (COVID-19). Clinically, COVID-19 shows a broad range of manifestations: from asymptomatic to severe and possibly lethal interstitial pneumonia. Several studies…
View details →Negative / Null Result ReportMedicine
J. B. Warren · 2020 · BMJ
Widespread prescribing has not reduced mental disability or suicide, raising questions about the assessment of evidence on effectiveness and safety of antidepressants, writes John Warren
View details →Negative / Null Result ReportOpen accessMedicine
Tracie C. Rosser, Jamie O. Edgin, George T. Capone et al. · 2018 · American Journal on Intellectual and Developmental Disabilities
The cause of the high degree of variability in cognition and behavior among individuals with Down syndrome (DS) is unknown. We hypothesized that birth defects requiring surgery in the first years of life (congenital heart defects and…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Felix Kwame Aveh, Dadson Awunyo‐Vitor · 2017 · Cogent Economics & Finance
This study seeks to examine the influence of firm-specific determinants of stock prices in an emerging market with particular reference to firms listed on the Ghana Stock Exchange. The study employs a data-set from all listed firms on the Ghana Stock Exchange from 2008 to 2014. The study used panel regression analysis to analyse the data. In general, the study found that accounting information, specifically earning per share, return on equity, book value and market capitalization of the firms, is relevant in explaining stock prices after the adoption of International Financial Reporting Standa
View details →Negative / Null Result ReportMathematics
Rebecca Kanive, Peter M. Nelson, Matthew K. Burns et al. · 2013 · The Journal of Educational Research
ABSTRACT The authors’ purpose was to determine the effects of computer-based practice and conceptual interventions on computational fluency and word-problem solving of fourth- and fifth-grade students with mathematics difficulties. A…
View details →Negative / Null Result ReportSocial Sciences
Jason E. Strickhouser, Ethan Zell, Kara Harris · 2018 · Social Psychological and Personality Science
Why do White Americans perceive less racism than Black Americans? Two provocative studies on the Marley hypothesis suggest that White Americans are more ignorant of historical instances of racism than Black Americans and that ignorance of…
View details →Negative / Null Result ReportOpen accessMedicine
Ngan T.K. Tran, Stella Aslibekyan, Hemant K. Tiwari et al. · 2015 · Frontiers in Genetics
Proprotein convertase subtilisin/kexin type 9 (encoded by PCSK9) plays a well-known role in the regulation of low-density lipoprotein (LDL) receptors, and an inhibitor of this enzyme is a promising new therapeutic for hyperlipidemia. Recently, animal and human studies also implicate PCSK9 genetic variation in the regulation of blood pressure. The goal of this study was to examine if common and rare polymorphisms in PCSK9 are associated with blood pressure in an African-American population at high risk for cardiovascular disease. Using genomic data assayed on the Affymetrix 6.0 array (n = 1199)
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
José‐Antonio Daròs, Verónica Aragonés, Teresa Cordero · 2018 · Scientific Reports
Viruses have been engineered into useful biotechnological tools for gene therapy or to induce the synthesis of products of interest, such as therapeutic proteins and vaccines, in animal and fungal cells, bacteria or plants. Viroids are a particular class of infectious agents of higher plants that exclusively consist of a small non-protein-coding circular RNA molecule. In the same way as viruses have been transformed into useful biotechnological devices, can viroids be converted into beneficial tools? We show herein that, by expressing Eggplant latent viroid (ELVd) derived RNAs in Escherichia c
View details →Negative / Null Result ReportAgricultural and Biological Sciences
Kateřina Hotová Svádová, Alice Exnerová, Michala Kopečková et al. · 2013 · Ethology
Abstract We tested the importance of innate wariness, avoidance learning, memory and generalization for the formation of predatory behaviour in naive great tits ( P arus major ) towards mimetic complex of four aposematic species of true…
View details →Negative / Null Result ReportMedicine
Owen M. Peters, Tatyana A. Shelkovnikova, Tatiana Tarasova et al. · 2013 · Journal of Alzheimer s Disease
Dimebon has been tested as a potential modifier of Alzheimer's disease (AD), resulting in mixed clinical trial outcomes. Originally utilized as an antihistamine, Dimebon was later found to ameliorate AD symptoms in initial human trials.…
View details →Negative / Null Result ReportOpen accessMedicine
Yolandi Swart, Caitlin Uren, Paul D. van Helden et al. · 2021 · Frontiers in Genetics
Pulmonary tuberculosis (TB), caused by Mycobacterium tuberculosis , is a complex disease. The risk of developing active TB is in part determined by host genetic factors. Most genetic studies investigating TB susceptibility fail to replicate association signals particularly across diverse populations. South African populations arose because of multi-wave genetic admixture from the indigenous KhoeSan, Bantu-speaking Africans, Europeans, Southeast Asian-and East Asian populations. This has led to complex genetic admixture with heterogenous patterns of linkage disequilibrium and associated traits.
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Matthew S. Clement, Nathan A. Kaib, John E. Chambers · 2019 · The Astronomical Journal
Abstract Of the solar system’s four terrestrial planets, the origin of Mercury is perhaps the most mysterious. Modern numerical simulations designed to model the dynamics of terrestrial planet formation systematically fail to replicate…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Yun‐Young Lee, Robert X. Black · 2013 · Journal of Geophysical Research Atmospheres
Abstract This study assesses the capability of CMIP5 models in representing primary modes of boreal winter extratropical low‐frequency variability. Rotated principal component analysis is applied to monthly mean output from historical…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Michael Talledo, Giovanni López, Jeroen R. Huyghe et al. · 2010 · Journal of Medical Virology
Human T-lymphotropic virus 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a complication that affects up to 5% of HTLV-1-infected individuals. Several host genetic and viral factors have been associated with the…
View details →Negative / Null Result ReportOpen accessNeuroscience
Anja Achtziger, Carlos Alós‐Ferrer, Sabine Hügelschäfer et al. · 2015 · Social Cognitive and Affective Neuroscience
Standard economic thinking postulates that increased monetary incentives should increase performance. Human decision makers, however, frequently focus on past performance, a form of reinforcement learning occasionally at odds with rational…
View details →Negative / Null Result ReportNeuroscience
So-Yeon Kim, Kelly S. Giovanello · 2011 · Journal of Cognitive Neuroscience
Numerous studies have documented that older adults (OAs) do not perform as well as young adults (YAs) when task demands require the establishment or retrieval of a novel link between previously unrelated information (relational memory:…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Alexis Dunkle, Ivan Dzhagalov, Y-W He · 2011 · Cell Death and Disease
Myeloid cell leukemia sequence-1 (Mcl-1) is a critical anti-apoptotic factor in T lymphocytes. However, in spite of the many pro-apoptotic proteins with proposed binding to Mcl-1, the specific interactions by which Mcl-1 regulates primary T-cell survival under different conditions have not been fully explored. Further, how different trophic cytokines modulate the specific role(s) of Mcl-1 is unknown. Here, we use genetic mouse models to dissect the roles of Mcl-1 in primary T lymphocytes. Using the inducible Mcl-1-floxed estrogen receptor-Cre fusion protein (Mcl-1(f/f)ERCre) deletion system in
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Sun-Hwa Shin, Won-Seok Choi · 2021 · Food Science of Animal Resources
This study examined the measurement conditions of the texture profile analysis (TPA) experiments that are typically used to measure the physical properties of sausage. As the measurement conditions (compression ratio and cross-head speed)…
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