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750 real negative results, null findings, and replication failures · Failed Experiment Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Failed Experiment ReportOpen accessMedicine

Effects of ischemic conditioning on head and neck free flap oxygenation: a randomized controlled trial

Se-Hee Min, Suk Hyung Choe, Won Shik Kim et al. · 2022 · Scientific Reports

Abstract Flap failure after microvascular reconstructive surgery is a rare but devastating complication caused by reperfusion injury and tissue hypoperfusion. Remote ischemic conditioning (RIC) provides protection against ischemia/reperfusion injury and reduces tissue infarction. We hypothesized that RIC would enhance flap oxygenation and exert organ-protective effects during head and neck free flap reconstructive surgery. Adult patients undergoing free flap transfer surgery for head and neck cancer were randomized to receive either RIC or sham-RIC during surgery. RIC consisted of four cycles

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Failed Experiment ReportOpen accessPublic aspects of medicine

The effectiveness of a pregnancy leaflt to promote health in Tshwane, South Africa

Susan C. Wright, Titilayo T. Biya, Majapi E. Chokwe · 2014 · Health SA Gesondheid: Journal of Interdisciplinary Health Sciences

Background: Pregnancy-related health education conveys basic information regarding healthy lifestyle choices and preventive healthcare in order to promote the health of the mother and foetus. Verbal education is supplemented frequently by means of healthpromotion leaflts. A pregnancy-related leaflt used in primary care clinics in Tshwane, South Africa titled: ‘Are you pregnant or planning to have a baby?’ was the focus of this research. Objectives: The study had two objectives, the fist of which was to explore whether the English pregnancy leaflt improved the knowledge of young female adults w

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Failed Experiment ReportOpen accessOphthalmology

CANBERRA: A Phase II Randomized Clinical Trial to Test the Therapeutic Potential of Oral Vicasinabin in Diabetic Retinopathy

Beatriz G. Armendariz, PhD, Ulrich F.O. Luhman, PhD, Brian Berger, MD et al. · 2025 · Ophthalmology Science

Objective: Nonproliferative diabetic retinopathy (NPDR) is a progressive disease that can lead to blindness. Current therapies for NPDR are invasive and not extensively used or accessible until the disease progresses, pointing to the need for an early noninvasive treatment. The objective of CANBERRA was to assess the safety, tolerability, and efficacy of oral administration of vicasinabin (RG7774) on the severity of diabetic retinopathy (DR) in participants with moderately severe to severe NPDR and good vision. Design: CANBERRA was a global, multicentric randomized, double-masked, parallel-gro

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Failed Experiment ReportOpen accessComputer Science

When Good Components Go Bad: Formally Secure Compilation Despite Dynamic Compromise

Carmine Abate, Arthur Azevedo de Amorim, Roberto Blanco et al. · 2018 · arXiv

We propose a new formal criterion for evaluating secure compilation schemes for unsafe languages, expressing end-to-end security guarantees for software components that may become compromised after encountering undefined behavior---for example, by accessing an array out of bounds. Our criterion is the first to model dynamic compromise in a system of mutually distrustful components with clearly specified privileges. It articulates how each component should be protected from all the others---in particular, from components that have encountered undefined behavior and become compromised. Each comp

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Failed Experiment ReportOpen accessComputer Science

Granularity Noise Limit in Atomic-Ensemble-Based Metrology

Chen-Rong Liu, Chuang Li, Runxia Tao et al. · 2026 · arXiv

Conventional noise analysis in atomic-ensemble sensing assumes a continuous-medium approximation, thereby treating the atomic system as a deterministic dielectric. Here, we demonstrate that this assumption breaks down due to the discrete, particulate nature of the ensemble, giving rise to an intrinsic "atomic granularity noise" (AGN) that fundamentally competes with the optical measurement noise (OMN, typically photon shot noise). By introducing a discrete-atom statistical framework, we derive a unified noise-scaling law governed by a single dimensionless resource ratio, $\mathcal{R} = \bar{N}

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Failed Experiment ReportOpen accessComputer Science

How to Fine-Tune a Reasoning Model? A Teacher-Student Cooperation Framework to Synthesize Student-Consistent SFT Data

Zixian Huang, Kaichen Yang, Xu Huang et al. · 2026 · arXiv

A widely adopted strategy for model enhancement is to use synthetic data generated by a stronger model for supervised fine-tuning (SFT). However, for emerging reasoning models like Qwen3-8B, this approach often fails to improve reasoning capabilities and can even lead to a substantial drop in performance. In this work, we identify substantial stylistic divergence between teacher generated data and the distribution of student as a major factor impacting SFT. To bridge this gap, we propose a Teacher-Student Cooperation Data Synthesis framework (TESSY), which interleaves teacher and student model

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Failed Experiment ReportOpen accessComputer Science

Token-Efficient RL for LLM Reasoning

Alan Lee, Harry Tong · 2025 · arXiv

We propose reinforcement learning (RL) strategies tailored for reasoning in large language models (LLMs) under strict memory and compute limits, with a particular focus on compatibility with LoRA fine-tuning. Building on early policy gradient methods with baseline subtraction, we design critic-free methods that operate on a small, informative subset of output tokens to reduce memory usage and stabilize training. We introduce S-GRPO, a stochastic variant of Group Relative Policy Optimization, and T-SPMO, a token-level prefix matching approach for fine-grained credit assignment. Applied to Qwen2

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Failed Experiment ReportOpen accessComputer Science

Significant improvement of lossy compression rate and speed of HPC data using perceptron parallelized compression

Xinzhe Chen, Jianjiang Li · 2023 · arXiv

The escalating surge in data generation presents formidable challenges to information technology, necessitating advancements in storage, retrieval, and utilization. With the proliferation of artificial intelligence and big data, the "Data Age 2025" report forecasts an exponential increase in global data production. The escalating data volumes raise concerns about efficient data processing. The paper addresses the predicament of achieving a lower compression ratio while maintaining or surpassing the compression performance of state-of-the-art techniques. This paper introduces a lossy compressio

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Failed Experiment ReportOpen accessPlant culture

Induction of somatic embryogenesis and cryopreservation of Abies pinsapo Boiss.

Laura Cabero-Moreno, Ignacio Landeras-López, María Victoria Bravo-Navas et al. · 2025 · Frontiers in Plant Science

Abies pinsapo is an endangered species, endemic to southern Spain. Somatic embryogenesis and cryopreservation constitute important biotechnological tools, which can be used in order to improve the management and conservation of threatened species. The objective of this work was to develop somatic embryogenesis and cryopreservation protocols for A. pinsapo. Somatic embryogenesis was induced from mature zygotic embryos of A. pinsapo cultured on solid MS medium with macroelements at half-strength and supplemented with 20 g L-1 sucrose and 5 mg L-1 6-benzylaminopurine (BA). Embryogenic cultures su

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Failed Experiment ReportOpen accessComputer Science

When Do LLM Agents Treat Surface Noise Differently from Semantic Noise? A 68-Cell Measurement Study with a Held-Out Trace-Level Validation

Liyun Zhang, Jiayi Guo · 2026 · arXiv

We document an empirical phenomenon in chain-of-thought and ReAct agents driven by ten large language models from seven architecture families: meaning-bearing perturbations (e.g., paraphrase, synonym) alter final answers more often than presentation perturbations (e.g., formatting, reordering) of comparable severity. Across 68 cells spanning GSM8K, MATH, and HotpotQA (1,530 originals and $\sim$11,150 variants), the inconsistency gap averages +19.69 pp after severity matching (paired $t=9.58$, $p<0.0001$), with 64/68 cells positive. The gap survives four severity-proxy audits and remains signif

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Failed Experiment ReportOpen accessPhysics

Self-interaction correction schemes for non-collinear spin-density-functional theory

Nicolas Tancogne-Dejean, Martin Lüders, Carsten A. Ullrich · 2023 · arXiv

We extend some of the well established self-interaction correction (SIC) schemes of density-functional theory to the case of systems with noncollinear magnetism. Our proposed SIC schemes are tested on a set of molecules and metallic clusters in combination with the widely used local spin-density approximation. As expected from the collinear SIC, we show that the averaged-density SIC works well for improving ionization energies but fails to improve more subtle quantities like the dipole moments of polar molecules. We investigate the exchange-correlation magnetic field produced by our extension

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Failed Experiment ReportOpen accessComputer Science

Evaluation and Improvement of Laruelle-Widgrén Inverse Banzhaf Approximation

Frits de Nijs, Daan Wilmer · 2012 · arXiv

The goal of this paper is to critically evaluate a heuristic algorithm for the Inverse Banzhaf Index problem by Laruelle and Widgrén. Few qualitative results are known about the approximation quality of the heuristics for this problem. The intuition behind the operation of this approximation algorithm is analysed and evaluated. We found that the algorithm can not handle general inputs well, and often fails to improve inputs. It is also shown to diverge after only tens of iterations. We present three alternative extensions of the algorithm that do not alter the complexity but can result in up t

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Failed Experiment ReportOpen accessPhysics

On the possibility of complete revivals after quantum quenches to a critical point

Khadijeh Najafi, M. A. Rajabpour · 2017 · arXiv

In a recent letter, J. Cardy, Phys. Rev. Lett. \textbf{112}, 220401 (2014), the author made a very interesting observation that complete revivals of quantum states after quantum quench can happen in a period which is a fraction of the system size. This is possible for critical systems that can be described by minimal conformal field theories (CFT) with central charge $c<1$. In this article, we show that these complete revivals are impossible in microscopic realizations of those minimal models. We will prove the absence of the mentioned complete revivals for the critical transverse field Ising

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Failed Experiment Report

Sainsbury’s Egyptian misadventure

· 2015 · Strategic Direction

Purpose – This paper aims to review the latest management developments across the globe and pinpoint practical implications from cutting-edge research and case studies. Design/methodology/approach – This briefing is prepared by an…

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Failed Experiment ReportMedicine

Dreaming up scale invariance via inverse renormalization group.

Rançon A, Rançon U, Ivek T et al. · 2026 · Physical review. E

We explore how minimal neural networks can invert the renormalization group (RG) coarse-graining procedure in the two-dimensional Ising model, effectively dreaming up microscopic configurations from coarse-grained states. This task,…

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Failed Experiment ReportMedicine

Efficacy and safety of adjunctive treatment with the fatty acid amide hydrolase inhibitor JNJ-42165279 in participants with major depressive disorder with anxious distress: A double-blind, placebo-controlled, randomised study.

Schmidt ME, Gargano C, Zhou X et al. · 2026 · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

JNJ-42165279 is a potent, selective inhibitor of fatty acid amide hydrolase (FAAH), the enzyme responsible for degradation of the endocannabinoid N-arachidonoylethanolamide (anandamide), which plays a role in regulation of fear and anxiety…

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Failed Experiment ReportOpen accessMedicine

Does the Fissure Last Technique Really Reduce Postoperative Airleak After Lung Resection? Results From a Prospective Randomized Controlled Trial.

Vaisitti F, Sobrero S, Rudella S et al. · 2026 · Interdisciplinary cardiovascular and thoracic surgery

Objectives The fissure last (FL) technique described in 1998 has the goal of minimizing postoperative airleak leaving the stapling of the fissure as the last step. The aim of this study was the reduction in airleak may be already evident…

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