Negative / Null Result ReportOpen accessMedicine
Miles Piper, Benjamin Van Court, Adam Mueller et al. · 2021 · Clinical Cancer Research
PURPOSE: Metastasis remains a major hurdle in treating aggressive malignancies such as pancreatic ductal adenocarcinoma (PDAC). Improving response to treatment, therefore, requires a more detailed characterization of the cellular…
View details →Negative / Null Result ReportOpen accessMedicine
Anna C. Navis, Sanne A. M. van Lith, Sander M. J. van Duijnhoven et al. · 2015 · Acta Neuropathologica
MET has gained interest as a therapeutic target for a number of malignancies because of its involvement in tumorigenesis, invasion and metastasis. At present, a number of inhibitors, both antibodies against MET or its ligand hepatocyte growth factor, and small molecule MET tyrosine kinase inhibitors are in clinical trials. We here describe a novel variant of MET that is expressed in 6% of high-grade gliomas. Characterization of this mutation in a glioma cell line revealed that it consists of an intronic deletion, resulting in a splice event connecting an intact splice donor site in exon 6 with
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sarah J. Higgins, Katharine He Xing, Hani Kim et al. · 2013 · Malaria Journal
BACKGROUND: Severe falciparum malaria (SM) pathogenesis has been attributed, in part, to deleterious systemic host inflammatory responses to infection. High mobility group box 1 (HMGB1) protein is an important mediator of inflammation implicated in sepsis pathophysiology. METHODS: Plasma levels of HMGB1 were quantified in a cohort of febrile Ugandan children with Plasmodium falciparum infection, enrolled in a prospective observational case-controlled study, using a commercial enzyme-linked immunosorbent assay. The utility of HMGB1 to distinguish severe malaria (SM; n = 70) from uncomplicated m
View details →Negative / Null Result ReportOpen accessMedicine
Khurum Khan, David Cunningham, Clare Peckitt et al. · 2016 · Oncotarget
// Khurum Khan 1 , David Cunningham 1 , Clare Peckitt 1 , Sarah Barton 1 , Diana Tait 1 , Maria Hawkins 1,2 , David Watkins 1 , Naureen Starling 1 , Sheela Rao 1 , Ruwaida Begum 1 , Janet Thomas 1 , Jacqui Oates 1 , Vincenza Guzzardo 3 , Matteo Fassan 3 , Chiara Braconi 1,4 and Ian Chau 1 1 Gastrointestinal Unit, The Royal Marsden NHS Foundation Trust, Sutton, UK 2 CRUK/MRC Oxford Institute for Radiation Oncology, Gray Laboratories, University of Oxford, Oxford, UK 3 Department of Medicine, University of Padua, Padua, IT 4 Division of Cancer Therapeutics, The Institute of Cancer Research, Sutt
View details →Negative / Null Result ReportMedicine
Ian R. Nelson, Jason Chen, Rebecca Love et al. · 2016 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: Anterior cruciate ligament reconstructions (ACLRs) in skeletally immature patients are increasing. The purpose of this study is to describe the demographics, graft usage, revision, and re-operation rates in skeletally immature…
View details →Negative / Null Result ReportOpen accessMedicine
Bengt Sorbe, CHRISTIAN JURESTA, Cecilia Ahlin · 2014 · Oncology Letters
The aim of the present study was to evaluate the natural history of endometrial cancer recurrences with regard to predictive and prognostic factors. Between 1990 and 1999, 100 patients were treated for recurrences of endometrial carcinoma…
View details →Negative / Null Result ReportOpen accessMedicine
Gonçalo N. Petrucci, Joaquim Henriques, Hugo Gregório et al. · 2020 · Journal of Feline Medicine and Surgery
Objectives Although feline mammary carcinomas (FMCs) are highly metastatic, the literature and treatment options pertaining to advanced tumours are scarce. This study aimed to investigate the clinical outcome of metastatic FMC with or…
View details →Negative / Null Result ReportOpen accessMedicine
Hye Jun Lee, Jae Eun Lee, Seung‐Yup Ku et al. · 2013 · Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine
OBJECTIVE: To investigate the influence of laparoscopic surgery on the natural conception rate in infertile women with endometriosis during the first year after the operation. METHODS: We retrospectively studied 43 infertile women with…
View details →Negative / Null Result ReportNeuroscience
Scott J. Young, Matteo Bertucco, Rebecca Sheehan-Stross et al. · 2012 · Journal of Child Neurology
Studies suggest that dystonia is associated with increased motor cortex excitability. Cathodal transcranial direct current stimulation can temporarily reduce motor cortex excitability. To test whether stimulation of the motor cortex can…
View details →Negative / Null Result ReportOpen accessMedicine
Ziad S. Saad, Derrek P. Hibar, Maggie Fedgchin et al. · 2020 · The International Journal of Neuropsychopharmacology
BACKGROUND: At ketamine and esketamine doses at which antidepressant doses are achieved, these agents are relatively selective, noncompetitive, N-methyl-D-aspartate receptor antagonists. However, at substantially higher doses, ketamine has…
View details →Negative / Null Result ReportOpen accessMedicine
Fulya Akpinar, Andrea C. Timm, John Yin · 2015 · Journal of Virology
UNLABELLED: Defective interfering particles (DIPs) are virus mutants that lack essential genes for growth. In coinfections with helper virus, the diversion of viral proteins to the replication and packaging of DIP genomes can interfere…
View details →Negative / Null Result ReportOpen accessNeuroscience
Jussi Palomäki, Anton Kunnari, Marianna Drosinou et al. · 2018 · Heliyon
The uncanny valley (UV) effect refers to an eerie feeling of unfamiliarity people get while observing or interacting with robots that resemble humans almost but not quite perfectly. The effect is not well understood, and it is also unclear…
View details →Negative / Null Result ReportOpen accessNeuroscience
Mürşide Değirmenci, Yılmaz Kemal Yüce, Matjaž Perc et al. · 2023 · Frontiers in Human Neuroscience
In recent studies, in the field of Brain-Computer Interface (BCI), researchers have focused on Motor Imagery tasks. Motor Imagery-based electroencephalogram (EEG) signals provide the interaction and communication between the paralyzed patients and the outside world for moving and controlling external devices such as wheelchair and moving cursors. However, current approaches in the Motor Imagery-BCI system design require effective feature extraction methods and classification algorithms to acquire discriminative features from EEG signals due to the non-linear and non-stationary structure of EEG
View details →Negative / Null Result ReportDecision Sciences
Vikram M. Narayan, Shreyas Gandhi, Kristin Chrouser et al. · 2018 · British Journal of Urology
OBJECTIVES: To use the Fragility Index to evaluate the robustness of statistically significant findings from urological randomised controlled trials (RCTs). MATERIALS AND METHODS: The 'Fragility Index' is defined as the minimum number of…
View details →Negative / Null Result ReportOpen accessComputer Science
Sung-Min Kim, Yosoon Choi · 2017 · International Journal of Environmental Research and Public Health
To develop appropriate measures to prevent soil contamination in abandoned mining areas, an understanding of the spatial variation of the potentially toxic trace elements (PTEs) in the soil is necessary. For the purpose of effective soil sampling, this study uses hot spot analysis, which calculates a z-score based on the Getis-Ord Gi* statistic to identify a statistically significant hot spot sample. To constitute a statistically significant hot spot, a feature with a high value should also be surrounded by other features with high values. Using relatively cost- and time-effective portable X-r
View details →Negative / Null Result ReportOpen accessArts and Humanities
Jack Grieve · 2021 · Linguistics
Abstract In this paper, I propose that replication failure in linguistics may be due primarily to inherent issues with the application of experimental methods to analyze an inextricably social phenomenon like language, as opposed to poor…
View details →Negative / Null Result ReportOpen accessMedicine
Juliane Jaitner, Tanja Morath, Robert A. Byrne et al. · 2012 · Circulation Cardiovascular Interventions
BACKGROUND: The prodrug clopidogrel requires intestinal absorption by the efflux pump P-glycoprotein MDR1 (multidrug resistant-1), encoded by the ABCB1 gene. Prior studies suggested that a common and functional genetic variant (C3435T,…
View details →Negative / Null Result ReportOpen accessMedicine
Sarah Cockayne, Caroline Fairhurst, Joy Adamson et al. · 2017 · Trials
BACKGROUND: Randomised controlled trials are generally regarded as the 'gold standard' experimental design to determine the effectiveness of an intervention. Unfortunately, many trials either fail to recruit sufficient numbers of participants, or recruitment takes longer than anticipated. The current embedded trial evaluates the effectiveness of optimised patient information sheets on recruitment of participants in a falls prevention trial. METHODS: A three-arm, embedded randomised methodology trial was conducted within the National Institute for Health Research-funded REducing Falls with ORth
View details →Negative / Null Result ReportOpen accessPsychology
Lisa M. DeBruine, Benedict C. Jones, David A. Frederick et al. · 2010 · Evolutionary Psychology
Over the last decade, a growing literature has shown that women in the fertile phase of the menstrual cycle demonstrate stronger preferences for men with masculine traits than they do when in the non-fertile phases of the cycle (see…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Salim Khan, Wang Yahong · 2021 · Frontiers in Environmental Science
Several researchers have studied the relationship between poverty and environmental degradation, as these concerns are remained at top priority in achieving Sustainable Development Goals (SDGs). However, the symmetric and asymmetric impact of poverty and income inequality along with population and economic growth on carbon emissions (CO 2 e) has not been studied in the case of Pakistan. For this purpose, the short and long-run impact of poverty, income inequality, population, and GDP per capita on CO 2 e investigated by applying the Autoregressive Distributive Lag (ARDL) along with Non-linear
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Haidong Zheng, Yue Zhang · 2016 · Chinese Management Studies
Purpose The purpose of this paper is to explore the relationship between firm size, the nature of ownership and corporate social responsibility (CSR) performance in China and to figure out the reason that state-owned enterprises (SOEs)…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Ulrike Fasbender, Anne Burmeister, Mo Wang · 2023 · Journal of Vocational Behavior
In this paper, we investigate the risks and side effects of workplace friendships for coworkers. Combining the dialectical perspective on workplace friendships with a self-regulatory perspective, we argue that workplace friendships can…
View details →Negative / Null Result ReportOpen accessHealth Professions
Hamzah Abdul Rahman, Mu’taman Jarrar, Mohammad Sobri Don · 2015 · Global Journal of Health Science
BACKGROUND AND OBJECTIVE: Nursing knowledge and skills are required to sustain quality of care and patient safety. The numbers of nurses with Bachelor degrees in Malaysia are very limited. This study aims to predict the impact of nurse level of education on quality of care and patient safety in the medical and surgical wards in Malaysian private hospitals. METHODOLOGY: A cross-sectional survey by questionnaire was conducted. A total 652 nurses working in the medical and surgical wards in 12 private hospitals were participated in the study. Multistage stratified simple random sampling performed
View details →Negative / Null Result ReportOpen accessNeuroscience
Jessica E. Salvatore, Alexis C. Edwards, Jeanette N. McClintick et al. · 2015 · Translational Psychiatry
Adult antisocial behavior (AAB) is moderately heritable, relatively common and has adverse consequences for individuals and society. We examined the molecular genetic basis of AAB in 1379 participants from a case-control study in which the cases met criteria for alcohol dependence. We also examined whether genes of interest were expressed in human brain. AAB was measured using a count of the number of Antisocial Personality Disorder criteria endorsed under criterion A from the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV). Participants were genotyped on the Illumi
View details →Negative / Null Result ReportSocial Sciences
Jolanda Jetten, S. Alexander Haslam, Fiona Kate Barlow · 2012 · Social Psychological and Personality Science
Why are conservatives happier than liberals? Napier and Jost (2008) argue that this is because conservative ideology has a palliative (system-justifying) function that protects conservatives’ (but not liberals’) happiness. We develop…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Fei Tian, Yanting Shen, Zhenzhu Chen et al. · 2017 · BioMed Research International
BACKGROUND: MicroRNAs (miRNAs) are small noncoding RNAs that are involved in many biological regulation processes. Studies have reported that miRNAs are enriched in human plasma and plasma-derived exosome as novel diagnostic biomarkers. The aim of this study was to determine whether the miRNA expression levels are different between plasma and plasma-derived exosome. METHODS: We sequenced and quantified the miRNAs in plasma and exosome from healthy blood samples and validated three miRNAs in the two groups of lung cancer samples by qRT-PCR. RESULTS: The sequencing results showed that only sever
View details →Negative / Null Result ReportOpen accessMedicine
Reina Yamaji, Shinya Yamada, Mai Quynh Le et al. · 2015 · Journal of Virology
UNLABELLED: Highly pathogenic H5N1 avian influenza viruses have caused outbreaks among poultry worldwide, resulting in sporadic infections in humans with approximately 60% mortality. However, efficient transmission of H5N1 viruses among…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Amparo Ferrero, Ana Esplugues, Marisa Estarlich et al. · 2017 · Environmental Pollution
derived from a lifetime risk of leukemia above 1/100 000. Monitoring season, maternal country of birth and parental tobacco consumption were associated with residential benzene exposure (indoor and outdoors). Additionally, indoor levels…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Chunyan Wang, Bernardo A. Huberman · 2012 · Scientific Reports
The massive amounts of data that social media generates has facilitated the study of online human behavior on a scale unimaginable a few years ago. At the same time, the much discussed apparent randomness with which people interact online…
View details →Negative / Null Result ReportOpen accessPsychology
Glenn I. Roisman, Cathryn Booth‐LaForce, Jay Belsky et al. · 2013 · Attachment & Human Development
This paper advises caution in relation to the increasing interest in molecular-genetic association studies in developmental psychology based on a set of empirical examples from the NICHD Study of Early Child Care and Youth Development…
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