Negative / Null Result ReportOpen accessMedicine
Sriram Balusu, Bart De Strooper · 2024 · Acta Neuropathologica
Although apoptosis, pyroptosis, and ferroptosis have been implicated in AD, none fully explains the extensive neuronal loss observed in AD brains. Recent evidence shows that necroptosis is abundant in AD, that necroptosis is closely linked to the appearance of Tau pathology, and that necroptosis markers accumulate in granulovacuolar neurodegeneration vesicles (GVD). We review here the neuron-specific activation of the granulovacuolar mediated neuronal-necroptosis pathway, the potential AD-relevant triggers upstream of this pathway, and the interaction of the necrosome with the endo-lysosomal p
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Manish R. Patel, Gerald S. Falchook, K Hamada et al. · 2021 · Cancer Medicine
Abstract Background Microsatellite‐stable (MSS) colorectal cancer (CRC) tends to be poorly immunogenic, with limited treatment options. In MSS CRC xenograft models, trifluridine/tipiracil (FTD/TPI) plus programed death 1 inhibitors resulted in synergistic antitumor activity and increased tumor immunogenicity. This phase 2 study evaluated FTD/TPI plus nivolumab in patients with MSS metastatic CRC. Methods This single‐arm, safety lead‐in study used a Simon's two‐stage design (enrolling 6 patients in the safety lead‐in, proceeding to stage 2 if ≥2 of the first 15 patients achieved a partial or co
View details →Negative / Null Result ReportOpen accessNursing
Tae Gun Shin, Youn‐Jung Kim, Seung Mok Ryoo et al. · 2019 · Journal of Clinical Medicine
Background: Intravenous vitamin C and thiamine administration may be a potential adjuvant therapy for septic shock. We aimed to investigate the impact of early vitamin C and thiamine administration in septic shock patients. Methods: This retrospective before-and-after cohort study used data extracted from the Korean Shock Society’s prospective septic shock registry. We compared 28-day and in-hospital mortality rates between patients treated with intravenous vitamin C (3 g/12 h or 1.5 g/6 h) and thiamine (200 mg/12 h) <6 h after shock recognition from July through December 2017 (n = 229) and
View details →Negative / Null Result ReportOpen accessMedicine
M. J. Ryan, Holly Morgan, Amedeo Chiribiri et al. · 2021 · European Heart Journal
Patients with ischaemic left ventricular dysfunction frequently undergo myocardial viability testing. The historical model presumes that those who have extensive areas of dysfunctional-yet-viable myocardium derive particular benefit from…
View details →Negative / Null Result ReportOpen accessMedicine
Christoph Röllig, Hubert Serve, Richard Noppeney et al. · 2021 · Leukemia
Early results of the randomized placebo-controlled SORAML trial showed that, in patients with newly diagnosed acute myeloid leukaemia (AML), sorafenib led to a significant improvement in event-free (EFS) and relapse-free survival (RFS). In order to describe second-line treatments and their implications on overall survival (OS), we performed a study after a median follow-up time of 78 months. Newly diagnosed fit AML patients aged ≤60 years received sorafenib (n = 134) or placebo (n = 133) in addition to standard chemotherapy and as maintenance treatment. The 5-year EFS was 41 versus 27% (HR 0.6
View details →Negative / Null Result ReportMedicine
Alice Monzani, Anna Rapa, P Fonio et al. · 2011 · Journal of Pediatric Gastroenterology and Nutrition
OBJECTIVE: The aim of this study was to evaluate performance of serum antibodies against deamidated gliadin peptides (a-DGPs) in detecting compliance with gluten-free diet (GFD) in children with celiac disease (CD). PATIENTS AND METHODS:…
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Chaolong Wang, Kari B Schroeder, Noah A Rosenberg · 2012 · Genetics
Abstract Allelic dropout is a commonly observed source of missing data in microsatellite genotypes, in which one or both allelic copies at a locus fail to be amplified by the polymerase chain reaction. Especially for samples with poor DNA…
View details →Negative / Null Result ReportBusiness, Management and Accounting
Thilo Kunkel, Matthew Walker, Courtney Hodge · 2018 · European Sport Management Quarterly
Research question: Analogous to traditional brands, athlete (i.e. personal) brands require management and maintenance. While the use of athlete endorsers is an effective marketing strategy for companies wanting to increase visibility,…
View details →Negative / Null Result ReportOpen accessMedicine
Levent Dizdar, Georg Fluegen, Guus van Dalum et al. · 2019 · Molecular Oncology
The GILUPI CellCollector (CC) is a novel in vivo circulating tumor cell (CTC) detection device reported to overcome the limitations of small blood sample volumes. The aim of this prospective, blinded study was to evaluate the clinical application of the CC and to compare its performance to the CellSearch (CS) system in M0 and M1 colorectal cancer (CRC) patients. A total of 80 patients (31 M0, 49 M1) with CRC were enrolled. CTCs were simultaneously measured in the peripheral blood using CS and the CC, and the results of both assays were correlated to clinicopathological variables and overall su
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Philipp Brun, Thomas Kiørboe, Priscilla Licandro et al. · 2016 · Global Change Biology
Statistical species distribution models (SDMs) are increasingly used to project spatial relocations of marine taxa under future climate change scenarios. However, tests of their predictive skill in the real-world are rare. Here, we use…
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Kotaro Makino, Kosaku Kato, Keisuke Takano et al. · 2018 · Scientific Reports
Abstract With rapid advances occurring in terahertz (THz) radiation generation techniques, the interaction between matter and intense THz fields has become an important research topic. Among different types of THz radiation sources, the…
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Marcelo Cajias, Franz Fuerst, Patrick McAllister et al. · 2014 · International Journal of Strategic Property Management
This paper investigates the relationship between corporate social and environmental performance and financial performance for a sample of publicly traded US real estate companies. Using the MSCI ESG (formerly KLD) database on seven…
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Harald Zandler, Thomas Senftl, Kim André Vanselow · 2020 · Scientific Reports
Abstract Global environmental research requires long-term climate data. Yet, meteorological infrastructure is missing in the vast majority of the world’s protected areas. Therefore, gridded products are frequently used as the only…
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EDWARD LEE, NORMAN STRONG, ZHENMEI (JUDY) ZHU · 2014 · Journal of Accounting Research
ABSTRACT Between 2000 and 2003 a series of disclosure and analyst regulations curbing abusive financial reporting and analyst behavior were enacted to strengthen the information environment of U.S. capital markets. We investigate whether…
View details →Negative / Null Result ReportOpen accessMedicine
Carla Wunderle, Franziska Stumpf, Philipp Schüetz · 2024 · Journal of Parenteral and Enteral Nutrition
The complex interplay between nutrition and inflammation has become a major focus of research in recent years across different clinical settings and patient populations. Inflammation has been identified as a key driver for disease-related…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Stéphanie Gaillard, Marianna Zahurak, Anup Sharma et al. · 2019 · Cancer
BACKGROUND: Epigenetic abnormalities are manifold in all solid tumors and include changes in chromatin configuration and DNA methylation. The authors designed a phase 1 study to evaluate the oral DNA methyltransferase inhibitor CC-486…
View details →Negative / Null Result ReportOpen accessMedicine
Jolien Schildermans, Greet De Vlieger · 2020 · Frontiers in Medicine
Cytomegalovirus (CMV) is one of the most pathogenic viruses in human. After a primary infection, CMV resides in the host for life as a latent infection. When immunity is reduced, CMV can escape the suppressive effects of the immune system and lead to viremia and antigenemia. This reactivation, first seen in transplant patients, has also been documented in non-immunocompromised CMV-seropositive critically ill patients and is associated with higher morbidity and mortality. In the latter, it is not clear whether CMV reactivation is an innocent bystander or the cause of this observed worse outcome
View details →Negative / Null Result ReportOpen accessMedicine
Wei‐Cheng Lin, Yi‐Fang Ding, Han‐Lin Hsu et al. · 2017 · Cancer
BACKGROUND: Few large, prospective, randomized studies have investigated the value and optimal application of neoadjuvant chemoradiotherapy followed by surgery (trimodality therapy) or definitive concurrent chemoradiotherapy (CCRT) for patients with thoracic esophageal squamous cell carcinoma (TESCC). METHODS: The authors analyzed data from patients with TESCC in the Taiwan Cancer Registry database. To compare their outcomes, patients with TESCC were enrolled and categorized into the following groups according to treatment modality: group 1, those who underwent surgery alone; group 2, those wh
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James R. Slauterbeck, Rebecca Choquette, Timothy W. Tourville et al. · 2019 · The American Journal of Sports Medicine
Background: Lower extremity injuries are common in high school sports and are costly, and some have poor outcomes. The FIFA 11+ injury prevention program has been shown to decrease injuries in elite athletes by up to 72%. Hypothesis: High…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Charlotte Brierley, Cristina Castilla‐Llorente, Myriam Labopin et al. · 2018 · Journal of Crohn s and Colitis
BACKGROUND AND AIMS: Autologous haematopoietic stem cell transplantation [AHSCT] is a therapeutic option for patients with severe, treatment-refractory Crohn's disease [CD]. The evidence base for AHSCT for CD is limited, with one…
View details →Negative / Null Result ReportOpen accessMedicine
Mira Johri, Valéry Ridde, Rolf Heinmüller et al. · 2014 · Bulletin of the World Health Organization
OBJECTIVE: To estimate the impact on maternal and child mortality after eliminating user fees for pregnant women and for children less than five years of age in Burkina Faso. METHODS: Two health districts in the Sahel region eliminated user fees for facility deliveries and curative consultations for children in September 2008. To compare health-care coverage before and after this change, we used interrupted time series, propensity scores and three independent data sources. Coverage changes were assessed for four variables: women giving birth at a health facility, and children aged 1 to 59 mont
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Brit Mollenhauer, Frederick DuBois Bowman, Daniel Drake et al. · 2018 · Journal of Neurochemistry
Abstract α‐Synuclein is the major component of Lewy bodies and a candidate biomarker for neurodegenerative diseases in which Lewy bodies are common, including Parkinson's disease and dementia with Lewy bodies. A large body of literature suggests that these disorders are characterized by reduced concentrations of α‐synuclein in cerebrospinal fluid (CSF), with overlapping concentrations compared to healthy controls and variability across studies. Several reasons can account for this variability, including technical ones, such as inter‐assay and inter‐laboratory variation (reproducibility). We co
View details →Negative / Null Result ReportOpen accessNeuroscience
Adrienne L. Romer, Annchen R. Knodt, Maria L. Sison et al. · 2019 · Molecular Psychiatry
Transdiagnostic research has identified a general psychopathology factor-often called the 'p' factor-that accounts for shared variation across internalizing, externalizing, and thought disorders in diverse samples. It has been argued that the p factor may reflect dysfunctional thinking present in serious mental illness. In support of this, we previously used a theory-free, data-driven multimodal neuroimaging approach to find that higher p factor scores are associated with structural alterations within a cerebello-thalamo-cortical circuit (CTCC) and visual association cortex, both of which are
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Yonghui Zhang, Feng Cheng, Xueting Du et al. · 2016 · Oncotarget
// Yong-Hui Zhang 1 , Feng Cheng 1 , Xue-Ting Du 1 , Jin-Lai Gao 1 , Xiao-Lin Xiao 1 , Na Li 1 , Shan-Liang Li 1 and De-Li Dong 1 1 Department of Pharmacology (The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin Medical University, Harbin, P.R.China Correspondence to: De-Li Dong, email: // Keywords : bone morphogenetic protein 11, growth differentiation factor 11, smad2/3, smad1/5/8,
View details →Negative / Null Result ReportOpen accessPsychology
Warren Tierney, Jay H. Hardy, Charles R. Ebersole et al. · 2020 · Journal of Experimental Social Psychology
How can we maximize what is learned from a replication study? In the creative destruction approach to replication, the original hypothesis is compared not only to the null hypothesis, but also to predictions derived from multiple alternative theoretical accounts of the phenomenon. To this end, new populations and measures are included in the design in addition to the original ones, to help determine which theory best accounts for the results across multiple key outcomes and contexts. The present pre-registered empirical project compared the Implicit Puritanism account of intuitive work and sex
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Daniel Romero-Álvarez, A. Townsend Peterson, Johanna S. Salzer et al. · 2020 · PLoS neglected tropical diseases
BACKGROUND: Bacillus cereus biovar anthracis (Bcbva) is an emergent bacterium closely related to Bacillus anthracis, the etiological agent of anthrax. The latter has a worldwide distribution and usually causes infectious disease in mammals associated with savanna ecosystems. Bcbva was identified in humid tropical forests of Côte d'Ivoire in 2001. Here, we characterize the potential geographic distributions of Bcbva in West Africa and B. anthracis in sub-Saharan Africa using an ecological niche modeling approach. METHODOLOGY/PRINCIPAL FINDINGS: Georeferenced occurrence data for B. anthracis and
View details →Negative / Null Result ReportOpen accessSocial Sciences
Myra Cheng, Cinoo Lee, Pranav Khadpe et al. · 2026 · Science
Despite rising concerns about sycophancy—excessive agreement or flattery from artificial intelligence (AI) systems—little is known about its prevalence or consequences. We show that sycophancy is widespread and harmful. Across 11 state-of-the-art models, AI affirmed users’ actions 49% more often than humans, even when queries involved deception, illegality, or other harms. In three preregistered experiments ( N = 2405), even a single interaction with sycophantic AI reduced participants’ willingness to take responsibility and repair interpersonal conflicts, while increasing their conviction tha
View details →Negative / Null Result ReportOpen accessMathematics
Rink Hoekstra, Rei Monden, Don van Ravenzwaaij et al. · 2018 · PLoS ONE
Efficient medical progress requires that we know when a treatment effect is absent. We considered all 207 Original Articles published in the 2015 volume of the New England Journal of Medicine and found that 45 (21.7%) reported a null result for at least one of the primary outcome measures. Unfortunately, standard statistical analyses are unable to quantify the degree to which these null results actually support the null hypothesis. Such quantification is possible, however, by conducting a Bayesian hypothesis test. Here we reanalyzed a subset of 43 null results from 36 articles using a default
View details →Negative / Null Result ReportOpen accessMedicine
Y Yamamura, Chisa Nakashima, Atsushi Otsuka · 2024 · Frontiers in Medicine
The pathogenesis of atopic dermatitis (AD) is understood to be crucially influenced by three main factors: dysregulation of the immune response, barrier dysfunction, and pruritus. In the lesional skin of AD, various innate immune cells, including Th2 cells, type 2 innate lymphoid cells (ILC2s), and basophils, produce Th2 cytokines [interleukin (IL)-4, IL-5, IL-13, IL-31]. Alarmins such as TSLP, IL-25, and IL-33 are also produced by epidermal keratinocytes, amplifying type 2 inflammation. In the chronic phase, not only Th2 cells but also Th22 and Th17 cells increase in number, leading to suppre
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Emily N. C. Manoogian, Michael J. Wilkinson, Monica A. O'Neal et al. · 2024 · Annals of Internal Medicine
BACKGROUND: Time-restricted eating (TRE), limiting daily dietary intake to a consistent 8 to 10 hours without mandating calorie reduction, may provide cardiometabolic benefits. OBJECTIVE: To determine the effects of TRE as a lifestyle…
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