A phase 1 trial of the oral DNA methyltransferase inhibitor CC‐486 and the histone deacetylase inhibitor romidepsin in advanced solid tumors
Stéphanie Gaillard; Marianna Zahurak; Anup Sharma; Jennifer N. Durham; Kim A. Reiss; Susan Sartorius‐Mergenthaler; Melinda Downs; Nicole M. Anders · 2019 · Cancer
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
BACKGROUND: Epigenetic abnormalities are manifold in all solid tumors and include changes in chromatin configuration and DNA methylation. The authors designed a phase 1 study to evaluate the oral DNA methyltransferase inhibitor CC-486…
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Metadata source: OpenAlex · DOI 10.1002/cncr.32138