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Browse the failure-mode index

19,915 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

A Retrospective Study of Outcome Predictive Models for Anterior Circulation Stroke Post Endovascular Thrombectomy: Are CT-Derived Morphomics Useful?

Manole C, Shet S, O Apos Brien A et al. · 2026 · Cerebrovascular diseases extra

Introduction In acute ischaemic stroke secondary to a large vessel occlusion, endovascular thrombectomy (EVT) is the standard of care. However, prediction of functional outcomes following EVT remains challenging. We sought to determine…

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Negative / Null Result ReportMedicine

CT-confirmed union rates following ankle and hindfoot arthrodesis with and without biological augmentation: A retrospective series.

Matheron G, Pearse R, Dellis S et al. · 2026 · Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons

Background Nonunion remains a major complication after ankle and hindfoot arthrodesis. Biologic augmentation is frequently used to mitigate this risk, but incremental benefit remains unproven. This study evaluated CT-verified union rates…

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Negative / Null Result Report

Evaluating eDNA Detection from Live and Dead Control Sources

Blankenship SM, Dean C, Karpenko K et al. · 2026 · Preprint

Environmental DNA (eDNA) methods offer a powerful tool for monitoring aquatic species, yet field applications remain challenged by uncertainty in DNA transport, mixing, and detection, particularly in flowing or tidally influenced systems.…

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Negative / Null Result ReportOpen accessMedicine

Effect of Phantom Containing Implants Angulation on the Amount of Metal Artifacts Around the Implants in CBCT Images.

Valizadeh S, Moshfeghi M, Bahrani Z et al. · 2026 · International journal of dentistry

Objective Artifacts from dental implants impact the clarity of cone-beam computed tomography (CBCT) scans, posing challenges to radiographic detection in adjacent areas. The aim of this in vitro study is to examine the effect of angling a…

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Negative / Null Result ReportMedicine

Monocyte-Containing Inflammatory Indices Show Stronger Association with 30-Day Mortality than the Systemic Immune-Inflammation Index in Elderly Sepsis: A Single-Center Retrospective Observational Cohort Study.

Irimie AI, Dinescu SN, Novac MB et al. · 2026 · Journal of clinical medicine

Background . Hematological inflammatory indices from the complete blood count have been proposed as inexpensive prognostic markers in sepsis. The systemic immune-inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR) are the…

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Negative / Null Result ReportMedicine

Postoperative duloxetine administration did not significantly modify overall pain trajectories following high tibial osteotomy: An open-label randomized controlled trial.

Sengoku M, Ogawa H, Nakamura Y et al. · 2026 · Journal of orthopaedic surgery (Hong Kong)

BackgroundDuloxetine is a potent analgesic that reduces pain associated with knee osteoarthritis. This study aimed to evaluate the analgesic effects of regular postoperative duloxetine after high tibial osteotomy (HTO) and its influence on…

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Negative / Null Result ReportMedicine

Impact of resistant starch from high amylose wheat compared to inulin on human gut microbiota and host immune responses using an artificial colon associated to human leukocytes.

Couturier I, Denis S, Rossary A et al. · 2026 · Food chemistry

Cooked High Amylose Wheat (HAW) products are dietary sources of resistant starch (RS). While its effects on gut microbiota are known, links to immune responses remain unclear. This study evaluated the antioxidant and anti-inflammatory…

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Negative / Null Result Report

Ergothioneine, alone or combined with vitamin K2, vitamin D3 and magnesium L-threonate, attenuates bone turnover, inflammatory and oxidative disturbances in ovariectomized mice

Liu W, Tang Y, Ding W et al. · 2026 · Preprint

Purpose: Estrogen deficiency drives bone loss through a complex interplay of endocrine, oxidative, inflammatory, and bone-remodeling disturbances. Ergothioneine (EGT) is a diet-derived thiol/thione antioxidant, yet its effects on the…

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Negative / Null Result ReportMedicine

Short-term intraocular pressure changes following intravitreal aflibercept 8 mg versus 2 mg in diabetic macular edema: a prospective observational study.

Hoshiyama K, Hirano T, Sekiya E et al. · 2026 · Scientific reports

This prospective observational study evaluated short-term intraocular pressure (IOP) changes and safety following intravitreal injection of aflibercept 8 mg versus 2 mg in diabetic macular edema (DME). We included 40 eyes from 36 patients…

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Negative / Null Result ReportMedicine

The impact of the vaginal birth after cesarean as a new delivery mode on quality of life, sexual function, sleep quality and urinary incontinence during the postpartum period and comparison with the results of vaginal birth and cesarean delivery.

Bektaş B, Ulusoy CO, Uslu H et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Objective In the present study, we aimed to evaluate the impact of vaginal birth after cesarean (VBAC) on quality of life, sexual function, sleep quality, and urinary incontinence and compare the results with those of vaginal birth (VB)…

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Negative / Null Result ReportMedicine

Comprehensive assessment of hyperoside: cytotoxic, anti-cancer, genoprotective, radical scavenging and computational toxicity properties through <i>in vitro</i> and <i>in silico</i> approaches.

Burgazli AY, Avuloglu Yilmaz E, Mamur S et al. · 2026 · Toxicology mechanisms and methods

Hyperoside (HYP), a plant-derived flavonoid, was evaluated for its cytotoxic, anti-cancer, genotoxic, antigenotoxic, and antioxidant properties, and potential mechanisms of action using an integrated in vitro and in silico approach.…

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Negative / Null Result ReportMedicine

<i>SLC28A3 </i>expression and fludarabine-emergent autoimmune hemolytic anemia in chronic lymphocytic leukemia: A new player in an old equation.

Vukovic V, Karan-Djurasevic T, Antic D et al. · 2026 · Biomolecules & biomedicine

Fludarabine treatment in patients with chronic lymphocytic leukemia (CLL) has been associated with immune dysregulation and the development of autoimmune hemolytic anemia (AIHA). Prior research indicates a potential correlation between the…

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Negative / Null Result ReportMedicine

Mechanisms Linking Bonding and Bridging Social Capital and Self-Rated Health Among U.S. Refugees: A Structural Equation Modeling Approach.

Thapa K, R Iyer A, A Cruz-Gonzalez M et al. · 2026 · Journal of racial and ethnic health disparities

Background Refugees often experience disruptions in social networks after resettlement. This study examined associations between bonding (within-group) and bridging (across-group) social capital and self-rated health among resettled U.S.…

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Negative / Null Result ReportMedicine

Effects of xylazine on blood biochemical, oxidative, and haematological to responses to transport distance stress in day-old broiler chicks.

Abdulameer HS, Zarrinkavyani K, Fathi M et al. · 2026 · Poultry science

Transport of day-old chicks is a major concern in the poultry industry, as it induces stress that can impair performance and health. This study investigated whether xylazine, an alpha-2 adrenergic agonist that reduces metabolic rate, could…

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Negative / Null Result ReportMedicine

Accuracy of full-arch digital implant impression and bite registration: effect of different reference object strategies and intraoral scanners.

Rutkūnas V, Kubilius A, Akulauskas M et al. · 2026 · Journal of dentistry

Objectives This in vitro study evaluated the accuracy of digital impressions for full-arch implantsupported restorations by assessing scan body (SB) positional accuracy and inter-arch registration under different intraoral scanners (IOS)…

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Negative / Null Result ReportMedicine

Does the methane-mitigating feed additive 3-nitrooxypropanol affect additive genetic variance and ranking of methane and yield traits in Holstein dairy cows?

Stephansen RB, Lassen J, Lund MS et al. · 2026 · Journal of dairy science

This study aimed to quantify the effect of the methane-mitigating feed additive 3-NOP on genetic parameters and potential genotype-by-environment (G × E) interaction for gas emission traits, i.e., methane (CH 4 ) and, carbon dioxide (CO 2…

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