Negative / Null Result ReportOpen accessMedicine
Katherine D. LaClair, Kebreten F. Manaye, Dexter L. Lee et al. · 2013 · Molecular Neurodegeneration
BACKGROUND: Though the precise cause(s) of Alzheimer's disease (AD) remain unknown, there is strong evidence that decreased clearance of β-amyloid (Aβ) from the brain can contribute to the disease. Therapeutic strategies to promote natural Aβ clearance mechanisms, such as the protein apolipoprotein-E (APOE), hold promise for the treatment of AD. The amount of APOE in the brain is regulated by nuclear receptors including retinoid X receptors (RXRs). Drugs that activate RXRs, including bexarotene, can increase APOE and ABCA1 production, and have been shown to decrease the Aβ burden and improve c
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Jean‐Frédéric Morin, Sikina Jinnah · 2018 · Environmental Politics
The regulatory contribution that preferential trade agreements (PTAs) make to global climate governance is assessed through an analysis of climate-related provisions found in 688 PTAs signed between 1947 and 2016. Provisions are analyzed…
View details →Negative / Null Result ReportSocial Sciences
Joseph Raffiee, Heejung Byun · 2019 · Academy of Management Journal
This study revisits the portability of performance paradox—the common finding that external hires fail to replicate prior performance after switching firms—by examining how the nature of an employee’s human capital and social capital…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
L. Easy, F. Militello, John Omotani et al. · 2014 · Physics of Plasmas
This paper presents simulations of isolated 3D filaments in a slab geometry obtained using a newly developed 3D reduced fluid code, written using the BOUT++ framework. First, systematic scans were performed to investigate how the dynamics…
View details →Negative / Null Result ReportOpen accessPsychology
Alecia C. Vogel, Steven E. Petersen, Bradley L. Schlaggar · 2012 · Cerebral Cortex
Regions in left occipitotemporal (OT) cortex, including the putative visual word form area, are among the most commonly activated in imaging studies of single-word reading. It remains unclear whether this part of the brain is more…
View details →Negative / Null Result ReportOpen accessComputer Science
Manamba Epaphra, Ales H. Mwakalasya · 2017 · Modern Economy
This paper analyzes the effect of foreign direct investment (FDI) on agricultural sector in Tanzania. The paper also examines the declining contribution of agriculture to real GDP growth despite the fact that the sector employs more than 70 percent of the total labour force. Annual time series data spanning from 1990 to 2015 are used to test the significance of the relationship between FDI inflow and agriculture value added-to-GDP ratio on one hand and FDI inflows and economic growth on the other hand. Also, the relationship between agriculture value added and economic growth rate is empirical
View details →Negative / Null Result ReportOpen accessNeuroscience
Tadeusz W. Kononowicz, Hedderik van Rijn · 2011 · Frontiers in Integrative Neuroscience
Numerous studies have shown that contingent negative variation (CNV) measured at fronto-central and parietal-central areas is closely related to interval timing. However, the exact nature of the relation between CNV and the underlying timing mechanisms is still a topic of discussion. On the one hand, it has been proposed that the CNV measured at supplementary motor area (SMA) is a direct reflection of the unfolding of time since a perceived onset, whereas other work has suggested that the increased amplitude reflects decision processes involved in interval timing. Strong evidence for the first
View details →Negative / Null Result ReportOpen accessSocial Sciences
Abd. Syakur, Tri Achmad Budi Susilo, Wike Wike et al. · 2020 · Budapest International Research and Critics Institute (BIRCI-Journal) Humanities and Social Sciences
This reserach was focused and related to effect of sustainability communication, bureaucracy structure and public support which have significant effect toward policy implementation performance and to execute Three Dharma (education, research and comunity service) in higher education. Communication, resources, bureaucracy structure and public support has its influence against disposition. In bureaucracy structure, public support has significant effect toward its main resources which is lecturer or its teaching staff. This study aimed to analyze the effect of communication and organizational cul
View details →Negative / Null Result ReportPsychology
Angela K.‐Y. Leung, Shyhnan Liou, Ella Miron‐Spektor et al. · 2017 · Journal of Personality and Social Psychology
Thriving in increasingly complex and ambiguous environments requires creativity and the capability to reconcile conflicting demands. Recent evidence with Western samples has suggested that paradoxical frames, or mental templates that…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Bria M. Coates, Kelly L. Staricha, Nandini Ravindran et al. · 2017 · Frontiers in Immunology
Influenza A virus (IAV) is a significant cause of life-threatening lower respiratory tract infections in children. Antiviral therapy is the mainstay of treatment, but its effectiveness in this age group has been questioned. In addition, damage inflicted on the lungs by the immune response to the virus may be as important to the development of severe lung injury during IAV infection as the cytotoxic effects of the virus itself. A crucial step in the immune response to IAV is activation of the NOD-like receptor protein 3 (NLRP3) inflammasome and the subsequent secretion of the inflammatory cytok
View details →Negative / Null Result ReportMedicine
Bahaa Aba Alkhail · 2015 · Medical Teacher
INTRODUCTION: A near-peer-assisted learning term (NPAL) is "a trainee one or more years senior to another trainee". The current study is aiming to determine the pattern of NPAL activities, to compare its effect on student's course…
View details →Negative / Null Result ReportMedicine
Mirko S. Gilardino, Mihiran Karunanayake, Taghreed Alhumsi et al. · 2015 · Journal of Craniofacial Surgery
BACKGROUND: Cranioplasty can be performed either with gold-standard, autologous bone grafts and osteotomies or alloplastic materials in skeletally mature patients. Recently, custom computer-generated implants (CCGIs) have gained popularity…
View details →Negative / Null Result ReportOpen accessMaterials Science
Darshil U. Shah, Ranajit Kumar Nag, Mike Clifford · 2016 · Cellulose
The drive towards sustainability, even in materials technologies, has fuelled an increasing interest in bio-based composites. Cellulosic fibres, such as flax and jute, are being considered as alternatives to technical synthetic fibres, such as glass, as reinforcements in fibre reinforced polymer composites for a wide range of applications. A critical bottleneck in the advancement of plant fibre composites (PFRPs) is our current inability to predict PFRP properties from data on fibre properties. This is highly desirable in the cost- and time-effective development and design of optimised PFRP ma
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jantina Toxopeus, Vladimı́r Košťál, Brent J. Sinclair · 2019 · Proceedings of the Royal Society B Biological Sciences
Freeze tolerance, the ability to survive internal ice formation, facilitates survival of some insects in cold habitats. Low-molecular-weight cryoprotectants such as sugars, polyols and amino acids are hypothesized to facilitate freeze…
View details →Negative / Null Result ReportOpen accessMedicine
Abha A. Gupta, James R. Anderson, Alberto S. Pappo et al. · 2011 · Cancer
BACKGROUND: Patients aged >10 years with rhabdomyosarcoma have an inferior outcome compared with patients ages 1 to 9 years, which may be explained by toxicities (adverse events [AEs]) that result in chemotherapy dose reductions. METHODS:…
View details →Negative / Null Result ReportOpen accessMedicine
Young-Hyo Ryu, Yong-Hee Kim, Jin‐Young Lee et al. · 2013 · PLoS ONE
Non-thermal plasma at atmospheric pressure has been actively applied to sterilization. However, its efficiency for inactivating microorganisms often varies depending on microbial species and environments surrounding the microorganisms. We investigated the influence of environmental factors (surrounding media) on the efficiency of microbial inactivation by plasma using an eukaryotic model microbe, Saccharomyces cerevisiae, to elucidate the mechanisms for differential efficiency of sterilization by plasma. Yeast cells treated with plasma in water showed the most severe damage in viability and ce
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Larry D. Mesner, Veena Valsakumar, Neerja Karnani et al. · 2010 · Genome Research
We have used a novel bubble-trapping procedure to construct nearly pure and comprehensive human origin libraries from early S- and log-phase HeLa cells, and from log-phase GM06990, a karyotypically normal lymphoblastoid cell line. When…
View details →Negative / Null Result ReportComputer Science
Başak Alper, Tobias Höllerer, JoAnn Kuchera-Morin et al. · 2011 · IEEE Transactions on Visualization and Computer Graphics
In this paper we present a new technique and prototype graph visualization system, stereoscopic highlighting, to help answer accessibility and adjacency queries when interacting with a node-link diagram. Our technique utilizes stereoscopic…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
T. Dassopoulos, Marla C. Dubinsky, J. L. Bentsen et al. · 2013 · Alimentary Pharmacology & Therapeutics
BACKGROUND: Azathioprine (AZA), a pro-drug metabolised to the active metabolites 6-tioguanine nucleotides (6TGN), is a steroid-sparing therapy for Crohn's disease (CD). AIM: To investigate whether AZA therapy is optimised by individualised…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Il‐Kang Na, Matthew Buckland, Carlo Agostini et al. · 2019 · European Journal Of Haematology
OBJECTIVE: Despite long-standing safe and effective use of immunoglobulin replacement therapy (IgRT) in primary immunodeficiency, clinical data on IgRT in patients with secondary immunodeficiency (SID) due to B-cell lymphoproliferative…
View details →Negative / Null Result ReportNeuroscience
Gonzalo Garcia Guerra, Charlene M.T. Robertson, Gwen Y. Alton et al. · 2011 · Pediatric Anesthesia
OBJECTIVES/AIM: To determine whether sedation/analgesia drugs used before, during, and after infant cardiac surgery are associated with neurodevelopmental outcome. BACKGROUND: Animal models suggest detrimental effects of anesthetic drugs…
View details →Negative / Null Result ReportMedicine
Yasin Çınar, Abdullah Kürşat Cingü, Fatih Mehmet Türkçü et al. · 2013 · Cutaneous and Ocular Toxicology
PURPOSE: To compare outcomes of accelerated and conventional corneal cross-linking (CXL) for progressive keratoconus (KC). MATERIALS AND METHODS: Patients were divided into two groups as the accelerated CXL group and the conventional CXL…
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Eli Ben‐Chetrit, Avraham Ben‐Chetrit, Yackov Berkun et al. · 2010 · Arthritis Care & Research
OBJECTIVE: To evaluate the outcome of pregnancies in women with familial Mediterranean fever (FMF) who are taking colchicine, and to reconsider the justification for amniocentesis in these women. METHODS: The outcome of 179 pregnancies in…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Michael A. Litzow, Mary E. Hunsicker · 2016 · Ecosphere
Abstract Early warning signals ( EWS ) might dramatically improve our ability to manage nonlinear ecological change. However, the degree to which theoretical EWS predictions are supported in empirical systems remains unclear. The goal of this study is to make recommendations for identifying the types of ecological transitions that are expected to show EWS . We conducted a review and meta‐analysis of published studies and comparative analysis of eight northeast Pacific Ocean time series to illustrate the importance of testing for nonlinearity in empirical EWS studies. We found that published st
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
J. Castro, Andrés Gómez, Bryan A. White et al. · 2016 · Journal of Dairy Science
The objective of this work was to assess the effects of age and gastrointestinal location (rumen vs. colon) on bacterial community diversity and composition, as well as short-chain fatty acid profiles of preruminant male Holstein calves on…
View details →Negative / Null Result ReportOpen accessDecision Sciences
Sujin Pyo, Jaewook Lee, Mincheol Cha et al. · 2017 · PLoS ONE
The prediction of the trends of stocks and index prices is one of the important issues to market participants. Investors have set trading or fiscal strategies based on the trends, and considerable research in various academic fields has been studied to forecast financial markets. This study predicts the trends of the Korea Composite Stock Price Index 200 (KOSPI 200) prices using nonparametric machine learning models: artificial neural network, support vector machines with polynomial and radial basis function kernels. In addition, this study states controversial issues and tests hypotheses abou
View details →Negative / Null Result Report
Lu (Lucy) Yan, Jianping Peng, Yong Tan · 2015 · Information Systems Research
Social networks have been shown to affect health. Because online social networking makes it easier for individuals to interact with experientially similar others in regard to health issues and to exchange social support, there has been an…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Nancy McCarthy, Talip Kilic, Josh Brubaker et al. · 2021 · Environment and Development Economics
Abstract Climate change is predicted to increase the frequency of extreme weather events, increasing the vulnerability of smallholder farmers dependent on rain-fed agriculture. We evaluate the extent to which farmers in Malawi suffer crop production losses due to extreme weather, and whether sustainable land management (SLM) practices help shield crop production losses from extreme events. We use a three period panel dataset where widespread floods and droughts occurred in separate periods, offering a unique opportunity to evaluate impacts using data collected immediately following these event
View details →Negative / Null Result ReportOpen accessMedicine
Maya Williams, Sandra V. Mayer, William L. Johnson et al. · 2014 · American Journal of Tropical Medicine and Hygiene
During 2010 and 2011, the Loreto region of Peru experienced a dengue outbreak of unprecedented magnitude and severity for the region. This outbreak coincided with the reappearance of dengue virus-2 (DENV-2) in Loreto after almost 8 years.…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Husam Rjoub, Mehmet Ağa, Ahmad Abu Alrub et al. · 2017 · Economies
The recognition of Foreign Direct Investment (FDI) as a source of funding to foster economic development in both developed and developing countries has been in ascendancy. The prime purpose of this study is to empirically investigate the determinants of FDI for the “landlocked countries” in Sub-Saharan Africa over the period 1995–2013. By employing panel data analysis, the result of the study revealed that domestic investment, trade (openness), human capital, political constraint, natural resource endowment and the market size (with the GDP growth as proxy) as having positive impact on determi
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