19,885 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Kalluri VS, Kalluri R · 2026 · Preprint
Tumstatin and Endostatin are endogenous extracellular matrix-derived inhibitors of angiogenesis generated from the non-collagenous domains of type IV and type XVIII collagens, respectively. Although both molecules suppress angiogenesis and…
View details →Mbaluto CM, Martinez-Goni XS, Tripathi A et al. · 2026 · Preprint
Cereal grafting using embryonic tissues has recently become technically feasible; however, the physiological consequences of cereal grafting remain uncharacterized. We systematically evaluate photosynthetic performance and stomatal…
View details →Segura-Chama P, Hernández VS, Zhang L · 2026 · Preprint
Adrenal chromaffin cells are key effectors of the sympathoadrenal response and play a central role in physiological adaptation to stress. While acetylcholine and pituitary ad-enylate cyclase-activating polypeptide (PACAP) are recognized…
View details →Chan A, Freschi L, de-Pinna GFAM · 2026 · Preprint
Abstract Leaf sheaths in monocotyledons may be open or closed, yet the developmental regulation of sheath margins remains unclear in Commelinaceae, a family with closed sheaths. This study investigated the morphogenesis of leaf sheaths in…
View details →Lanham BS, Morris RL · 2026 · Marine environmental research
The strength of biotic stressors (i.e., predation) can determine the success of shellfish reef restoration projects. In recruitment limited systems where seeding is a common restoration strategy, ensuring the survival of seeded individuals…
View details →Turner KM, Svegborn A, Robbins TW · 2026 · Psychopharmacology
Rationale Recent research on habits and skills has produced a wave of new theories regarding the shift in control from medial to lateral regions of the dorsal striatum, and how these regions are implicated in the selected and executed of…
View details →Aumtong S, Soongsoongnoen P, Wanwinit D · 2026 · Scientific reports
Biochar reshapes soil composition for years, yet most evidence comes from short-term, single-element laboratory incubations, leaving multi-element dynamics in tropical soils poorly resolved. We tracked 11 elements in longan-wood biochar…
View details →Heled E, Himai Y, Papelbaum M et al. · 2026 · Journal of psychiatric research
Impaired cognitive flexibility (CF) and elevated perfectionism are well-documented in anorexia nervosa (AN), yet their contribution to symptom severity remains unclear. The current study aimed to examine whether CF predicts symptom…
View details →Pirbornatan A, Chalmeh A, Pourjafar M et al. · 2026 · Veterinary journal (London, England : 1997)
Periparturient immunometabolic adaptations yield small, node-dependent shifts in endotoxin proxies and insulin-sensitivity indices. Direct-fed microbials (DFM) are mechanistically plausible but often produce modest metabolic readouts. Test…
View details →Baranovskaya I, Bilous I, Alexander S et al. · 2026 · Preprint
Mineralocorticoid receptor (MR) blockade exerts sex-specific effects in hypertension and cardiovascular disease; however, its role in blood pressure regulation in spontaneously hypertensive rats (SHR) remains unclear. We assessed the…
View details →Hura A, Green T, Kennedy C · 2026 · Archives of environmental contamination and toxicology
With increasing petroleum transport through coastal waters of the northeastern Pacific, understanding the ecological hazards of these mixtures is essential, yet the sublethal impacts on benthic filter feeders remain poorly characterized.…
View details →Herczeg D, Horváth G, Mikó Z et al. · 2026 · Preprint
The accumulation of microplastics (MP; plastic particles 1 μm – 1 mm in diameter) in the environment is an increasing global concern. Although the physiological effects of MP on organisms, including humans, are increasingly documented,…
View details →Hamilton WL, Moore J, Patel P et al. · 2026 · Preprint
Introduction: Invasive fungal infections (IFI) are an important cause of morbidity and mortality in haemato-oncology (haem-onc) patients with neutropenia, requiring rapid and accurate diagnosis. Gap Statement With widespread use of…
View details →De Gregorio DA, Castro DC · 2026 · Preprint
The mu opioid receptor system has long been recognized for its role in regulating ingestive behaviors and food palatability. However, beyond their robust expression in the brain, opioid receptors are also found throughout the body,…
View details →Wojciechowska M, Rodzeń W · 2026 · Preprint
Background: /Objectives: The present study aimed to examine the relationship between Dark Triad personality traits (narcissism, psychopathy, and machiavellianism) and conspiratorial thinking. Additionally, it sought to investigate whether…
View details →Jorgensen E, Modahl L, Noll A et al. · 2026 · The Journal of the Acoustical Society of America
This study investigated how hearing loss and hearing aid use affect environmental sound ratings in laboratory and real-world contexts using the soundscape framework. Forty-four participants (17 normal hearing, 14 with unaided hearing loss,…
View details →Parrish BP, McCool BA · 2026 · Neuropharmacology
Acute ethanol modulates an incredibly diverse number of neurotransmitter receptors and intracellular pathways. Presynaptic modulation by acute ethanol has been identified at some GABAergic synapses; but descriptions of acute ethanol…
View details →Straszewski A, Troyer S, Boyer MI et al. · 2026 · The Journal of hand surgery
Purpose Routine practices without a clear impact on patient care merit continuous reassessment. This retrospective study evaluated the value of routine histopathologic and culture analysis in patients who underwent flexor or extensor…
View details →Fang SH, Chiang MR, Li CY et al. · 2026 · Journal of muscle research and cell motility
Physical activity induces rapid myokine and metabolic responses in skeletal muscle, yet the immediate cellular adaptations to short-duration contractile activity remain incompletely defined. C2C12 myotubes were exposed to electrical pulse…
View details →Wong R, Robertson R, Meylakh N et al. · 2026 · Neurophysiologie clinique = Clinical neurophysiology
Objectives Electroencephalographic (EEG) studies suggest chronic migraine (CM) is associated with increased global power, especially in somatosensory cortex. Furthermore, recent studies suggest chronic pain is associated with a reduced…
View details →Lopes FM, Bantounas I, Sarov A et al. · 2026 · Nephron
Introduction Human fetal kidneys contain macrophages, innate immune cells postulated to enhance their development. Macrophages have also been implicated in the pathobiology of human kidney malformations and Wilms tumour. Human pluripotent…
View details →Prins PJ, Buga A, Storoschuk K et al. · 2026 · Journal of the American Nutrition Association
Background Exogenous ketone supplementation acutely elevates circulating beta-hydroxybutyrate ( R -BHB), but the impact of chronic repeated dosing on exercise performance, cognition, mood, and cardiometabolic health remains unclear.…
View details →Lee HW, Harris AN, Wall SM et al. · 2026 · American journal of physiology. Renal physiology
Hypokalemia activates intercalated cell acid secretion, but because hypokalemia is typically associated with metabolic alkalosis, this activation cannot be ascribed to extracellular pH. Metabolic acidosis induces responses similar to those…
View details →King JL, Effinger DP, Basquez-Pfeifer C et al. · 2026 · Translational psychiatry
The head-twitch response (HTR) is widely used as a preclinical assay for the hallucinogenic potential of compounds, with its utility based on 5HT 2A R activation. Here, we examine how the polypharmacological agonists lisuride and lysergic…
View details →Donate APG, Cousijn J, Rømer Thomsen K · 2026 · Psychopharmacology
Rationale People who use cannabis often report using it to improve sleep and/or manage mental health symptoms. Cannabis products differ in their typical cannabinoid composition, particularly in their relative THC and CBD content, which may…
View details →Brown KA, Max LNF, Struble SE et al. · 2026 · American journal of veterinary research
Objective Determine the acute effects of xylazine and detomidine on concentrations of selected growth factors, cytokines, and α2-macroglobulin (A2M) in platelet-rich plasma (PRP) and autologous protein solution (APS) and the long-term…
View details →Calder AE, Diehl VJ, Lietz MP et al. · 2026 · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Preclinical studies suggest that lysergic acid diethylamide (LSD) may induce lasting changes in brain function and learning ability, but evidence in humans is uncertain. Motor learning, in particular, has clinical relevance but has not…
View details →Uenishi R, Kawata R, Manabe T et al. · 2026 · Preprint
Neuroinflammation is a central driver of tauopathy, yet the precise chemokines that orchestrate the inflammatory microenvironment remain elusive. Here, we report C-X-C motif chemokine ligand 10 (CXCL10) is markedly upregulated in the…
View details →Dachille GP, Zuanna AD, Paiella M et al. · 2026 · Preprint
Abstract We quantify how the employment expansion accompanying Italy’s post-pandemic recovery mitigated the distributional consequences of the contemporaneous surge in prices, which disproportionately affected households at the bottom of…
View details →Cárdenas SA · 2026 · Preprint
Objective(s): Strategic overcharging involves threatening disproportionately harsh punishment to widen the differential between the potential sentence if convicted at trial (PTS) and the plea sentence. Though larger discounts increase plea…
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