19,786 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Tina Wong, Lei Zhou, Jing Li et al. · 2011 · Investigative Ophthalmology & Visual Science
PURPOSE: To identify the tear proteins associated with the long-term use of glaucoma medication by using proteomic analysis and to compare these proteins to those previously reported in primary dry eye disease. METHODS: Eighteen patients…
View details →Benjamin M. Basile, Gabriel R. Schroeder, Emily Kathryn Brown et al. · 2014 · Journal of Experimental Psychology General
Knowing the extent to which nonhumans and humans share mechanisms for metacognition will advance our understanding of cognitive evolution and will improve selection of model systems for biomedical research. Some nonhuman species avoid…
View details →Gal Avital, Mor Buchshtav, Ilia Zhidkov et al. · 2012 · Human Molecular Genetics
Heteroplasmy, the mixture of mitochondrial genomes (mtDNA), varies among individuals and cells. Heteroplasmy levels alter the penetrance of pathological mtDNA mutations, and the susceptibility to age-related diseases such as Parkinson's…
View details →Cosimo Magazzino · 2016 · Cogent Economics & Finance
This paper examines the relationship among real GDP, CO2 emissions, and energy use in the six Gulf Cooperation Council (GCC) countries. Using annual data for the years 1960–2013, stationarity, structural breaks, and cointegration tests have been conducted. The empirical evidence strongly supports the presence of unit roots. Cointegration tests reveal the existence of a clear long-run relationship only for Oman. Granger causality analysis shows that for three GCC countries (Kuwait, Oman, and Qatar) the predominance of the “growth hypothesis” emerges, since energy use drives the real GDP. Moreov
View details →Anahita Mostaghim, Hoi Yee Annie Lo, N.M. Khardori · 2017 · SAGE Open Medicine
Objective: This study aims to define risk factors as well as their association with microbiology and clinical outcomes in a large US infective endocarditis population. Methods: Hospital records were searched for appropriate infective…
View details →Carrie Wright, Anandita Rajpurohit, Emily E. Burke et al. · 2019 · BMC Genomics
BACKGROUND: RNA sequencing offers advantages over other quantification methods for microRNA (miRNA), yet numerous biases make reliable quantification challenging. Previous evaluations of these biases have focused on adapter ligation bias with limited evaluation of reverse transcription bias or amplification bias. Furthermore, evaluations of the quantification of isomiRs (miRNA isoforms) or the influence of starting amount on performance have been very limited. No study had yet evaluated the quantification of isomiRs of altered length or compared the consistency of results derived from multiple
View details →Amy Finkelstein, James M. Poterba · 2014 · Journal of Risk & Insurance
Abstract This article tests for asymmetric information in the U.K. annuity market of the 1990s by trying to identify “unused observables,” attributes of individual insurance buyers that are correlated both with subsequent claims experience…
View details →Danielle S. Gruen, Joshua B. Brown, Francis X. Guyette et al. · 2020 · JCI Insight
BACKGROUNDPrehospital plasma improves survival in severely injured patients transported by air ambulance. We hypothesized that prehospital plasma would be associated with a reduction in immune imbalance and endothelial damage.METHODSWe sampled blood from 405 trauma patients enrolled in the Prehospital Air Medical Plasma (PAMPer) trial upon hospital admission (0 hours) and 24 hours post admission across 6 U.S. sites. We assayed samples for 21 inflammatory mediators and 7 markers associated with endothelial function and damage. We performed hierarchical clustering analysis (HCA) of these biomark
View details →Xiujian Chen, Thomas F. Kelly · 2014 · Journal of Leadership & Organizational Studies
B-Corps are a growing group of social enterprises with a high level of commitment to maintaining a balance between profit motive and corporate social responsibility (CSR). This study has two purposes. First, it reviews the 6-year history…
View details →Nuala J. Meyer, John P. Reilly, Brian J. Anderson et al. · 2017 · Critical Care Medicine
OBJECTIVE: Plasma interleukin-1 beta may influence sepsis mortality, yet recombinant human interleukin-1 receptor antagonist did not reduce mortality in randomized trials. We tested for heterogeneity in the treatment effect of recombinant…
View details →Angela Dalia Ricci, Alessandro Rizzo, Fabiola Lorena Rojas Llimpe et al. · 2021 · Cancers
Human epidermal growth factor receptor 2 (HER2) is overexpressed and/or amplified in approximately 15–20% of gastric adenocarcinoma (GC) patients. In 2010, the landmark ToGA trial established the combination of trastuzumab plus chemotherapy as the first-line standard of care for HER2-positive GC patients with advanced disease. However, subsequent studies on HER2 targeted therapies in this setting failed to meet their primary endpoints, and not all HER2-positive GC patients benefit from targeted approaches. More recently, novel HER2-directed treatments have been investigated, including trastuzu
View details →Ho‐Chang Kuo, Kuender D. Yang, Suh‐Hang Hank Juo et al. · 2011 · PLoS ONE
Kawasaki disease (KD) is characterized by systemic vasculitis with unknown etiology. Previous studies from Japan indicated that a gene polymorphism of ITPKC (rs28493229) is responsible for susceptibility to KD. We collected DNA samples from 1,531 Taiwanese subjects (341 KD patients and 1,190 controls) for genotyping ITPKC. In this study, no significant association was noted for the ITPKC polymorphism (rs28493229) between the controls and KD patients, although the CC genotype was overrepresented. We further combined our data with previously published case/control KD studies in the Taiwanese pop
View details →Taryn Williams, Nicole Phillips, Dan J. Stein et al. · 2026 · Cochrane Database of Systematic Reviews
BACKGROUND: Posttraumatic stress disorder (PTSD) is a prevalent and disabling disorder. Evidence that PTSD is characterised by specific psychobiological dysfunctions has contributed to a growing interest in the use of medication in its…
View details →Els M. Gielis, Kristien J. Ledeganck, Amélie Dendooven et al. · 2019 · Nephrology Dialysis Transplantation
BACKGROUND: After transplantation, cell-free deoxyribonucleic acid (DNA) derived from the donor organ (ddcfDNA) can be detected in the recipient's circulation. We aimed to investigate the role of plasma ddcfDNA as biomarker for acute…
View details →Katarzyna Dziopa, Folkert W. Asselbergs, Jasmine Gratton et al. · 2022 · Diabetologia
AIMS/HYPOTHESIS: We aimed to compare the performance of risk prediction scores for CVD (i.e., coronary heart disease and stroke), and a broader definition of CVD including atrial fibrillation and heart failure (CVD+), in individuals with type 2 diabetes. METHODS: Scores were identified through a literature review and were included irrespective of the type of predicted cardiovascular outcome or the inclusion of individuals with type 2 diabetes. Performance was assessed in a contemporary, representative sample of 168,871 UK-based individuals with type 2 diabetes (age ≥18 years without pre-existi
View details →Thomas C. Jaramillo, Shunan Liu, Ami Pettersen et al. · 2014 · Autism Research
Multiple candidate genes have been identified for autism spectrum disorders. While some of these genes reach genome-wide significance, others, such as the R451C point mutation in the synaptic cell adhesion molecule neuroligin-3, appear to…
View details →John Colin Boyd, Craig A. Simpson, Mary E. Jung et al. · 2013 · PLoS ONE
OBJECTIVE: The purpose of this research was to determine if the adaptations to high intensity interval training (HIT) are mitigated when both intensity and training volume (i.e. exercise energy expenditure) are reduced. METHODS: 19 overweight/obese, sedentary males (Age: 22.7±3.9 yrs, Body Mass Index: 31.4±2.6 kg/m(2), Waist Circumference: 106.5±6.6 cm) performed 9 sessions of interval training using a 1-min on, 1-min off protocol on a cycle ergometer over three weeks at either 70% (LO) or 100% (HI) peak work rate. RESULTS: Cytochrome oxidase I protein content, cytochrome oxidase IV protein co
View details →P. Rizzo, Emanuela Raffone, Vincenzo Di Benedetto · 2010 · PubMed
OBJECTIVE: The aim of the study was to evaluate the efficacy of a treatment with myo-inositol plus folic acid plus melatonin compared with myo-inositol plus folic acid alone on oocyte quality in women underwent in vitro fertilization (IVF)…
View details →Heidrun H. Krämer, T. Eberle, Nurcan Üçeyler et al. · 2010 · Pain
Posttraumatic TNF-alpha signaling may be one of the factors responsible for pain and hyperalgesia in complex regional pain syndromes (CRPS). In order to further specify the role of TNF-alpha we investigated tissue (skin) and serum…
View details →Romy M. Heilmann, Nora Berghoff, Joanne Mansell et al. · 2018 · Journal of Veterinary Internal Medicine
BACKGROUND: Calprotectin is a marker of inflammation, but its clinical utility in dogs with chronic inflammatory enteropathies (CIE) is unknown. OBJECTIVE: Evaluation of fecal calprotectin in dogs with biopsy-confirmed CIE. ANIMALS: 127…
View details →Zoya Kuzmina, Hildegard Greinix, Roman Weigl et al. · 2010 · Blood
Manifestations of chronic graft-versus-host disease (cGVHD) can resemble those seen in immunodeficiency states and autoimmune disorders. Reports by us and others suggest an involvement of B cells in the pathogenesis of cGVHD. We…
View details →Ai Milojevic, Ben Armstrong, Masahiro Hashizume et al. · 2011 · Epidemiology
BACKGROUND: There is little information available on nontraumatic health risks as the result of floods, and on the factors that determine vulnerability to them (especially in low-income settings). We estimated the pattern of mortality,…
View details →Barbara C. Sorkin, Adam J. Kuszak, Gregory Bloss et al. · 2019 · The FASEB Journal
While great interest in health effects of natural product (NP) including dietary supplements and foods persists, promising preclinical NP research is not consistently translating into actionable clinical trial (CT) outcomes. Generally…
View details →Taranum Ruba Siddiqui, Saima Ghazal, Safia Bibi et al. · 2016 · PLoS neglected tropical diseases
BACKGROUND: Prevention is most effective in reducing dengue infection risk, especially in endemic countries like Pakistan. Evaluation of public awareness and health beliefs regarding dengue fever (DF) is important for devising disease control strategies. This study assessed dengue knowledge, health beliefs, and preventive practices against DF in different socioeconomic groups of Karachi, Pakistan. METHODOLOGY: In this community-based cross-sectional study, 6 randomly selected towns were visited, 2 persons (man and woman) per household were interviewed using a structured questionnaire, and hous
View details →Asher Berlin · 2016 · Physical Review Letters
We consider a class of models involving interactions between ultralight scalar dark matter and standard model neutrinos. Such couplings modify the neutrino mass splittings and mixing angles to include additional components that vary in…
View details →Shari L. Barkin, William J. Heerman, Evan C. Sommer et al. · 2018 · JAMA
Importance: Prevention of obesity during childhood is critical for children in underserved populations, for whom obesity prevalence and risk of chronic disease are highest. Objective: To test the effect of a multicomponent behavioral…
View details →David D. Luxton, Larry D. Pruitt, Amy W. Wagner et al. · 2016 · Journal of Consulting and Clinical Psychology
OBJECTIVE: Evidence of feasibility, safety, and effectiveness of home-based telebehavioral health (HBTBH) needs to be established before adoption of HBTBH in the military health system can occur. The purpose of this randomized controlled…
View details →Satoshi Ishikawa, Hiromitsu Hayashi, Kouichi Kinoshita et al. · 2013 · International Journal of Cancer
While statin intake has been proven to reduce the risk of colorectal cancer (CRC), the mechanism of antitumor effects and clinical significance in survival benefits remain unclear. Statin-induced antiproliferative effects and its…
View details →Heath D. Skinner, Chen Hu, Theodoros Tsakiridis et al. · 2021 · JAMA Oncology
IMPORTANCE: Non-small cell lung cancer (NSCLC) has relatively poor outcomes. Metformin has significant data supporting its use as an antineoplastic agent. OBJECTIVE: To compare chemoradiation alone vs chemoradiation and metformin in stage…
View details →Elizabeth L. Stegemöller, Hollie Radig, Paul R. Hibbing et al. · 2016 · Disability and Rehabilitation
Purpose Interventions focused on singing may provide additional benefits to established voice and respiratory therapies, due to their greater emphasis on the respiratory muscle control system in those with Parkinson's disease (PD)…
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