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Browse the failure-mode index

19,871 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Plant functional diversity does not dilute virus infection, but community virus prevalence positively correlates with net C3 grass production

Aguirre BA, Mudrak EL, Wright AJ et al. · 2026 · Journal of Ecology.

Plant diversity in wild and agricultural plant communities has been shown to protect plant communities from pathogens, and the effects of many aspects of diversity (genetic diversity, species richness, evenness and their combination) on…

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Negative / Null Result ReportMedicine

A Randomized Trial Evaluating Intraoperative Ischemic Preconditioning of Parathyroid Glands During Total Thyroidectomy: A Signal for Earlier Parathyroid Function Recovery.

Sheng Q, Zhang P, Zhang T et al. · 2026 · Journal of investigative surgery : the official journal of the Academy of Surgical Research

Background Ischemic preconditioning of parathyroid glands (IPCP) is biologically plausible but clinical evidence is limited. In this single-center randomized trial (ChiCTR2000039788), we compared IPCP versus control during total…

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Negative / Null Result ReportMedicine

Intravenous dexmedetomidine and blood loss during cesarean delivery under neuraxial anesthesia: a single-center retrospective study (2012-2016).

Yoshimura M, Sakamoto S, Nakanishi T et al. · 2026 · International journal of obstetric anesthesia

Background Intravenous dexmedetomidine may be given to reduce shivering and discomfort during cesarean delivery under neuraxial anesthesia. Dexmedetomidine lowers heart rate and blood pressure, reduces catecholamine release, may have a…

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Negative / Null Result ReportMedicine

The impact of tracheal intubation attempts on chest compression fraction during pediatric CPR: a report from the Videography in Pediatric Resuscitation (VIPER) collaborative.

Jariyasakoolroj T, O'Connell K, MacDonald T et al. · 2026 · Resuscitation

Aim To examine the association between tracheal intubation (TI) attempts and chest compression (CC) pauses on chest compression fraction (CCF) during pediatric CPR across a network of emergency departments. Methods Prospective…

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Negative / Null Result ReportMedicine

Deciphering serotonin's functional role in postharvest: Fruit-specific preservation of red fruit quality.

Arabia A, Muñoz P, Álvarez-Real S et al. · 2026 · Plant science : an international journal of experimental plant biology

Serotonin is a widely conserved signaling molecule essential for plant development and stress responses, but its role in fruit postharvest physiology remains largely unexplored. This study aimed to evaluate the effects of 100 μM exogenous…

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Negative / Null Result ReportMedicine

Lactated Ringer's Solution at a Standard Infusion Rate in Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis Prevention: A Retrospective Comparative Study.

Ko T, Sakai A, Nakano R et al. · 2026 · Digestive diseases and sciences

Background Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis is a common complication, and its prevention remains challenging. Although aggressive infusion of lactated Ringer's solution (hereafter Lactated Ringer's)…

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Negative / Null Result Report

Using Narrative to Explain Uncertainty in Climate Change

Freeman G, Rousseau A, Brunton M et al. · 2025 · Preprint

Abstract This study presents the findings on the use of narrative when communicating complex scientific uncertainties. A growing body of evidence in narrative cognition and communication has shown promise for the use of narrative in…

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Negative / Null Result ReportMedicine

Longitudinal Reliability of Rheumatology Patient Safety Measures and Implications for CMS Case Minimums.

Roberts ET, Schmajuk G, Fitzpatrick J et al. · 2026 · Joint Commission journal on quality and patient safety

Background Metrics with acceptable reliability are necessary to ensure that quality measures reward performance. Low metric reliability may result from a lack of differences between reporting entities or low numbers of eligible patients.…

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Negative / Null Result ReportOpen accessMedicine

Long-term changes in overjet in individuals with and without orthodontic treatment : A 30-year cohort study.

Bokan J, Schmid JQ, Middelberg C et al. · 2026 · Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie

Purpose Large overjet increases the risk of traumatic dental injury (TDI). This study, part of the Münster Long-Term Study (MLS), aimed to investigate long-term changes in overjet with or without orthodontic treatment and to evaluate…

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Negative / Null Result ReportMedicine

High-flow nasal cannula improves pulmonary gas exchange during endoscopic retrograde cholangiopancreatography: A single-center randomized controlled trial.

Martínez-Ocón J, Pérez M, Calvo A et al. · 2026 · Journal of clinical anesthesia

Background Sedation during endoscopic retrograde cholangiopancreatography procedures (ERCP) increases the risk of hypoxemia and the need for respiratory support in high-risk patients. High flow nasal cannula (HFNC) provides humidified gas…

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Negative / Null Result Report

Effectiveness of an mHealth Exercise Program on Fall Incidence, Fall Risk, and Fear of Falling in Nursing Home Residents: The Cluster Randomized Controlled BeSt Age Trial

Diener J, Krafft J, Rayling S et al. · 2025 · Preprint

The global rise in nursing home (NH) populations presents substantial challenges, as residents frequently experience physical and cognitive decline, low physical activity, and high fall risk. This study evaluated the effectiveness of the…

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Negative / Null Result Report

Dexamethasone as an Adjuvant to Erector Spinae Plane Block in Cardiac Surgery: A Randomized Controlled Trial on Postoperative Recovery and Pain chronification

Linares LAR, Martinez RCR, Carvalho VH et al. · 2026 · Preprint

Abstract Background and Objectives: Pain control after cardiac surgery remains suboptimal, and concerns about neuraxial techniques under anticoagulation limit the use of thoracic epidurals. The erector spinae plane (ESP) block offers a…

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Negative / Null Result ReportMedicine

Use of Virtual Reality for Pain Relief During Cervical Conization Under Local Anesthesia: A Randomized Controlled Trial.

Michaan N, Michaan N, Laskov I et al. · 2026 · Journal of lower genital tract disease

Objectives Cervical conization (loop electrosurgical excision procedure) under local anesthesia is often associated with anxiety and procedural pain. Virtual reality (VR) glasses may enhance patient experience and reduce discomfort during…

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Negative / Null Result ReportMedicine

Incidence, Predictors, and Outcomes of Stroke Following Transcatheter Aortic Valve Implantation: A Multicenter Australian Experience.

Butala AD, Nanayakkara S, Johnston R et al. · 2026 · The American journal of cardiology

Stroke is a serious complication following transcatheter aortic valve implantation, associated with increased disability and mortality. Despite this, there is a lack of patient-level data examining stroke in contemporary, lower-risk…

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Negative / Null Result ReportMedicine

Letter to the Editor: Comment on Adamovich-Zeitlina et al's "Clinical Outcomes of Boston Type 1 Keratoprosthesis With and Without Endophthalmitis During the Covid-19 Pandemic".

Geoffrion D, Mikhail D, Rizk M et al. · 2025 · Ocular immunology and inflammation

Authors reported an 18% rate of endophthalmitis in Boston type 1 keratoprosthesis (KPro) patients, higher than previously reported rates. Most cases occurred during the COVID-19 pandemic, likely due to reduced access to care. Bandage…

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