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Browse the failure-mode index

20,230 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Retrospective Comparative Analysis of Diffusion Tensor and Constrained Spherical Deconvolution Tractography Models in a Clinical Neurosurgical Navigation Platform.

Watanabe A, Furukawa M, Hiruta R et al. · 2026 · Neurologia medico-chirurgica

Tractography is a technique for visualizing the trajectories of white matter pathways. The most widely used model, the diffusion tensor imaging, assumes a single fiber orientation within each voxel. In contrast, the constrained spherical…

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Negative / Null Result ReportMedicine

Enzalutamide Plus Metformin Versus Enzalutamide Alone in Metastatic Castration-resistant Prostate Cancer: A Randomized Phase 2 Trial (SAKK 08/14).

Gillessen S, Gobat K, Cathomas R et al. · 2026 · European urology oncology

Background and objective The aim of our study is to determine whether the addition of metformin to enzalutamide can improve the outcomes of men with metastatic castration-resistant prostate cancer (mCRPC). Methods From 2016 to 2021,…

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Negative / Null Result ReportMedicine

Modulation of neuroendocrine and autonomic responses to competitive stress by slow cortical potentials training in golfers: An exploratory randomized controlled trial.

Lizama E, Carcamo-Herrera B, López G et al. · 2026 · Psychoneuroendocrinology

Performance in precision sports such as golf depends on the athlete's ability to regulate psychophysiological responses under competitive pressure. Heart rate variability (HRV), cortisol, and DHEA provide complementary indices of autonomic…

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Negative / Null Result ReportOpen accessMedicine

Gene-specific response to muscle specific kinase agonist antibody in the treatment of congenital myasthenic syndromes.

Ho K, Adjei-Afriyie O, Carmona-Martinez R et al. · 2026 · Brain communications

Congenital myasthenic syndromes (CMS) are a group of rare disorders characterized by fatigable muscle weakness and caused by impaired neuromuscular junction (NMJ) function. CMS symptoms are highly variable, but it can be detrimental and…

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Negative / Null Result ReportMedicine

[Anti-leucine-rich glioma-inactivated 1 antibody-positive encephalitis with a poor response to corticosteroids 2 months after onset of impaired memory: a case report].

Araga Y, Nakamura Y, Sugita C et al. · 2026 · Rinsho shinkeigaku = Clinical neurology

The patient was a 30-year-old man who was admitted to our department 2 months after the onset of anterograde amnesia. Cognitive function tests indicated memory impairment only. MRI FLAIR images of the head showed a high signal in the…

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Negative / Null Result ReportMedicine

Modeling variable interactions using Bayesian networks to identify direct predictors of radiation-induced optic neuropathy after proton therapy: implications for personalized toxicity risk stratification.

Pham TN, Chamseddine I, Lebhertz D et al. · 2026 · Physics in medicine and biology

Introduction. Radiation-induced optic neuropathy (RION) is a rare but functionally-disabling complication of radiotherapy for brain and head/neck tumors. Even with modern proton therapy and adherence to dose constraints, about 6% of…

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Negative / Null Result ReportMedicine

Comparative performance of one-stage and two-stage deep learning models for instance segmentation of overhanging dental restorations on bitewing radiographs.

Hatipoğlu Ö, Başar Ö, Mağat G et al. · 2026 · Scientific reports

Accurate detection of overhanging dental restorations on bitewing radiographs is clinically important but remains challenging due to subtle marginal discrepancies. This study aimed to develop and compare deep learning-based instance…

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Negative / Null Result ReportMedicine

The sonographic subpubic area is a predictor of anal incontinence after a first vaginal delivery: A prospective cohort study.

Packet B, Van Severen R, Cattani L et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology

Objectives To study the association between the subpubic arch angle and area, the latter a novel estimator of maternal pelvic outlet dimensions, and postpartum anal incontinence. Methods Convenience sample from a prospective observational…

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Negative / Null Result ReportMedicine

Hand therapy or not following collagenase treatment for Dupuytren's disease? A randomized controlled trial.

Aglen T, Matre KH, Selles RW et al. · 2026 · Journal of hand therapy : official journal of the American Society of Hand Therapists

Background Collagenase treatment can improve finger extension and hand function in patients with Dupuytren's disease. The role of hand therapy in enhancing or prolonging these effects remains unclear. Purpose The primary aim was to examine…

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Negative / Null Result ReportMedicine

Psychometric Evaluation and Discriminative Validity of the Short-Form Brief Pain Inventory Across Nociceptive, Neuropathic, and Nociplastic Pain Mechanisms.

Steen JP, Jaiswal KS, Dilipkumar J et al. · 2026 · The journal of pain

The measurement performance of the Short-Form Brief Pain Inventory (BPI-SF) across IASP-recognized pain mechanisms remains unclear. We evaluated the reliability and structural validity of BPI-SF across clinician-assigned predominant…

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Negative / Null Result ReportMedicine

Mature oocyte yield in patients with diminished ovarian reserve treated with luteal estradiol priming with or without GnRH antagonist.

Ghofranian A, Baird M, Reckhow J et al. · 2026 · Minerva obstetrics and gynecology

Background Luteal phase E2 priming is commonly used in patients with DOR to 30 synchronize follicular development before controlled ovarian hyperstimulation (COH). Some protocols 31 incorporate a GnRH antagonist during the luteal phase to…

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Negative / Null Result ReportMedicine

Acute effects of an individually timed lower-limb post-activation performance enhancement protocol on 50 m front crawl performance and race kinematics in national-level swimmers.

Stanula A, Strzała M, Sadowski W et al. · 2026 · Scientific reports

Post-activation performance enhancement (PAPE) has been proposed as an acute strategy to improve explosive performance, yet its effects on sprint-swimming performance remain unclear, particularly when individualized recovery timing is…

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Negative / Null Result Report

Belgian endive-derived biostimulant activity in Arabidopsis, lettuce and sweet pepper at different developmental stages, environmental conditions, and application methods

Ogunsanya HY, Petit C, Audenaert K et al. · 2026 · Preprint

Belgian endive-derived biostimulant (BEE) was previously shown to enhance root and shoot growth of Arabidopsis thaliana and Plectranthus esculentus in in vitro culturing conditions. In this study, we evaluated the effect of BEE on A.…

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Negative / Null Result ReportMedicine

<i>Enterobacter</i>-based dietary supplements in both larvae and adult diet affect thermal response of sterile males.

Papadogiorgou G, Koskinioti P, Rodovitis V et al. · 2026 · Bulletin of entomological research

Thermal stress can affect the field performance of sterile males used in the sterile insect technique (SIT). We tested whether adding autoclaved Enterobacter as a dietary supplement improves thermal tolerance in sterile Vienna 8 genetic…

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Negative / Null Result ReportOpen accessMedicine

Multiple Arterial Grafting in Hemodialysis Patients.

Hachiro K, Takashima N, Kamiya K et al. · 2026 · Circulation reports

Background The effectiveness of multiple arterial grafting (MAG) for hemodialysis (HD) patients is unclear. Methods and results We retrospectively analyzed 149 HD patients who underwent either MAG (n=97) or single arterial grafting (SAG)…

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Negative / Null Result ReportMedicine

Evaluation of postoperative analgesia with perioperative electroacupuncture in clinical dog patients undergoing surgery for cranial cruciate ligament rupture (Tibial Tuberosity Advancement).

Lienert M, Stadler L, Kipfer N et al. · 2026 · Veterinary journal (London, England : 1997)

Objectives To investigate the effect of electroacupuncture on postoperative analgesia in dogs undergoing Tibial Tuberosity Advancement surgery. We hypothesise that acupuncture will reduce pain scores and the need for rescue analgesia…

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Negative / Null Result ReportMedicine

Responsiveness and Minimal Important Change of the Haemophilia Activities List in Patients With Inherited Bleeding Disorders.

Blokzijl J, Kuijlaars IAR, Pisters MF et al. · 2026 · Haemophilia : the official journal of the World Federation of Hemophilia

Introduction The Haemophilia Activities List (HAL) is a disease-specific patient-reported outcome measure (PROM) that is widely used in both healthcare and research in people with inherited bleeding disorders (PWBD), but information on…

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Negative / Null Result ReportMedicine

Effect of Piperine Codelivery on the Oral Bioavailability of Cannabidiol: Insights from <i>In Vitro</i> Digestion and <i>In Vivo</i> Pharmacokinetics.

Vardanega R, Lüdtke FL, Loureiro L et al. · 2026 · Journal of agricultural and food chemistry

This study investigated whether coencapsulation of cannabidiol (CBD) and piperine (PIP) in food-grade nanostructured lipid carriers (NLCs) enhances the CBD oral bioavailability. NLCs containing long-chain fatty acids were formulated with…

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