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Browse the failure-mode index

20,230 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

A randomized controlled trial comparing two processes of exposure therapy: Extinction learning and habituation.

Treanor M, Zbozinek TD, Rosenberg BM et al. · 2025 · Journal of consulting and clinical psychology

Objective To investigate the role of extinction learning and habituation by comparing inhibitory retrieval to habituation-focused exposure for social anxiety and panic disorder. Method In this assessor-blinded, parallel-group, two-arm…

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Negative / Null Result ReportMedicine

Prognostic and Predictive Factors in Metastatic Breast Cancer Patients Treated with CDK4/6 Inhibitors.

Demirel N, Yildiz B, Demir M · 2026 · Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

Objective To evaluate the safety and efficacy of CDK4/6 inhibitors in combination with hormone therapy, and to investigate potential predictive markers of treatment in metastatic breast cancer (MBC). Study design An observational study.…

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Negative / Null Result ReportMedicine

Long-term Clinical and Radiographic Outcomes After Salto Talaris Total Ankle Arthroplasty: Long-term Follow-up of a Previously Published Cohort.

Slowinski J, Lutnick E, Frappa N et al. · 2026 · Foot & ankle international

Background This study aimed to demonstrate long term clinical follow-up and implant survivorship of Salto Talaris-type primary total ankle arthroplasty (TAA) by 1 foot and ankle-trained surgeon at a single institution. Methods Patients…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of Rabeprazole for Gastrointestinal Protection in Acute Coronary Syndrome Patients Treated with Aspirin and Ticagrelor: A Pilot Study.

Hyun HK, Lee OH, Roh JW et al. · 2026 · Yonsei medical journal

Purpose Patients with acute coronary syndrome (ACS) on ticagrelor-based dual antiplatelet therapy (DAPT) have an increased risk of gastrointestinal (GI) bleeding. However, evidence supporting the protective role of proton pump inhibitors…

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Negative / Null Result ReportMedicine

Endoscopic three-layer graft myringoplasty without tympanomeatal flap elevation for repairing subtotal and total perforations.

Lou Z, Yang H · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

OBJECTIVE: The objective of this study was to evaluate the graft success rate, hearing outcomes, and complications associated with three-layer graft myringoplasty for repairing subtotal and total perforations. MATERIALS AND METHODS:…

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Negative / Null Result ReportMedicine

Outcomes from a structured conflict management programme implemented at three paediatric healthcare sites: a mixed-methods evaluation.

Phillipson J, Menson E, Barclay S et al. · 2026 · Archives of disease in childhood

Objective Evaluation of the Medical Mediation Foundation's Conflict Management Programme (CMP)-a structured process for managing conflict. Design Mixed-methods evaluation using Kirkpatrick's framework, a four-level model for evaluating…

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Negative / Null Result ReportMedicine

Daily-life posttraumatic stress symptoms, posttraumatic cognitions, and affect following the processing of positive memories technique: An open-label case-control daily diary study.

Greene T, Dicker-Oren SD, Sznitman SR et al. · 2026 · Journal of traumatic stress

The processing of positive memories technique (PPMT) is a promising new treatment for posttraumatic stress disorder (PTSD) involving the detailed narration and processing of specific positive autobiographical memories. This study used an…

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Negative / Null Result ReportOpen accessMedicine

The Effect of Ocrelizumab on Anti-JC Virus Antibody Index.

Virupakshaiah A, Gill AJ, Schoeps VA et al. · 2026 · Brain and behavior

Purpose/introduction The anti-JC virus (JCV) antibody index is used to stratify the risk of progressive multifocal leukoencephalopathy (PML) in multiple sclerosis (MS), particularly with natalizumab therapy. B-cell-depleting therapies may…

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Negative / Null Result ReportMedicine

Impact of low-flow desflurane versus sevoflurane anesthesia on thiol-disulfide homeostasis in adults undergoing elective thyroidectomy: a randomized controlled trial.

Sen E, Aytekin A · 2026 · Revista da Associacao Medica Brasileira (1992)

Objective Thiol-disulfide homeostasis is a marker of oxidative stress. The aim of the study was to compare the effects of low-flow desflurane and sevoflurane anesthesia on perioperative changes in thiol-disulfide balance in patients…

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Negative / Null Result ReportMedicine

Long-term outcomes of patients with moderate-severe pediatric systemic lupus erythematosus treated with combination rituximab and cyclophosphamide therapy: A single center cohort experience and review of literature.

Achar A, Houser P, Cherian J et al. · 2026 · Lupus

ObjectiveTo determine the long-term outcomes of patients with moderate-severe pediatric systemic lupus erythematosus (pSLE) treated with systematic administration of combination rituximab (RTX) and cyclophosphamide (CYC) at our…

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Negative / Null Result Report

Epidemiology of Microbial Keratitis on Uganda: A 7-year update

Arunga S, Ebong A, Orishaba F et al. · 2026 · Preprint

Purpose To provide the latest update on the epidemiology of microbial keratitis in Uganda. Methods We prospectively recruited patients presenting with microbial keratitis (MK) at three eye units in Uganda between November 2023 and June…

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