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20,227 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Longitudinal Associations between Mattering Dimensions and Loneliness in Adolescents: Bidirectional Effects at between- and Within-Person Levels.

Li HM, Flett GL, Cao CH et al. · 2026 · Journal of youth and adolescence

Although cross-sectional research links mattering to reduced adolescent loneliness, longitudinal studies examining temporal dynamics and distinctions between analytical levels or mattering dimensions are scarce. Without understanding…

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Negative / Null Result ReportMedicine

Subjective well-being mediates the longitudinal effect of insomnia symptoms on internalizing symptoms in community-dwelling older adults.

Ying Y, Meng R, Xu J et al. · 2026 · The journals of gerontology. Series B, Psychological sciences and social sciences

Objectives The associations between insomnia symptoms and internalizing symptoms are well-established, particularly in older adults; however, the mediating factors remain inconsistent. This study seeks to explore the longitudinal…

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Negative / Null Result Report

Attention-Deficit/Hyperactivity Disorder across the Menstrual Cycle: Late-Luteal Symptom Exacerbation, Medication Use, and the Role of Sleep Quality and Perceived Stress

Nayman S, Del Din J, Ríos MB et al. · 2025 · Preprint

BackgroundEmerging evidence indicates perimenstrual exacerbation of Attention-Deficit/Hyperactivity Disorder (ADHD) in females and reduced perceived stimulant responsiveness during the luteal phase. Prospective clinical studies jointly…

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Negative / Null Result ReportMedicine

Clinical impact of TP53 classifications in previously treated advanced driver-negative non-small cell lung cancer: A biomarker analysis of the OAK and POPLAR randomized clinical trials.

Zhou DD, Lord SJ, Lin FP et al. · 2026 · Lung cancer (Amsterdam, Netherlands)

Background In NSCLC, TP53 mutations are heterogeneous with varied effects on protein synthesis, function and clinical outcomes. We hypothesize that a refined classification of TP53 mutations, beyond binary categorization, could improve…

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Negative / Null Result ReportMedicine

Computed Tomography Measurement of Optic Nerve Sheath Diameter in Thrombolysis-Treated Ischemic Stroke: Association with Post-Thrombolytic Intracranial Hemorrhage.

Coşkun Yaş S, Üçöz Kocaşaban D, Güler S et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Optic nerve sheath diameter (ONSD) measurement is a non-invasive marker of intracranial pressure. Its role in predicting post-thrombolytic intracranial hemorrhage in acute ischemic stroke patients remains unclear. This study aimed to…

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Negative / Null Result ReportMedicine

Survival implications of computed tomography-derived muscle mass changes in patients with epithelial ovarian cancer undergoing bowel surgery.

Kim J, Lee YY, Kim TJ et al. · 2026 · International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

Objective Sarcopenia is a known adverse prognostic factor in gastrointestinal cancers undergoing bowel resection; however, its prognostic relevance in epithelial ovarian cancer remains unclear. This study aimed to evaluate the prognostic…

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Negative / Null Result Report

Sleep Benefits to Spatial Source Memory in Older Adults

Kuhlmann BG, Shakoor S, Schicker LA et al. · 2025 · Preprint

While it is well-established that sleep benefits episodic memory, most evidence is on younger adults. The current study examined sleep benefits in older adults and chose spatial source memory as a target measure for which a recent study in…

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Negative / Null Result Report

Consolidating Climate Anxiety Scales Using Rasch Modelling

Gago T, Sargisson RJ, Milfont TL · 2025 · Preprint

Despite being an important mental health consequence of climate change, climate anxiety assessment has been fragmented. Reviews of measures of climate anxiety raise concerns about content and convergent validity. We aimed to select the…

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Negative / Null Result ReportMedicine

Predictors and Outcomes Associated with Clinically Significant Improvements in Anxiety and Depression Symptoms Following Cardiac Rehabilitation.

Hernández L, Williamson TM, Campbell T et al. · 2025 · The Canadian journal of cardiology

Background Cardiac rehabilitation (CR) participation improves depressive and anxious symptoms post-coronary catheterization, yet it is unclear to what extent improvements are clinically significant. This study characterized the proportion…

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Negative / Null Result ReportMedicine

Water deficit induced by polyethylene glycol leads to the depletion of phenolic compounds but did not alter lignification in roots of Scots pine (Pinus sylvestris).

Ivanov YV, Kartashov AV, Ivanova AI et al. · 2026 · Functional plant biology : FPB

Global climate change is accompanied by an increase in the frequency and severity of droughts, which negatively impact plant growth. One of the protective mechanisms that allows plants to withstand the negative drought effects is the…

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Negative / Null Result Report

Cereal grafting in rice and pearl millet preserves photosynthetic performance and stomatal dynamics, establishing a platform for root-shoot communication studies

Mbaluto CM, Martinez-Goni XS, Tripathi A et al. · 2026 · Preprint

Cereal grafting using embryonic tissues has recently become technically feasible; however, the physiological consequences of cereal grafting remain uncharacterized. We systematically evaluate photosynthetic performance and stomatal…

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Negative / Null Result ReportMedicine

Comparative effects of inactivation and dopamine receptor agents in the dorsolateral and dorsomedial striatum on performance of action sequences in rats.

Turner KM, Svegborn A, Robbins TW · 2026 · Psychopharmacology

Rationale Recent research on habits and skills has produced a wave of new theories regarding the shift in control from medial to lateral regions of the dorsal striatum, and how these regions are implicated in the selected and executed of…

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Negative / Null Result ReportMedicine

Reduced electroencephalogram power and no change in peak alpha frequency in individuals with chronic migraine: a cross-sectional investigation.

Wong R, Robertson R, Meylakh N et al. · 2026 · Neurophysiologie clinique = Clinical neurophysiology

Objectives Electroencephalographic (EEG) studies suggest chronic migraine (CM) is associated with increased global power, especially in somatosensory cortex. Furthermore, recent studies suggest chronic pain is associated with a reduced…

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Negative / Null Result ReportMedicine

The Effects of 31-Day Exogenous Ketone Consumption on Running Performance, Cognitive Function, Metabolism, Body Composition, Hemodynamics, and Mood in Recreational Runners: A Randomized-Control Trial.

Prins PJ, Buga A, Storoschuk K et al. · 2026 · Journal of the American Nutrition Association

Background Exogenous ketone supplementation acutely elevates circulating beta-hydroxybutyrate ( R -BHB), but the impact of chronic repeated dosing on exercise performance, cognition, mood, and cardiometabolic health remains unclear.…

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Negative / Null Result ReportMedicine

Characterizing non-hallucinogenic psychedelics beyond the head twitch response: phenotypic fingerprinting of lisuride and LSD.

King JL, Effinger DP, Basquez-Pfeifer C et al. · 2026 · Translational psychiatry

The head-twitch response (HTR) is widely used as a preclinical assay for the hallucinogenic potential of compounds, with its utility based on 5HT 2A R activation. Here, we examine how the polypharmacological agonists lisuride and lysergic…

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