Clinical impact of TP53 classifications in previously treated advanced driver-negative non-small cell lung cancer: A biomarker analysis of the OAK and POPLAR randomized clinical trials.
Zhou DD; Lord SJ; Lin FP; Cooper WA; Zaheed M; Simes RJ; John T; Lee CK · 2026 · Lung cancer (Amsterdam, Netherlands)
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Background In NSCLC, TP53 mutations are heterogeneous with varied effects on protein synthesis, function and clinical outcomes. We hypothesize that a refined classification of TP53 mutations, beyond binary categorization, could improve…
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Metadata source: Europe PMC · DOI 10.1016/j.lungcan.2025.108891