19,847 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Yin Q, Shu T, Chen Z et al. · 2025 · Preprint
Abstract Background To investigate the relationship between emotional dysregulation, as measured by the emotional go/nogo task, and the multidimensional profile of borderline personality disorder (BPD). Methods Eighty-two participants (32…
View details →Normann SS, Andersen HR, Lund LC et al. · 2025 · Environmental research
Background Over the past decade, the use of organophosphate insecticides including chlorpyrifos has faced increasing restrictions due to health concerns, leading to a rise in use of pyrethroids. Concerns about neurodevelopmental insults…
View details →Razeghi M, Abdoli S, Mardanian Dehkordi L · 2024 · Applied nursing research : ANR
Aim Identify the relationship between a sense of belonging and psychosocial well-being in individuals with type 1 diabetes (T1D) in Iran. Background Understanding this relationship is vital for tailored nursing interventions to enhance…
View details →Gao Y, Hsu V, Kil A et al. · 2026 · The Journal of clinical endocrinology and metabolism
Context Previous animal studies show association between osteocalcin (OC) and type 2 diabetes-related quantitative traits (QTs), with some suggesting these effects being mediated by adipokines. Replication in humans has been inconsistent.…
View details →Fitzgerald M · 2024 · Trends in Food Science & Technology.
The messaging around processed food recently is that it is unhealthy and associated with the onset of chronic disease. However, food is processed for many reasons that range from preservation to safety, and then more recently in response…
View details →Dousset J, Curnock MI, Wang JZ et al. · 2026 · Environmental management
As the Great Barrier Reef (GBR, the Reef) faces unprecedented threats, reducing anthropogenic pressures and fostering stewardship within coastal communities are among the strategic priorities identified in the Australian and Queensland…
View details →Huh K, Kang M, Jung J · 2023 · European heart journal
Background and aims An increased risk of aortic aneurysm and aortic dissection (AA/AD) has been reported with fluoroquinolone (FQ) use. However, recent studies suggested confounding factors by indication. This study aimed to investigate…
View details →Hecht S, Rojas-Ruiz A, Boucher M et al. · 2025 · Lung
Introduction A recent study on BALB/c and C57BL/6 mice demonstrated a clear lack of association between the in vivo response to nebulized methacholine and the degree of airway narrowing ex vivo in a model of asthma induced by a daily…
View details →Govender V, Govender K, Moodley D · 2026 · BMC infectious diseases
BACKGROUND: Maintaining viral suppression in the postpartum period is critical for preventing HIV transmission to sexual partners and breastfed infants. Despite systemic viral suppression, genital HIV shedding may still occur in some…
View details →Kambara M, Ikawa F, Hidaka T et al. · 2025 · Neurosurgery
Background and objectives Some reports suggest that older patients with traumatic brain injury (TBI) are more likely to experience acute intracranial hemorrhage, resulting in poor outcomes. However, the association between precise…
View details →Rodriguez JA, Palermo NE, Song W et al. · 2026 · Diabetes technology & therapeutics
Continuous glucose monitors (CGMs) are becoming increasingly available, yet the relationship between CGM metrics and hemoglobin A1c (HbA1c) among individuals with prediabetes and normoglycemia remains unclear. We examined associations…
View details →de Luis D, Primo D, Izaola O et al. · 2024 · European review for medical and pharmacological sciences
Objective Sarcopenia is a condition characterized by muscle mass loss. Skeletal muscle is capable of producing and secreting different molecules called myokines, and apelin is one of them. The literature contains contradictory data on the…
View details →Leibold P, Lteif C, Duarte JD · 2025 · Frontiers in genetics
Introduction Hypertension (HTN) is a leading risk factor for several cardiovascular diseases. While some previous studies reported that CYP3A5 variants were associated with decreased blood pressure and risk of HTN, others reported no…
View details →Solanki JD, Joshi DR, Atodaria KA et al. · 2025 · Journal of family medicine and primary care
Introduction Cardiovascular health is adversely affected by menopausal transition with reduced heart rate variability (HRV) as a manifest. Electrocardiogram (ECG) based 5 min HRV has worsening trend from premenopausal to postmenopausal…
View details →Chang RC, Olbrich H, Wang YF et al. · 2026 · JID innovations : skin science from molecules to population health
Bullous pemphigoid (BP) is an autoimmune blistering disease caused by autoantibodies to collagen type 17 ( COL17A1 ) and is a recognized immune-related adverse event in patients receiving immune checkpoint inhibitors (ICIs). We…
View details →Goldenholz DM, Cheng JC, Chang C et al. · 2025 · Preprint
ABSTRACT Importance Medication adherence is widely emphasized in epilepsy management, with a belief that missing even single doses can trigger seizures. However, scientific evidence supporting this specific claim is limited, particularly…
View details →Simonin EM, Switkowski KM, Rifas-Shiman SL et al. · 2026 · Frontiers in pediatrics
Introduction There are currently no known biomarkers associated with the diagnosis of infant colic, a common early disorder of gut brain interaction (DGBI) that has been found to predict adverse health outcomes, including atopy, migraines…
View details →Soltanizadeh A, Tirgar A, Zamanian Y et al. · 2025 · Frontiers in oncology
Background Apelin, a peptide implicated in various physiological processes, has been shown to be involved in cancer development and progression. However, its role in breast cancer remains unclear. This study aimed to investigate serum…
View details →McEvoy LK, Zhang B, Nguyen S et al. · 2026 · Aging
Epigenetic clocks of biological aging have been associated with cognitive impairment and dementia. Less is known about whether they are associated with an older-appearing brain or with an atrophy pattern associated with dementia. We…
View details →Cristiani R, Hansson F, Senorski EH et al. · 2025 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
Purpose To evaluate factors associated with revision anterior cruciate ligament reconstruction (ACLR) within 5 years of primary ACLR in children and adolescents. Methods Children and adolescents (age Results A total of 1888 patients (mean…
View details →Silva MJA, Figueira LRT, Sardinha DM et al. · 2025 · Frontiers in genetics
Coronavirus disease 2019 (COVID-19) is a multisystemic disease caused by SARS-CoV-2 that can lead to several pulmonary illnesses according to the immunological contexts of the individual. Haplotypes consist of single-nucleotide…
View details →Ma Y, Mayes MD, Guo X et al. · 2024 · Scientific reports
This study aimed to examine whether a reported SSc-associated SNP rs2841277 in the PLD4 gene identified in an Asian population was also associated with SSc in European American (EA). The EA cohort consisting of 1005 SSc patients and 961…
View details →Reveley M, Owen GR, Tumba N et al. · 2026 · Developmental neurobiology
Autism spectrum disorder (ASD) has recently been described as a synaptopathy where dysregulation at the level of the synapse is thought to evoke an excitation-inhibition (E/I) imbalance implicated in its pathogenesis. The mechanisms…
View details →McHenry MS, Huo Y, Williams PL et al. · 2026 · Journal of acquired immune deficiency syndromes (1999)
Background Our objective was to evaluate the association between inflammatory biomarkers and NIH Toolbox cognitive outcomes in young adults with perinatal HIV exposure but uninfected (YAPHEU) and those with perinatal HIV (YAPHIV), with or…
View details →Bontrager M, Worthy SJ, Leventhal L et al. · 2025 · Preprint
Summary Herbarium specimens are broadly distributed in space and time, enabling investigation of climate impacts on phenology and fitness. We reconstructed specimen “lived” climate from knowledge of germination cues and collection dates…
View details →Hunter JWS, Van Den Heuvel C, Stephenson L et al. · 2025 · The American journal of forensic medicine and pathology
Abstract Both obesity and opioid abuse are increasing in numbers globally. As these entities may be associated with significant respiratory compromise, it was hypothesized that synergism may occur and that as a result of this obese…
View details →Christian K, Moritz C, Skelton K et al. · 2024 · Preprint
1. Reptiles are challenged with maintaining stable hydric states and viable body temperatures in a variable terrestrial environment. Reptiles can use behaviour to select favourable microhabitats as well as physiological adaptations, such…
View details →Eskandarian S, Zafarani A, Tandel P et al. · 2025 · Molecular biology reports
Background Clopidogrel is a widely used antiplatelet drug for treating acute coronary syndrome. Its metabolism primarily involves the CYP2C19 isoenzyme, with CYP2C192 and CYP2C193 alleles associated with reduced metabolic activity.…
View details →Dias ALB, Nascimento JR, Brito-Sousa JD et al. · 2025 · PloS one
Background Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is a common genetic disorder that impairs the cellular antioxidant response and has been hypothesized as a potential risk factor for severe outcomes in viral infections,…
View details →van Dijkman SC, Félices M, Pandurangavittal B et al. · 2026 · British journal of clinical pharmacology
Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack…
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