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Browse the failure-mode index

20,227 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

HSP90 is involved in curcumin-mediated inhibition of tau aggregation.

Kam MK, Kim JW, Choi JY et al. · 2026 · Biochemical and biophysical research communications

Tau aggregation in neurons is a pathological hallmark of Alzheimer's disease (AD). The development of therapeutic drugs that inhibit tau aggregation in tauopathies, including AD, remains challenging. Herein, we developed a tau…

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Negative / Null Result ReportMedicine

Daily administration of long-acting adrenocorticotropic hormone (ACTH) alters the developmental pattern of plasma fibrinogen in juvenile rats.

Takeda Y, Sakakibara T, Horiuchi K et al. · 2026 · Brain & development

Background We previously reported that adrenocorticotropic hormone (ACTH) therapy for infantile epileptic spasm syndrome (IESS) decreases plasma fibrinogen (Fbg) levels. However, the underlying mechanism(s) has not been elucidated. An…

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Negative / Null Result ReportMedicine

Exploring the Effects of Saturated and Transition-Metal-Substituted Dawson Doping on Electrocatalytic CO<sub>2</sub> Reduction Activity in P<sub>2</sub>W<sub>18</sub>@PCN-222 and P<sub>2</sub>W<sub>17</sub>M@PCN-222 (M = Co, Mn, Ni) Composites.

Li C, Shu L, Teng YL et al. · 2026 · Inorganic chemistry

To exploit the electron-sponge properties of polyoxometalates (POMs) and elucidate the mechanistic impact of doping with saturated versus metal-substituted Dawson-type POMs on electrocatalytic CO 2 reduction, P 2 W 18 @PCN-222 and P 2 W 17…

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Negative / Null Result ReportMedicine

Effect of a parent-supported psychosocial development program on psychosocial outcomes of children aged 1-3 years: a waiting-list randomized controlled trial.

Cirlak A, Kacan H · 2026 · Irish journal of medical science

BACKGROUND: Parent-supported psychosocial development programs aim to strengthen the parent-child relationship and promote healthy early childhood development, particularly in settings where access to structured preventive interventions is…

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Negative / Null Result ReportMedicine

Overcoming doramectin failure: field efficacy of pour-on 5% fluralaner and an experimental 1% oral formulation for the prevention of Cochliomyia hominivorax-associated umbilical myiasis in newborn calves.

de Freitas MDB, Rodrigues DC, de Paiva PEM et al. · 2026 · Parasites & vectors

Background Myiasis caused by Cochliomyia hominivorax larvae is a reemerging challenge in the Americas due to the recent reappearance of this species in areas where it had been eradicated and reports of doramectin inefficacy, despite its…

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Negative / Null Result ReportOpen accessMedicine

Cardiovascular pharmacotherapy in 2025.

Tamargo J, Agewall S, Ambrosio G et al. · 2026 · European heart journal. Cardiovascular pharmacotherapy

Despite recent advances in cardiovascular pharmacotherapy, prevention and treatment of many cardiovascular diseases remain limited with a clear need for more effective and safer pharmacological strategies. Here, we summarize the most…

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Negative / Null Result ReportMedicine

Myofilament-level effects of aficamten increase diastolic chamber volumes and maintain cardiac output through preserved length-dependent force generation in healthy rat and canine myocardium.

Sárkány F, Priksz D, Juhász B et al. · 2026 · Basic research in cardiology

Clinical trial experience supports the use of myosin inhibitors in hypertrophic cardiomyopathy (HCM), while early proof-of-concept studies suggest potential benefit in selected patients with heart failure with preserved ejection fraction…

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Negative / Null Result ReportMedicine

Do coexistent overactive bladder symptoms affect the outcome of single-incision sling in women with urodynamic stress incontinence?

Hsieh TH, Liang CC, Liang CY et al. · 2026 · Taiwanese journal of obstetrics & gynecology

Objective To explore whether preoperative overactive bladder (OAB) symptoms affect the outcome of single-incision slings (SIS) for urodynamic stress incontinence (USI). Materials and methods This retrospective study involved 106 patients…

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Negative / Null Result ReportMedicine

Antimicrobial strategies for ureteral stent removal after radical cystectomy: a comparative cohort study.

Mangold MH, Kazmierczak J, Gerigk M et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

INTRODUCTION: Patients undergoing radical cystectomy (RC) face a heightened risk of infectious complications around the time of ureteral stent removal. This study aimed to determine whether a culture-guided antimicrobial strategy reduces…

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Negative / Null Result ReportMedicine

Single-injection adductor canal block with perineural dexamethasone versus continuous adductor canal catheter for total knee arthroplasty: a randomized controlled trial.

Kim DH, Beathe J, Wetmore DS et al. · 2026 · Regional anesthesia and pain medicine

Background The adductor canal block (ACB), known for its motor-sparing properties, has gained popularity as part of the multimodal analgesic regimen in total knee arthroplasty (TKA) patients. However, the duration of single-injection…

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Negative / Null Result Report

Effect of a community-based intervention for cardiovascular risk factor control on stroke mortality in rural Gadchiroli, India: a cluster-randomised controlled trial

Kalkonde Y, Jadhao S, Bhusari V et al. · 2026 · Preprint

Background: Stroke is the second leading cause of death globally. We tested whether it was feasible to deliver a community-based intervention package for prevention of stroke and, whether such an intervention would reduce stroke mortality…

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Negative / Null Result ReportOpen accessMedicine

Combined effects of mesenchymal stromal cells and antibiotic therapy on Enterobacter ventilator-associated pneumonia in rabbits.

Jacquier M, Laroye C, Bensoussan D et al. · 2026 · Respiratory research

Background Although mesenchymal stromal cells (MSCs) have shown promising effects in preclinical pneumonia models, their ability to improve outcomes in ventilator-associated pneumonia (VAP) remains poorly explored, despite VAP being a…

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Negative / Null Result ReportMedicine

Systemic Administration of an Anti-CD18 Antibody Prevents the Accumulation of Peripheral Leukocytes in Pericontusional Tissue, but Does Not Improve Outcome after Traumatic Brain Injury in Mice.

Guo Y, Hu S, Wang Z et al. · 2026 · Journal of neurotrauma

The formation of brain edema is one of the key factors that determine patient outcomes following traumatic brain injury (TBI). Despite decades of research, no causal treatment is available to date. Among the many factors discussed,…

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Negative / Null Result ReportMedicine

Early recurrence after primary TURBT for non-muscle-invasive bladder cancer in Iceland: the critical role of surgical quality.

Björnsson O, Geirsson G, Leifsson ÁS et al. · 2026 · Scandinavian journal of urology

Introduction Transurethral resection of bladder tumor (TURBT) is the standard treatment for non-muscle-invasive bladder cancer (NMIBC), but early recurrences remain frequent. The objective of this study was to standardize TURBT management…

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