Negative / Null Result ReportOpen accessMedicine
Andrew X. Zhu, Olivier Rosmorduc, T.R. Jeffry Evans et al. · 2014 · Journal of Clinical Oncology
PURPOSE: To compare the clinical outcomes of sorafenib plus either erlotinib or placebo in patients with advanced hepatocellular carcinoma (HCC) in a multicenter, multinational, randomized, phase III trial. PATIENTS AND METHODS: Patients…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Calvin K. Lai, Allison L. Skinner, Erin Cooley et al. · 2016 · Journal of Experimental Psychology General
Implicit preferences are malleable, but does that change last? We tested 9 interventions (8 real and 1 sham) to reduce implicit racial preferences over time. In 2 studies with a total of 6,321 participants, all 9 interventions immediately…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Thomas Klopstock, Patrick Yu‐Wai‐Man, Konstantinos Dimitriadis et al. · 2011 · Brain
Major advances in understanding the pathogenesis of inherited metabolic disease caused by mitochondrial DNA mutations have yet to translate into treatments of proven efficacy. Leber's hereditary optic neuropathy is the most common…
View details →Negative / Null Result ReportSocial Sciences
Marco Manacorda, Alan Manning, Jonathan Wadsworth · 2011 · Journal of the European Economic Association
Immigration to the UK, particularly among more educated workers, has risen appreciably over the past 30 years and as such has raised labor supply. However studies of the impact of immigration have failed to find any significant effect on…
View details →Negative / Null Result ReportOpen accessMedicine
Kentaro Suzuki, Yuji Matsumaru, Masataka Takeuchi et al. · 2021 · JAMA
IMPORTANCE: Whether intravenous thrombolysis is needed in combination with mechanical thrombectomy in patients with acute large vessel occlusion stroke is unclear. OBJECTIVE: To examine whether mechanical thrombectomy alone is noninferior…
View details →Negative / Null Result ReportSocial Sciences
Tyler W. Watts, Greg J. Duncan, Haonan Quan · 2018 · Psychological Science
We replicated and extended Shoda, Mischel, and Peake's (1990) famous marshmallow study, which showed strong bivariate correlations between a child's ability to delay gratification just before entering school and both adolescent achievement…
View details →Negative / Null Result ReportOpen accessMedicine
Mark A. Socinski, Makoto Nishio, Robert M. Jotte et al. · 2021 · Journal of Thoracic Oncology
INTRODUCTION: We report the final overall survival (OS) analyses of atezolizumab-carboplatin-paclitaxel (ACP [experimental arm]) and OS data with approximately 39.8 months of median follow-up with…
View details →Negative / Null Result ReportOpen accessMedicine
Obbina Abani, Ali Abbas, Fatima Abbas et al. · 2021 · The Lancet
BACKGROUND: Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19. METHODS: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. Eligible and consenting patients were randomly assigned (1:1) to receive either usual care al
View details →Negative / Null Result ReportOpen accessMedicine
The ICU-ROX Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group · 2019 · New England Journal of Medicine
BACKGROUND: ) and have a high arterial oxygen tension. The conservative use of oxygen may reduce oxygen exposure, diminish lung and systemic oxidative injury, and thereby increase the number of ventilator-free days (days alive and free…
View details →Negative / Null Result ReportOpen accessMedicine
Horng H. Chen, Kevin J. Anstrom, Michael M. Givertz et al. · 2013 · JAMA
IMPORTANCE: Small studies suggest that low-dose dopamine or low-dose nesiritide may enhance decongestion and preserve renal function in patients with acute heart failure and renal dysfunction; however, neither strategy has been rigorously…
View details →Negative / Null Result ReportOpen accessMedicine
Michael Lim, Michael Weller, Ahmed Idbaïh et al. · 2022 · Neuro-Oncology
BACKGROUND: Nearly all patients with newly diagnosed glioblastoma experience recurrence following standard-of-care radiotherapy (RT) + temozolomide (TMZ). The purpose of the phase III randomized CheckMate 548 study was to evaluate RT + TMZ…
View details →Negative / Null Result ReportMedicine
US Preventive Services Task Force, Susan J. Curry, Alex H. Krist et al. · 2019 · JAMA
Importance: Perinatal depression, which is the occurrence of a depressive disorder during pregnancy or following childbirth, affects as many as 1 in 7 women and is one of the most common complications of pregnancy and the postpartum…
View details →Negative / Null Result ReportMedicine
Joshua D. Harris, Jefferson C. Brand, Mark P. Cote et al. · 2017 · Arthroscopy The Journal of Arthroscopic and Related Surgery
Patient-reported outcomes (PROs) are increasingly being used in today's rapidly evolving health care environment. The value of care provision emphasizes the highest quality of care at the lowest cost. Quality is in the eye of the beholder,…
View details →Negative / Null Result ReportOpen accessMedicine
T-K Clarke, Mark J. Adams, Gail Davies et al. · 2017 · Molecular Psychiatry
Alcohol consumption has been linked to over 200 diseases and is responsible for over 5% of the global disease burden. Well-known genetic variants in alcohol metabolizing genes, for example, ALDH2 and ADH1B , are strongly associated with alcohol consumption but have limited impact in European populations where they are found at low frequency. We performed a genome-wide association study (GWAS) of self-reported alcohol consumption in 112 117 individuals in the UK Biobank (UKB) sample of white British individuals. We report significant genome-wide associations at 14 loci. These include single-nuc
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Kevork N. Abazajian, Manoj Kaplinghat · 2012 · Physical review. D. Particles, fields, gravitation, and cosmology/Physical review. D, Particles, fields, gravitation, and cosmology
We show the existence of a statistically significant, robust detection of a gamma-ray source in the Milky Way Galactic Center that is consistent with a spatially extended signal using about 4 years of Fermi-LAT data. The gamma-ray flux is…
View details →Negative / Null Result ReportPhysics and Astronomy
Lorenz Roth, Joachim Saur, K. D. Retherford et al. · 2013 · Science
In November and December 2012, the Hubble Space Telescope (HST) imaged Europa's ultraviolet emissions in the search for vapor plume activity. We report statistically significant coincident surpluses of hydrogen Lyman-α and oxygen OI…
View details →Negative / Null Result ReportOpen accessMedicine
John P. Clancy, Steven M. Rowe, Frank J. Accurso et al. · 2011 · Thorax
BACKGROUND: VX-809, a cystic fibrosis transmembrane conductance regulator (CFTR) modulator, has been shown to increase the cell surface density of functional F508del-CFTR in vitro. METHODS: A randomised, double-blind, placebo-controlled…
View details →Negative / Null Result ReportOpen accessMedicine
Markus Waldén, I. Atroshi, Henrik Magnusson et al. · 2012 · BMJ
OBJECTIVE: To evaluate the effectiveness of neuromuscular training in reducing the rate of acute knee injury in adolescent female football players. DESIGN: Stratified cluster randomised controlled trial with clubs as the unit of…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Erin L. Kelly, Phyllis Moen, J. Michael Oakes et al. · 2014 · American Sociological Review
Schedule control and supervisor support for family and personal life are work resources that may help employees manage the work-family interface. However, existing data and designs have made it difficult to conclusively identify the…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Catherine Happer, Greg Philo · 2013 · Journal of Social and Political Psychology
The media play a central role in informing the public about what happens in the world, particularly in those areas in which audiences do not possess direct knowledge or experience. This article examines the impact the media has in the construction of public belief and attitudes and its relationship to social change. Drawing on findings from a range of empirical studies, we look at the impact of media coverage in areas such as disability, climate change and economic development. Findings across these areas show the way in which the media shape public debate in terms of setting agendas and focus
View details →Negative / Null Result ReportEconomics, Econometrics and Finance
Dean Karlan, Jonathan Zinman · 2011 · Science
Microcredit institutions spend billions of dollars fighting poverty by making small loans primarily to female entrepreneurs. Proponents argue that microcredit mitigates market failures, spurs micro-enterprise growth, and boosts borrowers'…
View details →Negative / Null Result ReportOpen accessMedicine
J. Michael Wells, George R. Washko, MeiLan K. Han et al. · 2012 · New England Journal of Medicine
BACKGROUND: Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with accelerated loss of lung function and death. Identification of patients at risk for these events, particularly those requiring hospitalization,…
View details →Negative / Null Result ReportOpen accessArts and Humanities
Idoia Elola, Ana Oskoz · 2010 · Language learning & technology
The use of social technologies, such as wikis and chats, has brought a renewed attention to L2 collaborative writing.Yet, a question that still remains to be answered is the extent to which learners' writing is enhanced when using these…
View details →Negative / Null Result ReportMedicine
Tiffany N. Castillo, Michael A. Pouliot, Hyeon Joo Kim et al. · 2010 · The American Journal of Sports Medicine
BACKGROUND: Clinical studies claim that platelet-rich plasma (PRP) shortens recovery times because of its high concentration of growth factors that may enhance the tissue repair process. Most of these studies obtained PRP using different…
View details →Negative / Null Result ReportOpen accessMedicine
Eva Haglind, Stefan Carlsson, Johan Stranne et al. · 2015 · European Urology
BACKGROUND: Robot-assisted laparoscopic radical prostatectomy (RALP) has become widely used without high-grade evidence of superiority regarding long-term clinical outcomes compared with open retropubic radical prostatectomy (RRP), the…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Αιμιλία Πρωτόγερου, Yannis Caloghirou, Spyros Lioukas · 2011 · Industrial and Corporate Change
This article seeks to empirically explore the relationship between dynamic capabilities and firm performance. In particular, it addresses the question of whether dynamic capabilities impact directly or indirectly on performance. In doing…
View details →Negative / Null Result ReportMedicine
Roberto Castricini, Umile Giuseppe Longo, Massimo De Benedetto et al. · 2010 · The American Journal of Sports Medicine
BACKGROUND: After reinsertion on the humerus, the rotator cuff has limited ability to heal. Growth factor augmentation has been proposed to enhance healing in such procedure. PURPOSE: This study was conducted to assess the efficacy and…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Young‐Seoub Hong, Ki-Hoon Song, Jin‐Yong Chung · 2014 · Journal of Preventive Medicine and Public Health
Arsenic is a unique element with distinct physical characteristics and toxicity whose importance in public health is well recognized. The toxicity of arsenic varies across its different forms. While the carcinogenicity of arsenic has been…
View details →Negative / Null Result ReportOpen accessMedicine
Abdulaziz N. Alagaili, Thomas Briese, Nischay Mishra et al. · 2014 · mBio
The Middle East respiratory syndrome (MERS) is proposed to be a zoonotic disease; however, the reservoir and mechanism for transmission of the causative agent, the MERS coronavirus, are unknown. Dromedary camels have been implicated through reports that some victims have been exposed to camels, camels in areas where the disease has emerged have antibodies to the virus, and viral sequences have been recovered from camels in association with outbreaks of the disease among humans. Nonetheless, whether camels mediate transmission to humans is unresolved. Here we provide evidence from a geographic
View details →Negative / Null Result ReportComputer Science
Youngjoon Choi, Miju Choi, Munhyang Oh et al. · 2019 · Journal of Hospitality Marketing & Management
Hotel industry started to adopt service robots, which are considered a future workforce. However, no attempt was conducted to examine the dimensionality of service quality of service robots. This paper aims to understand the influence of…
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