A randomized placebo-controlled trial of idebenone in Leber’s hereditary optic neuropathy
Thomas Klopstock; Patrick Yu‐Wai‐Man; Konstantinos Dimitriadis; Jacinthe Rouleau; Suzette Heck; Maura Bailie; Alaa Atawan; Sandip Chattopadhyay · 2011 · Brain
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Major advances in understanding the pathogenesis of inherited metabolic disease caused by mitochondrial DNA mutations have yet to translate into treatments of proven efficacy. Leber's hereditary optic neuropathy is the most common…
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Metadata source: OpenAlex · DOI 10.1093/brain/awr170