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Browse the failure-mode index

19,843 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Dietary folate education versus once-weekly iron folic acid supplementation for improving folate status in reproductive-aged women: a quasi-experimental study.

Sroypechr K, Hutchinson C, Satheannoppakao W et al. · 2026 · BMC nutrition

Background The folate status of women of reproductive age (WRA) in Thailand is suboptimal for reducing risk of neural tube defects (NTD). This research aimed to compare the effect of dietary folate education based on the health belief…

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Negative / Null Result ReportOpen accessMedicine

Incremental Value of Adding S100B to NSE for High-Specificity Rule-in of Poor Neurological Outcome After Out-of-Hospital Cardiac Arrest.

Hong S, Lee S, Park JS et al. · 2026 · Journal of clinical medicine

Background : We evaluated whether adding S100B to NSE improved discrimination or high-specificity rule-in of poor neurological outcome after out-of-hospital cardiac arrest (OHCA). Methods : In this single-center retrospective cohort study,…

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Negative / Null Result ReportMedicine

Do Laser and Light Activation Improve In-Office Dental Bleaching Outcomes? An Umbrella Review of Efficacy, Tooth Sensitivity, and Biological Safety.

Allende JB, Campos-Bijit V, Morales-Gómez C et al. · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]

Objective To synthesize umbrella-level evidence on laser or light activation and photobiomodulation in in-office dental bleaching, including whitening efficacy, tooth sensitivity, and biological safety. Systematic reviews were searched in…

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Negative / Null Result ReportMedicine

Evaluating the efficacy of G12C inhibitors in conjunction with Gamma Knife radiosurgery for KRAS-mutant non-small cell lung cancer brain metastases.

Andrade A, Mureb M, Karaman N et al. · 2026 · Journal of neuro-oncology

PURPOSE: KRAS G12C mutations occur in approximately 11% of non-small-cell lung cancer (NSCLC) patients and are associated with aggressive disease and poor prognosis. Although KRAS G12C-inhibitors are now approved, their impact on Gamma…

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Negative / Null Result ReportMedicine

The Effects of a Powdered Meal Replacement on Inflammation, Gut Microbiota, and Metabolism in People With Excess Body Weight-A Randomized Controlled Trial.

Montenegro J, Oliveira CL, Nguyen NK et al. · 2026 · The Journal of nutrition

Background Excess body weight is associated with chronic low-grade inflammation and metabolic abnormalities, such as insulin resistance, and dyslipidemia. Objectives This study aimed to assess the impact of a soy protein-yogurt-honey…

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Negative / Null Result ReportMedicine

Performance, non-carcass components, serum biochemistry panel and intestinal morphology of Texel lambs fed with bioactive peptides.

Nascimento GO, Otávio KS, Ferreira J et al. · 2026 · Tropical animal health and production

Bioactive peptides (BP) have been investigated as potential functional feed additives due to their reported immunomodulatory and metabolic properties. This study evaluated the effects of dietary BP supplementation on growth performance,…

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Negative / Null Result ReportMedicine

Endogenous Theta as a Function of Task Load and Working Memory Capacity: Revisiting the Role of Slower Frequencies in Theta-Gamma Coupling.

Tortajada M, Rodríguez-Larios J, Martínez-Pérez V et al. · 2026 · Journal of cognitive neuroscience

Recent findings have shown the influential role of theta-gamma cross-frequency coupling in the maintenance of items in working memory (WM). Specifically, it has been proposed that individual items are represented within gamma oscillations…

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Negative / Null Result ReportMedicine

Real-World Data on Treatment Compliance and Visual Outcomes Between Patients With Diabetic Macular Edema or Retinal Vein Occlusion Receiving Antivascular Endothelial Growth Factor Injections or Intravitreal Corticosteroid Implants.

Kim SB, Lopez A, Gu X et al. · 2026 · Journal of vitreoretinal diseases

Purpose: To evaluate real-world differences in treatment frequency, appointment compliance, and visual outcomes among patients with DME or RVO whose eyes either remained on antivascular endothelial growth factor (anti-VEGF) therapy or were…

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Negative / Null Result ReportMedicine

Testing the efficacy of a defocusing intervention to improve affective forecasting accuracy in younger and older adults.

Sobel Misieczko M, Barber SJ · 2026 · Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition

Affective forecasting, the process of predicting future feelings, is key for decision-making, but prone to errors. Prior research suggests that age differences in forecasting accuracy vary by event valence such that older adults tend to be…

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Negative / Null Result Report

Acute profound thrombocytopenia associated with glycoprotein IIb/IIIa receptor inhibitor after percutaneous coronary intervention: therapy insights from a single center 6-year experience

Wu Y, Feng K, Liu L et al. · 2026 · Preprint

Abstract Background Acute profound thrombocytopenia is an infrequent, but potentially serious, even fatal complication associated with intravenous glycoprotein IIb/IIIa receptor inhibitors (GPI), which are widely used in acute coronary…

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Negative / Null Result ReportMedicine

Effects of Dry-Land Versus In-Water Resistance Priming Exercise on Performance Parameters of Young Female Water Polo Players.

Brisola GMP, da Cruz AL, Belorio LGDS et al. · 2026 · Journal of strength and conditioning research

Abstract Brisola, GMP, da Cruz, AL, Belorio, LGdS, Grossi, JP, De Poli, RAB, Zagatto, AM, Esco, MR, and Mendes, OdC. Effects of dry-land versus in-water resistance priming exercise on performance parameters of young female water polo…

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Negative / Null Result ReportMedicine

A single autoregressive integrated moving average with exogenous variable outperforms ensembles of autoregressive models for forecasting influenza hospitalizations in the contiguous United States.

Arraes Rocha Felix V, Rohani P, Drake JM · 2026 · Journal of the Royal Society, Interface

Infectious disease forecasting is important to public health decision-making, particularly for mitigating the burden of seasonal influenza. We propose and evaluate comprehensive autoregressive modelling approaches (autoregressive…

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Negative / Null Result ReportMedicine

Mycorrhizal inoculation and crop rotation as soil sustainable management strategies to reduce fertilizer use and water consumption in horticultural crops

Vargas Ribera PR, Nogales A, Calvet C et al. · 2026 · Applied Soil Ecology.

Crop rotation enhances agroecosystem sustainability by reducing nutrient loss, improving soil fertility, and decreasing crop evapotranspiration. Arbuscular mycorrhizal fungi (AMF) inoculation further supports enhanced nutrient and water…

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Negative / Null Result ReportMedicine

Does air abrasion improve the retention of restorations in non-carious cervical lesions? An 18-month split-mouth randomized controlled trial.

Forville H, Coppla FM, Naupari-Villasante R et al. · 2026 · Journal of dentistry

Objective To evaluate whether dentin airborne-particle abrasion (APA) with aluminum oxide affects the retention and clinical performance of composite resin restorations in non-carious cervical lesions (NCCLs). Methods This prospective,…

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Negative / Null Result ReportMedicine

Efficacy of a short multimodal workshop including stress management and communication skills training on objective structured clinical examination performance and exam-related anxiety in French medical students: a randomized controlled study.

Vedrenne-Cloquet M, de Montmollin E, Gaudemer A et al. · 2026 · Journal of educational evaluation for health professions

Purpose To assess the effectiveness of a short multimodal workshop, including stress-management and communication-skills training, on objective structured clinical examination (OSCE) performance and exam-related anxiety among medical…

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Negative / Null Result Report

Endogenous Theta as a Function of Task Load and Working Memory Capacity: Revisiting the Role of Slower Frequencies in Theta-Gamma Coupling

Tortajada M, Rodriguez-Larios J, Martínez-Pérez V et al. · 2026 · Preprint

Recent findings have shown the influential role of theta-gamma cross-frequency coupling in the maintenance of items in Working Memory (WM). Specifically, it has been proposed that individual items are represented within gamma oscillations…

View details →