20,217 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Liu Y, Wang X, Qian P et al. · 2026 · Preprint
Abstract Background Patients with locally advanced esophageal squamous cell carcinoma (ESCC) undergoing surgery after neoadjuvant chemotherapy (NCT) or neoadjuvant chemoimmunotherapy (NICT) remain at risk of disease progression. Currently,…
View details →Kitowski A, Heise C, Sperling S et al. · 2026 · British journal of pharmacology
Background and purpose Nano-formulated chemotherapeutics prolong systemic availability of drugs and can reduce systemic toxicity, but their accumulation in solid tumours is often limited and unpredictable. Broadly applicable strategies to…
View details →Grossmann I, Rudnev M, Clark CJ et al. · 2026 · Preprint
Experts and pundits routinely forecast societal trends, yet these predictions often fall short, leading to poor policy decisions. What distinguishes accurate forecasters? In a three-year longitudinal tournament (N = 520), we tested whether…
View details →Talathi R, Hubbard RA, Somasundar P et al. · 2026 · Surgery
Background The Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma (STRASS 2) trial is evaluating the impact of neoadjuvant chemotherapy versus surgery in patients with high-risk, resectable…
View details →Zhao A, Chen W, Liang Y et al. · 2026 · Cancer treatment and research communications
Objective To compare and analyze the efficacy and safety of an overall strategy of immunotherapy combined with chemoradiotherapy in patients with limited-stage small cell lung cancer (LS-SCLC)-including induction immunotherapy plus…
View details →Sarica C, Darmani G, Ramezanpour H et al. · 2026 · Science translational medicine
Transcranial ultrasound stimulation (TUS) is a promising noninvasive technique for modulating deep brain targets and circuits with high spatial precision. For its successful clinical translation, confirmation of target engagement, together…
View details →Riestra JM, Levin-Carrion Y, Sutar R et al. · 2026 · Human psychopharmacology
Treatment-resistant depression (TRD) remains a formidable challenge in psychiatry, with nearly one-third of patients with major depressive disorder (MDD) failing to respond adequately to first-line pharmacological treatments.…
View details →Nandi D, Gajarski RJ, Zhao H et al. · 2026 · Pediatric transplantation
Purpose Human Leukocyte Antigen (HLA) sensitization can adversely impact heart transplant (HTx) outcomes. We evaluated the effect of panel-reactive antibody (PRA) and desensitization (DS) strategies on outcomes of pediatric HTx recipients…
View details →Silva-García J, Eurolo I, Fuentes-Flores R et al. · 2026 · Brain research
Ischemic stroke is a leading cause of death and disability worldwide. Among survivors, one-third live with permanent impairments, and two-thirds experience upper limb dysfunction. Despite advances in acute care, no universally effective…
View details →Hayashi T, Go M, Kawasumi K et al. · 2026 · Preprint
Abstract Introduction Maintaining dose intensity is essential for the efficacy of adjuvant S-1 chemotherapy in gastric cancer. Although pharmacist interventions can reduce toxicity and improve adherence, multicenter evidence regarding…
View details →Saloojee H, Gramanie MC, Mwale R et al. · 2026 · Medical teacher
Background Generative artificial intelligence (AI) tools are entering clinical training faster than curricula and assessments can adapt. It is currently unknown whether point-of-care access to large language models (LLMs) improves…
View details →An DW, Wang Y, Cheng YB et al. · 2026 · Hypertension (Dallas, Tex. : 1979)
Background Whether central systolic blood pressure (cSBP) compared with brachial systolic blood pressure (bSBP) improves risk stratification remains debated. This study investigated whether cSBP is more closely associated with total and…
View details →Durmuş Ece BŞ, Yozgat Z, Işık MU et al. · 2026 · Journal francais d'ophtalmologie
Purpose To determine the effect of trabecular meshwork (TM) peeling on gonioscopy-assisted transluminal trabeculotomy (GATT) surgical outcomes in patients with open-angle glaucoma. Methods In this retrospective cross-sectional study,…
View details →Forville H, Coppla FM, Naupari-Villasante R et al. · 2026 · Journal of dentistry
Objective To evaluate whether dentin airborne-particle abrasion (APA) with aluminum oxide affects the retention and clinical performance of composite resin restorations in non-carious cervical lesions (NCCLs). Methods This prospective,…
View details →Vedrenne-Cloquet M, de Montmollin E, Gaudemer A et al. · 2026 · Journal of educational evaluation for health professions
Purpose To assess the effectiveness of a short multimodal workshop, including stress-management and communication-skills training, on objective structured clinical examination (OSCE) performance and exam-related anxiety among medical…
View details →Tortajada M, Rodriguez-Larios J, Martínez-Pérez V et al. · 2026 · Preprint
Recent findings have shown the influential role of theta-gamma cross-frequency coupling in the maintenance of items in Working Memory (WM). Specifically, it has been proposed that individual items are represented within gamma oscillations…
View details →Badulescu S, Gill H, Shah H et al. · 2026 · Med (New York, N.Y.)
Background Evidence suggests that glucagon-like peptide 1 receptor agonists (GLP-1RAs) might have pro-cognitive effects. No prior study has evaluated the efficacy and safety of a GLP-1RA for the treatment of cognitive dysfunction in adults…
View details →Muller M, Agrawal A, Thomas N et al. · 2026 · Substance use & addiction journal
Background Patients with opioid use disorder (OUD) are frequently hospitalized and often need post-acute care, but face high rates of rejection from post-acute and long-term care (PALTC) facilities. This study aimed to assess the impact of…
View details →Munazir M, Kausar N, Qureshi R et al. · 2026 · Scientific reports
Untreated municipal wastewater is widely used for irrigation in peri-urban agriculture where freshwater is limited, yet its effects on edible vegetable crops remain context dependent. This study evaluated the morphological, physiological,…
View details →David-Neto E, David AER, Alves B et al. · 2026 · Transplantation
Background Chronic allograft dysfunction (CAD) remains a leading cause of graft loss after kidney transplantation. Dapagliflozin (DAPA) has shown renal and cardiometabolic benefits in nontransplanted patients with chronic kidney disease.…
View details →dong y, Liu S, Wang Y · 2026 · Preprint
Abstract Background Recent research on spread through air spaces (STAS) has gained prominence. The presence of STAS is not only an independent factor associated with lung cancer recurrence and prognosis, but it remains unclear whether…
View details →Yoo C, Jeong H, Park I et al. · 2026 · Annals of surgical oncology
Background Prospective data on stereotactic body radiation therapy (SBRT) combined with modified 5-fluorouracil, leucovorin, irinotecan, and oxaliplatin (mFOLFIRINOX) in patients with locally advanced unresectable pancreatic adenocarcinoma…
View details →Akbas F, Baykan O, Avcikurt AS et al. · 2026 · BMC psychiatry
Background Major depressive disorder (MDD) has been increasingly associated with low-grade inflammation, with neutrophils playing a central role. Calprotectin is a mainly neutrophil-derived inflammatory mediator. We investigated whether…
View details →Li M, Jiang C, Wang R et al. · 2026 · Clinical rehabilitation
DesignPragmatic, two-arm, parallel-group, superiority randomised controlled trial with assessor-blinding and statistician-blinding.SettingSingle orthopaedic centre in Shanghai, China.ParticipantsOne hundred and eighty adults (aged 18-50…
View details →Anteby M, Wertheimer KO, Dominsky O et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
Objective To compare maternal and neonatal outcomes between women with hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome with and without associated hypertension. Methods This was a retrospective cohort study at a…
View details →Otowa Y, Matsuda T, Ando M et al. · 2026 · Surgery today
Background The benefit of neoadjuvant chemoradiotherapy (NACRT) for elderly patients with locally advanced rectal cancer (LARC) remains unclear because these patients are often excluded from trials. We evaluated the safety and oncologic…
View details →Hu X, Murakami G, Hasegawa H · 2026 · International journal of sports physiology and performance
Purpose This study evaluated the practical feasibility of the CORE sensor for noninvasive tracking of changes in estimated core body temperature (Est-Tcore) during simulated beach volleyball match-play in the heat and examined the effects…
View details →Cao H, Zhou Y, Gu N et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
Objectives This study evaluates oral azithromycin's effectiveness in reducing intrapartum and puerperal infection rates in term pregnant women undergoing labor induction to guide antibiotic prophylaxis. Methods This single-center…
View details →Hsia B, Liebman J, Garber L et al. · 2026 · Journal of cardiovascular electrophysiology
Background Pulmonary vein isolation (PVI) and posterior wall isolation (PWI) are frequently used in the treatment of persistent atrial fibrillation (AF). Minimal data support adjunct PWI, possibly due to lack of durability via epicardial…
View details →Kamio S, Ogura K, Sato K et al. · 2026 · Journal of surgical oncology
Background Postoperative infections remain a critical concern in the management of osteosarcoma, particularly after limb salvage surgery. While infections are often perceived as detrimental, emerging evidence suggests that under certain…
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