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19,843 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Endoscopic-Assisted Osteotomy with Absorbable Plate as Internal Attachment Point for External Spring Distraction Osteogenesis in the Treatment of Sagittal Synostosis in Infants.

Shen W, Cui J, Ji Y et al. · 2026 · World neurosurgery

Background Sagittal synostosis (SS) is the premature closure of sagittal sutures. To investigate the use of absorbable plates as internal attachment points for external spring (ES) traction in the treatment of sagittal craniosynostosis in…

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Negative / Null Result ReportOpen accessMedicine

Postoperative Outcomes After Rectal Cancer Surgery With or Without Primary Anastomosis: A Propensity Score-Weighted Study.

Sanda NA, Filip PV, Bobirca FT et al. · 2026 · Diagnostics (Basel, Switzerland)

Background: The role of primary anastomosis in rectal cancer surgery remains debated, particularly due to concerns regarding postoperative morbidity. Evidence from randomized trials is limited, and observational studies are frequently…

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Negative / Null Result ReportMedicine

Evaluating the Effectiveness of Bloom's Taxonomy-Based Occupational Exposure Prevention in Oral Emergency Departments: A Quasi-Experimental Study.

Shi Y, Shen Y, Zhou X et al. · 2026 · European journal of dental education : official journal of the Association for Dental Education in Europe

Objective To evaluate a Bloom's Taxonomy-based occupational exposure (OE) prevention program's impact on dental trainees' competencies compared to conventional training, assessing knowledge, skills, satisfaction, and exposure rates to…

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Negative / Null Result ReportMedicine

CLINICAL CHARACTERISTICS, IMAGING EFFICACY, AND SAFETY OF MRI-GUIDED FOCUSED ULTRASOUND ABLATION (FUS-MRI) IN THE TREATMENT OF UTERINE FIBROIDS: A SINGLE-CENTER EXPERIENCE.

Meirmanova M, Abiltayeva A, Noso Y et al. · 2026 · Georgian medical news

Introduction Uterine fibroids remain one of the most common benign tumors of the female reproductive system and a significant cause of menorrhagia, pain, symptoms of pelvic organ compression, and a reduced quality of life. Due to the…

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Negative / Null Result ReportMedicine

A Biodegradable Polymeric Sealant Applied to Transected Margin Following Stapled Distal Pancreatectomy Reduces Overall Complication: A Randomised Controlled Trial.

Furtado R, Weinberg L, Haghighi KS et al. · 2026 · ANZ journal of surgery

Background Postoperative pancreatic fistula (POPF) is the primary cause of morbidity after distal pancreatectomy (DP). This trial investigated the application of a combined polyethylene glycol (PEG) and recombinant human albumin sealant…

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Negative / Null Result ReportMedicine

Functional and quality of life outcomes following surgical treatment for cauda equina syndrome: A retrospective tertiary centre study.

Kumar A, Aduri TT, Dhatt SS et al. · 2026 · Journal of clinical orthopaedics and trauma

Background This study evaluated bladder, bowel, and sexual function outcomes following surgical decompression for cauda equina syndrome (CES) using urodynamic studies (UDS) and patient-reported outcome measures (PROMs), and explored the…

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Negative / Null Result ReportMedicine

Effect of 0.01% Atropine on Choroidal Thickness and Ocular Growth in Pre-myopic Children.

He M, Wang L, Zhang S et al. · 2026 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

Purpose To investigate the effect of nightly 0.01% atropine eye drops on choroidal thickness (ChT) in pre-myopic children (at risk of myopia). Methods In a 12-month randomised, double-blind, placebo-controlled trial, 54 children aged 5-12…

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Negative / Null Result ReportMedicine

Potentially impaired dynamic ankle control despite increased eversion and first-ray plantarflexion strength after peroneus longus tendon harvest for anterior cruciate ligament reconstruction: an observational study.

Masoud M, El-Assal MA, Ibrahim MA et al. · 2026 · International orthopaedics

Background The peroneus longus tendon (PLT) has emerged as a promising graft option for anterior cruciate ligament reconstruction (ACLR), with acceptable outcomes; however, concerns have been raised about potential donor-site morbidity,…

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Negative / Null Result ReportMedicine

Association between echocardiographic parameters and white matter hyperintensities in patients with ischemic cerebrovascular disease.

Zhang Y, Wang Y, You S et al. · 2026 · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Background White matter hyperintensities (WMHs) are associated with an increased risk of stroke, cognitive decline, and all-cause mortality. However, the relationship between cardiac function, particularly left ventricular ejection…

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Negative / Null Result ReportMedicine

Evaluation of 4 Different Suture Threads in A Sample of Dentistry Suture-Naïve Students: A Randomised Controlled Trial.

Davide S, Domenico M, Fabio C et al. · 2026 · European journal of dental education : official journal of the Association for Dental Education in Europe

Introduction Suturing is a crucial step in oral surgery, directly affecting wound healing quality. Simple interrupted suture is widely used in dentistry, often performed by novices using silk sutures due to their ease of use and low cost.…

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Negative / Null Result ReportMedicine

Night shift work and epigenetic modifications: cardiovascular-related miRNA expression within a European cohort of night shift workers.

Harding BN, Jiang Z, Pineda D et al. · 2026 · Environmental health : a global access science source

Background The major pathways contributing to cardiovascular disease among night shift workers remain poorly understood. MicroRNAs (miRNAs) have been identified as novel regulators of cardiovascular risk factors. Our objective was to…

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Negative / Null Result ReportMedicine

Development of a therapeutic education program for patients with chronic rhinosinusitis with nasal polyps.

Perrignon C, Baudouin R, Perrignon M et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Introduction Chronic rhinosinusitis with nasal polyps (CRSwNP) is a long-lasting inflammatory disease that affects 1-4% of the population and markedly impairs quality of life, daily functioning, and socio-professional activities. As no…

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Negative / Null Result ReportMedicine

Association of Prophylactic Corticosteroids with Post-Extubation Outcomes in Pediatric Cardiac Critical Care: A Retrospective Propensity-Weighted Cohort Study.

Saengsin K, Jirattikanwong N, Wongyikul P et al. · 2026 · Journal of clinical medicine

Background/Objectives : Post-extubation stridor (PES) is common in pediatric critical care and may contribute to extubation failure, particularly in children with heart disease. Prophylactic corticosteroids are frequently used before…

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Negative / Null Result ReportMedicine

Does a non-dipping heart rate profile predict adverse maternal-fetal outcomes? evidence from 24-h ambulatory monitoring in the second half of high-risk pregnancies.

Espeche W, Minetto J, Cerri G et al. · 2026 · Hypertension research : official journal of the Japanese Society of Hypertension

Hypertensive disorders of pregnancy are a leading cause of maternal-fetal morbidity and mortality, with preeclampsia representing a major contributor to adverse outcomes. Ambulatory blood pressure monitoring (ABPM) has improved risk…

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Negative / Null Result ReportMedicine

Clinical Evaluation of a Real-Time Wearable System for Monitoring In-Hospital Ambulatory Patients With COVID-19: Retrospective Data Study.

Vollam S, Roman C, Santos M et al. · 2026 · JMIR medical informatics

Background Many studies have evaluated the use of wearable monitoring systems to improve patient safety in hospital. Although some have demonstrated effects on intensive care admissions, there remains little evidence of impact on patient…

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Negative / Null Result Report

Physical activity during anthracycline chemotherapy: exploratory secondary analysis of a randomized trial of functional capacity, free-living activity, and ejection fraction

Appiah KN, Sharma N, Adu N et al. · 2026 · Preprint

Abstract Background: Anthracycline-based chemotherapy produces progressive functional decline and cardiotoxicity in adults with cancer. Physical activity interventions may attenuate these effects, yet evidence across multiple domains…

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Negative / Null Result Report

Colocalization Reprioritizes the Major Depressive Disorder Druggable Genome: Demotion of the Top TWAS Signal (DRD2) and Nomination of SLC12A5/FURIN/DCC by Direction-Aware, Confirmation-Gated Analysis of 635 GWAS Loci

Kang B · 2026 · Preprint

Abstract Background: Major depressive disorder (MDD) is highly polygenic, yet translating genome-wide association study (GWAS) findings into therapeutics remains challenging. Using PGC MDD2025, we integrated gene-level mapping, brain TWAS,…

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Negative / Null Result ReportMedicine

Relationships Between Estradiol Levels and Vaginal Lactobacillus Abundance Across the Menstrual Cycles in Women.

Koczur K, Blukacz M, Galbarczyk A et al. · 2026 · American journal of human biology : the official journal of the Human Biology Council

Objectives Microbiota of the urogenital tract is crucial for women's reproductive and sexual health and is largely dominated by Lactobacillus strains. A reduction of these bacteria within the vaginal microbial community has been linked to…

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