Pembrolizumab plus enzalutamide and androgen deprivation therapy versus placebo plus enzalutamide and androgen deprivation therapy for metastatic hormone-sensitive prostate cancer: the randomized, double-blind, phase III KEYNOTE-991 study.
Gratzke C; Özgüroğlu M; Peer A; Sendur MAN; Retz M; Goh JC; Loidl W; Jayram G · 2025 · Annals of oncology : official journal of the European Society for Medical Oncology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Background Despite treatment advances, most patients with metastatic hormone-sensitive prostate cancer (mHSPC) experience disease progression to castration-resistant disease within 5 years. The placebo-controlled, double-blind, phase III…
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Metadata source: Europe PMC · DOI 10.1016/j.annonc.2025.05.008