Safety and efficacy of the anti-α-synuclein monoclonal antibody amlenetug for the treatment of patients with multiple system atrophy (AMULET): a phase 2, randomised, double-blind, multicentre trial.
Kjærsgaard L; Wiedemann J; Singer W; Takeda A; Berger AK; Flensburg MF; Hansen L; Kallunki P · 2026 · The Lancet. Neurology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Background Pathological aggregation and propagation of α-synuclein species drive disease progression in multiple system atrophy (MSA). We assessed the efficacy and safety of amlenetug, a monoclonal antibody targeting aggregated…
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Metadata source: Europe PMC · DOI 10.1016/s1474-4422(26)00100-6