Failed Experiment ReportOpen accessComputer Science
P. Danielewicz, D. Kiderlen · 1997 · arXiv
Generalization of Gaussian trial wave functions in quantum molecular dynamics models is introduced, which allows for long-range correlations characteristic for composite nuclear fragments. We demonstrate a significant improvement in the description of light fragments with the correlations. Utilizing either type of Gaussian wave functions, with or without correlations, however, we find that we cannot describe fragment formation in a dynamic situation. Composite fragments are only produced in simulations if these fragments are present as clusters in the substructure of original nuclei. The diffi
View details →Failed Experiment ReportOpen accessComputer Science
Adeel Mahmood, Aaron B. Wagner · 2024 · arXiv
Channel coding for discrete memoryless channels (DMCs) with mean and variance cost constraints has been recently introduced. We show that there is an improvement in coding performance due to cost variability, both with and without feedback. We demonstrate this improvement over the traditional almost-sure (per-codeword) cost constraint that prohibits any cost variation above a fixed threshold. Our result simultaneously shows that feedback does not improve the second-order coding rate of simple-dispersion DMCs under the almost-sure cost constraint. This finding parallels similar results for unco
View details →Failed Experiment ReportOpen accessDermatology
Stefan J. Jodl, Margitta Worm, Frauke Friedrichs et al. · 2025 · Dermatology and Therapy
Abstract Introduction Interleukin-1 receptor-associated kinase 4 (IRAK4) is expressed in various immune cells and regulates proinflammatory cytokine production. Its inhibition represents a novel, promising therapeutic option in the treatment of atopic dermatitis (AD). Zabedosertib (BAY1834845) is a potent, selective IRAK4 inhibitor that suppresses markers of local and systemic immune responses. This study aimed to evaluate the efficacy and safety of zabedosertib in adults with moderate-to-severe AD. Methods DAMASK was a randomized, double-blind, 12-week, placebo-controlled, phase 2a, proof-of-
View details →Failed Experiment ReportOpen accessTherapeutics. Pharmacology
Girish Parthan, Shobhit Bhansali, Anura V. Kurpad et al. · 2018 · BMC Pharmacology and Toxicology
Abstract Background Dipeptidyl peptidase 4 (DPP4) inhibitors improve glycemic control by promoting GLP1-mediated glucose-dependent insulin secretion and suppression of glucagon. Sitagliptin and vildagliptin have been shown to improve insulin sensitivity in patients with type 2 diabetes mellitus (T2DM). However, these patients had uncontrolled blood glucose at inclusion; therefore, the improvement in insulin sensitivity observed in these studies could be attributed to the drug per se and/or reduction in glucotoxicity. This study examines the effect of linagliptin on insulin sensitivity and β-ce
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Almira Ada Diken Türksayar, Simge Baytur · 2023 · Sabiad
Objective: The aim of this in vitro study was to compare the biaxial flexural strengths of permanent restorative materials produced by additive manufacturing and milling after thermal aging. Material and methods: For this study, three study groups were formed by producing disc-shaped specimens with a 3D printer (Form3, Formlabs) using permanent crown material (Permanent Crown, Somerville, MA) and two different resin-containing materials (Brilliant Crios,Coltene/ Whaledent; Cerasmart, GC Europe) by the milling method (n=10). The entire production process was carried out in accordance with the m
View details →Failed Experiment ReportOpen accessGeriatrics
Yuda N, Tanaka M, Yamauchi K et al. · 2020 · Clinical Interventions in Aging
Naoki Yuda,1 Miyuki Tanaka,1 Koji Yamauchi,1 Fumiaki Abe,1 Izumi Kakiuchi,2 Kyoko Kiyosawa,2 Mitsunaga Miyasaka,2 Naoki Sakane,3 Masahiko Nakamura4 1Food Ingredients and Technology Institute, Morinaga Milk Industry Co., Ltd., Zama, Kanagawa, Japan; 2Department of Nursing, Matsumoto Junior College, Matsumoto, Nagano, Japan; 3Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan; 4Matsumoto City Hospital, Matsumoto, Nagano, JapanCorrespondence: Naoki YudaFood Ingredients and Technology Institute, Morinaga Milk Industry Co.
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Chen-Ju Feng, Chin-Hui Wu, Yi-Hui Huang et al. · 2022 · Scientific Reports
Abstract This study was to determine the significance of factors considered for the measurement accuracy of personal dosimeter in dosimetry services such as dosimetry service, irradiation category, years of use and readout frequency. The investigation included management information questionnaire, on-site visit and blind test. The blind test with random selected personal badge was used in inter-comparison of eight dosimetry services, and the test results followed ANSI/HPS N13.11 criteria. This study also analyzed the measurement deviations if they felt in the criteria of ICRP 75 or not. One-wa
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Larine de Paiva Mendonça, Khalid Haddi, Wesley Augusto Conde Godoy · 2023 · PLoS ONE
In drosophilids, competition and coexistence can impact survivorship, growth, and reproductive output. Here, we evaluated direct competition between two co-occurring fruit flies, the spotted-wing drosophila Drosophila suzukii and the African fig fly Zaprionus indianus, comparing results from field collections with laboratory experiments. Field collections were conducted to evaluate co-occurrence between species. In the laboratory, different densities of eggs of each species were provided an artificial diet, and intra- and interspecific densities were evaluated regarding biological traits such
View details →Failed Experiment ReportOpen accessMiscellaneous systems and treatments
Doaa Mohamed, Faten Abd Alazim, Elham Salem et al. · 2020 · Bulletin of Faculty of Physical Therapy
Abstract Background The treatment for children and adolescents with acute lymphoblastic leukemia (ALL) can lead to multiple adverse effects, including poor physical capacity and muscle weakness. This study aimed to determine which is more effective, aerobic exercises or modified strength training program, on muscle strength and quality of life (QOL) for children with ALL. Results In terms of muscle strength, there was a significant difference (P 0.05) between groups on QOL. Conclusion The outcomes of the study showed that there was a significant difference in the selected group of muscles at b
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Jim Sheedy (20157615) · 2009
Mental rehearsal is thought to have positive effects upon the learning and retention of gross motor skills such as those demanded in many sports. A field study using 30 participants from the sport of lawn bowls failed to demonstrate a…
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Heyman, S, McAfee, J G, Davis, M A et al. · 1980
Eight neonates with jaundice were studied simultaneously with 99mTc-p-butyl-IDA and 131I-rose bengal. Due to physical decay, 99mTc-p-butyl-IDA failed to demonstrate delayed excretion through the patent extrahepatic biliary tract in 3 of 5…
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George Ampat, Emma Tixerant · 2019 · BMJ Case Reports
A 52-year-old woman sustained a direct soft tissue injury to the right knee following a fall onto the right knee. X-rays did not identify any bony injury. Physiotherapy decreased pain but instability persisted. MRI scans identified early…
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Mrityunjoy Hazra, Ashok Kumar Singh · 2023 · International Journal of Engineering Materials and Manufacture
Present work describes the metallurgical failure investigation of a failed towing arm/bar. Aircraft attached with this incident travelled a distance of 2 km with normal towing speed (8 km/hr). The component is said to have broken while…
View details →Failed Experiment ReportOpen accessPhysics
Nicholas J. Ramer, Kimberly A. Stiso · 2004 · arXiv
We present the computation of structural and polarization for a ferroelectric polymer, specifically, the beta-phase of poly(vinylidene fluoride) or (-CH$_2$-CF$_2$-)$_n$. Two structures have been described in the literature: one containing an undistorted carbon backbone (planar-zigzag) and the other containing alternatively deflected -CF$_2$- groups. Previous studies have indicated that these deflections have no significant effect on calculated elastic properties. We employ density functional theory within the generalized gradient approximation to find relaxed atomic positions for the planar-z
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Moreno-Sanchez PM, Oudin A, Kisakol B et al. · 2025 · Preprint
ABSTRACT Immune-based strategies have so far failed to demonstrate clinical benefit in glioblastoma (GBM), largely due to the profound immunosuppressive tumor microenvironment (TME). To achieve more predictive preclinical insights,…
View details →Failed Experiment ReportOpen accessMedicine
Christian Marcus Pedersen, Anders Rehfeld · 2022 · F1000Research
Opposing findings have been published on the regulation of the sperm-specific Ca2+ channel CatSper (cation channel of sperm) in human sperm cells by the plant triterpenoids lupeol and pristimerin. While the original study on this topic found these triterpenoids to act as potent inhibitors of human CatSper, subsequent studies have failed to replicate such an inhibitory effect. It has been suggested that these issues could in part be due to purity issues and/or batch variation between the plant-derived extracts of lupeol and pristimerin obtained for the studies. The aim of this study was to eluc
View details →Failed Experiment ReportOpen accessMedical physics. Medical radiology. Nuclear medicine
Ma Li, Men Yu, Feng Lingling et al. · 2019 · Radiology and Oncology
The mainstay therapy for locally advanced non-small cell lung cancer is concurrent chemoradiotherapy. Loco-regional recurrence constitutes the predominant failure patterns. Previous studies confirmed the relationship between increased biological equivalent doses and improved overall survival. However, the large randomized phase III study, RTOG 0617, failed to demonstrate the benefit of dose-escalation to 74 Gy compared with 60 Gy by simply increasing fraction numbers.
View details →Failed Experiment ReportOpen accessMedicine
Wallon S, Williamsson C, Karlsson V et al. · 2026 · Trials
Background Routine use of surgical drains after abdominal operations has largely been abandoned over the past decades. Studies have failed to demonstrate benefits of routine drainage following liver, gallbladder, gastric, and colorectal…
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Diel A, Lewis M · 2023 · Preprint
The uncanny valley describes the negative evaluation of near humanlike artificial entities. Previous research with synthetic and real voices failed to find an uncanny valley of voices. This may have been due to the selection of stimuli. In…
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Gauthier PT, Mackova M, Hirji A et al. · 2023 · American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
In lung transplantation, antibody-mediated rejection (AMR) diagnosed using the International Society for Heart and Lung Transplantation criteria is uncommon compared with other organs, and previous studies failed to find molecular AMR…
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Zeidan AM, Aakko S, Stahl M et al. · 2026 · Expert review of anticancer therapy
Introduction Higher-risk myelodysplastic syndromes (HR-MDS) remain an area of high unmet need in which multiple randomized late-stage trials have failed to improve outcomes beyond hypomethylating agent monotherapy, despite encouraging…
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Olluri A · 2025 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Experimental drugs lowering brain tau are heralded as improvements in the treatment of Alzheimer's disease. However, the outcomes in clinical trials testing these agents have consistently failed to improve patient outcomes, i.e. slow down…
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Barakzie A, Jansen AJG, Cavalcante F et al. · 2025 · Journal of thrombosis and haemostasis : JTH
Background Intravenous thrombolysis (IVT) using recombinant tissue plasminogen activator prior to endovascular thrombectomy treatment (EVT) failed to improve treatment effect in acute ischemic stroke (AIS) patients compared with EVT alone.…
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Li H, Man X, Cai T · 2024 · Journal of environmental management
Despite decades of recovery, soil carbon in heavily burned areas has failed to reach pre-fire levels. It is unclear whether stand management practices can promote soil organic carbon accumulation at such sites. This study evaluated the…
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Turner D, DeMaet MA, Bundage D et al. · 2026 · American journal of infection control
During an 87-week interrupted time series, we evaluated screening positivity after de-escalating dedicated cohort units for Candida auris and later implementing enhanced nursing engagement. Discontinuing cohort units did not increase…
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Kanazawa R, Goto R, Harada T et al. · 2024 · Scandinavian journal of immunology
Graft-infiltrating lymphocytes (GILs) play an important role in promoting rejection after organ transplantation. We recently reported that GILs that accumulated up to 3 days post-transplantation did not promote rejection, whereas GILs…
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Lindsay JO, Hind D, Swaby L et al. · 2024 · The lancet. Gastroenterology & hepatology
Background A previous controlled trial of autologous haematopoietic stem-cell transplantation (HSCT) in patients with refractory Crohn's disease did not meet its primary endpoint and reported high toxicity. We aimed to assess the safety…
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Guinard P, Pécaut J, Le-Goff A et al. · 2026 · Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
In order to mitigate superoxide-induced damage, cells rely on superoxide dismutases (SODs), a family of metalloenzymes that catalyze the dismutation of superoxide. These enzymes display a positively-charged substrate entrance channel for…
View details →Failed Experiment ReportOpen accessEconomics, Econometrics and Finance
Aleksandar Mijatović, Mikhail Urusov · 2011 · arXiv
Modelling stock prices via jump processes is common in financial markets. In practice, to hedge a contingent claim one typically uses the so-called delta-hedging strategy. This strategy stems from the Black--Merton--Scholes model where it perfectly replicates contingent claims. From the theoretical viewpoint, there is no reason for this to hold in models with jumps. However in practice the delta-hedging strategy is widely used and its potential shortcoming in models with jumps is disregarded since such models are typically incomplete and hence most contingent claims are non-attainable. In this
View details →Failed Experiment ReportOpen accessComputer Science
Tilman Plehn, Michael Spannowsky, Michihisa Takeuchi · 2011 · arXiv
In time for the first tests on LHC data we introduce a set of improvements and tests of purely kinematic top tagging algorithms. First, we show how different jet algorithms can be used for different transverse momentum regimes. Combining pruning and filtering in the reconstruction can enhance the signal over background ratio significantly, while larger jet radii only give minor improvements. Finally, bottom tagging can be added to the top tagger, but at least for the HEPTopTagger does not improve the kinematic selection algorithm.
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