Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Joanna Hajduk, Cyrill Brunner, Sebastian Malik et al. · 2020 · mAbs
Minor changes in the quality of biologically manufactured monoclonal antibodies (mAbs) can affect their bioactivity and efficacy. One of the most important variations concerns the N-glycosylation pattern, which directly affects an anti-tumor mechanism called antibody-dependent cell-meditated cytotoxicity (ADCC). Thus, careful engineering of mAbs is expected to enhance both protein-receptor binding and ADCC. The specific aim of this study is to evaluate the influence of terminal carbohydrates within the Fc region on the interaction with the FcγRIIIa/CD16a receptor in native and label-free condi
View details →Negative / Null Result ReportOpen accessMedicine (General)
Sepide Ghasemian, Zahra Hojjati Zidashti · 2018 · Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum
Background and Objectives: Iron can play an important role in exercise performance of women. The purpose of the present research was to determine the effects of combined exercise training and Feroglobin supplementation on serum iron and lipid profile in Women with iron deficiency anemia. Methods: In this study, 36 trained females with iron deficiency anemia (mean age, 26.8±6.3 years and body mass index, 19.55±4.4kg/m2) of Lahijan city, were selected as subjects and randomly divided into three groups of supplement+combined training, placebo+combined training, and control. Iron lev
View details →Negative / Null Result ReportOpen accessAgriculture (General)
Eleftheria Bempelou, Kyriaki Varikou, Antonios Nikolakakis et al. · 2026 · Agriculture
In Greece, the protection of olive orchards against the olive fruit fly ( Bactrocera oleae ), the most serious pest of olive fruits, is implemented through a national control program. This program is implemented by the Ministry of Rural Development and Food in co-operation with various public and private organizations. A new approach followed for this goal is the use of insecticide spray solutions combined with trophic attractant to attract and kill the olive fruit fly. In the present study, a method for the determination of the major insecticides, lambda-cyhalothrin and Spinosad, in their spr
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Wang J, Lu S, Zhang C et al. · 2025 · Drug Design, Development and Therapy
Jinglong Wang, Shijia Lu, Chenxiao Zhang, Junjie Wang, Huiru Wu, Guofei Li Department of Pharmacy, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People’s Republic of ChinaCorrespondence: Guofei Li, Department of Pharmacy, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Shenyang, 110004, People’s Republic of China, Tel/Fax +86-24-23925108, Email sylgf2009@163.comPropose: The co-treatment of ulcerative colitis with berberine hydrochloride (BBR), the Janus kinase(JAK) inhibitor Tofacitinib (TOFA), and Fligotinib (FIGA) is feasible and sophisti
View details →Negative / Null Result ReportOpen accessPhysiology
Lin Chang, Silin Fu, Jianghua Li et al. · 2022 · Frontiers in Physiology
Background: Knee injury is common in half-marathon runners, however, the effect of compression running pants on fatigue and knee proprioception remains unclear.Objectives: The study aims to investigate whether wearing compression running pants (CRP) and treadmill running stages affect knee proprioception and fatigue-related physiological responses during half-marathon running.Methods: Eighteen half-marathon runners completed two self-paced 21 km treadmill running trials, once wearing CRP and once wearing loose running shorts (LRS). For each 21 km run, RPE, heart rate, blood lactic acid, and kn
View details →Negative / Null Result ReportOpen accessMedicine
Galiya Iskakova, Bauyrzhan Iztayev, Auyelbek Iztayev et al. · 2025 · Scientific Reports
Abstract The quality of food products and a balanced diet play a key role in maintaining health and improving the quality of life. Due to the high popularity of pasta, a promising direction is the development of recipes that include whole grain flour, carrot powder and ion-ozonated water, which increase the nutritional value of the product and improve its chemical composition. The aim of this study was to optimise the technological modes of production of durum wheat pasta using carrot powder and ion-ozonated water to minimise the loss of dry matter (DM) during cooking and increase the protein
View details →Negative / Null Result ReportOpen accessBibliography. Library science. Information resources
WANG Weizheng, QIAO Hong, LI Xiaojun, WANG Jingjing · 2024 · Nongye tushu qingbao xuebao
[Purpose/Significance] Generative artificial intelligence (AI) technology has been widely used in many fields, and the application of this technology has become popular among researchers. However, there are few studies on the willingness of researchers willingness to accept generative AI. This leads to an insufficient understanding of the psychological mechanism, cognitive process and behavioral pattern of users' acceptance of generative AI, which limits the ability of theoretical innovation and practical exploration in user information behavior. This study focuses on researchers acceptance of
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Michael P Thompson, Ilana Graetz, Naleef Fareed et al. · 2017 · Circulation: Cardiovascular Quality and Outcomes
Objective: With the goal of improving healthcare quality, Medicare has implemented a series of pay-for-performance initiatives and allocated substantial financial resources to promote meaningful use of electronic health records (EHRs). The…
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Sally Caine, Mariam Alaverdashvili, Frederick Colbourne et al. · 2024 · PLOS ONE
Malnutrition after stroke may lessen the beneficial effects of rehabilitation on motor recovery through influences on both brain and skeletal muscle. Enriched rehabilitation (ER), a combination of environmental enrichment and forelimb…
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Abigail Silva, Arielle Guzman, Charlotte Picard et al. · 2020 · Cancer Epidemiology, Biomarkers & Prevention
Abstract Background: Through its various provisions, the Patient Protection and Affordable Care Act (ACA) has the potential to increase access to cancer care, particularly among the most vulnerable, and reduce disparities in cancer care…
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Siobhan Dickinson, Maryam Naghsh‐Nejad, Kees Van Gool et al. · 2026 · Australian Economic Review
ABSTRACT Research Question/Issue This study examines the impact of the Chronic Disease Dental Scheme (CDDS), introduced in 2007 to provide subsidised dental care for people with chronic conditions. Specifically, it asks whether the CDDS…
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Hugh Adler, Kwong Tsang, Michael Abouyannis et al. · 2024 · Journal of Healthcare Simulation
Introduction: The Centre for Snakebite Research & Interventions at the Liverpool School of Tropical Medicine (LSTM) houses >150 venomous snakes. This includes the black mamba (Dendroaspis polylepis) which can cause life-threatening…
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K Hirono, K Tsuboi, H Nakaoka et al. · 2025 · European Heart Journal
Abstract Background Dilated cardiomyopathy (DCM) is a progressive myocardial disorder with significant morbidity in children. Although pathogenic gene variants are detected in approximately 30–40% of DCM cases, the impact of sarcomere gene…
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Yanbin Shen, Sung Woo Kim, Hans H. Stein et al. · 2025 · Frontiers in Animal Science
Three experiments evaluated the effects of a novel milk ingredient blend (FXP) in phase 1 and 2 nursery pig diets on growth performance, diarrhea score, and survival. In Experiment 1, pigs were fed a 3-phase nursery regimen, with phases 1,…
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Hadi Praseno, Kumara Adji Kusuma, Rifdah Abadiyah et al. · 2024 · Academia Open
This study examines the productivity differences between disabled and non-disabled workers at PT. United Pharmatic Indonesia. Using a quantitative approach, data were collected from 120 employees in the production department through…
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Nativ Henkin, Ifat Karilker, Sergio L. Kobal et al. · 2023 · Journal of Clinical Medicine
Echocardiographic stress tests are often used to evaluate patients who complain of chest pain. However, some patients fail to reach the target heart rate required for the test to be conclusive (usually defined as 85% of the predicted…
View details →Negative / Null Result ReportOpen accessComputer Science
Anatoly A. Krasnovsky · 2025 · arXiv
While distributed tracing and chaos engineering are becoming standard for microservices, resilience models remain largely manual and bespoke. We revisit a trace-discovered connectivity model that derives a service dependency graph from traces and uses Monte Carlo simulation to estimate endpoint availability under fail-stop service failures. Compared to earlier work, we (i) derive the graph directly from raw OpenTelemetry traces, (ii) attach endpoint-specific success predicates, and (iii) add a simple asynchronous semantics that treats Kafka edges as non-blocking for immediate HTTP success. We
View details →Negative / Null Result ReportOpen accessComputer Science
Jun Ye · 2026 · arXiv
Decoherence in superconducting qubits arises from both multilevel dynamics and structured environmental noise, yet perturbative models cannot capture all resulting signatures. Here, EmuPlat couples instruction-set-architecture-level waveform generation to the hierarchical equations of motion HEOM under $1/f$ non-Markovian pure dephasing. In the resulting non-perturbative regime -- where filter-function predictions become quantitatively uninformative -- CPMG scaling of a three-level superconducting transmon yields one calibration result, two physical findings, and one structural null. Y-CPMG ex
View details →Negative / Null Result ReportOpen accessPhysics
A. T. Deller, J. P. W. Verbiest, S. J. Tingay et al. · 2008 · arXiv
Using the recently upgraded Long Baseline Array, we have measured the trigonometric parallax of PSR J0437-4715 to better than 1% precision, the most precise pulsar distance determination made to date. Comparing this VLBI distance measurement to the kinematic distance obtained from pulsar timing, which is calculated from the pulsar's proper motion and apparent rate of change of orbital period, gives a precise limit on the unmodeled relative acceleration between the Solar System and PSR J0437-4715, which can be used in a variety of applications. Firstly, it shows that Newton's gravitational cons
View details →Negative / Null Result ReportOpen accessPhysics
Hao Wei, Minzi Feng · 2019 · arXiv
LIGO/Virgo S190814bv is the first high-probability neutron star - black hole (NSBH) merger candidate, whose gravitational waves (GWs) triggered LIGO/Virgo detectors at 21:10:39.012957 UT, 14 August 2019. It has a probability $>99\%$ of being an NSBH merger, with a low false alarm rate (FAR) of 1 per 1.559e+25 years. For an NSBH merger, electromagnetic counterparts (especially short gamma-ray bursts (GRBs)) are generally expected. However, no electromagnetic counterpart has been found in the extensive follow-up observing campaign. In the present work, we propose a novel explanation to this null
View details →Negative / Null Result ReportOpen accessComputer Science
Chris Kouvaris, Niklas Grønlund Nielsen · 2015 · arXiv
We study the effect of gravitational focusing of the earth on dark matter. We find that the effect can produce a detectable diurnal modulation in the dark matter signal for part of the parameter space which for high dark matter masses is larger than the diurnal modulation induced by the fluctuations in the flux of dark matter particles due to the rotation of the earth around its own axis. The two sources of diurnal modulation have different phases and can be distinguished from each other. We demonstrate that the diurnal modulation can potentially check the self-consistency of experiments that
View details →Negative / Null Result ReportOpen accessComputer Science
Chuan-Ren Chen, Yu-Xiang Lin, Van Que Tran et al. · 2018 · arXiv
Pair production of Higgs boson at the Large Hadron Collider (LHC) is known to be important for the determination of Higgs boson self-coupling and the probe of new physics beyond the Standard Model (SM), especially the existence of new fundamental scalar boson. In this paper we study in detail the Higgs pair production at the LHC in a well-motivated model, the Gauged Two Higgs Doublet Model (G2HDM) in which the two Higgs doublets are properly embedded into a gauged $SU(2)_H$ and a dark matter candidate emerges naturally due to the gauge symmetry. Besides the deviations of Higgs couplings from t
View details →Negative / Null Result ReportOpen accessComputer Science
Vedant Pandya · 2026 · arXiv
JEPA-family world models use a static predictor whose weights do not adapt when test-time dynamics diverge from training. We compare two mechanisms for incorporating accumulated experience into a JEPA predictor under distribution shift: operand-side injection, where a compressed experience representation is added as a residual to the predictor's hidden state (EI-JEPA), and operator-side modulation, where the same representation generates low-rank weight deltas via LoRA applied to the predictor's weights (EPM-JEPA). On a pre-registered comparison (Moving MNIST, gravity shift), EPM-JEPA (D_shift
View details →Negative / Null Result ReportOpen accessPhysics
Björn Ahlgren, Josefin Larsson · 2020 · arXiv
Macrolensing of gamma-ray bursts (GRBs) is expected to manifest as a GRB recurring with the same light curve and spectrum as a previous one, but with a different flux and a slightly offset position. Identifying such lensed GRBs may give important information about the lenses, cosmology, as well as the GRBs themselves. Here we present a search for lensed GRBs among $\sim 2700$ GRBs observed by the Fermi Gamma-ray Burst Monitor (GBM) during 11 years of operations. To identify lensed GRBs, we perform initial cuts on position, time-averaged spectral properties and relative duration. We then use th
View details →Negative / Null Result ReportOpen accessPhysics
N. Kains, D. M. Bramich, K. C. Sahu et al. · 2016 · arXiv
We discuss the potential of the gravitational microlensing method as a unique tool to detect unambiguous signals caused by intermediate-mass black holes in globular clusters. We select clusters near the line of sight to the Galactic Bulge and the Small Magellanic Cloud, estimate the density of background stars for each of them, and carry out simulations in order to estimate the probabilities of detecting the astrometric signatures caused by black hole lensing. We find that for several clusters, the probability of detecting such an event is significant with available archival data from the Hubb
View details →Negative / Null Result ReportOpen accessComputer Science
O. J. E. Maroney · 2012 · arXiv
Quantum pre- and post-selection (PPS) paradoxes occur when counterfactual inferences are made about different measurements that might have been performed, between two measurements that are actually performed. The 3 box paradox is the paradigm example of such a paradox, where a ball is placed in one of three boxes and it is inferred that it would have been found, with certainty, both in box 1 and in box 2 had either box been opened on their own. Precisely what is at stake in PPS paradoxes has been unclear, and classical models have been suggested which are supposed to mimic the essential featur
View details →Negative / Null Result ReportOpen accessPhysics
Eli Visbal, Rupert A. C. Croft · 2007 · arXiv
The UV radiation from a quasar leaves a characteristic pattern in the distribution of ionized hydrogen throughout the surrounding space. This pattern or light echo propagates through the intergalactic medium at the speed of light, and can be observed by its imprint on the Ly-alpha forest spectra of background sources. As the echo persists after the quasar has switched off, it offers the possibility of searching for dead quasars, and constraining their luminosities and lifetimes. We outline a technique to search for and characterize these light echoes. To test the method, we create artificial L
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Mathias Mesfin · 2026 · arXiv
This paper tests whether intraday momentum signals derived from open-high-low-close-volume (OHLCV) data produce a statistically significant trading edge in Micro E-mini Nasdaq 100 futures (MNQ) under realistic execution constraints. Using 947 trading days of five-minute data (2021-2025), fourteen signal families are evaluated, including opening range breakouts, gap strategies, volume signals, cross-session momentum, liquidity grabs, volatility-conditioned classifiers, and news-driven strategies. All signals are assessed using strict institutional criteria: out-of-sample walk-forward validation
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Rasmus Ingemann Tuffveson Jensen, Joras Ferwerda, Christian Remi Wewer · 2023 · arXiv
Objectives: To combat money laundering, banks raise and review alerts on transactions that exceed confidential thresholds. However, the thresholds may be leaked to criminals, allowing them to break up large transactions into amounts under the thresholds. This paper introduces a data-driven approach to detect the phenomenon, popularly known as smurfing. Methods: Our approach compares an observed transaction distribution to a counterfactual distribution estimated using a high-degree polynomial. We investigate the approach with simulation experiments and real transaction data from a systemically
View details →Negative / Null Result ReportOpen accessComputer Science
Shasvath J. Kapadia, Daniel Kennefick, Kostas Glampedakis · 2013 · arXiv
This paper examines the possibility of floating or non-decaying orbits for extreme mass ratio binary black holes. In the adiabatic approximation, valid in the extreme mass ratio case, if the orbital flux lost due to gravitational radiation reaction is compensated for by the orbital flux gained from the spins of the black holes via superradiant scattering (or, equivalently, tidal acceleration) the orbital decay would be stalled, causing the binary to "float". We show that this flux balance is not, in practice, possible for extreme mass ratio binary black holes with circular equatorial orbits; f
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